Håvard Takle Lindholm
About
This website is no longer updated because I have started as a postdoctoral fellow at Daniel De Carvalhos lab in Princess Margaret Cancer Centre in Canada. Please find information from before my move below.
I am a member of Menno Oudhoffs lab at Centre of Molecular Inflammation Research (CEMIR) and I am researching how cells of the intestinal epithelium change and develop upon a challenge, whether that challenge is from an infection or other external factors. My speciality is to use informatics tools, such as sequencing analysis and image analysis, to explore relevant biological questions in development of the intestinal epithelium.
Research interests:
- The role of epigenetic regulators in damage response in the intestinal epithelium
- Changes in the intestinal epithelium upon response to signals from the immune system
Methods/tools used:
- Intestinal organoid cultures
- Sequencing analysis, i.e. RNAseq and ChIPseq
- Neural Networks
- Image segmentation
Publications
2022
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Lindholm, Håvard Takle;
Parmar, Naveen;
Drurey, Claire;
Poveda, Marta Campillo;
Vornewald, Pia;
Ostrop, Jenny.
(2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology
Academic article
2021
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens
Academic article
-
Lindholm, Håvard Takle;
Oudhoff, Menno J..
(2021)
Defining changes in the intestinal epithelium in early life and in response to infections.
NTNU
Doctoral dissertation
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications
Academic article
-
Drurey, Claire;
Lindholm, Håvard Takle;
Oudhoff, Menno;
Maizels, Rick.
(2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Journal of Experimental Medicine (JEM)
Interview Journal
-
Ostrop, Jenny;
Zwiggelaar, Rosalie Theda Margien;
Terndrup Pedersen, Marianne;
Gerbe, François;
Bösl, Korbinian;
Lindholm, Håvard Takle.
(2021)
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Frontiers in Cell and Developmental Biology
Academic article
2020
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances
Academic article
Journal publications
-
Lindholm, Håvard Takle;
Parmar, Naveen;
Drurey, Claire;
Poveda, Marta Campillo;
Vornewald, Pia;
Ostrop, Jenny.
(2022)
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.
Science immunology
Academic article
-
Parmar, Naveen;
Burrows, Kyle;
Vornewald, Pia;
Lindholm, Håvard Takle;
Zwiggelaar, Rosalie Theda Margien;
Sanchez, Alberto Diez.
(2021)
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection.
PLoS Pathogens
Academic article
-
Alonso, Mara Martin;
Iqbal, Sharif;
Vornewald, Pia;
Lindholm, Håvard Takle;
Damen, Mirjam J.;
Martínez, Fernando.
(2021)
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage.
Nature Communications
Academic article
-
Drurey, Claire;
Lindholm, Håvard Takle;
Oudhoff, Menno;
Maizels, Rick.
(2021)
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
Journal of Experimental Medicine (JEM)
Interview Journal
-
Ostrop, Jenny;
Zwiggelaar, Rosalie Theda Margien;
Terndrup Pedersen, Marianne;
Gerbe, François;
Bösl, Korbinian;
Lindholm, Håvard Takle.
(2021)
A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation.
Frontiers in Cell and Developmental Biology
Academic article
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances
Academic article
Report
-
Lindholm, Håvard Takle;
Oudhoff, Menno J..
(2021)
Defining changes in the intestinal epithelium in early life and in response to infections.
NTNU
Doctoral dissertation