Background and activities
Prof. Duan Chen (MD, PhD) is Principal Investigator of Research Group of Experimental Surgery and Pharmacology at the Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU. He graduated from the University of Lund, Sweden and is a full professor at NTNU. Currently, he is leader of Unit for Molecular Biology at the department, chairman of Gastrointestinal Section of International Union of Basic and Clinical Pharmacology (IUPHAR), and work-package leader in the European FP7 project entitled “Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health”. He was member of International Advisory Group on Carcinogenic Hazard Identification of IARC.
Please see the links below for more details about his research
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2016) A Potential New Regimen (“Tricyclie”) for Treatment of Gastric Cancer: Targeting Glutamine-Dependent Wnt/β-Catenin-mTOR Signaling. Gastroenterology. vol. 150 (4).
- (2016) Intragastric Injection of Botulinum Toxin a to Treat Obesity: Mechanism of Action and a Randomized, Double-Blind, Placebo-Controlled Phase II Trial With Open-Label Extension Study. Gastroenterology. vol. 150 (4).
- (2016) PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery. Cell reports. vol. 15 (5).
- (2016) Roux-En-Y Gastric Bypass Surgery Restores Impaired Islet Architecture and Function in Type-2 Diabetes by Elevation of Plasma PYY. Gastroenterology. vol. 150 (4).
- (2015) 565Glutamine Metabolism As a Therapeutic Target for Gastric Cancer: Effects of Vagotomy Gastroenterology,Volume 148, Issue 4, Supplement 1, April 2015, Pages S-565–S-566. Gastroenterology. vol. 148 (4).
- (2015) Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjectshypergastrinaemia in healthy subjects. British Journal of Clinical Pharmacology. vol. 79 (5).
- (2015) NGF Promotes Gastrointestinal Cancer Development Through Tumor-Associated Neurogenesis. Gastroenterology. vol. 148 (4).
- (2015) CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. Gut. vol. 64 (4).
- (2015) Comparison of different surgical procedures in animal models for a better consideration of personalized bariatric surgery. Gastroenterology. vol. 148 (4).
- (2014) Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. Nutrition and Diabetes. vol. 4 (JUNE).
- (2014) Preclinical Trial of Gastric Injection of Botulinum Toxin Type A as Weight-Loss-Surgery. Gastroenterology. vol. 146 (5).
- (2014) Acetic acid induces cell death: An in vitro study using normal rat gastric mucosal cell line and rat and human gastric cancer and mesothelioma cell lines. Journal of Gastroenterology and Hepatology. vol. 29 (S4).
- (2014) The role of red and processed meat in colorectal cancer development: a perspective. Meat Science. vol. 97 (4).
- (2014) Denervation suppresses gastric tumorigenesis. Science Translational Medicine. vol. 6 (250).
- (2014) Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors. Regulatory Peptides. vol. 192-193.
- (2014) Triple Roles of Autophagy in Cytoprotection, Cell Death and Tumorigenesis With Special Reference to Gastric ECL Cells. Gastroenterology. vol. 146 (5).
- (2014) Reduced neurons in the ileum of proctocolectomized rat models. Medical Molecular Morphology. vol. 48 (3).
- (2014) Preclinical Trial of Botulinum Toxin Type a Injection in the Treatment of Gastric Cancer. Gastroenterology. vol. 146 (5).
- (2014) Naturally occurring phenethyl isothiocyanate-induced inhibition of gastric cancer cell growth by disruption of microtubules. Journal of Gastroenterology and Hepatology. vol. 29 (4).
- (2014) Plant phytochemicals: Potential anticancer agents against gastric cancer. Current opinion in pharmacology (Print). vol. 19.