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Språkvelger

Norsk

Astrid Hyldbakk

Astrid Hyldbakk

Student
Faculty of Medicine and Health Sciences

astrid.hyldbakk@ntnu.no
+4748055851 Realfagbygget, D4-164, Gløshaugen, Høgskoleringen 5, 7034 Trondheim
About Publications Media

About

Biological effects of polymeric nanoparticles for drug delivery - from single cell to whole body distribution

Encapsulation of drugs in biocompatible nanoparticles has shown promise in improving the efficiency and bioavailability of important therapeutics, like anti-cancer drugs and antibiotics. The process of implementing these new strategies in clinical use requires extensive characterization, optimization and development. My PhD project do therefore seek in-depth knowledge on how polymeric nanomedical particles interact with biological systems. This involves degradation, cellular uptake and toxicity, nanoparticle distribution and drug release in vivo. 

Competencies

  • Drug delivery
  • Mass spectrometry
  • Nanomedicine
  • Nanoparticles

Publications

  • Chronological
  • By category
  • See all publications in Cristin

2023

  • Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg. (2023) Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models. Nanomedicine: Nanotechnology, Biology and Medicine. volum 48.
    Academic article

2022

  • Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti. (2022) Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery. Marine Drugs. volum 20 (12).
    Academic article
  • Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick. (2022) Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach. International Journal of Pharmaceutics: X. volum 4.
    Academic article
  • Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F.. (2022) A comparative biodistribution study of polymeric and lipid-based nanoparticles. Drug Delivery and Translational Research. volum 12.
    Academic article

2021

  • Fernández, Yolanda; Movellan, Julie; Foradada, Laia; Giménez, Vanessa; García-Aranda, Natalia; Mancilla, Sandra; Armiñán, Ana; Borgos, Sven Even F.; Hyldbakk, Astrid; Bogdanska, Anna; Gobbo, Oliviero L.; Prina-Mello, Adriele; Ponti, Jessica; Calzolai, Luigi; Zagorodko, Oleksandr; Gallon, Elena; Niño-Pariente, Amaya; Paul, Alison; Schwartz Jr, Simó; Abasolo, Ibane; Vicent, María J.. (2021) In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy. Advanced Healthcare Materials.
    Academic article
  • Mildner, Robert; Hak, Sjoerd; Parot, Jérémie; Hyldbakk, Astrid; Borgos, Sven Even F.; Some, Dan; Johann, Cristoph; Caputo, Fanny. (2021) Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery. European journal of pharmaceutics and biopharmaceutics. volum 163.
    Academic article

2020

  • Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange. (2020) Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model. Ultrasound in Medicine and Biology. volum 46 (11).
    Academic article

2018

  • Brakstad, Odd Gunnar; Sørensen, Lisbet; Zahlsen, Kolbjørn; Bonaunet, Kristin; Hyldbakk, Astrid; Booth, Andy. (2018) Biotransformation in water and soil of nitrosamines and nitramines potentially generated from amine-based CO2 capture technology. International Journal of Greenhouse Gas Control. volum 70.
    Academic article

2016

  • Fytianos, Georgios; Ucar, Seniz; Grimstvedt, Andreas Magnar; Hyldbakk, Astrid; Svendsen, Hallvard Fjøsne; Knuutila, Hanna K.. (2016) Corrosion and degradation in MEA based post-combustion CO2 capture. International Journal of Greenhouse Gas Control. volum 46.
    Academic article
  • Hyldbakk, Astrid; Glomm, Wilhelm; Borgos, Sven Even F.. (2016) Nanostructured lipid carriers for controlled and triggered drug delivery - synthesis and advanced characterisation. 2016.
    Master thesis

2015

  • Sørensen, Lisbet; Zahlsen, Kolbjørn; Hyldbakk, Astrid; Silva, Eirik Falck da; Booth, Andy. (2015) Photodegradation in natural waters of nitrosamines and nitramines derived from CO2 capture plant operation. International Journal of Greenhouse Gas Control. volum 32.
    Academic article

2014

  • Brakstad, Odd Gunnar; Hyldbakk, Astrid; Zahlsen, Kolbjørn. (2014) Biodegradation of nitramines in water. 2014. ISBN 9788214057355. SINTEF Rapport.
    Report

2010

  • Hyldbakk, Astrid. (2010) Immunocytochemical staining of SERCA2a and RyR2 in rat cardiomyocytes. 2010.
    Report

Scientific articles

  • Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg. (2023) Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models. Nanomedicine: Nanotechnology, Biology and Medicine. volum 48.
    Academic article
  • Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti. (2022) Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery. Marine Drugs. volum 20 (12).
    Academic article
  • Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick. (2022) Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach. International Journal of Pharmaceutics: X. volum 4.
    Academic article
  • Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F.. (2022) A comparative biodistribution study of polymeric and lipid-based nanoparticles. Drug Delivery and Translational Research. volum 12.
    Academic article
  • Fernández, Yolanda; Movellan, Julie; Foradada, Laia; Giménez, Vanessa; García-Aranda, Natalia; Mancilla, Sandra; Armiñán, Ana; Borgos, Sven Even F.; Hyldbakk, Astrid; Bogdanska, Anna; Gobbo, Oliviero L.; Prina-Mello, Adriele; Ponti, Jessica; Calzolai, Luigi; Zagorodko, Oleksandr; Gallon, Elena; Niño-Pariente, Amaya; Paul, Alison; Schwartz Jr, Simó; Abasolo, Ibane; Vicent, María J.. (2021) In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy. Advanced Healthcare Materials.
    Academic article
  • Mildner, Robert; Hak, Sjoerd; Parot, Jérémie; Hyldbakk, Astrid; Borgos, Sven Even F.; Some, Dan; Johann, Cristoph; Caputo, Fanny. (2021) Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery. European journal of pharmaceutics and biopharmaceutics. volum 163.
    Academic article
  • Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange. (2020) Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model. Ultrasound in Medicine and Biology. volum 46 (11).
    Academic article
  • Brakstad, Odd Gunnar; Sørensen, Lisbet; Zahlsen, Kolbjørn; Bonaunet, Kristin; Hyldbakk, Astrid; Booth, Andy. (2018) Biotransformation in water and soil of nitrosamines and nitramines potentially generated from amine-based CO2 capture technology. International Journal of Greenhouse Gas Control. volum 70.
    Academic article
  • Fytianos, Georgios; Ucar, Seniz; Grimstvedt, Andreas Magnar; Hyldbakk, Astrid; Svendsen, Hallvard Fjøsne; Knuutila, Hanna K.. (2016) Corrosion and degradation in MEA based post-combustion CO2 capture. International Journal of Greenhouse Gas Control. volum 46.
    Academic article
  • Sørensen, Lisbet; Zahlsen, Kolbjørn; Hyldbakk, Astrid; Silva, Eirik Falck da; Booth, Andy. (2015) Photodegradation in natural waters of nitrosamines and nitramines derived from CO2 capture plant operation. International Journal of Greenhouse Gas Control. volum 32.
    Academic article

Report

  • Hyldbakk, Astrid; Glomm, Wilhelm; Borgos, Sven Even F.. (2016) Nanostructured lipid carriers for controlled and triggered drug delivery - synthesis and advanced characterisation. 2016.
    Master thesis
  • Brakstad, Odd Gunnar; Hyldbakk, Astrid; Zahlsen, Kolbjørn. (2014) Biodegradation of nitramines in water. 2014. ISBN 9788214057355. SINTEF Rapport.
    Report
  • Hyldbakk, Astrid. (2010) Immunocytochemical staining of SERCA2a and RyR2 in rat cardiomyocytes. 2010.
    Report

Media

2022

  • Poster
    Hyldbakk, Astrid; Fleten, Karianne Giller; Flatmark, Kjersti; Åslund, Andreas; Snipstad, Sofie; Borgos, Sven Even F.; Mørch, Ýrr Asbjørg. (2022) The in vivo fate of poly(alkyl cyanoacrylate) (PACA) nanoparticles and their payload. Controlled Release Society Annual Conference 2022 . Controlled Release Society; Montreal, Canada. 2022-07-11 - 2022-07-15.
  • Academic lecture
    Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Ruth Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg. (2022) ENPERITO: polymeric nanoparticles for treatment of peritoneal metastases - a toxicity, biodstribution and efficacy study. Biophysics and medical physics spring meeting . NTNU; Trondheim. 2022-05-12 - 2022-05-13.

2021

  • Lecture
    Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Folkesson, Evelina; Flatmark, Kjersti; Mørch, Ýrr Asbjørg. (2021) ENPERITO: Polymeric nanoparticles for treatment of peritoneal metastases. Controlled Release Society Annual Conference 2021 . Controlled Release Society; Digital. 2021-07-25 - 2021-07-29.
  • Lecture
    Hyldbakk, Astrid; Borgos, Sven Even F.; Mørch, Ýrr Asbjørg. (2021) A high-throughput method for drug release measurements in complex media. COST WG2 CONFERENCE "CHARACTERISATION OF NANOMATERIALS TOWARDS SAFE AND EFFICIENT NANODRUGS" . COST Action CA17140: Nano2Clinic; Digital. 2021-06-22 - 2021-06-23.
  • Lecture
    Åslund, Andreas; Fleten, Karianne Giller; Snipstad, Sofie; Hyldbakk, Astrid; Aursand, Eli Grong; Falck, Annbjørg Eide; Schmid, Ruth; Mørch, Ýrr Asbjørg. (2021) PACAB: A nanoparticle technology platform for hard-to-treat cancers. Nanomedicine Europe 2021 . European Technology Platform for Nanomedicine; Digitalt. 2021-09-07 - 2021-09-09.

2016

  • Academic lecture
    Nordborg, Anna; Hyldbakk, Astrid; Vernstad, Kai; Løvmo, Cathrine; Borgos, Sven Even F.; Glomm, Wilhelm; Mørch, Ýrr Asbjørg; Schmid, Ruth; Zahlsen, Kolbjørn. (2016) Analytical strategies for MS-based physicochemical characterisation of targeted drug delivery nanomedicines. 25th Organikerdagarna & 23rd Analysdagarna . Swedish Chemical Society; Umeå. 2016-06-14 - 2016-06-17.

2015

  • Academic lecture
    Borgos, Sven Even F.; Brunsvik, Anders; Holten, Torunn; Hyldbakk, Astrid; Kristiansen, Alexander; Männle, Ferdinand; Mørch, Ýrr Asbjørg; Nordborg, Anna; Schmid, Ruth; Vernstad, Kai; Zahlsen, Kolbjørn. (2015) Nanoparticles for Targeted Drug Delivery – Mass Spectrometry and Advanced Separation Technology for Comprehensive Characterization. 15NSMS . Norsk Selskap for Massespektrometri; Hafjell. 2015-01-18 - 2015-01-21.

2014

  • Poster
    Sørensen, Lisbet; Brakstad, Odd Gunnar; Hyldbakk, Astrid; Zahlsen, Kolbjørn; Booth, Andy. (2014) Biodegradation of Nitrosamines and Nitramines under Anoxic Conditions. 24th Annual SETAC Europe Meeting ; Basel. 2014-04-11 - 2014-04-15.

2013

  • Academic lecture
    Sørensen, Lisbet; Brakstad, Odd Gunnar; Hyldbakk, Astrid; Zahlsen, Kolbjørn; Silva, Eirik Falck da; Booth, Andy. (2013) Environmental Fate of Nitramines and Nitrosamines Released as Degradation Products from Post Combustion CO2-Capture Plants. IEAGHG 2nd Post Combustion Capture Conference (PCCC2) . IEAGHG; Bergen. 2013-09-17 - 2013-09-20.
  • Academic lecture
    Sørensen, Lisbet; Brakstad, Odd Gunnar; Vernstad, Kai; Hyldbakk, Astrid; Zahlsen, Kolbjørn; Silva, Eirik Falck da; Booth, Andy. (2013) Environmental Degradation of Nitramines and Nitrosamines Released from Post Combustion CO2-Capture Plants by Physical and Microbial Processes. 7th Trondheim CCS Conference (TCCS-7) ; Trondheim. 2013-06-04 - 2013-06-06.
  • Popular scientific lecture
    Sørensen, Lisbet; Brakstad, Odd Gunnar; Zahlsen, Kolbjørn; Hyldbakk, Astrid; Vernstad, Kai; Silva, Eirik Falck da; Booth, Andrew. (2013) Environmental fate of nitramines and nitrosamines released as degradation products from post combustion CO2-capture plants. 23rd Annual SETAC Europe Meeting ; Glasgow. 2013-05-12 - 2013-05-16.
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