Marco Giampa
About
I obtained my Master degree in “Pharmaceutical chemistry and technologies” at Sapienza Università di Roma (Italy). I have been always interested in the interpretation and investigation of biological processes using mass spectrometry-based techniques. So I chose to study during my master thesis the structure and reactivity correlation of solvent-free ions of anti-cancer platinum derivatives using mass spectrometry. Then I began my PhD studies at Bielefeld University (Germany) with a project about analytical development in MALDI-ToF-mass spectrometry imaging of human tissues. I applied my expertise in mass spectrometry and ion chemistry in this new and promising field of mass spectrometry and was able to cope with several biological questions regarding defensive mechanisms in insects, evaluation of CO2 release from beads and phenotyping of biotechnologically relevant bacteria. Besides that, I also developed skills in the design and organic synthesis of new MALDI matrices. A vacuum stable proton sponge derivative, maleic anhydride proton sponge was synthesized and applied as a deprotonating and reactive matrix in MALDI-MSI to detect important cancer biomarkers and alcoholic compounds, respectively. After my PhD, I continued my research during a postdoctoral fellowship still at Bielefeld University to study new matrix materials as well as new mechanisms of analytes ionization. I investigated a new class of matrix based on conjugated polymers e.g. polythiophene and applied it in the detection of low molecular weight compounds without any related-polymeric matrix interference. Now, since October 2019 my research career continues at the Norwegian University of Science and Technology in the field of MSI-based method development in combination with gas chromatography-mass spectrometry aiming to unravel the complex chemistry of biology and to fill the gap between fundamental and applicative research. In detail, my research interest is to characterize the cellular membrane composition of breast cancer tissues and investigate its role in communication within microenvironments.
Competencies
Publications
2023
-
Giampà , Marco;
Andersen, Maria Karoline;
Krossa, Sebastian;
Denti, Vanna;
Smith, Andrew;
Moestue, Siver Andreas.
(2023)
Visualization of Small Intact Proteins in Breast Cancer FFPE Tissue.
Methods in molecular biology
Academic article
-
Giampà , Marco;
Corinti, Davide;
Maccelli, Alessandro;
Fornarini, Simonetta;
Berden, Giel;
Oomens, Jos.
(2023)
Binding Modes of a Cytotoxic Dinuclear Copper(II) Complex with Phosphate Ligands Probed by Vibrational Photodissociation Ion Spectroscopy.
Inorganic Chemistry
Academic article
-
Andersen, Maria Karoline;
Giampà , Marco;
Midtbust, Elise;
Høiem, Therese Stork;
Krossa, Sebastian;
Tessem, May-Britt.
(2023)
Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging.
Methods in molecular biology
Academic article
2022
-
Herrera, Maria Georgina;
Giampà , Marco;
Tonali, Nicolo;
Dodero, Veronica I..
(2022)
Multimodal Methods to Study Protein Aggregation and Fibrillation.
Elsevier
Chapter
-
Timir, Tripathi;
Giampà , Marco.
(2022)
Advances in Protein Molecular and Structural Biology Methods.
Elsevier
Elsevier
Textbook
-
Høiem, Therese Stork;
Andersen, Maria Karoline;
Martin-Lorenzo, Marta;
Longuespée, Rémi;
Claes, Britt S.R.;
Nordborg, Anna.
(2022)
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue.
Proteomics
Academic article
2021
-
Giampà , Marco;
Amundarain, Marìa J.;
Herrera, Maria Georgina;
Tonali, Nicolo;
Dodero, Veronica I..
(2021)
Implementing Complementary Approaches to Shape the Mechanism of α-Synuclein Oligomerization as a Model of Amyloid Aggregation.
Molecules
Academic literature review
-
Sgobba, Elvira;
Daguerre, Yohann;
Giampà, Marco.
(2021)
Unravel the local complexity of biological environments by MALDI mass spectrometry imaging.
International Journal of Molecular Sciences
Academic literature review
-
Horatz, Kilian;
Giampà, Marco;
Qiao, Zhi;
Moestue, Siver A.;
Lissel, Franziska.
(2021)
Polymerization as a Strategy to Improve Small Organic Matrices for Low-Molecular-Weight Compound Analytics with MALDI MS and MALDI MS Imaging.
ACS Applied Polymer Materials
Academic article
-
Denti, Vanna;
Andersen, Maria Karoline;
Smith, Andrew;
Bofin, Anna M.;
Nordborg, Anna;
Magni, Fulvio.
(2021)
Reproducible lipid alterations in patient-derived breast cancer xenograft FFPE tissue identified with MALDI MSI for pre-clinical and clinical application.
Metabolites
Academic article
2020
-
Sahin, Mikail;
Neumann, Judith M;
Riefke, Björn;
Bednarz, Hanna;
Gutberlet, Katrin;
Giampà, Marco.
(2020)
Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity.
Toxicology Letters
Academic article
-
Neumann, Judith M;
Sahin, Mikail;
Slopianka, Markus;
Giampà, Marco;
Bednarz, Hanna;
Ernst, Rainer.
(2020)
Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model.
Toxicology Letters
Academic article
-
Giampà, Marco;
Sgobba, Elvira.
(2020)
Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry.
Molecules
Academic literature review
2019
-
Schafermann, Johanna;
Kliewer, Georg;
Losch, Jan;
Bednarz, Hanna;
Giampà, Marco;
Niehaus, Karsten.
(2019)
Immersion by rotation‐based application of the matrix for fast and reproducible sample preparations and robust results in mass spectrometry imaging.
Journal of Mass Spectrometry
Academic article
Journal publications
-
Giampà , Marco;
Andersen, Maria Karoline;
Krossa, Sebastian;
Denti, Vanna;
Smith, Andrew;
Moestue, Siver Andreas.
(2023)
Visualization of Small Intact Proteins in Breast Cancer FFPE Tissue.
Methods in molecular biology
Academic article
-
Giampà , Marco;
Corinti, Davide;
Maccelli, Alessandro;
Fornarini, Simonetta;
Berden, Giel;
Oomens, Jos.
(2023)
Binding Modes of a Cytotoxic Dinuclear Copper(II) Complex with Phosphate Ligands Probed by Vibrational Photodissociation Ion Spectroscopy.
Inorganic Chemistry
Academic article
-
Andersen, Maria Karoline;
Giampà , Marco;
Midtbust, Elise;
Høiem, Therese Stork;
Krossa, Sebastian;
Tessem, May-Britt.
(2023)
Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging.
Methods in molecular biology
Academic article
-
Høiem, Therese Stork;
Andersen, Maria Karoline;
Martin-Lorenzo, Marta;
Longuespée, Rémi;
Claes, Britt S.R.;
Nordborg, Anna.
(2022)
An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue.
Proteomics
Academic article
-
Giampà , Marco;
Amundarain, Marìa J.;
Herrera, Maria Georgina;
Tonali, Nicolo;
Dodero, Veronica I..
(2021)
Implementing Complementary Approaches to Shape the Mechanism of α-Synuclein Oligomerization as a Model of Amyloid Aggregation.
Molecules
Academic literature review
-
Sgobba, Elvira;
Daguerre, Yohann;
Giampà, Marco.
(2021)
Unravel the local complexity of biological environments by MALDI mass spectrometry imaging.
International Journal of Molecular Sciences
Academic literature review
-
Horatz, Kilian;
Giampà, Marco;
Qiao, Zhi;
Moestue, Siver A.;
Lissel, Franziska.
(2021)
Polymerization as a Strategy to Improve Small Organic Matrices for Low-Molecular-Weight Compound Analytics with MALDI MS and MALDI MS Imaging.
ACS Applied Polymer Materials
Academic article
-
Denti, Vanna;
Andersen, Maria Karoline;
Smith, Andrew;
Bofin, Anna M.;
Nordborg, Anna;
Magni, Fulvio.
(2021)
Reproducible lipid alterations in patient-derived breast cancer xenograft FFPE tissue identified with MALDI MSI for pre-clinical and clinical application.
Metabolites
Academic article
-
Sahin, Mikail;
Neumann, Judith M;
Riefke, Björn;
Bednarz, Hanna;
Gutberlet, Katrin;
Giampà, Marco.
(2020)
Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity.
Toxicology Letters
Academic article
-
Neumann, Judith M;
Sahin, Mikail;
Slopianka, Markus;
Giampà, Marco;
Bednarz, Hanna;
Ernst, Rainer.
(2020)
Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model.
Toxicology Letters
Academic article
-
Giampà, Marco;
Sgobba, Elvira.
(2020)
Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry.
Molecules
Academic literature review
-
Schafermann, Johanna;
Kliewer, Georg;
Losch, Jan;
Bednarz, Hanna;
Giampà, Marco;
Niehaus, Karsten.
(2019)
Immersion by rotation‐based application of the matrix for fast and reproducible sample preparations and robust results in mass spectrometry imaging.
Journal of Mass Spectrometry
Academic article
Books
-
Timir, Tripathi;
Giampà , Marco.
(2022)
Advances in Protein Molecular and Structural Biology Methods.
Elsevier
Elsevier
Textbook
Part of book/report
-
Herrera, Maria Georgina;
Giampà , Marco;
Tonali, Nicolo;
Dodero, Veronica I..
(2022)
Multimodal Methods to Study Protein Aggregation and Fibrillation.
Elsevier
Chapter
Knowledge Transfer
2023
-
Academic lectureAndersen, Maria Karoline; Midtbust, Elise; Krossa, Sebastian; Viset, Trond; Størkersen, Øystein; Vandenbosch, Michiel. (2023) Spatial multiomics show lipid metabolism alterations in prostate cancer. Regional Mass Spectrometry Imaging Spring Workshop , Uppsala 2023-04-27 - 2023-04-29
2021
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Academic lectureGiampà , Marco. (2021) Alterations of cellular membrane lipids in breast cancer revealed by MALDI mass spectrometry imaging. Simonetta Fornarini Visiting external collaborators , Sapienza University of Rome 2021-12-20 - 2021-12-20
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Academic lectureAndersen, Maria Karoline; Midtbust, Elise; Claes, Britt S.R.; Giampà, Marco; Balluff, Benjamin; Heeren, Ron M.A.. (2021) Vacuum storage at -80°C offers optimal metabolite detection with MALDI-MSI. OurCon2021 , Digitalt 2021-10-12 - 2021-10-13
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PosterDenti, Vanna; Andersen, Maria Karoline; Smith, Andrew; Bofin, Anna M.; Nordborg, Anna; Magni, Fulvio. (2021) Reproducible Lipid Alterations in Patient-Derived Breast Cancer Xenograft FFPE Tissue Identified with MALDI MSI for Pre-Clinical and Clinical Application. OurCon2021 2021-10-12 - 2021-10-13