Eventhough DNA is the carrier molecule of genetic information it is surprisingly unstable. Both internal cellular processes and external factors continiously damage DNA. The lesions caused are both mutagenic and potentially lethal to cells if left unrepaired. The human proteome contains more than 150 known repair proteins involved in a several DNA-repair mechanisms. Defects in these mechanism can cause developmend disorders, defects in the immune system, cancer and premature ageing.
Goals and Perspectives
The DNA repair research group focuses it's research mainly on how the DNA-repair strategies work, how dysfunctions may cause cancer, and how some of the DNA-repair proteins are involved in the adaptive immune system.
While having contributed to the understanding of several of the known DNA-repair strategies, the group focuses on repair of damaged bases.
- Uracil in DNA
- Example: "APIM a small peptide with huge cancer treatment potential!" Read more..
- Example: "What about RNA repair?" Read more..
- Example: "In silico biology: or how our group stopped worrying about and love huge databases"
The research group coaches currently 12 research fellows and 7 Post docs. The research group has since 1992 resulted in 13 candidates to PhD. Some of these have taken Ph.D. or Dr.scient. and therefore formally been credited to other faculties at the University of Oslo. The Research Group has guided more than 30 candidates to cand.scient., Siv.ing. or master's degree.