Astrid Hyldbakk
About
Biological effects of polymeric nanoparticles for drug delivery - from single cell to whole body distribution
Encapsulation of drugs in biocompatible nanoparticles has shown promise in improving the efficiency and bioavailability of important therapeutics, like anti-cancer drugs and antibiotics. The process of implementing these new strategies in clinical use requires extensive characterization, optimization and development. My PhD project do therefore seek in-depth knowledge on how polymeric nanomedical particles interact with biological systems. This involves degradation, cellular uptake and toxicity, nanoparticle distribution and drug release in vivo.
Competencies
Publications
2023
-
Hyldbakk, Astrid;
Fleten, Karianne Giller;
Snipstad, Sofie;
Åslund, Andreas;
Davies, Catharina de Lange;
Flatmark, Kjersti;
Mørch, Ýrr Asbjørg.
(2023)
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models.
Nanomedicine: Nanotechnology, Biology and Medicine.
volum 48.
Academic article
2022
-
Fleten, Karianne Giller;
Hyldbakk, Astrid;
Einen, Caroline;
Benjakul, Sopisa;
Strand, Berit Løkensgard;
Davies, Catharina de Lange;
Mørch, Ýrr Asbjørg;
Flatmark, Kjersti.
(2022)
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery.
Marine Drugs.
volum 20 (12).
Academic article
-
Hyldbakk, Astrid;
Mørch, Ýrr Asbjørg;
Snipstad, Sofie;
Åslund, Andreas;
Klinkenberg, Geir;
Nakstad, Vu;
Wågbø, Ane Marit;
Schmid, Ruth Baumberger;
Molesworth, Peter Patrick.
(2022)
Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach.
International Journal of Pharmaceutics: X.
volum 4.
Academic article
-
Åslund, Andreas;
Vandebriel, Rob J.;
Caputo, Fanny;
de Jong, Wim H.;
Delmaar, Christiaan;
Hyldbakk, Astrid;
Rustique, Emilie;
Schmid, Ruth Baumberger;
Snipstad, Sofie;
Texier, Isabelle;
Vernstad, Kai;
Borgos, Sven Even F..
(2022)
A comparative biodistribution study of polymeric and lipid-based nanoparticles.
Drug Delivery and Translational Research.
volum 12.
Academic article
2021
-
Fernández, Yolanda;
Movellan, Julie;
Foradada, Laia;
Giménez, Vanessa;
García-Aranda, Natalia;
Mancilla, Sandra;
Armiñán, Ana;
Borgos, Sven Even F.;
Hyldbakk, Astrid;
Bogdanska, Anna;
Gobbo, Oliviero L.;
Prina-Mello, Adriele;
Ponti, Jessica;
Calzolai, Luigi;
Zagorodko, Oleksandr;
Gallon, Elena;
Niño-Pariente, Amaya;
Paul, Alison;
Schwartz Jr, Simó;
Abasolo, Ibane;
Vicent, María J..
(2021)
In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy.
Advanced Healthcare Materials.
Academic article
-
Mildner, Robert;
Hak, Sjoerd;
Parot, Jérémie;
Hyldbakk, Astrid;
Borgos, Sven Even F.;
Some, Dan;
Johann, Cristoph;
Caputo, Fanny.
(2021)
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery.
European journal of pharmaceutics and biopharmaceutics.
volum 163.
Academic article
2020
-
Fagerland, Stein-Martin Tilrum;
Berg, Sigrid;
Hill, Deborah Katherine;
Snipstad, Sofie;
Sulheim, Einar;
Hyldbakk, Astrid;
Kim, Jana;
Davies, Catharina de Lange.
(2020)
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model.
Ultrasound in Medicine and Biology.
volum 46 (11).
Academic article
2018
-
Brakstad, Odd Gunnar;
Sørensen, Lisbet;
Zahlsen, Kolbjørn;
Bonaunet, Kristin;
Hyldbakk, Astrid;
Booth, Andy.
(2018)
Biotransformation in water and soil of nitrosamines and nitramines potentially generated from amine-based CO2 capture technology.
International Journal of Greenhouse Gas Control.
volum 70.
Academic article
2016
-
Fytianos, Georgios;
Ucar, Seniz;
Grimstvedt, Andreas Magnar;
Hyldbakk, Astrid;
Svendsen, Hallvard Fjøsne;
Knuutila, Hanna K..
(2016)
Corrosion and degradation in MEA based post-combustion CO2 capture.
International Journal of Greenhouse Gas Control.
volum 46.
Academic article
-
Hyldbakk, Astrid;
Glomm, Wilhelm;
Borgos, Sven Even F..
(2016)
Nanostructured lipid carriers for controlled and triggered drug delivery - synthesis and advanced characterisation.
2016.
Master thesis
2015
-
Sørensen, Lisbet;
Zahlsen, Kolbjørn;
Hyldbakk, Astrid;
Silva, Eirik Falck da;
Booth, Andy.
(2015)
Photodegradation in natural waters of nitrosamines and nitramines derived from CO2 capture plant operation.
International Journal of Greenhouse Gas Control.
volum 32.
Academic article
2014
-
Brakstad, Odd Gunnar;
Hyldbakk, Astrid;
Zahlsen, Kolbjørn.
(2014)
Biodegradation of nitramines in water.
2014. ISBN 9788214057355. SINTEF Rapport.
Report
2010
-
Hyldbakk, Astrid.
(2010)
Immunocytochemical staining of SERCA2a and RyR2 in rat cardiomyocytes.
2010.
Report
Scientific articles
-
Hyldbakk, Astrid;
Fleten, Karianne Giller;
Snipstad, Sofie;
Åslund, Andreas;
Davies, Catharina de Lange;
Flatmark, Kjersti;
Mørch, Ýrr Asbjørg.
(2023)
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models.
Nanomedicine: Nanotechnology, Biology and Medicine.
volum 48.
Academic article
-
Fleten, Karianne Giller;
Hyldbakk, Astrid;
Einen, Caroline;
Benjakul, Sopisa;
Strand, Berit Løkensgard;
Davies, Catharina de Lange;
Mørch, Ýrr Asbjørg;
Flatmark, Kjersti.
(2022)
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery.
Marine Drugs.
volum 20 (12).
Academic article
-
Hyldbakk, Astrid;
Mørch, Ýrr Asbjørg;
Snipstad, Sofie;
Åslund, Andreas;
Klinkenberg, Geir;
Nakstad, Vu;
Wågbø, Ane Marit;
Schmid, Ruth Baumberger;
Molesworth, Peter Patrick.
(2022)
Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach.
International Journal of Pharmaceutics: X.
volum 4.
Academic article
-
Åslund, Andreas;
Vandebriel, Rob J.;
Caputo, Fanny;
de Jong, Wim H.;
Delmaar, Christiaan;
Hyldbakk, Astrid;
Rustique, Emilie;
Schmid, Ruth Baumberger;
Snipstad, Sofie;
Texier, Isabelle;
Vernstad, Kai;
Borgos, Sven Even F..
(2022)
A comparative biodistribution study of polymeric and lipid-based nanoparticles.
Drug Delivery and Translational Research.
volum 12.
Academic article
-
Fernández, Yolanda;
Movellan, Julie;
Foradada, Laia;
Giménez, Vanessa;
García-Aranda, Natalia;
Mancilla, Sandra;
Armiñán, Ana;
Borgos, Sven Even F.;
Hyldbakk, Astrid;
Bogdanska, Anna;
Gobbo, Oliviero L.;
Prina-Mello, Adriele;
Ponti, Jessica;
Calzolai, Luigi;
Zagorodko, Oleksandr;
Gallon, Elena;
Niño-Pariente, Amaya;
Paul, Alison;
Schwartz Jr, Simó;
Abasolo, Ibane;
Vicent, María J..
(2021)
In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy.
Advanced Healthcare Materials.
Academic article
-
Mildner, Robert;
Hak, Sjoerd;
Parot, Jérémie;
Hyldbakk, Astrid;
Borgos, Sven Even F.;
Some, Dan;
Johann, Cristoph;
Caputo, Fanny.
(2021)
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery.
European journal of pharmaceutics and biopharmaceutics.
volum 163.
Academic article
-
Fagerland, Stein-Martin Tilrum;
Berg, Sigrid;
Hill, Deborah Katherine;
Snipstad, Sofie;
Sulheim, Einar;
Hyldbakk, Astrid;
Kim, Jana;
Davies, Catharina de Lange.
(2020)
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model.
Ultrasound in Medicine and Biology.
volum 46 (11).
Academic article
-
Brakstad, Odd Gunnar;
Sørensen, Lisbet;
Zahlsen, Kolbjørn;
Bonaunet, Kristin;
Hyldbakk, Astrid;
Booth, Andy.
(2018)
Biotransformation in water and soil of nitrosamines and nitramines potentially generated from amine-based CO2 capture technology.
International Journal of Greenhouse Gas Control.
volum 70.
Academic article
-
Fytianos, Georgios;
Ucar, Seniz;
Grimstvedt, Andreas Magnar;
Hyldbakk, Astrid;
Svendsen, Hallvard Fjøsne;
Knuutila, Hanna K..
(2016)
Corrosion and degradation in MEA based post-combustion CO2 capture.
International Journal of Greenhouse Gas Control.
volum 46.
Academic article
-
Sørensen, Lisbet;
Zahlsen, Kolbjørn;
Hyldbakk, Astrid;
Silva, Eirik Falck da;
Booth, Andy.
(2015)
Photodegradation in natural waters of nitrosamines and nitramines derived from CO2 capture plant operation.
International Journal of Greenhouse Gas Control.
volum 32.
Academic article
Report
-
Hyldbakk, Astrid;
Glomm, Wilhelm;
Borgos, Sven Even F..
(2016)
Nanostructured lipid carriers for controlled and triggered drug delivery - synthesis and advanced characterisation.
2016.
Master thesis
-
Brakstad, Odd Gunnar;
Hyldbakk, Astrid;
Zahlsen, Kolbjørn.
(2014)
Biodegradation of nitramines in water.
2014. ISBN 9788214057355. SINTEF Rapport.
Report
-
Hyldbakk, Astrid.
(2010)
Immunocytochemical staining of SERCA2a and RyR2 in rat cardiomyocytes.
2010.
Report
Media
2022
-
PosterHyldbakk, Astrid; Fleten, Karianne Giller; Flatmark, Kjersti; Åslund, Andreas; Snipstad, Sofie; Borgos, Sven Even F.; Mørch, Ýrr Asbjørg. (2022) The in vivo fate of poly(alkyl cyanoacrylate) (PACA) nanoparticles and their payload. Controlled Release Society Annual Conference 2022 . Controlled Release Society; Montreal, Canada. 2022-07-11 - 2022-07-15.
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Academic lectureHyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Ruth Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg. (2022) ENPERITO: polymeric nanoparticles for treatment of peritoneal metastases - a toxicity, biodstribution and efficacy study. Biophysics and medical physics spring meeting . NTNU; Trondheim. 2022-05-12 - 2022-05-13.
2021
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LectureHyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Folkesson, Evelina; Flatmark, Kjersti; Mørch, Ýrr Asbjørg. (2021) ENPERITO: Polymeric nanoparticles for treatment of peritoneal metastases. Controlled Release Society Annual Conference 2021 . Controlled Release Society; Digital. 2021-07-25 - 2021-07-29.
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LectureHyldbakk, Astrid; Borgos, Sven Even F.; Mørch, Ýrr Asbjørg. (2021) A high-throughput method for drug release measurements in complex media. COST WG2 CONFERENCE "CHARACTERISATION OF NANOMATERIALS TOWARDS SAFE AND EFFICIENT NANODRUGS" . COST Action CA17140: Nano2Clinic; Digital. 2021-06-22 - 2021-06-23.
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LectureÅslund, Andreas; Fleten, Karianne Giller; Snipstad, Sofie; Hyldbakk, Astrid; Aursand, Eli Grong; Falck, Annbjørg Eide; Schmid, Ruth; Mørch, Ýrr Asbjørg. (2021) PACAB: A nanoparticle technology platform for hard-to-treat cancers. Nanomedicine Europe 2021 . European Technology Platform for Nanomedicine; Digitalt. 2021-09-07 - 2021-09-09.
2016
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Academic lectureNordborg, Anna; Hyldbakk, Astrid; Vernstad, Kai; Løvmo, Cathrine; Borgos, Sven Even F.; Glomm, Wilhelm; Mørch, Ýrr Asbjørg; Schmid, Ruth; Zahlsen, Kolbjørn. (2016) Analytical strategies for MS-based physicochemical characterisation of targeted drug delivery nanomedicines. 25th Organikerdagarna & 23rd Analysdagarna . Swedish Chemical Society; Umeå. 2016-06-14 - 2016-06-17.
2015
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Academic lectureBorgos, Sven Even F.; Brunsvik, Anders; Holten, Torunn; Hyldbakk, Astrid; Kristiansen, Alexander; Männle, Ferdinand; Mørch, Ýrr Asbjørg; Nordborg, Anna; Schmid, Ruth; Vernstad, Kai; Zahlsen, Kolbjørn. (2015) Nanoparticles for Targeted Drug Delivery – Mass Spectrometry and Advanced Separation Technology for Comprehensive Characterization. 15NSMS . Norsk Selskap for Massespektrometri; Hafjell. 2015-01-18 - 2015-01-21.
2014
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PosterSørensen, Lisbet; Brakstad, Odd Gunnar; Hyldbakk, Astrid; Zahlsen, Kolbjørn; Booth, Andy. (2014) Biodegradation of Nitrosamines and Nitramines under Anoxic Conditions. 24th Annual SETAC Europe Meeting ; Basel. 2014-04-11 - 2014-04-15.
2013
-
Academic lectureSørensen, Lisbet; Brakstad, Odd Gunnar; Hyldbakk, Astrid; Zahlsen, Kolbjørn; Silva, Eirik Falck da; Booth, Andy. (2013) Environmental Fate of Nitramines and Nitrosamines Released as Degradation Products from Post Combustion CO2-Capture Plants. IEAGHG 2nd Post Combustion Capture Conference (PCCC2) . IEAGHG; Bergen. 2013-09-17 - 2013-09-20.
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Academic lectureSørensen, Lisbet; Brakstad, Odd Gunnar; Vernstad, Kai; Hyldbakk, Astrid; Zahlsen, Kolbjørn; Silva, Eirik Falck da; Booth, Andy. (2013) Environmental Degradation of Nitramines and Nitrosamines Released from Post Combustion CO2-Capture Plants by Physical and Microbial Processes. 7th Trondheim CCS Conference (TCCS-7) ; Trondheim. 2013-06-04 - 2013-06-06.
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Popular scientific lectureSørensen, Lisbet; Brakstad, Odd Gunnar; Zahlsen, Kolbjørn; Hyldbakk, Astrid; Vernstad, Kai; Silva, Eirik Falck da; Booth, Andrew. (2013) Environmental fate of nitramines and nitrosamines released as degradation products from post combustion CO2-capture plants. 23rd Annual SETAC Europe Meeting ; Glasgow. 2013-05-12 - 2013-05-16.