Background and activities
I work as a PostDoc on the ERC “ProstOmics” project in the group of May-Britt Tessem. With my current research I want to contribute to a better understanding of prostate cancer and improve its diagnostics by using big data from a multilevel ‘omics approach. Together with my colleagues I am collecting genomics, transcriptomics, proteomics, metabolomics, and metallomics data directly from a large cohort of prostate cancer tissue, ideally with spatial resolution, by using modern imaging and high-throughput technologies. Next, we want to integrate and mine this big data set with the help of multivariate statistics and deep learning approaches to find biomarker patterns that are suitable to better and individually predict cancer aggressiveness and recurrence.
I studied biochemistry and did my PhD in structural biology/X-ray crystallography at the Kiel University in Northern Germany. During that time, I mainly researched the structure, function and biological role of proteins related to cancer and the polyamine metabolism. I have a broad multidisciplinary methodological background with a strong emphasize on proteomics, but I am also experienced in many cell biology, molecular biology, and metabolomics techniques. In addition, I have a great interest in modern, computer-based data mining approaches and have acquired a good understanding of some programming and scripting languages.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2020) Simultaneous detection of zinc and its pathway metabolites using MALDI MS imaging of prostate tissue. Analytical Chemistry. vol. 92 (4).
- (2019) Simultaneous detection of the cancer biomarkers zinc and citrate in prostate cancer tissue using mass spectrometry imaging. European urology. Supplement. vol. 18 (8).
- (2019) KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases. Cellular Physiology and Biochemistry. vol. 52 (4).
- (2019) Detectable biomarkers in urine for prostate cancer prognosis. European urology. Supplement. vol. 18 (8).
- (2018) Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17. Scientific Reports. vol. 8.
- (2017) GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation. FEBS Letters. vol. 591 (21).
- (2016) Transmembrane chemokines act as receptors in a novel mechanism termed inverse signaling. eLIFE. vol. 5.
- (2016) Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase–an Essential Enzyme of the Polyamine Metabolism. Scientific Reports. vol. 6.
- (2015) Impact of chemokines on the properties of spinal cord-derived neural progenitor cells in a rat spinal cord lesion model. Journal of Neuroscience Research. vol. 93 (4).
- (2015) Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1. OncoTarget. vol. 6 (25).