Caroline Einen
About
Understanding ultrasound-mediated delivery of nanoparticles in cancer treatment
A combination of ultrasound and microbubbles can be used as a strategy to obtain enhanced targeted delivery of nanoparticles to tumors, a potentially useful tool in the treatment of cancer. We have seen that the application of ultrasound in the presence of microbubbles has given an increased nanoparticle delivery and therapeutic efficacy in tumor models in mice. This enhanced delivery is mainly originating from mechanical effects from the ultrasound, but the exact interplay of these mechanisms are not fully understood. In my PhD I am attempting to increase our knowlegde of the effects of ultrasound and microbubbles on the delivery of nanoparticles to tumors using both in vivo and in vitro tumor models.
Publications
2023
-
Einen, Caroline;
Price, Sebastian Everard Nordby;
Ulvik, Kim Andre;
Gjennestad, Magnus Aashammer;
Hansen, Rune;
Kjelstrup, Signe.
(2023)
Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound.
Gels
Academic article
-
Lage Fernandez, Jessica;
Årbogen, Sara Beate Stjern;
Sadeghinia, Mohammadjavad;
Haram, Karin Margrete;
Snipstad, Sofie;
Torp, Sverre Helge.
(2023)
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery.
Cancers
Academic article
2022
-
Khosravi, Bahareh;
Austegard, Anders;
Stang, Hans Georg Jacob;
Einen, Caroline;
Jakobsen, Jana Poplsteinova;
Snustad, Ingrid.
(2022)
A new facility for viscosity and density measurements for CO2 – rich mixtures relevant for CO2 transport and storage.
International Conference on Greenhouse Gas Control Technologies
Academic article
-
Fleten, Karianne Giller;
Hyldbakk, Astrid;
Einen, Caroline;
Benjakul, Sopisa;
Strand, Berit Løkensgard;
Davies, Catharina de Lange.
(2022)
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery.
Marine Drugs
Academic article
2021
-
Khosravi, Bahareh;
Løvseth, Sigurd Weidemann;
Austegard, Anders;
Einen, Caroline;
Stang, Hans Georg Jacob;
Snustad, Ingrid.
(2021)
A new facility on accurate viscosity and density measurements.
SINTEF akademisk forlag
Academic chapter/article/Conference paper
2020
-
Einen, Caroline;
Roussanaly, Simon;
Rohde, Daniel;
Jordal, Aina Benedikte Kristin.
(2020)
Forstudie: CCS i Midt-Norge : kartlegging av aktører i regionen og innledende logistikkanalyser av mulige
verdikjeder for karbonhåndtering.
SINTEF Rapport (2020:00479)
Report
Journal publications
-
Einen, Caroline;
Price, Sebastian Everard Nordby;
Ulvik, Kim Andre;
Gjennestad, Magnus Aashammer;
Hansen, Rune;
Kjelstrup, Signe.
(2023)
Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound.
Gels
Academic article
-
Lage Fernandez, Jessica;
Årbogen, Sara Beate Stjern;
Sadeghinia, Mohammadjavad;
Haram, Karin Margrete;
Snipstad, Sofie;
Torp, Sverre Helge.
(2023)
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery.
Cancers
Academic article
-
Khosravi, Bahareh;
Austegard, Anders;
Stang, Hans Georg Jacob;
Einen, Caroline;
Jakobsen, Jana Poplsteinova;
Snustad, Ingrid.
(2022)
A new facility for viscosity and density measurements for CO2 – rich mixtures relevant for CO2 transport and storage.
International Conference on Greenhouse Gas Control Technologies
Academic article
-
Fleten, Karianne Giller;
Hyldbakk, Astrid;
Einen, Caroline;
Benjakul, Sopisa;
Strand, Berit Løkensgard;
Davies, Catharina de Lange.
(2022)
Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery.
Marine Drugs
Academic article
Part of book/report
-
Khosravi, Bahareh;
Løvseth, Sigurd Weidemann;
Austegard, Anders;
Einen, Caroline;
Stang, Hans Georg Jacob;
Snustad, Ingrid.
(2021)
A new facility on accurate viscosity and density measurements.
SINTEF akademisk forlag
Academic chapter/article/Conference paper
Report
-
Einen, Caroline;
Roussanaly, Simon;
Rohde, Daniel;
Jordal, Aina Benedikte Kristin.
(2020)
Forstudie: CCS i Midt-Norge : kartlegging av aktører i regionen og innledende logistikkanalyser av mulige
verdikjeder for karbonhåndtering.
SINTEF Rapport (2020:00479)
Report
Knowledge Transfer
2024
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PosterNordlund, Veronica; Haram, Margrete; Lorck Bjørgen, Jenny Josefine; Snipstad, Sofie; Einen, Caroline; Davies, Catharina de Lange. (2024) Uptake and microdistribution of doxorubicin in murine tumors treated with SonoVue and focused ultrasound. European Symposium on Ultrasound Contrast Imaging , Rotterdam 2024-01-18 - 2024-01-19
2023
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PosterEinen, Caroline; Price, Sebastian Everard Nordby; Ulvik, Kim; Gjennestad, Magnus Aashammer; Hansen, Rune; Kjelstrup, Signe. (2023) Hydrogel modelling the extracellular matrix for investigating the effect of acoustic radiation force on nanoparticle transport. International Society for Therapeutic Ultrasound (ISTU) International Symposium on Therapeutic Ultrasound , Lyon 2023-04-17 - 2023-04-20
2022
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PosterEinen, Caroline; Ulvik, Kim; Davies, Catharina de Lange. (2022) Composite hydrogel platform for investigating the effect of acoustic radiation force on nanoparticle movement. NTNU Biophysics and Medical Physics Spring Meeting , Trondheim 2022-05-12 - 2022-05-13
2020
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Academic lectureKhosravi, Bahareh; Løvseth, Sigurd Weidemann; Austegard, Anders; Einen, Caroline; Jakobsen, Jana Poplsteinova; Stang, Hans Georg Jacob. (2020) Impact of CO2 impurities and additives on thermophysical properties in CCS (ImpreCCS): Viscosity & density measurement. 15th International Conference on Greenhouse Gas Control Technologies GHGT-15 , Abu Dhabi 2020-10-05 - 2021-10-08