Keynote speakers

We are very pleased that the distinguished scientists, thought leaders and excellent speakers Denis Noble, Tom Kirkwood, Peter Hunter and Yoram Rudy will each open one of the four plenary sessions of the conference:

Denis NobleIs the digital patient possible: What are the roadblocks and how do we negotiate them?

Professor Denis Noble, University of Oxford


Tom KirkwoodUntangling the complexity of ageing

Professor Tom Kirkwood, Newcastle University


Peter HunterReproducible modeling: Standards, databases and software tools

Professor Peter Hunter, University of Auckland


Yoram RudyMulti-scale Integration of Cardiac Excitation: From Molecular Structure to the Human Heart

Professor Yoram Rudy, Washington University in St. Louis



Asset Publisher

Cardiovascular modelling

Cardiovascular modelling Organizer:  Arun Holden,  Multidisciplinary Cardiovascular Research Centre, University of Leeds Co-organizer: Molly Maleckar, Simula...

Computational integration of organ physiology

Computational integration of organ physiology Organizer: Dan Beard, Department of Molecular and 
Integrative Physiology, University of Michigan, Ann Arbor Co-organizer: Dirk...

Interoperability infrastructures bridging molecular- to organ-level data and models

Interoperability infrastructures bridging molecular- to organ-level data and models Organizer: Bernard de Bono, CHIME Institute, University College London & Auckland...

Multiscale modelling of cancer

Multiscale modelling of cancer Organizer: Georgios S. Stamatakos, In Silico Oncology Group, Institute of Communication and Computer Systems, National Technical University of...

Metamodelling methodology for easing model construction and validation

Metamodelling methodology for easing model construction and validation Organizer: Kristin Tøndel, Simula Research, Oslo Co-organizer: Gunnar Cedersund, Department of biomedical...

Mathematical challenges of multiscale modelling

Mathematical challenges of multiscale modelling Organizer: Merryn Tawhai, Auckland Bioengineering 
Institute, University of Auckland Co-organizer: Blanca Rodriguez,...

Model-guided medical device design and assessment

Model-guided medical device design and assessment Organizer: Marco Viceconti, Department of 
Mechanical Engineering, University of Sheffield Co-organizer: Claudio Cobelli,...

Make them run: modelling challenges identified by exercise physiology

Make them run: modelling challenges identified by exercise physiology Organizer: Trine Karlsen, 
Department of Circulation and Medical Imaging, NTNU Co-organizer: Allen...

Model-guided tissue engineering and stem cell therapy

Model-guided tissue engineering and stem cell therapy Organizer: Liesbet Geris, Biomechanical 
Engineering, University of Liege Co-organizer: Jose Manuel Garcia-Aznar,...

ePoster presentations

ePoster presentations

TAILORED-treatment – developing algorithms for diagnosing the septic patient
J. Hays

Ultrasound-guided regional anaesthesia assisted by patient specific VPH models
F. Lindseth, I. Reinertsen, E. Smistad, C. Askeland, K. Johansen

Drug synergies in a gastric cancer cell line discovered by signal transduction modeling
Å. Flobak, A. Baudot, E. Remy, L. Thommesen, D. Thieffry, M. Kuiper, A. Lægreid

Modeling of the human induced pluripotent stem cell-derived cardiomyocyte action potential
M. Paci, S. Severi, J. Hyttinen

The inter-sample structural variability of regular tissue-engineered scaffolds affects significantly the local cell environment
A. Campos Marin, D. Lacroix

Mathematical modelling of bone formation based on local Ca2+ concentrations in calcium phosphate scaffolds
V. Manhas, Y. Guyot, Y. Chai, G. Kerckhofs, A. Carlier, L. Geris

The GRECO consortium: Taking care of gene regulation knowledge
M. Kuiper, A. Lægreid, T. Greco

Logic synthesis methods for medical data mining
G. Borowik, A. Grzanka, T. Łuba, A. Kra´sniewski

s-core network decomposition: A generalization of k-core analysis to weighted networks
M. Eidsaa, E. Almaas

Ultrasound-mediated delivery of nanoparticles to tumour tissue
C. Davies, S. Eggen, A. Åslund, R. Hansen, B. Angelsen, Y. Mørch, S. Berg

Long-term liver motion tracking with 4D ultrasound
S. Muller, S. Vijayan, T. Langø

Reinterpreting b-adrenergic sensitivity from time-resolved data via minimal mechanistic modelling
W. Lövfors, E. Nyman, K. Lundengård, J. Altimiras, G. Cedersund

A cellular potts model of a stented arterial vessel to study the role of initial smooth muscle cells migration in neointimal development
H. Tahir, I. Niculesco, R. Merks, A. Hoekstra

Three-layer-isotropic skull conductivity representation in the EEG forward problem using spherical head models
H. Hallez, E. Cuartas-Morales, G. Castellanos-Gonzales, B. Vanrumste

Multi-level modeling of insulin signaling: Merging of islands of high-quality models with a background systems-level model for the entire proteome
R. Magnusson

Temporal control and activation of inflammatory genes in endo thelial cells in response to wall shear stress.
D. Baeriswyl, R. Shipley, Y. Ventikos

A 3-D electrophysiological model of the human left ventricle
S. Pravdin, H. Dierckx, A. Panfilov, V. Berdyshev, L. Katsnelson, O. Solovyova,
V. Markhasin

Generating patient-specific finite-element meshes by parametric constrained image registration
D. Silva, D. Barber, R. Hose

Verification and validation of computational modelling of medical devices and treatment: Critical considerations in view of multi-physics modeling of in vivo processes
E. Neufeld, N. Kuster

Creating patient specific models to optimise multipolar lead pacing
protocols following reverse remodelling in cardiac resynchronisation therapy patients

A. Lee, M. Sohal, G. Plank, R. Razavi, P. Lamata, C. Rinaldi, S. Niederer

A generalized model of tumor growth and response to treatment using the PUN approach
C. Guiot, I. Stura

Nano network of neurons from communication engineering perspective
M. Veletic, P. Floor, F. Mesiti, I. Balasingham

INEX – A simple but effective computational model to simulate neuronal-astrocytic activity
K. Lenk, I. Vornanen, E. Räisänen, J. Hyttinen

The digital salmon: Virtual physiology in aquaculture
J. Vik, A. Gjuvsland, J. Torgersen, S. Lien, S. Omholt

3D model of a heart in blender
M. Michalska, A. Grzanka

A flexible one dimensional simulation framework for blood flow in arterial networks
V. Eck, L. Hellevik

VPH-share: Patient-centred multiscale cloud-enabled computational  workflows
S. Varma, M. Villa-Uriol, E. Manchini, E. Schileo, P. Lamata, N. Smith, R. Hose

MR-Elastography in nonlinear deformable materials: Towards cardiac MRE
D. Nordsletten, O. Holub, S. Lambert, L. Bilston, R. Sinkus

Mechanistic modelling investigates the neural basis behind the hemodynamic response in fMRI
K. Lundengård, B. Svensson, S. Sten, J. Schyberg, G. Cedersund, F. Elinder,
M. Engström

Visual features in phonemes classification
M. Sobotka,A. Grzanka

Computational prediction the effect of V241F KCNQ1 mutation on human atrial fibrillation
K. Lim, R. Imaniastuti, J. Yeom, E. Shim

Determination of the role of AQP-4 channels in neuromyelitis optica through mathematical modelling
S. Laranjeira, M. Symmonds, J. Palace2, S. Payne, P. Orlowski

A first truly systems level mechanistic model – unravelling the gene regulation of Th2 differentiation
M. Köpsén, W. Lövfors, G. Cedersund, M. Benson, M. Gustafsson

‘E-SPINE', The virtual physiological Korean spine project
Y. Kim

Privacy-preserving scalable data federation with applications to research patient registries
S. Varma

Introduction of Korean human project; Digital Korean and visible Korean
S. Lee, S. Lee, S. Lee, H. Par

Asthma sputum inflammatory phenotypes, a transcriptome analysis using taverna a knowledge discovery framework
A. Maleki-Dizaji, C. Newby, R. Berair, R. Smallwood, C. Brightling

Differential gene co-expression networks in human tissue
A. Voigt, K. Nowick, E. Almaas

The gene eXpression knowledge base
A. Venkatesan, S. Tripathi, A. Sans De Galdeano, W. Blondé, A. Lægreid, V. Mironov, M. Kuiper

Mathematical model of ammonia handling in the rat renal medulla
L. Noiret, S. Thomas

Electrotonic and structural effects of fibrosis on the genesis of atrial fibrillation: Insights from 3D human atria model
R. Morgan, M. Colman, M. Kruger, G. Seemann, K. Rhode, O. Aslanidi

Practical identifiability of cardiac constitutive laws using 3D tagged MRI
D. Nordsletten, M. Hadjicharalambous, R. Chabiniok, L. Asner, N. Smith, R. Razavi

Human dentofacial system as an element of project "Virtual Physiological Human"
Y. Nyashin, V. Lokhov

GPU accelerated finite element analysis of trabecular bone tissue
C. Nita, Y. Chen, L. Lazar, V. Mihalef, L. Itu, M. Viceconti, C. Suciu

Independent stress and deformation control at medical treatment
V. Lokhov, Y. Nyashin

A biophysically detailed model of cardiac contraction predicts the cooperative interactions between crossbridges and tropomyosin
S. Land, N. Smith, S. Niederer

Neuronal stimulation scenarios at nanoscale
F. Mesiti, P. Floor, M. Veletic, I. Balasingham

Non-invasive relative pressure estimates from fluid energy using PCMRI
D. Fabrizio, P. Lamata, C. Figueroa, N. Smith, D. Nordsletten

Physiology of human muscle oxygenation after treatment of patients suffering ischemic heart disease
A. Paiziev, N. Sayfiev, S. Payzieva

A simple finger tracking computerized test: Identification of parametric VPH motor model
F. Kharaman, M. Da Lio, L. Zaccarian, M. De Cecco, M. Confalonieri

Modelling the functional impact of KCNA5 mutations on the physiological and mechanical activities of the human atria
H. Ni, M. Colman, H. Zhang

P300 generators in Parkinson's disease according to symptoms: A LORETA modelling study
O. Ivanenko, S. Kryzhanovskyi, A. Cherninskyi, I. Zyma, I. Karaban

NoTremor: Virtual, physiological and computational neuromuscular models for the predictive treatment of Parkinson's disease.
K. Moustakas, K. Votis, D. Tzovaras, K. Gurney, P. Brown, M. Hu, M. Da Lio

A computational framework for describing the saccadic eye movement system of the Parkinsonian digital patient
S. James, A. Blenkinsop, S. Anderson, C. Papapavlou, K. Moustakas, K. Gurney

Intelligent predictive artificial pancreas by biomimicry of the native beta cells – concept, prototype and the future
N. Skjaervold, A. Fougner, N. Elvemo

Modelling insulin and glucose dynamics in diabetes mellitus type 1: Intravenous, subcutaneous and intraperitoneal approach
K. Kölle, A. Fougner, H. Frøyen, Ø. Stavdahl

Mathematical modelling of glucose homeostasis for usage in an intensive care unit
A. Hjelm, G. Cedersund, F. Sjöberg, M. S Chew, L. Bergenzaun, R. Johansson, H. Naga

Comprehensive laboratory animal monitoring system
H. Johannessen, M. Olsen, C. Zhao,D. Chen

Systems biology based analysis of metalloproteins of Mycobacterium tuberculosis
S. Soumi, E. Almaas

Hands on demonstrations of VPH-compliant software

Hands on demonstrations of VPH-compliant software

Share, discover and access biomedical resources:  VPH-Share in action

Debora Testi, VPH-Share Platform

The VPH-Share presented the software platform which allows biomedical researchers and clinicians to share data, and tools and to compose them in complex workflows to build new knowledge. The system is accessible via an easy to use web interface and allows searching for resources, the upload/creation of new resources, the remote execution of tools and workflows relying on an efficient cloud platform.

VPH tools from the Auckland Bioengineering Institute

Poul Michael Fonss Nielsen

This tutorial highlighted three VPH-compliant tools, PMR2, OpenCOR, and MAP Client. PMR2 is a software framework for providing data and knowledge repositories, with the data encapsulated in version controlled workspaces. OpenCOR is a tool for model editing, annotation, and simulation, initially based on CellML but extensible to other model encoding standards. The MAP Client is a workflow editor and execution tool being developed in order to capture the semantics of workflows.


The Flower of Life: Vessels in the human lungs (red) and first generations of branches starting from the trachea (green).

Photo: Solveig Fadnes, MI Lab and Department of Circulation and Medical Imaging, NTNU