Postal address

Department of Circulation and Medical Imaging Norwegian University of Science and Technology Postboks 8905 7491 Trondheim Norway

Background and activities

Trained anesthesiologist and clinical pharmacologist. Worked at St.Olavs University Hospital/Medical Faculty since 1978. Four research sabbaticals abroad

See brief CV


 Publications 2008 – 2013 (About 120 publications listed in PubMed,)

I Original publications including international reviews
  • Bjelland TW, Klepstad P, Haugen BO, Nilsen T, Salvesen Ø, Dale O. Concentrations of remifentanil, propofol, fentanyl, and midazolam during rewarming from therapeutic hypothermia. Acta Anaesth Scand 2014; in press
  • Barratt DT, Bandak B, Klepstad P, Dale O, Kaasa S, Christrup LL, Tuke J, Somogyi AA. Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study. Pharmacegenet Genomics 2014 Jan 26 (E pub ahead of print)
  • Landmark T, Romundstad P, Dale O, Borchgrevink PC, Vatten Lars, Kaasa S. Chronic pain: One year prevalence and associated characteristics (the HUNT pain study). Scand J Pain (2013),
  • Husum B, Stenqvist O, Alahuhta S, Sigurdsson GH, Dale O. Current use of nitrous oxide in public hospitals in Scandinavian countries. Acta Anaesthesiol Scand. 2013:57;1131-7. E pub Jul 29. doi: 10.1111/aas.12165.
  • Landmark T, Romundstad PR, Borchgrevink PC, Kaasa S, Dale O. Longitudinal associations between exercise and pain in the general population--the HUNT pain study. PLoS One. 2013;12; 8:e65279. doi: 10.1371/journal.pone.0065279. Print 2013.
  • Fladvad T, Klepstad P, Langaas M, Dale O, Kaasa S, Caraceni A, Skorpen F.Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain. Pharmacogenet Genomics. 2013 Mar;23(3):117-26. doi: 10.1097/FPC.0b013e32835ce485.
  • Paulsen O, Aass N, Kaasa S, Dale O. Do Corticosteroids Provide Analgesic Effects in Cancer Patients? A Systematic Literature Review.J Pain Symptom Manage. 2013;46:96-105. doi: 10.1016/j.jpainsymman.2012.06.019. Epub 2012 Nov 11.
  • Bjelland TW, Klepstad P, Haugen BO, T. Nilsen, Dale O Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients Drug Disp Metab  2013 ;41:214-23. doi: 10.1124/dmd.112.045567. Epub 2012 Oct 31.
  • Dale O, Somogyi AA, LI y, Sullivan T, Shavit Y. Does intra-operative ketamine attenuate inflammatory reactivity following surgery? A systematic review and meta-analysis. Anesteh Analg 2012;115:934-43. Epub 2012 Jul 23.
  • Landmark T, Romundstad P, Dale O, Borchgrevink PC, Kaasa S. Estimating  the prevalence of  chronic pain : validation of of recall against longitudinell reporting (the HUNT pain study. Pain. 2012 ;153:1368-73. doi: 10.1016/j.pain.2012.02.004. Epub 2012 May 9.
  • Upton RN, Foster DJR, Christrup LL, Dale O, Moksnes K, Popper. A physiologically based recirculatory meta-model for nasal fentanyl in man. J Pharmacokin Pharmacodyn 2012; 39: DOI 10.1007/s10928-012-9268-y
  • Bjelland TW, Dale O, Kaisen K, Lydersen S, Strand K, Klepstad P. Propofol and remifentanil versus midazolam and fentanyl for sedation during hypothermia after cardiac arrest: a randomised trial. Intensive Care Med. 2012;38:959-67
  • Caraceni A, Hanks G, Kaasa S, Bennett MI, Brunelli C, Cherny N, Dale O, De Conno F, Fallon M, Hanna M, Haugen DF, Juhl G, King S, Klepstad P, Laugsand EA, Maltoni M, Mercadante S, Nabal M, Pigni A, Radbruch L, Reid C, Sjogren P, Stone PC, Tassinari D, Zeppetella G; European Palliative Care Research Collaborative (EPCRC); European Association for Palliative Care (EAPC).Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC.Lancet Oncol. 2012 Feb;13:58-68.
  • Moksnes K, Kaasa S, Paulsen Ø, Rosland JH, Spigset O, Dale O. Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. Eur J Clin Pharmacol 2012, 68;1147-56
  • Andreassen TN, Klepstad P, Davies A, Bjordal K, Lundström S,  Kaasa S,  Dale O. Is oxycodone efficacy reflected in serum concentrations? – A multicentre cross-sectional study in 456 adult cancer patients. J Pain Symptom Manage 2012;43:694-705.
  • Andreassen TN, Eftedal I, Klepstad P, Davies A, Bjordal K, Lundström S, Kaasa S, Dale O. Do the CYP2D6 genotypes reflect oxycodone requirements in cancer pain patients? A cross-sectional multicentre study. Eur J Clin Pharmacol 2012 ;68:55-64
  • Moksnes K ,Dale O,Rosland JH, Paulsen Ø, Klepstad P, Kaasa S . How to switch from morphine or oxycodone to methadone in cancer patients? A randomized clinical phase II trial. Eur J Oncol 2011;47:2463-70
  • Landmark T, Romundstad P, Borchgrevink PC, Kaasa S, Dale O. Associations between recreational exercise and chronic pain in the general population - Evidence from the HUNT study. Pain 2011;152:2241-7
  • Klepstad P, Fladvad T, Skorpen F, Bjordal K, Caraceni A, Dale O et al. Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients. Pain 2011; Mar 11. [ [Epub ahead of print]: doi:10.1016/j.pain.2011.01.040
  • Svendsen K, Borchgrevink PC, Fredheim O, Hamunen K, Mellbye A, Dale O. Choosing a unit of measurement counts: the use of Oral Morphine Equivalents in studies of opioid consumption is a useful addition to Defined Daily Doses. Palliative Med 2011;25:725-32
  • Andreassen TN, Klepstad P, Davies A, Bjordal K, Lundström S, Kaasa S, Dale O. Influences on the pharmacokinetics of oxycodone – A multicentre cross-sectional study in 439 adult cancer patients. Eur J Clin Pharmacol 2011;67:493-506
  • Bertheussen GF, Romundstad P, Landmark T, Kaasa S, Dale  O, Helbostad  JL. Associations between physical activity and physical and mental health -a HUNT 3 study. Med Sci Sports Exerc 2011;43:1220-8.
  • Dale O, Moksnes M, Kaasa M. EPCRC Pain Guidelines: Opioid switching to improve analgesia or reduce side effects. A systematic review. Palliative Med Palliat Med. 2011;25:494-503
  • Bjelland TW, Hjertner O, Klepstad P, Kaisen K, Dale O, Haugen BO Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest. Resuscitation. 2010; 81:1627-31
  • Fredheim OM, Dale O, Kaasa S, Borchgrevink PC. Morphine or oxycodone tablets for pain? Tidsskr Nor Laegeforen. 2010;130:1479-81.
  • Mayyas F, Fayers P, Kaasa S, Dale O. A systematic review of oxymorphone in the management of chronic pain. J Pain Symptom Management 2010;39;296-308
  • Lötsch J, Klepstad P, Doehring A, Dale O. A GTP hydroxylase 1 genetic variant delays cancer pain. Pain 2010; 49; 103-6
  • Dale O, Piribauer M, Kaasa S, Moksnes M, Knobel H, Klepstad P. A double-blind randomized clinical and a pharmacokinetic comparison between double-dose of immediate morphine versus single-dose morphine at bedtime to cancer patients. J Pain Symptom Management 2009;37: 68-76.
  • Tveita T, Thoner J, Klepstad P, Dale O, Jystad Å, Borchgrevink PC. A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety. Acta Anaesth Scand 2008; 52(7):920-5
  • Fredheim OM, Moksnes K, Borchgrevink PC, Kaasa S, Dale O. Clinical pharmacology of methadone for pain. Acta Anaesthesiol Scand. 2008; 2(7):879-89.
  • Moksnes K, Fredheim OM,, Klepstad K, Kaasa S,Angelsen A, Nilsen T, Dale O. Early pharmacokinetics of nasal fentanyl: Is there a significant arterio-venous difference? Eur J Clin Pharmacol 2008; 64:497-502.

    II. Editorials, book chapters and letters

  • Dale O. Clinical trials- only for industry? Tidsskr Nor Laegeforen. 2013 May 28;133(10):1043. doi: 10.4045/tidsskr.13.0492. Norwegian
  • Bjelland TW, Hjertner O, Klepstad P, Kaisen K, Dale O, Haugen BO. Eur J Clin Pharmacol. 2013 Sep;69(9):1727. doi: 10.1007/s00228-013-1522-8. Epub 2013 May 1
  • Dale O; Svendsen K, Borchgrevink P. The Morphine Manifesto. Tidsskr Nor Laegeforen 2012;132:935-6.
  • Dale O .Principles of drug action: Alternative routes of drug administration. In Evers AS, Maze M, Kharasch ED: Anesthetic Pharmacology, 2nd ed. Cambridge: Cambridge University Press 2011;123-32
  • Dale O. Your nose--not only for blowing! Tidsskr Nor Laegeforen. 2010;130:1326.(combined with podcast interview)
  • Rørtveit G, Staff  A, Schem B, Busund L, Nakken, K O, Walstad M, Dale O, Vigen T. [What does the Tidsskriftet's editorial committee do?],Tidsskr Nor Laegeforen 2009:129;175
  • Scientific, academic and artistic work

    A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database

    Journal publications