Background and activities
Professor Ursula Sonnewald main research interest is in neurochemistry.
At present her research is carried out using a wide range of advanced analytical methods with application to both preclinical and basic research. The main focus of her group is to study glial neuronal interactions in neurodegenerative diseases, especially Alzheimer’s dementia and epilepsy. Our main tools are 13C-and 1H- Magnetic Resonance Spectroscopy, mass spectrometry and HPLC. The low natural abundance of 13C (1.1%) is an advantage in that 13C-enriched precursors can be used for metabolic pathway mapping with little or no background interference from endogenous metabolites. Using animal models of human disease and injection of 13C labeled substrates such as [1-13C]glucose information about metabolic deficiencies can be discovered and new treatment can de designed. She has successfully supervised 19 PhD and 21 master students. Published full scientific papers: 186; citations 2515.