Genome-Wide Association Study - K.G. Jebsen Center for Genetic Epidemiology
Genome-Wide Association Study (GWAS)
The impact on medical care from genome-wide association studies can be substantial, laying the groundwork for implementing personalized medicine, based on studies of genetic variation on a population level.
Great improvements have been made in the cost and efficiency of genome-wide scans and other innovative technologies, using such tools to provide patients with individualized information about their risk of developing certain diseases and to tailor prevention programs to each person's unique genetic makeup.
When a person reaches a disease endpoint, GWAS-based approaches may be used to select the treatments most likely to be effective. Since most inactivating mutations are rare due to negative natural selection, statistical power remains a challenge. To address this, we are well placed to coordinate collaborations with other large-scale studies, and we plan to do reciprocal look-up and meta-analyze results with studies of similar size to improve power. We will also participate in a range of consortia focused on discovery for a wide variety of traits.
Our group run a large project called ALL-IN where we look at a wide range of diseases. This is done in close collaboration with clinicians and researchers who specialize in the different areas. Look below for more details and contact information.
- Supraventricular tachycardia - Jan Pål Loennechen, MD, PhD, St. Olavs Hospital and NTNU
- Bicuspid aortic valves - Jonas Bille Nielsen, MD, PhD, University of Michigan
- Blood pressure - Jostein Holmen, MD, PhD, ISM/NTNU
- Familial hypercholesterolemia - Kjetil Retterstøl, MD, PhD, Professor, Seksjon for klinisk ernæring (OUS) and MD at Lipidklinikken
- Reduced heart function - Håvard Dalen, MD, PhD, Levanger Hospital and ISB/NTNU
- Fitness and chronic disease - Ulrik Wisløff, PhD, ISB/NTNU
- Cardiovascular diseases - Kristian Hveem, MD, PhD, ISM/NTNU
- Peripheral artery disease - Jonas Bille Nielsen, MD, PhD, University of Michigan
- Physical activity - Tom Ivar Lund Nilsen, PhD, ISM/NTNU
- Subarachnoid bleeding and untreated intracranial aneurysms - Marie Sandvei, MD, PhD, Nordlandssykehuset Bodø and ISM/NTNU
- Socioeconomic and cognitive factors in cardiovascular risk - Øyvind Næss, PhD, UiO, NIPH
- High sensitive troponin - Torbjørn Omland, MD, PhD, MPH, KLINMED/UiO/Ahus
- Venous thrombosis - Kristian Hveem, MD, PhD, ISM/NTNU
- Healthy obesity - Kirsti Kvaløy, DPhil, ISM/NTNU
- LADA diabetes - Bjørn Olav Åsvold, MD, PhD, St. Olavs Hospital and NTNU
- Osteoporosis and fracture - Arnulf Langhammer, MD, PhD, ISM/NTNU
- Thyroidea - Bjørn Olav Åsvold, MD, PhD, St. Olavs Hospital and NTNU
- Type 1 diabetes - Bjørn Olav Åsvold, MD, PhD, St. Olavs Hospital and NTNU
- Type 2 diabetes - Bjørn Olav Åsvold, MD, PhD, St. Olavs Hospital and NTNU
- Vitamin D - Xiao-Mei Mai, MD, PhD, ISM/NTNU
- Hemochromatosis - Kristian Hveem, MD, PhD, ISM/NTNU
- Inflammatory bowel disease - Arne Sandvik, MD, PhD, St. Olavs Hospital og NTNU
- Irritable bowel syndrome - Eivind Ness-Jensen, MD, PhD, ISM/NTNU
- Gastroesophageal reflux disease - Eivind Ness-Jensen, MD, PhD, ISM/NTNU
Contact: John-Anker Zwart, MD, PhD, FORMI/UIO
- Cognitive impairment
- Common psychiatric conditions
- Eating disorders
- Epilepsy
- Headache and migraine
- Surgical treatment of neck and back disorders
- Neurodegenerative diseases
- Pain conditions
- Parkinsons disease
- Sleep conditions
- Cerebrovascular disease
- Brain tumour
- Breast feeding - Kristian Hveem, MD, PhD, ISM/NTNU
- Endometriosis - Mari Løset, MD, PhD, ISM/NTNU
- Gestational age - Bo Jacobsson, MD, PhD, University of Gothenburg, Sweden
- Incontinence - Signe Stafne, PhD, ISM/NTNU
- PCOS - Eszter Vanky, MD at St. Olavs Hospital and Professor at LBK/NTNU
- Preeclampsia - Ann-Charlotte Iversen, PhD, CEMIR/IKM/NTNU
- BRCA1 and return of results - Siv Hege Stemshaug, MD, PhD, ISM/NTNU
- Colorectal cancer - Eivind Ness-Jensen, MD, PhD, ISM/NTNU
- Hereditary colon cancer - Eivind Ness-Jensen, MD, PhD, ISM/NTNU
- Lung cancer - Anne Heidi Skogholt, PhD, ISM/NTNU
- Skin cancer - Mari Løset, MD, PhD, ISM/NTNU
- Common skin disorders - Mari Løset, MD, PhD, ISM/NTNU
- Psoriasis - Mari Løset, MD, PhD, ISM/NTNU
- Hearing impairment - Anne-Sofie Helvik, Philos, ISM/NTNU
- Common infection diseases - Erik Solligård, MD, PhD, ISB/NTNU
- Kidney failure - Solfrid Romundstad, MD, PhD, Levanger Hospital og IKM/NTNU
- Common lung diseases - Arnulf Langhammer, MD, PhD, ISM/NTNU
- Asthma and overweight - Kirsti Kvaløy, researcher, MSc, DPhil, ISM/NTNU
- Age-related macular degeneration - Kristian Hveem, MD, PhD, ISM/NTNU
- Humor and health - Sven Svebak, PhD, INM/NTNU
- Education and cognitive skills - Ben Michael Brumpton, PhD, ISM/NTNU
- Population structures - Maiken Elvestad Gabrielsen, Postdoc, PhD, LBK/NTNU
- Spirituality - Torgeir Sørensen, Cand. Theol, PhD, Centre for Psychology of Religion (Innlandet Hospital Trust) and MF Norwegian School of Theology
- Cardio pharmacogenetics - Christian Jonasson, PhD, ISM/NTNU
- PheCode - Kristian Hveem, MD, PhD, ISM/NTNU
- Inflammatory joint disease - Vibeke Videm, MD, PhD, LBK/NTNU
- eQTL and PrediXan - Pål Sætrom, Professor, PhD, IDI/IKOM/NTNU