Postal address

Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology Postboks 8905 7491 Trondheim Norway
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Magne Børset

Professor and Head of Department

Background and activities

 

Mini-CV

  • M.D. 1988
  • Ph.d. 1996
  • Adjunct professor in cell biology and hematological cancer
  • Specialist in clinical immunology and transfusion medicine
  • Consultant in Dept. of Immunology and Transfusion Medicine, St. Olavs Hospital

 

Research highlights of the multiple myeloma (MM) research group at NTNU, Trondheim

  • 1993: Description of a new separation method for MM cells based on antibodies against syndecan-1 (CD138).
  • 1994: Establishment of OH-2, an IL-6- and TNF-dependent MM cell line that has since been shown to be a unique hyperdiploid cell line without IgH translocations.
  • 1996: The first publication ever on NF-kappa-B activation in human MM cells

·        1996: First publications on expression of hepatocyte growth factor (HGF) and autocrine stimulation of the HGF receptor c-Met in MM cells.

·        1996: Elevation of HGF in serum from patients with MM compared to healthy controls

  • 1998: Serum HGF concentration is a prognostic factor for patients with MM and is reduced after response to treatment.
  • 1999: Description of a dual role of Fas in myeloma cells; induction of both apoptosis and proliferative responses.
  • 1999: HGF induces production of the osteoclast-stimulating cytokine IL-11 in osteoblastic cells.
  • 1999: First paper showing proliferation of myeloma cells induced by IL-15 and production of IL-15 mRNA in MM cells.
  • 1999: Establishment of a mouse model for MM showing depletion of osteoblasts from affected skeletal tissue.
  • 2000: First paper on prognostic impact of serum level of syndecan-1 in patients with MM
  • 2000: Polarization of syndecan-1 and heparin-binding molecules on the surface of MM cells
  • 2000: High levels of syndecan-1 in MM bone marrow modulate the activity of HGF.
  • 2000: First paper on expression of urokinase plasminogen activator (uPA) and the aPA receptor in MM cells.
  • 2001: Bone morphogenetic protein-4 (BMP-4) induces apoptosis in MM cells.
  • 2001: First paper showing reduced levels of osteoprotegerin (OPG) in serum from patients with MM
  • 2002: First paper on proliferative effect of IL-21 on MM cells.
  • 2002: Serum IGF-1 is not elevated in MM patients, but is still a prognostic factor
  • 2002: OPG is bound and internalized by MM cells.
  • 2004: BMP-5, -6 and -7 induce apoptosis in MM cells.
  • 2004: Osteopontin is an adhesive factor for MM cells and is increased in serum from patients with MM
  • 2005: An inhibitor of HGF receptor c-Met blocks autocrine growth of MM cells.
  • 2005: HGF induces adhesion of MM cells to fibronectin
  • 2006: First paper showing that toll-like receptors mediate proliferation of MM cells.
  • 2007: HGF inhibits BMP-induced osteoclastogensis.
  • 2008: Metastasis-associated phosphatase PRL-3 is expressed in malignant but not in healthy plasma cells.
  • 2008: HGF promotes migration of MM cells
  • 2008: Elevated serum levels of HGF activator in patients with MM
  • 2010: Myeloma cell line OH-2 is hyperdiploid and represents a subgroup of myeloma cases that are frequent but rarely give rise to cell lines.
  • 2011: The kinase SGK-1 is expressed in myeloma cells where it promotes cell growth.
  • 2012: BMPs induce apoptosis of myeloma cells by repressing MYC.
  • 2013: Anti-c-Met nanobodies as potetial myeloma drug.
  • 2013: Synergy between HGF, IGF-1 and SGK-1 in promoting myeloma cell growth.

Scientific, academic and artistic work

Displaying a selection of activities. See all publications in the database

Journal publications

  • Rø, Torstein Baade; Holien, Toril; Fagerli, Unn-Merete; Hov, Håkon; Misund, Kristine; Waage, Anders; Sundan, Anders; Holt, Randi Anny Utne; Børset, Magne. (2013) HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase. Experimental Hematology. volum 41 (7).
  • Slørdahl, Tobias Schmidt; Denayer, Tinneke; Moen, Siv Helen; Standal, Therese; Børset, Magne; Ververken, Cedric; Rø, Torstein Baade. (2013) Anti-c-MET Nanobody® – a new potential drug in multiple myeloma treatment. European Journal of Haematology. volum 91 (5).
  • Holien, Toril; Våtsveen, Thea Kristin; Hella, Hanne; Rampa, Christoph Samuel; Brede, Gaute; Grøseth, Lill Anny Gunnes; Rekvig, Magne; Børset, Magne; Standal, Therese; Waage, Anders; Sundan, Anders. (2012) Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC. Leukemia. volum 26.
  • Wader, Karin Fahl; Fagerli, Unn-Merete; Børset, Magne; Lydersen, Stian; Hov, Håkon; Sundan, Anders; Bofin, Anna M.; Waage, Anders. (2012) Immunohistochemical analysis of hepatocyte growth factor and c-Met in plasma cell disease. Histopathology. volum 60 (3).
  • Fagerli, Unn-Merete; Ullrich, K; Stühmer, Thorsten; Holien, Toril; Köchert, K; Holt, Randi Utne; Bruland, Ove; Chatterjee, Manik; Nogai, H; Lenz, G; Shaughnessy, JD; Mathas, Stephan; Sundan, Anders; Bargou, Ralf C.; Dörken, Bernd; Børset, Magne; Janz, Martin. (2011) Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells. Oncogene. volum 30 (28).
  • Skliris, A; Happonen, KE; Terpos, Evangelos; Labropoulou, V; Børset, Magne; Heinegård, Dick; Blom, AM; Theocharis, AD. (2011) Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: Implications for multiple myeloma. European Journal of Immunology. volum 41 (2).
  • Wader, Karin Fahl; Fagerli, Unn-Merete; Holt, Randi Utne; Børset, Magne; Sundan, Anders; Waage, Anders. (2011) Soluble c-Met in serum of patients with multiple myeloma: correlation with clinical parameters. European Journal of Haematology. volum 87 (5).
  • Vatsveen, TK; Våtsveen, Thea Kristin; Tian, Erming; Kresse, Stine H; Meza-Zepada, Leonardo; Meza, Leonardo Zepeda; Gabrea, Ana; Glebov, Oleg; Dai, Hong Yan; Sundan, Anders; Kuehl, WM; Kuehl, Michael; Borset, M; Børset, Magne. (2009) OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus. Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. volum 33 (12).
  • Våtsveen, Thea Kristin; Brenne, Anne-Tove; Dai, HY; Waage, Anders; Sundan, Anders; Børset, Magne. (2009) FGFR3 is expressed and is important for survival in INA-6, a human myeloma cell line without a t(4;14). European Journal of Haematology. volum 83 (5).
  • Fagerli, Unn-Merete; Holt, Randi Utne; Holien, Toril; Våtsveen, Thea Kristin; Zhan, FH; Egeberg, Kjartan Wøllo; Barlogie, B; Waage, Anders; Aarset, H; Dai, HY; Shaughnessy, JD; Sundan, Anders; Børset, Magne. (2008) Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. Blood. volum 111.
  • Holt, RU; Fagerli, UM; Ro, TB; Baykov, V; Waage, Anders; Sundan, Anders; Børset, Magne. (2007) HGF promotes migration of myeloma cells. Haematologica. volum 92.
  • Bohnhorst, Janne Øvrebø; Rasmussen, T; Moen, Siv H; Fløttum, Marianne; Knudsen, L; Børset, Magne; Espevik, Terje; Sundan, Anders. (2006) Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia. volum 20.
  • Standal, Therese; Abildgaard, Niels; Fagerli, Unn-merete; Størdal, Berit Fladvad; Hjertner, Øyvind; Børset, Magne; Sundan, Anders. (2006) HGF Inhibits BMP-Induced Osteoblastogenesis: Implications for the Bone Disease in Multiple Myeloma. Blood. volum 108.
  • Holt, Randi Utne; Baykov, Vadim; Rø, Torstein Baade; Brabrand, Sigmund; Waage, Anders; Sundan, Anders; Børset, Magne. (2005) Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor. Haematologica. volum 90 (4).
  • Holt, Randi Utne; Hjorth-Hansen, Henrik; Waage, Anders; Hjertner, ¯yvind; Sundan, Anders; Børset, Magne. (2004) Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells. Oncogene. volum 23 (17).
  • Hov, Håkon; Holt, Randi Utne; Rø, Torstein Baade; Fagerli, Unn-Merete; Hjort-Hansen, Henrik; Baykov, Vadim; Christensen, James G; Waage, Anders; Sundan, Anders; Børset, Magne. (2004) A Selective c-Met Inhibitor Blocks an Autocrine Hepatocyte Growth Factor Growth Loop in ANBL-6 Cells and Prevents Migration and Adhesion of Myeloma cells. Clinical Cancer Research. volum 10.
  • Brenne, Anne Tove; Rø, Torstein Baade; Waage, Anders; Sundan, Anders; Børset, Magne; Hjorth-Hansen, Henrik. (2002) Interleukin-21 is a growth and survival factor for human myeloma cells. Blood. volum 99.
  • Standal, Therese; Børset, Magne; Lenhoff, S.; Wisløff, Finn; Størdal, Berit Fladval; Sundan, Anders; Waage, Anders; Seidel, Carina. (2002) Serum insulin-like growth factor is not increased in patients with multiple myelomna but is still a prognostic factor. Blood. volum 100.
  • Feuerherm, Astrid; Børset, Magne; Seidel, Carina; Sundan, Anders; Leistad, Lilian; Østensen, Monica; Faxvaag, Arild. (2001) Elevated levels of osteoprotegerin (OPG) and hepatocyte growth factor (HGF) in rheumatoid arthritis. Scandinavian Journal of Rheumatology. volum 30 (4).
  • Hjertner, ¯yvind; Hjorth-Hansen, Henrik; Børset, Magne; Seidel, Carina; Waage, Anders; Sundan, Anders. (2001) Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells. Blood. volum 97 (2).
  • Seidel, Carina; Hjertner, ¯yvind; Abildgaard, Niels; Heikendorff, Lene; Hjorth, M.; Westin, Jan; Lanng Nielsen, Johan; Hjorth-Hansen, Henrik; Waage, Anders; Sundan, Anders; Børset, Magne. (2001) Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood. volum 98 (7).
  • Børset, Magne; Hjertner, ¯yvind; Yaccoby, Shmuel; Epstein, Joshua; Sanderson, Ralph D.. (2000) Syndecan-1 is targeted to the uropods of polarized myeloma cells where it promotes adhesion and sequesters heparing-binding proteins. Blood. volum 96.
  • Seidel, Carina; Børset, Magne; Hjertner, ¯yvind; Cao, Dianjun; Abildgaard, Niels; Hjorth-Hansen, Henrik; Sanderson, Ralph D; Waage, Anders; Sundan, Anders. (2000) High levels of soluble syndecan-1 in myeloma-derived bone marrow : modulation of hepatocyte growth factor activity. Blood. volum 96 (9).
  • Seidel, Carina; Sundan, Anders; Hjorth, Martin; Turesson, Ingemar; Dahl, Inger Marie S.; Abildgaard, Niels; Waage, Anders; Børset, Magne. (2000) Serum syndecan-1: a new independent prognostic marker in multiple myeloma. Blood. volum 95.
  • Børset, Magne; Hjort-Hansen, Henrik; Johnsen, Ann-Charlotte; Seidel, Carina; Waage, Anders; Espevik, Terje; Sundan, Anders. (1999) Apoptosis, proliferation and NF-k(kappa)B activation induced by agonistic Fas antibodies in the human myeloma cell line OH-2: amplification of Fas-mediated apoptosis by tumor necrosis factor. European Journal of Haematology. volum 63.
  • Hjertner, ¯yvind; Torgersen, Maria Lyngaas; Seidel, Carina; Hjort-Hansen, Henrik; Waage, Anders; Børset, Magne; Sundan, Anders. (1999) Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Sedretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease. Blood.
  • Hjort-Hansen, Henrik; Waage, Anders; Børset, M.. (1999) Interleukin-15 blocks apoptosis and induces proliferation of the human myeloma cell line OH-2 and freshly isolated myeloma cells. British Journal of Haematology.
  • Hjorth-Hansen, H.; Seifert, MF.; Børset, M.; Aarset, H.; Ostlie, A.; Sundan, A.; Waage, Anders. (1999) Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice. Journal of Bone and Mineral Research.
  • Seidel, C; Børset, M; Turesson, I; Abilgaard, N; Sundan, A.; Waage, Anders. (1998) Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group. Blood.
  • Børset, Magne; Hjorth-Hansen, Henrik; Seidel, Carina; Sundan, Anders; Waage, Anders. (1996) Hepatocyte growth factor and its receptor c-MET in multiple myeloma. Blood. volum 88 (10).
  • Børset, Magne; Lien, Egil; Espevik, Terje; Helseth, Eirik; Waage, Anders; Sundan, Anders. (1996) Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. Journal of Biological Chemistry. volum 271 (40).
  • Børset, Magne; Medvedev, Andrei E.; Sundan, Anders; Espevik, Terje. (1996) The role of the two TNF receptors in proliferation, NF-_KB activation and discrimination between TNF and LT_a signalling in the human myeloma cell line OH-2. Cytokine. volum 8 (6).