Abba Elizabeth Coron
Background and activities
My research is focused on alginate hydrogel microspheres intended for cell therapy, e.g. in the treatment of type 1 diabetes. The work involves elucidation of the biocompatibility of different alginate-based microspheres through mechanistic studies such as protein adsorption and proteomic analysis, and animal studies. The project aims to produce host tolerable alginate microspheres through novel tailored materials and microsphere designs and give insight into the foreign host reactions we observe for implanted alginate microspheres. This is also highly relevant for other systems of cell therapy and tissue engineering.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2022) Sulfated alginate reduces pericapsular fibrotic overgrowth on encapsulated cGMP-compliant hPSC-hepatocytes in mice. Frontiers in Bioengineering and Biotechnology. vol. 9.
- (2021) Pericapsular fibrotic overgrowth mitigated in immunocompetent mice through microbead formulations based on sulfated or intermediate G alginates. Acta Biomaterialia. vol. 137.
- (2017) Current and Future Perspectives on Alginate Encapsulated Pancreatic Islet. Stem Cells Translational Medicine. vol. 6 (4).
- (2016) Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. Journal of Controlled Release. vol. 229.