Mari Løset

MD, PhD

Department of Public Health and Nursing Faculty of Medicine and Health Sciences

mari.loset@ntnu.no +4790799117

Øya helsehus, Øya

I work as a Postdoctoral Fellow at K.G. Jebsen Center for Genetic Epidemiology, NTNU, and as a Clinical Resident at Department of Dermatology, St. Olavs hospital, Trondheim, Norway. I’m interested to learn more about how genes contribute to the development of inflammatory skin diseases, including psoriasis and atopic dermatitis. My work includes genetic studies using data from the Nord-Trøndelag Health Study (HUNT) in combination with regional- and national health registries, and RNA sequencing data from psoriasis-related skin samples. In my group we aim to reveal novel mechanisms for disease development and to translate these insights into prevention strategies and treatments.

You can read more about our ongoing projects and collaborations here:

Uttrykksfull hud – Genuttrykk ved psoriasis

Genetisk informasjon kan bidra til ny og mer målrettet behandling av psoriasis

Using HUNT to study disease-causing genetic variation

Scientific, academic and artistic work

Displaying a selection of activities. See all publications in the database

2019

Budu-Aggrey, Ashley; Brumpton, Ben Michael; Tyrrell, Jess; Watkins, Sarah; Modalsli, Ellen Heilmann; Celis-Morales, Carlos; Ferguson, Lyn D.; Vie, Gunnhild Åberge; Palmer, Tom; Fritsche, Lars; Løset, Mari; Nielsen, Jonas Bille; Zhou, Wei; Tsoi, Lam C.; Wood, Andrew R.; Jones, Samuel E.; Beaumont, Robin; Saunes, Marit; Romundstad, Pål Richard; Siebert, Stefan; McInnes, Iain B.; Elder, James T.; Smith, George Davey; Frayling, Timothy M.; Åsvold, Bjørn Olav; Brown, Sara J.; Sattar, Naveed; Paternoster, Lavinia. (2019) Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. Nature Methods. vol. 16:e1002739 (1).
Løset, Mari; Brown, Sara J.; Saunes, Marit; Hveem, Kristian. (2019) Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance. Dermatology. vol. 235 (5).
Søum, Veronika; Løset, Mari. (2019) Høyere vekt øker risikoen for psoriasis. Gemini [Fagblad]. 2019-05-01.

2018

Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Solvin, Åshild Øksnevad; Holmen, Oddgeir Lingaas; Gabrielsen, Maiken Elvestad; Fritsche, Lars; Zhou, Wei; Nielsen, Jonas Bille; Brumpton, Ben Michael; Skogholt, Anne Heidi; Romundstad, Pål Richard; Abecasis, Goncalo R; Willer, Cristen; Saunes, Marit; Hveem, Kristian. (2018) 743 HUNTing for genes that affect inflammatory skin disease in 4,071 cases and 40,430 controls. Journal of Investigative Dermatology. vol. 138 (5).

2017

Aakervik, Anne-Lise; Snekvik, Ingrid; Modalsli, Ellen Heilmann; Solvin, Åshild Øksnevad; Løset, Mari; Saunes, Marit. (2017) Brikker i et gigantisk puslespill. Hud & Helse [Tidsskrift]. 2017-09-01.
Ferreira, Manuel A.; Vonk, Judith M; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Van Dongen, Jenny; Lu, Yi; Ruschendorf, Franz; Esparza-Gordillo, Jorge; Medway, Christopher W.; Mountjoy, Edward; Burrows, Kimberley; Hummel, Oliver; Grosche, Sarah; Brumpton, Ben Michael; Witte, John S; Hottenga, Jouke-Jan; Willemsen, Gonneke; Zheng, Jie; Rodriguez, Elke; Hotze, Melanie; Franke, Andre; Revez, Joana A; Beesley, Jonathan; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Bain, Lisa M; Fritsche, Lars; Gabrielsen, Maiken Elvestad; Balliu, Brunilda; Nielsen, Jonas B.; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir Lingaas; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten Oliver; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B; Hinds, David A; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik K E; Jansen, Rick; Jorgenson, Eric; Lee, Young-Ae; Boomsma, Dorret I; Almqvist, Catarina; Karlsson, Robert; Koppelman, Gerard H; Paternoster, Lavinia. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics. vol. 49 (12).
Solvin, Åshild Øksnevad; Løset, Mari. (2017) Genetisk informasjon kan bidra til ny og mer målrettet behandling av psoriasis.

2016

Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Zhou, Wei; Chu, Yunhan; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Romundstad, Pål Richard; Abecasis, Goncalo; Willer, Cristen; Hveem, Kristian; Saunes, Marit. (2016) HUNTing for Genes that Affect Psoriasis in ~2,900 Cases and ~48,000 Controls. The 33rd Nordic Congress of Dermatology and Venereolgy ; 2016-04-27 - 2016-04-29.
Løset, Mari; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Zhou, Wei; Chu, Yunhan; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Romundstad, Pål Richard; Abecasis, Goncalo; Willer, Cristen; Hveem, Kristian; Saunes, Marit. (2016) HUNTing for Genes that Affect Psoriasis in ~2,900 Cases and ~48,000 Controls. Forum for Nordic Dermato-Venereology. vol. 21 (1).
Solvin, Åshild Øksnevad; Modalsli, Ellen Heilmann; Snekvik, Ingrid; Gabrielsen, Maiken Elvestad; Holmen, Oddgeir Lingaas; Saunes, Marit; Hveem, Kristian; Løset, Mari. (2016) Establishing a biobank for gene expression studies of psoriasis. Frampeik ; Bergen. 2016-10-21 - 2016-10-23.

2014

Løset, Mari. (2014) Genetic predisposition to preeclampsia. Genetic association studies on population-based cohorts and transcriptional studies on decidua basalis tissue. Tapir Akademisk Forlag. 2014. Doktoravhandlinger ved NTNU (47).
Løset, Mari. (2014) Genetisk disposisjon for utvikling av preeklampsi. Tidsskrift for Den norske legeforening.
Løset, Mari; Johnson, Matthew P.; Melton, Philip E.; Ang, Wei; Huang, Rae-Chi; Mori, Trevor; Beilin, Lawrence J.; Pennell, Craig E.; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, Christine E.; Blangero, John; Brennecke, Shaun P.; Moses, Eric K. (2014) Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy Hypertension. vol. 4 (2).

2013

Løset, Mari. (2013) Svangerskap og hjertehelse. Bergens Tidende.
Løset, Mari; Johnson, Matthew P; Melton, P; Ang, W; Marsh, J; Huang, RC; Mori, T; Beilin, L; Pennell, CE; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, CE; Blangero, John; Brennecke, Shaun P.; Moses, Eric. (2013) A SNP associated with susceptibility to preeclampsia near the Inhibin, beta B gene, is also associated with cardiovascular disease risk traits. European Congress of the International Society for the Study of Hypertension in Pregnancy ; Tromsø. 2013-06-12 - 2013-06-14.
Løset, Mari; Johnson, MP; Melton, P; Ang, W; Marsh, J; Huang, RC; Mori, T; Beilin, L; Pennell, C.; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, CE; Blangero, J; Brennecke, SP; Moses, Eric. (2013) A SNP associated with susceptibility to preeclampsia near the Inhibin, beta B gene, is also associated with cardiovascular disease risk traits. Pregnancy Hypertension. vol. 3 (2).

2012

Johnson, Matthew P; Løset, Mari; Brennecke, Shaun P.; Peralta, J.; Dyer, Thomas D.; East, Christine; Pennell, Craig E.; Huang, Rae-Chi; Mori, Trevor; Beilin, L; Blangero, John; Moses, Eric K. (2012) Exome sequencing identifies likely functional variants influencing preeclampsia and CVD risk. Pregnancy Hypertension 2012: Vol. 2, Issue 3, Pages 203-204 ; 2012-07-09 - 2012-07-12.
Løset, Mari; Johnson, Matthew P; Pennell, C.; Huang, RC; Mori, T; Beilin, L; Melton, P; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Ausgtulen, Rigmor; East, C; Blangero, J; Brennecke, SP; Moses, Eric K. (2012) Shared genetic risk factors for preeclapmsia and cardiovascular disease. The XVIII ISSHP World Congress . ISSHP; Geneva. 2012-07-09 - 2012-07-12.
Løset, Mari; Johnson, Matthew P; Pennell, C.; Huang, RC; Mori, T; Beilin, L; Melton, P; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, C; Blangero, John; Brennecke, Shaun P.; Moses, Eric K. (2012) Shared genetic risk factors for preeclampsia and cardiovascular disease. Pregnancy Hypertension. vol. 2 (3).

2011

Løset, Mari; Mundal, Siv Boon; Johnson, Matthew; Fenstad, Mona Høysæter; Freed, Katherine A.; Lian, Ingrid Alsos; Eide, Irina Poliakova; Bjørge, Line; Blangero, John; Moses, Eric K; Austgulen, Rigmor. (2011) A transcriptional profile of the decidua in preeclampsia. American Journal of Obstetrics and Gynecology. vol. 204 (1).
Johansson, Åsa; Løset, Mari; Mundal, Siv Boon; Johnson, Matthew; Freed, Katy A.; Fenstad, Mona Høysæter; Moses, Eric; Austgulen, Rigmor; Blangero, John. (2011) Partial correlation network analyses to detect altered gene interactions in human disease: using preeclampsia as a model. Human Genetics. vol. 129 (1).
Lian, Ingrid Alsos; Løset, Mari; Mundal, Siv Boon; Fenstad, Mona Høysæter; Johnson, Matthew; Eide, Irina Poliakova; Bjørge, Line; Freed, Katherine; Moses, Eric; Austgulen, Rigmor. (2011) Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre-eclampsia. Placenta. vol. 32 (11).
Lian, Ingrid Alsos; Løset, Mari; Mundal, Siv Boon; Fenstad, Mona Høysæter; Johnson, Matthew; Freed, Katherine; Eide, Irina Poliakova; Bjørge, Line; Blangero, John; Moses, Eric; Austgulen, Rigmor. (2011) Endoplasmic reticulum stress in decidual tissue from pregnancies complicated by pre-eclampsia and fetal growth restriction. Placenta. vol. 32 (9).

2010

Fenstad, Mona Høysæter; Johnson, Matthew; Løset, Mari; Mundal, Siv Boon; Roten, Linda Tømmerdal; Eide, Irina Poliakova; Bjørge, Line; Sande, Ragnar; Johansson, Åsa; Dyer, TD; Forsmo, Siri; Blangero, John; Moses, EK; Austgulen, Rigmor. (2010) STOX2 but not STOX1 is differently expressed in preeclampstic decidua from Norwegian women: data from the Second Nord-Trondelag Health Study. Molecular human reproduction. vol. 16 (12).
Lian, Ingrid Alsos; Løset, Mari; Mundal, Siv Boon; Johnson, Matthew; Freed, KA; Fenstad, Mona Høysæter; Eide, Irina Poliakova; Bjørge, Line; Blangero, John; Moses, EK; Austgulen, Rigmor. (2010) Endoplasmatic reticulum stress in decidual tissue from pregnancies complicated with preeclampsia. Hypertension in Pregnancy. vol. 1.