Pål Sætrom

Professor Department of Computer Science Department of Clinical and Molecular Medicine Faculty of Information Technology and Electrical Engineering Faculty of Medicine and Health Sciences

pal.satrom@ntnu.no +47 73594796 +47 98203874

Laboratoriesenteret, Øya

pal.satrom@ntnu.no

Pål Sætrom works to develop and use computational models to predict how changes in gene regulation can control development and cause disease.

Research

Sætrom’s research focuses on non-coding RNAs (ncRNAs) and their roles in gene regulation and disease. Three major areas of research are (i) developing and validating computer models that can predict how genetic variation affects gene regulation (Nucleic Acids Res, 2011; PLoS Comput Biol, 2012; Bioinformatics, 2014); (ii) understanding the roles of ncRNAs in epigenetics and cell cycle regulation (Nucleic Acids Res, 2013; DNA Repair, 2015); and (iii) designing artificial RNAs for targeted gene regulation and therapy (Mol Ther, 2010; RNA, 2010; Hepatology, 2014).

Biographical Sketch

Education/training

YEAR(s)	INSTITUTION AND LOCATION	DEGREE	FIELD OF STUDY
2005	NTNU, Trondheim, Norway	DPhil	Computer science (bioinformatics)
1996-2001	NTNU, Trondheim, Norway	M.Sc.	Computer science (algorithms)

Positions and Employment

2013-present	Adjunct Professor, Faculty of Biosciences and Aquaculture, University of Nordland, Norway
2012-present	Professor in bioinformatics, Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
2011-present	Professor in bioinformatics, Department of Computer and Information Science, NTNU, Trondheim, Norway
2011	Guest researcher, Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden with Dr. Mikael Benson
2008-2011	Adjunct Associate Professor, Department of Computer and Information Science, NTNU, Trondheim, Norway
2007-2011	Post doctoral fellowship (Career development fellowships from NTNU and the Norwegian Research Council), Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
2007	Adjunct Senior Lecturer, Department of Computer and Information Science, NTNU, Trondheim, Norway
2006-2007	Post doctoral fellowship (Leiv Erikson research scholarship from the Norwegian Research Council), Department of Molecular and Cellular Biology, City of Hope, Duarte, CA (12 months) with Prof. John J. Rossi
2002-2006	Research scientist, Interagon AS, Trondheim, Norway
2001-2002	Software Developer, Fast Search & Transfer ASA, Trondheim, Norway

Honors

2014	Outstanding Academic Fellow, NTNU
2008	PNAS Cozzarelli Prize in Biological Sciences (with D.H. Kim, O. Snøve, Jr., and J.J. Rossi)
2007-2010	Career research fellowship, Norwegian Functional Genomics Program (FUGE), Norwegian Research Council (NRC)
2007-2009	Career fellowship in Medical Technology, NTNU
2006	Research scholarship, FUGE, NRC
2006	Leiv Erikson research scholarship, NRC

Publications listed in publication databases

Scientific, academic and artistic work

A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database

Journal publications

Olsen, Lene Christin; O'Reilly, Kally; Liabakk, Nina-Beate; Witter, Menno; Sætrom, Pål. (2017) MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex. Brain Structure and Function.
Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra. (2017) NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. vol. 18.
Skogholt, Anne Heidi; Ryeng, Einar; Erlandsen, Sten Even; Skorpen, Frank; Arentz Schønberg, Svanhild Margrethe; Sætrom, Pål. (2017) Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks. BMC Research Notes.
Langkilde, Ane; Olsen, Lene Christin; Sætrom, Pål; Drabløs, Finn Sverre; Besenbacher, Søren; Raaby, Line; Johansen, Claus; Iversen, Lars. (2016) Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α. PLoS ONE. vol. 11 (12).
Robles, Ana I.; Olsen, Karina Standahl; Tsui, Dana W.T.; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A.; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B.; Krokan, Hans Einar; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf Dimitri. (2016) Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway. Journal of Translational Medicine. vol. 14:295.
Røe, Oluf Dimitri; Mjelle, Robin; Sætrom, Pål; Andreassen, Trygve; Bathen, Tone Frost; Hveem, Kristian. (2016) Serum microRNAs/enriched pathways in lung cancer 1-4 years before diagnosis: A pilot study from the HUNT Biobank, Norway. Journal of Clinical Oncology.
Stracquadanio, Giovanni; Wang, Xuting; Wallace, Marsha D; Grawenda, Anna M.; Zhang, Ping; Hewitt, Juliet; Zeron-Medina, Jorge; Castro-Giner, Francesc; Tomlinson, Ian P; Goding, Colin R.; Cygan, Kamil J; Fairbrother, William G; Thomas, Laurent; Sætrom, Pål; Gemignani, Federica; Landi, Stefano; Schuster-Böckler, Benjamin; Bell, Douglas A; Bond, Gareth L.. (2016) The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nature Reviews. Cancer. vol. 16 (4).
Yoon, Sorah; Huang, Kai-Wen; Reebye, Vikash; Mintz, Paul; Tien, Yu-Wen; Lai, Hong-Shiee; Sætrom, Pål; Reccia, Isabella; Swiderski, Piotr; Armstrong, Brian; Jozwiak, Agnieszka; Spalding, Duncan; Jiao, Long; Habib, Nagy; Rossi, John J. (2016) Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth in Vivo. Molecular Therapy. vol. 24 (6).
Achar, Avinash; Sætrom, Pål. (2015) RNA motif discovery: a computational overview. Biology Direct. vol. 10 (1).
Hansen, Maren Fridtjofsen; Johansen, Jostein; Bjørnevoll, Inga; Sylvander, Anna Elisabeth; Steinsbekk, Kristin Solum; Sætrom, Pål; Sandvik, Arne Kristian; Drabløs, Finn; Sjursen, Wenche. (2015) A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. Familial Cancer. vol. 14 (3).
Hansen, Maren Fridtjofsen; Johansen, Jostein; Bjørnevoll, Inga; Sylvander, Anna Elisabeth; Steinsbekk, Kristin Solum; Sætrom, Pål; Sandvik, Arne Kristian; Drabløs, Finn; Sjursen, Wenche. (2015) A novel POLE variant, identified by exome sequencing, causes colorectal- and extra-colonic cancers. Familial Cancer. vol. 14 (1).
Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair. vol. 30.
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål; Kavli, Bodil Merete; Krokan, Hans Einar. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair. vol. 25.
Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Johnsen, Roar; Storrø, Ola; Sætrom, Pål; Øien, Torbjørn. (2015) Human breast milk miRNA, maternal probiotic supplementation and atopic dermatitis in offspring. PLoS ONE. vol. 10:e0143496 (12).
Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair. vol. 19.
Lange, LA; Hu, Y; Zhang, H; Xue, C; Schmidt, EM; Tang, ZZ; Bizon, C; Lange, EM; Smith, JD; Turner, EH; Jun, G; Kang, HM; Peloso, G; Auer, P; Li, KP; Flannick, J; Zhang, J; Fuchsberger, C; Gaulton, K; Lindgren, C; Locke, A; Manning, A; Sim, X; Rivas, MA; Holmen, Oddgeir; Gottesman, O; Lu, Y; Ruderfer, D; Stahl, EA; Duan, Q; Li, Y; Durda, P; Jiao, S; Isaacs, A; Hofman, A; Bis, JC; Correa, A; Griswold, ME; Jakobsdottir, J; Smith, AV; Schreiner, PJ; Feitosa, MF; Zhang, Q; Huffman, JE; Crosby, J; Wassel, CL; Do, R; Franceschini, N; Martin, LW; Robinson, JG; Assimes, TL; Crosslin, DR; Rosenthal, EA; Tsai, M; Rieder, MJ; Farlow, DN; Folsom, AR; Lumley, T; Fox, ER; Carlson, CS; Peters, U; Jackson, RD; Van Duijn, CM; Uitterlinden, AG; Levy, D; Rotter, JI; Taylor, HA; Gudnason, V; Siscovick, DS; Fornage, M; Borecki, IB; Hayward, C; Rudan, I; Chen, YE; Bottinger, EP; Loos, RJF; Sætrom, Pål; Hveem, Kristian; Boehnke, M; Groop, L; McCarthy, M; Meitinger, T; Ballantyne, CM; Gabriel, SB; O'Donnell, CJ; Post, WS; North, KE; Reiner, AP; Boerwinkle, E; Psaty, BM; Altshuler, D; Kathiresan, S; Lin, DY; Jarvik, GP; Cupples, LA; Kooperberg, C; Wilson, JG; Nickerson, DA; Abecasis, GR; Rich, SS; Tracy, RP; Willer, CJ. (2014) Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics. vol. 94 (2).
Mintz, PJ; Huang, KW; Reebye, V; Nteliopoulos, G; Lai, HS; Sætrom, Pål; Kasahara, N; Jensen, S; Pai, M; Gordon, MYA; Marley, SB; Behan, R; Spalding, DR; Haoudi, A; Emara, MM; Nicholls, J; Rossi, JJ; Habib, NA. (2014) Exploiting Human CD34(+) Stem Cell-conditioned Medium for Tissue Repair. Molecular Therapy. vol. 22 (1).
Razick, Sabry; Mocnik, Rok; Thomas, Laurent; Ryeng, Einar; Drabløs, Finn; Sætrom, Pål. (2014) The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences. Database: The Journal of Biological Databases and Curation.
Reddy, MA; Chen, Z; Park, JT; Wang, M; Lanting, L; Zhang, Q; Bhatt, K; Leung, A; Wu, X; Putta, S; Sætrom, Pål; Devaraj, S; Natarajan, R. (2014) Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA. Diabetes. vol. 63 (12).
Reebye, V; Sætrom, Pål; Mintz, PJ; Huang, KW; Swiderski, P; Peng, L; Liu, C; Liu, XX; Lindkaer-Jensen, S; Zacharoulis, D; Kostomitsopoulos, N; Kasahara, N; Nicholls, JP; Jiao, LR; Pai, M; Spalding, DR; Mizandari, M; Chikovani, T; Emara, MM; Haoudi, A; Tomalia, DA; Rossi, JJ; Habib, NA. (2014) A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo. Hepatology. vol. 59 (1).