Viral Vector Core

Adeno-associated virus mediated transgene expression (yellow and green color) in medial entorhinal cortex of rat brain. Neurons are shown in red color. This specific gene expression is driven by a medial entorhinal cortex specific enhancer.

 

Viral Vector Core

Infrastructure

Viral Vector Core


The Viral Vector Core at Kavli Institute for Systems Neuroscience is a well-equipped facility having rare expertise to make high quality viruses for research purposes. We are a non-profit facility that offers consultation, design and construction of a wide variety of viral vectors to augment scientific research.

 

Recombinant viruses

Recombinant viruses are highly efficient gene delivery vehicles for introducing molecular tools to difficult-to-transfect primary cells, to create stable cell lines, to transduce tissues in vivo for elucidating underlying biological mechanisms and nowadays for gene therapy applications in clinics.

A combinatorial approach using viral vectors with the vast repertoire of transgenic animals available is a powerful strategy to target specific cells in complex organs such as mammalian brains. 

Adeno-associated virus, Moloney murine leukemia virus, Lenti virus and pseudotyped G-deleted rabies virus are all common transgene-delivery agents, each having distinct characteristics making them suitable for specific research questions.

Depending on the scientific question, one may need viral tools with specific features, demanding novel vector designs.

 

Learn more about our products, services and prices

  

Viral vector Core