CEMIR has also attracted collaborators from universities around the world:
Egil Liens' research emphasises on cellular activation by microbes and microbial compounds via Toll-like receptors (TLRs), CD14, inflammasomes and related molecules. Investigations of mechanisms of adjuvant activity. TLRs and NLRs in sterile inflammation. Hecompleted his PhD in the Espevik lab and is currently Associate professor at the University of Massachusetts, Dept. of Medicine, Section for Infectious Diseases, and a prof. II at NTNU. Dr. Lien is highly productive and is now among the most recognized and respected scientist in the TLR/bacterial immune evasion field with a large active network of collaborators. He has in depth knowledge of several inflammatory disease models in TLR and inflammasome transgenic animals (one study is published in Nature Immunology). Lien has recently started to work on a new member in the inflammasome family, NLRP12
Kate Fitzgerald PhD
Professor at the University of Massachusetts, USA. She has published many breakthroughs describing the molecular details on the TLR responses that involve production of type I interferon and on inflammasomes. Research interests: innate immune signaling following recognition of microbial pathogens. Pathways for induction of type I IFN by viruses and bacteria. TLR signaling. Mechanisms for inflammsome activation by NLRs and ALRs (Aim2-like receptors).
Eicke Latz MDPhD
Professor and Director of the Institute of Innate Immunity, University of Bonn, Germany. Dr Latz is an exceptionally talented researcher and has in depth knowledge in imaging techniques such as: FRET, FLIM and photo-activatable probes related to PRR studies. He has 13 joint publications with the Espevik group (published in NatImmunol, Immunity, Nature) and he is a co-investigator on an ERC advanced grant application submitted by Espevik, March 2011. His research focus is to decipher the molecular mechanisms involved in immune receptor activation.
Tom Eirik Mollnes MDPhD
Professor of Immunology, University of Oslo and University of Tromsø. Dr. Mollnes is among the world leading experts in the field of complement activation and interaction between complement system and PRR responses He is an active collaborator with the Espevik group that has resulted in several important joint publications. Research interests: Complement research with focus on establishing new methods to detect complement activation and application of these in basic and clinical research.
Professor and director of the Centre of Cancer Biomedicine, UiO, and prof II at NTNU. Stenmark is a world-class expert in the field of intracellular sorting and trafficking mechanism and has been a collaborator and co-author on papers from the Espevik group published in EMBO J and Immunity. He is also collaborating with the Bjørkøy group on autophagy mechanisms. Research focus: basic cell biological research on endocytosis, autophagy, cytokinesis and tumour suppressors.
David Underhill PhD
has championed the role of phagocytes in immunity and the role of phagocytosis in signal transduction, first in the lab of Alan Aderem and now as Associate professor at the Imunobiology Research Institute, Cedars-Sinai Medical Center, LA. His work on TLR2 and Dectin-1 is published in highranking journals (Nature, JExpMed).
Research focus: For over a decade my laboratory has studied basic mechanisms of innate immunity. We have been particularly focused on the role of phagocytosis in macrophages and dendritic cells in modulating inflammatory signaling. We have made important contributions to defining Toll-like receptor ligands, characterizing Toll-like receptor signaling pathways, characterizing C-type lectin signaling pathways and in defining the role of microbial degradation in triggering innate immune responses including inflammasome activation. With our move to Cedars-Sinai in 2005, we have been focusing these interests on the role of these innate immune signaling pathways in inflammatory bowel disease.