Kristine Misund

Research Scientist Department of Clinical and Molecular Medicine
+47 72825286
Prinsesse Kristinas gate 1, Gastro * * Gastro *

Background and activities

Research Scientist at Centre of Myeloma Research the Department of Cancer Research and Molecular Medicine.

Multiple myeloma is a type of cancer that begins in plasma cells, which are the antibody-producing cells of the immune system. A characteristic for multiple myeloma is that the malignant plasma cells, except during the very last stages of the disease, are found within the bone marrow. It is generally believed that growth and survival of myeloma cells is critically dependent on the bone marrow microenvironment. My main focus is to examine the interplay between the bone marrow microenvironment and the myeloma cells. I perform drug sensitivity testing of myeloma cells, and do these experiments in co-cultures, where myeloma cells are cultured together with bone marrow stromal cells, in an attempt to mimicking aspect of the bone marrow microenvironment. We study the interaction between myeloma cells and stromal cells, and look at mechanism involved in the stroma-protective effect on myeloma cell viability and in their resistance to some common drugs.

I am also involved in the “Personalized cancer medicine” project at the Norwegian Cancer Genomics Consortium, for Multiple Myeloma. In this project we will perform whole exome sequencing on primary myeloma cells. One goal is to detect important driver mutations in individual myeloma patients, and hopefully these mutation profiles can be important for therapeutic decisions. More info about this project: http://cancergenomics.no/index.php?page=home

Scientific, academic and artistic work

A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database

Journal publications