Course content

The basic 1D and 2D NMR experiments will be reviewed with the aim to prepare students for introduction to multidimensional homo- and heteronuclear experiments. Application of NMR spectroscopy in post-genomic research will be demonstrated on selected examples. The procedure of determination of three-dimensional structures of bio-macromolecules will be illustrated. Advantages and disadvantages of NMR spectroscopy with respect to other structural techniques will be reviewed. The basis of application of NMR spectroscopy monitor interaction between macromolecules and small organic molecules for structure-based drug design used in pharmaceutics as well as application of NMR spectroscopy to study various equilibria in solutions containing biopolymers through exchange phenomena will be elucidated. The course will be partly theoretical, partly training on the NMR spectrometers available in the NMR laboratory. The course will be taught during short periods of concentrated teaching.

Learning outcome

Give the students an overview of advanced NMR techniques and their practical application in studies of organic and biological derived molecules.

Learning methods and activities

The teaching will be given as lectures, study groups and exercises.

Due to a limited number of students, the responsible teacher needs to be contacted.
In case of few students the written exam can be replaced by an oral examination.

Compulsory assignments

• Exercises

Required previous knowledge

It is assumed that the students have had an introduction course in basic NMR.

Credit reductions