Background and activities

Physiologist and molecular biologist working on the intracellular mechanisms responsible for the benefits of exercise training in chronic diseases, such as heart failure, muscle diseases and obesity. Jose's long-term goal is to develop innovative drug therapies based on the molecular mechanisms activated by exercise.

Jose Bianco Moreira has extensive experience in physiology, with focus in cardiovascular physiology. He has been working over the past years on the intracellular effects of exercise training in skeletal and cardiac muscles of experimental animals and humans. Jose holds a M.Sc. in Exercise Physiology from the University of Sao Paulo (Brazil) and a PhD in Molecular Medicine from NTNU, Norway (Department of Circulation and Medical Imaging, KG Jebsen Center of Exercise in Medicine).

Jose coordinates an ambitious project aiming to develop heart-specific gene therapies to induce the benefits of exercise artificially. The project is funded by the Norwegian Health Association (Nasjonalforeningen for Folkehelsen) and supervised by Professor Ulrik Wisløff. If you wish to support/donate to Nasjonalforeningen for Folkehelsen, please click HERE.

Jose is also the manager of an international collaboration between Norway (NTNU) and Brazil (University of Sao Paulo) in research and education on exercise physiology (link: UTFORSK project). The goal of this initiative is to promote exchange of students and researchers for participation in courses and research activity. The project is funded by the Norwegian Centre for International Cooperation in Education and the Research Council of Norway.


Scientific production (all peer-reviwed articles). Click HERE for Pubmed records.
  • Moreira JB, Wohlwend M, Åmellem I, Jannig PR. Age-dependent effects of bed rest in human skeletal muscle: exercise to the rescue. The Journal of Physiology. Jan 15;594(2):265-6. doi: 10.1113/JP271758. LINK TO THE ARTICLE
  • Reis FC, Haro AS, Bacurau AV, Hirabara SM, Wasinski F, Ormanji MS, Moreira JB, Kiyomoto BH, Bertoncini CR, Brum PC, Curi R, Bader M, Bacurau RF, Pesquero JB, Araújo RC. Deletion of Kinin B2 Receptor Alters Muscle Metabolism and Exercise Performance. Plos One. PLoS One. 2015 Aug 24;10(8):e0134844. LINK TO THE ARTICLE.
  • Kraljevic J, Høydal MA, Ljubkovic M, Moreira JB, Jørgensen K, Ness HO, Bækkerud FH, Dujic Z, Wisløff U, Marinovic J.Role of KATP Channels in Beneficial Effects of Exercise in Ischemic Heart Failure. Med Sci Sports Exerc. 2015 Jun 8. LINK TO THE ARTICLE....
  • Moreira JB, Wohlwend M, Alves MN, Wisløff U, Bye A. A small molecule activator of AKT does not reduce ischemic injury of the heart. Journal of Translational Medicine. 2015 Mar 1; 13:72 . LINK TO THE ARTICLE.
  • Slagsvold KH*, Moreira JB*, Øivind Rognmo, Morten Høydal, Anja Bye, Ulrik Wisløff, Alexander Wahba. Remote Ischemic Preconditioning Preserves Mitochondrial Function and Activates Pro-survival Protein kinase Akt in the Left Ventricle During Cardiac Surgery. Int J Cardiol. 2014 Dec 15;177(2):409-17.  LINK TO THE ARTICLE.    *SHARED FIRST AUTHORSHIP
  • Bechara LR, Moreira JB, Jannig PR, Voltarelli VA, Dourado PM, Vasconcelos AR, Scavone C, Ramires PR, Brum PC. NADPH oxidase hyperactivity induces skeletal muscle atrophy in heart failure rats. Int J Cardiol. 2014 Aug 20;175(3):499-507.LINK TO THE ARTICLE
  • Moreira JB, Bechara LR, Bozi LH, Jannig PR, Monteiro AW, Dourado PM, Wisloff U, Brum PC. High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats. J Appl Physiol. 2013 Feb 21. > LINK TO THE ARTICLE
  • Brum PC, Bacurau AV, Cunha TF, Bechara LR, Moreira JB. Skeletal Myopathy in Heart Failure: Effects of Aerobic Exercise Training. Exp Physiol. 2013 Nov 22. > LINK TO THE ARTICLE
  • Jannig PR, Moreira JB, Bechara LR, Bozi LH, Bacurau AV, Monteiro AW, Dourado PM, Wisløff U, Brum PC. Autophagy signaling in skeletal muscle of infarcted rats. PLoS One. 2014 Jan 10;9(1):e85820. LINK TO THE ARTICLE
  • Cunha TF, Moreira JB, Paixão NA, Campos JC, Monteiro AW, Bacurau AV, Bueno CR Jr, Ferreira JC, Brum PC. Aerobic exercise training upregulates skeletal muscle calpain and ubiquitin-proteasome systems in healthy mice. J Appl Physiol. 2012 Jun;112(11):1839-46. > LINK TO THE ARTICLE
  • Cunha TF, Bacurau AV, Moreira JB, Paixão NA, Campos JC, Ferreira JC, Leal ML, Negrão CE, Moriscot AS, Wisløff U, Brum PC. Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure. PLoS One. 2012;7(8):e41701. > LINK TO THE ARTICLE
  • Ferreira JC, Moreira JB, Campos JC, Pereira MG, Mattos KC, Coelho MA, Brum PC. Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure. Life Sci. 2011 Mar 28;88(13-14):578-85. > LINK TO THE ARTICLE
  • Bozi LH, Maldonado IR, Baldo MP, Silva MF, Moreira JB, Novaes RD, Ramos RM, Mill JG, Brum PC, Felix LB, Gomes TN, Natali AJ. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats. Clinics. 2013 Apr;68(4):549-56. > LINK TO THE ARTICLE
Other projects:
  • Member in the OptimEx project: a large translational study aiming to develop Optimized Exercise regimens for patients with heart failure and preserved ejection fraction (HFPEF). The project is coordinated by CERG and has several international collaborators. The project is funded by the European Comission. For further information: