HUNT-MCE Family-Based Genomics Group

HUNT-MCE Family-Based Genomics Group

The HUNT-MCE Family-Based Genomics Group is a research group with a focus on using family-based designs for genetic epidemiology.

Study designs include:

  • Intergenerational GWAS and MR
  • Within-family MR
  • Sibling and trio GWAS

We primarily use data from the Trøndelag Health Study (HUNT) but also access and collaborate with others working on MoBa, UK Biobank and ASLPAC cohorts among others. Please find a selection of studies below and key contacts.

Publications

Publications

Bhatta et. al. (2024). Intergenerational genome-wide association analyses to detect parent-offspring effects on birthweight and cardiometabolic outcomes. 

Bhatta et. al. (2024). Leveraging parental genotypes to understand the effect of maternal glycemic traits on offspring cardiometabolic factors in adulthood: an intergenerational Genome-Wide Association and Mendelian randomization Study.

Bond et. al. (2024). Parental body mass index and offspring cardiovascular risk factors in adulthood: an intergenerational Mendelian randomization study.

Parent-offspring designs (Intergenerational GWAS)

Parent-offspring designs (Intergenerational GWAS)

The parent-offspring data is used to apply novel and robust intergenerational approach to investigate parent-offspring effects. 

Code for the analysis can be found on Github and Tom Bond can be reached for questions.

GWAS

Birthweight

Birthweight
  • Mother GWAS (marginal, conditional) 
  • Father GWAS (marginal, conditional) 
  • Offspring GWAS (marginal, conditional) 

Body mass index (BMI)

Body mass index (BMI)
  • Mother GWAS (marginal, conditional) 
  • Father GWAS (marginal, conditional) 
  • Offspring GWAS (marginal, conditional) 

Waist-to-hip ratio (WHR) 

Waist-to-hip ratio (WHR) 
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 
     

Systolic blood pressure (SBP)

Systolic blood pressure (SBP)
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 

Diastolic blood pressure

Diastolic blood pressure
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 

Blood glucose

Blood glucose
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 


 

Glycated hemoglobin (HbA1c) 

Glycated hemoglobin (HbA1c) 
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 

 

Total cholesterol (TC)

Total cholesterol (TC)
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 

High-density lipoprotein (HDL-C) 

High-density lipoprotein (HDL-C) 
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 

Low-density lipoprotein (LDL-C)

Low-density lipoprotein (LDL-C)
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 

Triglycerides (TG)

Triglycerides (TG)
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional)

C-reactive protein (CRP) 

C-reactive protein (CRP) 
  • Mother (marginal, conditional) 
  • Father (marginal, conditional) 
  • Offspring (marginal, conditional) 
     

person-portlet

Group Leader

person-portlet

Contact

References

References

  1. Åsvold, B.O. et al. Cohort Profile Update: The HUNT Study, Norway. Int J Epidemiol (2022)
  2. Krokstad S, et al. Cohort Profile: the HUNT Study, Norway. Int J Epidemiol. (2013)
  3. Brumpton, B.M. et al. The HUNT study: A population-based cohort for genetic research. Cell Genomics 2, 100193 (2022)