Background and activities
Professor Ursula Sonnewald main research interest is in neurochemistry.
At present her research is carried out using a wide range of advanced analytical methods with application to both preclinical and basic research. The main focus of her group is to study glial neuronal interactions in neurodegenerative diseases, especially Alzheimer’s dementia and epilepsy. Our main tools are 13C-and 1H- Magnetic Resonance Spectroscopy, mass spectrometry and HPLC. The low natural abundance of 13C (1.1%) is an advantage in that 13C-enriched precursors can be used for metabolic pathway mapping with little or no background interference from endogenous metabolites. Using animal models of human disease and injection of 13C labeled substrates such as [1-13C]glucose information about metabolic deficiencies can be discovered and new treatment can de designed. She has successfully supervised 19 PhD and 21 master students. Published full scientific papers: 186; citations 2515.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2014) The GLT-1 (EAAT2; Slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse. Journal of Neurochemistry. vol. 128 (5).
- (2014) The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury. Journal of Cerebral Blood Flow and Metabolism. vol. 34.
- (2014) Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. Journal of Neurochemistry. vol. 129 (1).
- (2014) Altered astrocyte-neuronal interactions after hypoxia-ischemia in the neonatal brain in female and male rats. Stroke. vol. 45 (9).
- (2014) Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain. Neurochemical Research. vol. 39 (3).
- (2014) Early Differences in Dorsal Hippocampal Metabolite Levels in Males But Not Females in a Transgenic Rat Model of Alzheimer's Disease. Neurochemical Research. vol. 39 (2).
- (2014) Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism. vol. 34 (5).
- (2014) Glutamate synthesis has to be matched by its degradation - where do all the carbons go?. Journal of Neurochemistry. vol. 131 (4).
- (2014) A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo. Journal of Cerebral Blood Flow and Metabolism. vol. 34 (8).
- (2014) The Glutamine–Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism. Neurochemical Research.
- (2013) Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy. Epilepsy Research. vol. 105 (1-2).
- (2013) [1,6-C-13] glucose metabolism in immature and in differentiated oligodendrocytes in vitro. Glia. vol. 61.
- (2013) Pyruvate carboxylation in astrocytes and the pentose phosphate pathway are affected after neonatatal hypoxic brain injury - a C-13 NMR spectroscopic study. Glia. vol. 61.
- (2013) The pentose phosphate pathway in the neonatal brain. Journal of Neurochemistry. vol. 125.
- (2013) Impairment of glial-neuronal interaction in GLT-1 knockout mice: an NMR spectroscopy study. Journal of Neurochemistry. vol. 125.
- (2013) Region- and age-dependent alterations of glial-neuronal metabolic interactions correlate with CNS pathology in a mouse model of globoid cell leukodystrophy. Journal of Cerebral Blood Flow and Metabolism. vol. 33 (7).
- (2013) Glucose and acetate metabolism and glutamate-glutamine cycle in postnatal brain development. Journal of Neurochemistry. vol. 125.
- (2013) Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of Cerebral Blood Flow and Metabolism. vol. 33 (5).
- (2013) Mitochondrial metabolic dysfunction and glutamate reduction in the pilocarpine model of temporal lobe epilepsy in mice. Journal of Neurochemistry. vol. 125.
- (2013) THE ANTICONVULSANT TRIHEPTANOIN SHOWS ANAPLEROTIC ACTIVITY IN THE PILOCARPINE MODEL OF TEMPORAL LOBE EPILEPSY IN MICE. Epilepsia. vol. 54.