Course - Systembiology, Modelling and Analysis - KP8130
Systembiology, Modelling and Analysis
About
About the course
Course content
The course will introduce some topics in molecular and cell biology and how to model them using
mathematical methods.
The course will introduce some topics in molecular and cell biology and how to model them using
mathematical methods.
The topics in biology are: enzymes (enzyme activity and cellular mechanisms for enzyme regulation); intracellular signaling (receptors, G proteins, and the MAP kinase cascade); regulation of gene expression
(transcription factors and positive, negative, and sigmoid feedback); and genetical and metabolic networks.
Topics in modeling are: enzyme kinetics (the concept of steady state in the cell, two-substrate-kinetics, and inhibition and promotion of enzyme activity), reconstruction and structural analysis of biological networks (graph representation, network decomposition, and software tools), and control and analysis of metabolic and genetical pathways and networks (flux control; the connectivity theorem; the construction
of complex networks; sensitivity analysis; robustness; and bifurcation analysis).
Learning outcome
To be able to describe biochemical and genetical networks using differential equations and Boolean models. To be able to analyse models.
Recommended previous knowledge
TKP4140 Process Control or similar. Molecular Genetics or similar.
Required previous knowledge
Mathematics 1 to 4, (TMA4100, TMA4105, TMA4110 and TMA 4115N) or similar courses, differential equations and/or numerical analysis, and/or modeling dynamical systems.
Course materials
"System Modeling in Cellular Biologi, from concepts to nuts and
bolts", Z. Szallasi, J. Stelling and V. Periwal.
Hand outs.
Subject areas
- Process Control
- Technological subjects