Nadra J. Nilsen
About
Research Scientist at the Centre of Molecular Inflammation Research (CEMIR), Center for Myeloma Research and the Colorectal Cancer (CRC) Research Center
My research focuses on basic mechanisms of innate immunity. In particular, I am interested in how signaling pattern recognition receptors (PRRs) recognize and respond to microbial and endogenous components, and how this shapes the subsequent immune response. I am currently interested in how PRR signaling affects cancer progression, with emphasis on the cancers Multiple Myeloma and colorectal cancer.
Publications
2017
-
Bugge, Marit;
Bergstrøm, Bjarte;
Eide, Oda K.;
Solli, Helene;
Kjønstad, Ingrid Fadum;
Stenvik, Jørgen.
(2017)
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness.
Journal of Biological Chemistry
Academic article
2016
-
Bugge, Marit;
Nilsen, Nadra J.;
Espevik, Terje.
(2016)
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells.
Norwegian University of Science and Technology
Doctoral dissertation
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Academic article
2015
-
Nilsen, Nadra;
Gregory I., Vladimer;
Stenvik, Jørgen;
Ørning, Mathias Pontus;
Zeid-Kilani, Maria Vanessa;
Bugge, Marit.
(2015)
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Journal of Biological Chemistry
Academic article
2013
-
Østvik, Ann Elisabet;
Granlund, Atle;
Bugge, Marit;
Nilsen, Nadra;
Torp, Sverre Helge;
Waldum, Helge.
(2013)
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation.
Inflammatory Bowel Diseases
Academic article
2012
-
Østvik, Ann Elisabet;
Nilsen, Nadra;
Granlund, Atle;
Torp, Sverre Helge;
Flatberg, Arnar;
Waldum, Helge.
(2012)
Enhanced expression of CXCL10 in inflammatory bowel disease-role of mucosal TLR3 stimulation.
Journal of Crohn’s and Coltis Supplements
Abstract
2010
-
Etokebe, GE;
Skjeldal, F;
Nilsen, Nadra;
Rodionov, Dmitrii;
Knezevic, Jelena;
Bulat-Kardum, Ljiljana.
(2010)
Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele.
Scandinavian Journal of Immunology
Academic article
-
Husebye, Harald;
Aune, Marie Hjelmseth;
Stenvik, Jørgen;
Samstad, Eivind Ottersen;
Skjeldal, Frode Miltzow;
Halaas, Øyvind.
(2010)
The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes.
Immunity
Academic article
2009
-
Iversen, Ann-Charlotte;
Steinkjer, Bjørg;
Nilsen, Nadra;
Bohnhorst, Janne Øvrebø;
Moen, Siv Helen;
Vik, Randi.
(2009)
A proviral role for CpG in cytomegalovirus infection.
Journal of Immunology
Academic article
2008
-
Nilsen, Nadra;
Espevik, Terje;
Lien, Egil.
(2008)
Toll-like receptor 2 expression, regulation and signaling.
Tapir Akademisk Forlag
Tapir Akademisk Forlag
Doctoral dissertation
-
Nilsen, Nadra;
Deininger, S;
Nonstad, Unni;
Skjeldal, F;
Husebye, Harald;
Rodionov, D.
(2008)
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36.
Journal of Leukocyte Biology
Academic article
2005
-
Manukyan, M;
Triantafilou, K;
Triantafilou, M;
Mackie, A;
Nilsen, Nadra Jesmine;
Espevik, Terje.
(2005)
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.
European Journal of Immunology
Academic article
2004
-
Campa, Christiana;
Holtan, Synnøve;
Nilsen, Nadra;
Bjerkan, Tonje M;
Stokke, Bjørn Torger;
Skjåk-Bræk, Gudmund.
(2004)
Biochemical analysis of the processive mechanism for epimerization of alginate by mannuronan C-5 epimerase AlgE4.
Biochemical Journal
Academic article
-
Nilsen, Nadra;
Nonstad, Unni;
Kahn, Naseema;
Knetter, Cathrine;
Akira, Shizuo;
Sundan, Anders.
(2004)
Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88.
Journal of Biological Chemistry
Academic article
-
Latz, E;
Schoenemeyer, A;
Visintin, A;
Fitzgerald, KA;
Monks, BG;
Knetter, Cathrine.
(2004)
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature Immunology
Academic article
2003
-
Schjetne, KW;
Thompson, KM;
Nilsen, Nadra;
Flo, Trude Helen;
Fleckenstein, B;
Iversen, JG.
(2003)
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target.
Journal of Immunology
Academic article
Journal publications
-
Bugge, Marit;
Bergstrøm, Bjarte;
Eide, Oda K.;
Solli, Helene;
Kjønstad, Ingrid Fadum;
Stenvik, Jørgen.
(2017)
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness.
Journal of Biological Chemistry
Academic article
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Academic article
-
Nilsen, Nadra;
Gregory I., Vladimer;
Stenvik, Jørgen;
Ørning, Mathias Pontus;
Zeid-Kilani, Maria Vanessa;
Bugge, Marit.
(2015)
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Journal of Biological Chemistry
Academic article
-
Østvik, Ann Elisabet;
Granlund, Atle;
Bugge, Marit;
Nilsen, Nadra;
Torp, Sverre Helge;
Waldum, Helge.
(2013)
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation.
Inflammatory Bowel Diseases
Academic article
-
Østvik, Ann Elisabet;
Nilsen, Nadra;
Granlund, Atle;
Torp, Sverre Helge;
Flatberg, Arnar;
Waldum, Helge.
(2012)
Enhanced expression of CXCL10 in inflammatory bowel disease-role of mucosal TLR3 stimulation.
Journal of Crohn’s and Coltis Supplements
Abstract
-
Etokebe, GE;
Skjeldal, F;
Nilsen, Nadra;
Rodionov, Dmitrii;
Knezevic, Jelena;
Bulat-Kardum, Ljiljana.
(2010)
Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele.
Scandinavian Journal of Immunology
Academic article
-
Husebye, Harald;
Aune, Marie Hjelmseth;
Stenvik, Jørgen;
Samstad, Eivind Ottersen;
Skjeldal, Frode Miltzow;
Halaas, Øyvind.
(2010)
The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes.
Immunity
Academic article
-
Iversen, Ann-Charlotte;
Steinkjer, Bjørg;
Nilsen, Nadra;
Bohnhorst, Janne Øvrebø;
Moen, Siv Helen;
Vik, Randi.
(2009)
A proviral role for CpG in cytomegalovirus infection.
Journal of Immunology
Academic article
-
Nilsen, Nadra;
Deininger, S;
Nonstad, Unni;
Skjeldal, F;
Husebye, Harald;
Rodionov, D.
(2008)
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36.
Journal of Leukocyte Biology
Academic article
-
Manukyan, M;
Triantafilou, K;
Triantafilou, M;
Mackie, A;
Nilsen, Nadra Jesmine;
Espevik, Terje.
(2005)
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.
European Journal of Immunology
Academic article
-
Campa, Christiana;
Holtan, Synnøve;
Nilsen, Nadra;
Bjerkan, Tonje M;
Stokke, Bjørn Torger;
Skjåk-Bræk, Gudmund.
(2004)
Biochemical analysis of the processive mechanism for epimerization of alginate by mannuronan C-5 epimerase AlgE4.
Biochemical Journal
Academic article
-
Nilsen, Nadra;
Nonstad, Unni;
Kahn, Naseema;
Knetter, Cathrine;
Akira, Shizuo;
Sundan, Anders.
(2004)
Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88.
Journal of Biological Chemistry
Academic article
-
Latz, E;
Schoenemeyer, A;
Visintin, A;
Fitzgerald, KA;
Monks, BG;
Knetter, Cathrine.
(2004)
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature Immunology
Academic article
-
Schjetne, KW;
Thompson, KM;
Nilsen, Nadra;
Flo, Trude Helen;
Fleckenstein, B;
Iversen, JG.
(2003)
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target.
Journal of Immunology
Academic article
Report
-
Bugge, Marit;
Nilsen, Nadra J.;
Espevik, Terje.
(2016)
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells.
Norwegian University of Science and Technology
Doctoral dissertation
-
Nilsen, Nadra;
Espevik, Terje;
Lien, Egil.
(2008)
Toll-like receptor 2 expression, regulation and signaling.
Tapir Akademisk Forlag
Tapir Akademisk Forlag
Doctoral dissertation
Media
2018
-
Academic lectureBugge, Marit; Espevik, Terje; Nilsen, Nadra. (2018) Altered Toll-Like Receptor Expression and Signaling in Colorectal Cancer Cells promotes Invasiveness. NTNU/St. Olav’s Hospital 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer: From diagnosis to immunotherapy – why is precision medicine so difficult? , Trondheim 2018-06-14 - 2018-06-15
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PosterBugge, Marit; EIde, Oda Kamilla; Solli, Helene; Kjønstad, Ingrid Fadum; Stenvik, Jørgen; Bergstrøm, Bjarte. (2018) SURFACE TOLL-LIKE RECEPTOR 3 EXPRESSION IN METASTATIC INTESTINAL EPITHELIAL CELLS INDUCES INFLAMMATORY CYTOKINE PRODUCTION AND PROMOTES INVASIVENESS. UMASS Medical School and University of Freiburg Toll 2018 Translating Innate Immunity , Porto 2018-06-06 - 2018-06-09
2017
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PosterBugge, Marit; Bergstrøm, Bjarte Aune; Eide, Oda K.; Solli, Helene; Kjønstad, Ingrid Fadum; Stenvik, Jørgen. (2017) Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Inflammatory Cytokine Production and Promotes Invasiveness. Universitats Klinikum Freiburg Development of Tissue- and Pathogen-specific Cellular Innate Immunity , Freiburg 2017-09-27 - 2017-09-29
2015
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PosterBugge, Marit; Solli, Helene; Kjønstad, Ingrid F.; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra J.. (2015) Metastatic Intestinal Epithelial Cells Express Surface Toll-Like Receptor 3. The University of Massachusetts Medical School Toll 2015 Targeting Innate Immunity , Marbella 2015-09-30 - 2015-10-03
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PosterNilsen, Nadra J.; Espevik, Terje; Vladimer, G; Stenvik, Jørgen; Orning, M. Pontus A.; Zeid-Kilani, Maria Vanessa. (2015) THE ADAPTOR PROTEINS TRAM AND TRIF MEDIATE TOLL-LIKE RECEPTOR 2 SIGNALING. Wellcome Trust Innate Immune Memory , Hinxton, Cambridge 2015-03-18 - 2015-03-20
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LectureNilsen, Nadra J.; Espevik, Terje; Vladimer, G; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit. (2015) THE ADAPTOR PROTEINS TRAM AND TRIF MEDIATE TOLL-LIKE RECEPTOR 2 SIGNALING. UMass Medical School, MA; Universitats Klinikum Freiburg, D Toll2015 Targeting Innate Immunity , Marbella 2015-09-30 - 2015-10-03
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PosterNilsen, Nadra J.; Espevik, Terje; Gjerdingen, Thea Johannne; Bugge, Marit; Kjønstad, Ingrid Fadum. (2015) A TOLL-LIKE RECEPTOR 7/8 LIGAND SECRETED BY MYELOMA CELLS INDUCES PRIMARY BONE MARROW STROMAL CELLS TO PRODUCE CYTOKINES THAT PROMOTE MYELOMA SURVIVAL. Toll2015 Targeting Innate Immunity 2015-09-30 - 2015-10-03
2013
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PosterBugge, Marit; Nilsen, Nadra; Espevik, Terje. (2013) A potential role for TLR3 expression and TLR3 mediated responses in the progression of colorectal cancer. Keystone Symposia on Cancer Immunology and Immunotherapy , Vancouver 2013-01-27 - 2013-02-01
2010
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Academic lectureNilsen, Nadra; Espevik, Terje; Lien, Egil. (2010) The Adaptor Proteins TRAM and TRIF mediate Toll-Like Receptor 2- induced RANTES/CCL5 Release. International Congress of Immunology 14th International Congress of Immunology , Kobe 2010-08-22 - 2010-08-27
2008
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PosterIversen, Ann-Charlotte; Steinkjer, Bjørg; Nilsen, Nadra; Bohnhorst, Janne Øvrebø; Moen, Siv Helen; Vik, Randi. (2008) A proviral role for CpG in cytomegalovirus infection. UMASS, Boston, MA Toll 2008 Conference , Cascais 2008-09-24 - 2008-09-27
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PosterNilsen, Nadra; Deininger, Susanne; Nonstad, Unni; Skjeldal, Frode; Husebye, Harald; Rodionov, Dmitrii. (2008) Toll-like receptor 2 signaling occurs preferentially at the plasma membrane, independent of internalization, and is facilitated by both CD36 and CD14. UMASS Medical School / Fundacao Calouste Gulbenkian TOLL2008 , Caiscais 2008-09-24 - 2008-09-27
2004
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Academic lectureNilsen, Nadra; Espevik, Terje. (2004) Molecular associations of lipopeptides with CD14 and TLR2. Toll 2004 , Sicilia 2004-05-08 - 2004-05-11
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Academic lectureNilsen, Nadra; Nonstad, U; Knetter, Cathrine; Sundan, Anders; Espevik, Terje; Lien, Egil. (2004) Lipopolysaccharide- and dsRNA-Induced Upregulation of Mouse Tollike Receptor 2 is Myeloid Differentiation Factor 88-Independent. Toll 2004 , Sicilia 2004-05-08 - 2004-05-11
2003
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PosterManoukian, M; Triantafilou, M; Triantafilou, K; Mackie, A; Nilsen, Nadra; Espevik, Terje. (2003) Molecular mechanisms of lipopeptide interaction with CD14 and TLR2. 34th Annual Meeting of the German Society of Immunology , Berlin, Germany 2003-09-27 -
2002
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PosterNilsen, Nadra; Nonstad, Unni; Sundan, Anders; Espevik, Terje; Lien, Egil. (2002) Function and expression of mouse Toll-like receptor 2, a receptor for bacterial, fungal and viral components. The 7th Biennial Conference of the International Endotoxin Society. , Washington, USA 2002-07-21 -