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  1. Employees

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Ben Michael Brumpton

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Ben Michael Brumpton

Associate Professor in Genetic Epidemiology
Department of Public Health and Nursing

ben.brumpton@ntnu.no
+4773597564 +4746229495 Øya Helsehus, 153.04.020, Øya, Håkon Jarls gate 11
About Publications Teaching

About

My research concerns the use of genetic data and phenotypic information collected from population-based health surveys, electronic health records and other omics within epidemiological frameworks to make causal inference. My methodologies include Mendelian randomization and genetic epidemiology.

Major research projects:

  • HUNT genotyping
  • HUNT-COVID questionnaire
  • HUNT-metabolomics
  • HUNT-methylation

Competencies

  • DNA methylation
  • epidemiology
  • genetic epidemiology
  • metabolomics
  • omics

Publications

  • Chronological
  • By category
  • All publications registered in NVA

2022

  • Howe, Laurence J.; Brumpton, Ben Michael; Rasheed, Humaira; Åsvold, Bjørn Olav; Smith, George Davey; Davies, Neil Martin. (2022) Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study. eLIFE
    Academic article

2021

  • Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E; Hansen, Ailin Falkmo; Wolford, Brooke N; Taliun, Sarah A Gagliano; Lefaive, Jonathon; Rasheed, Humaira. (2021) Genome-wide association study of cardiac troponin i in the general population. Human Molecular Genetics
    Academic article
  • Bhatta, Laxmi; Cepelis, Aivaras; Vikjord, Sigrid Anna Aalberg; Malmo, Vegard; Laugsand, Lars Erik; Dalen, Håvard; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B; Brumpton, Ben Michael. (2021) Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study. European Journal of Epidemiology (EJE)
    Academic article

2020

  • Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco. (2020) GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nature Communications
    Academic article
  • Surakka, Ida; Fritsche, Lars; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A.; Lu, Haocheng; Brumpton, Ben Michael; Nielsen, Jonas B.; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi. (2020) MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk. Nature Communications
    Academic article
  • Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy; Fritsche, Lars; Taliun, Sarah Gagliano; Sidore, Carlo; Liu, Yuhao. (2020) Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nature Communications
    Academic article
  • Brumpton, Ben Michael; Sanderson, Eleanor; Heilbron, Karl; Hartwig, FP; Harrison, S; Vie, Gunnhild Åberge; Cho, Y; Howe, LD; Hughes, A; Boomsma, D. (2020) Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nature Communications
    Academic article
  • Bhatta, Laxmi; Leivseth, Linda; Mai, Xiao-Mei; Henriksen, Anne Hildur; Carslake, David; Yue, Chen; Martinez-Camblor, Pablo; Langhammer, Arnulf; Brumpton, Ben Michael. (2020) Spirometric Classifications of COPD Severity as Predictive Markers for Clinical Outcomes: The HUNT Study. American Journal of Respiratory and Critical Care Medicine
    Academic article
  • Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I.; Wang, Geng; Neale, Michael C.; Freathy, Rachel M.; Smith, George Davey; Lawlor, Debbie A.. (2020) Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort. Nature Communications
    Academic article

2019

  • Richmond, Rebecca C.; Anderson, Emma L.; Dashti, Hassan S.; Jones, Samuel E.; Lane, Jacqueline M.; Strand, Linn B; Brumpton, Ben Michael; Rutter, Martin K.; Wood, Andrew R.; Straif, Kurt. (2019) Investigating causal relations between sleep traits and risk of breast cancer in women: Mendelian randomisation study. The BMJ
    Academic article
  • Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei. (2019) Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study. Thorax
    Academic article
  • Budu-Aggrey, Ashley; Brumpton, Ben Michael; Tyrrell, Jess; Watkins, Sarah; Modalsli, Ellen Heilmann; Celis-Morales, Carlos; Ferguson, Lyn D.; Vie, Gunnhild Åberge; Palmer, Tom; Fritsche, Lars. (2019) Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. Nature Methods
    Academic article
  • Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad. (2019) Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition. Circulation: Genomic and precision medicine
    Academic article

2018

  • Cepelis, Aivaras; Brumpton, Ben Michael; Malmo, Vegard; Laugsand, Lars Erik; Loennechen, Jan Pål; Ellekjær, Hanne; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B. (2018) Associations of asthma and asthma control with atrial fibrillation risk: Results from the Nord-Trøndelag health study (HUNT). JAMA cardiology
    Academic article
  • Sun, Yi-Qian; Brumpton, Ben Michael; Bonilla, Carolina; Lewis, Sarah J.; Burgess, Stephen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei. (2018) Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study. European Respiratory Journal
    Academic article

2017

  • Ferreira, Manuel A.; Vonk, Judith M; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Dongen, Jenny Van. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics
    Academic article
  • Brumpton, Ben Michael; Mai, Xiao-Mei; Langhammer, Arnulf; Laugsand, Lars Erik; Janszky, Imre; Strand, Linn B. (2017) Prospective study of insomnia and incident asthma in adults: The HUNT study. European Respiratory Journal
    Academic article

2014

  • Mai, Xiao-Mei; Brumpton, Ben Michael. (2014) Risk factors for the development of asthma in adults: adiposity, metabolic syndrome, mental distress and their interplay. Norges teknisk-naturvitenskapelige universitet
    Doctoral thesis

Journal publications

  • Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco. (2020) GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nature Communications
    Academic article
  • Surakka, Ida; Fritsche, Lars; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A.; Lu, Haocheng; Brumpton, Ben Michael; Nielsen, Jonas B.; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi. (2020) MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk. Nature Communications
    Academic article
  • Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy; Fritsche, Lars; Taliun, Sarah Gagliano; Sidore, Carlo; Liu, Yuhao. (2020) Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nature Communications
    Academic article
  • Brumpton, Ben Michael; Sanderson, Eleanor; Heilbron, Karl; Hartwig, FP; Harrison, S; Vie, Gunnhild Åberge; Cho, Y; Howe, LD; Hughes, A; Boomsma, D. (2020) Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nature Communications
    Academic article
  • Richmond, Rebecca C.; Anderson, Emma L.; Dashti, Hassan S.; Jones, Samuel E.; Lane, Jacqueline M.; Strand, Linn B; Brumpton, Ben Michael; Rutter, Martin K.; Wood, Andrew R.; Straif, Kurt. (2019) Investigating causal relations between sleep traits and risk of breast cancer in women: Mendelian randomisation study. The BMJ
    Academic article
  • Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei. (2019) Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study. Thorax
    Academic article
  • Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E; Hansen, Ailin Falkmo; Wolford, Brooke N; Taliun, Sarah A Gagliano; Lefaive, Jonathon; Rasheed, Humaira. (2021) Genome-wide association study of cardiac troponin i in the general population. Human Molecular Genetics
    Academic article
  • Cepelis, Aivaras; Brumpton, Ben Michael; Malmo, Vegard; Laugsand, Lars Erik; Loennechen, Jan Pål; Ellekjær, Hanne; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B. (2018) Associations of asthma and asthma control with atrial fibrillation risk: Results from the Nord-Trøndelag health study (HUNT). JAMA cardiology
    Academic article
  • Sun, Yi-Qian; Brumpton, Ben Michael; Bonilla, Carolina; Lewis, Sarah J.; Burgess, Stephen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei. (2018) Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study. European Respiratory Journal
    Academic article
  • Bhatta, Laxmi; Cepelis, Aivaras; Vikjord, Sigrid Anna Aalberg; Malmo, Vegard; Laugsand, Lars Erik; Dalen, Håvard; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B; Brumpton, Ben Michael. (2021) Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study. European Journal of Epidemiology (EJE)
    Academic article
  • Ferreira, Manuel A.; Vonk, Judith M; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Dongen, Jenny Van. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics
    Academic article
  • Bhatta, Laxmi; Leivseth, Linda; Mai, Xiao-Mei; Henriksen, Anne Hildur; Carslake, David; Yue, Chen; Martinez-Camblor, Pablo; Langhammer, Arnulf; Brumpton, Ben Michael. (2020) Spirometric Classifications of COPD Severity as Predictive Markers for Clinical Outcomes: The HUNT Study. American Journal of Respiratory and Critical Care Medicine
    Academic article
  • Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I.; Wang, Geng; Neale, Michael C.; Freathy, Rachel M.; Smith, George Davey; Lawlor, Debbie A.. (2020) Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort. Nature Communications
    Academic article
  • Howe, Laurence J.; Brumpton, Ben Michael; Rasheed, Humaira; Åsvold, Bjørn Olav; Smith, George Davey; Davies, Neil Martin. (2022) Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study. eLIFE
    Academic article
  • Brumpton, Ben Michael; Mai, Xiao-Mei; Langhammer, Arnulf; Laugsand, Lars Erik; Janszky, Imre; Strand, Linn B. (2017) Prospective study of insomnia and incident asthma in adults: The HUNT study. European Respiratory Journal
    Academic article
  • Budu-Aggrey, Ashley; Brumpton, Ben Michael; Tyrrell, Jess; Watkins, Sarah; Modalsli, Ellen Heilmann; Celis-Morales, Carlos; Ferguson, Lyn D.; Vie, Gunnhild Åberge; Palmer, Tom; Fritsche, Lars. (2019) Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. Nature Methods
    Academic article
  • Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad. (2019) Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition. Circulation: Genomic and precision medicine
    Academic article

Student thesis or dissertation

  • Mai, Xiao-Mei; Brumpton, Ben Michael. (2014) Risk factors for the development of asthma in adults: adiposity, metabolic syndrome, mental distress and their interplay. Norges teknisk-naturvitenskapelige universitet
    Doctoral thesis

Teaching

Courses

  • SMED8020 - Genetic epidemiology
  • SMED8021 - Genetic epidemiology - theory only

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