Course content

The course will be given every second year, next time autumn 2010. The course give students an understanding of how cells and organisms respond to chemical agents: xenobiotic metabolism; oxidative stress; inflammation; nuclear receptor-mediated toxicity; DNA damage inflicted by toxic chemicals and carcinogenic compounds; the role of signal transduction systems and gene regulation; cell cycle regulation; DNA repair; apoptotic and necrotic cell death; gene – environment interactions, genetic susceptibility; toxicogenomics.

Learning outcome

Enhance the student`s understanding of the harmful interactions between environmental agents and biological targets aiming at molecular mechanisms and pathways underlying these effects.

Learning methods and activities

Lectures. Intensive course 7-8 weeks
Exam: written. In case of few students the written exam can be replaced by an oral examination. The course will be given in English if necessary.

Compulsory assignments

• Exercises

Recommended previous knowledge

TBT4100 Biochemistry, Basic course and TBT4145 Molecular Genetics.

Course materials

Review articles.

Credit reductions