Background and activities
Group Leader Inflammation in Pregnancy Research Group / Theme Leader in CEMIR
My main research focus is to utilize knowledge from basic molecular immunity into clinical research on the major human inflammatory diseases; cardiovascular disease and preeclampsia. Use of new knowledge on molecular inflammation to approach inflammatory diseases with new hypotheses of underlying abnormal immune mechanisms, provides a more solid foundation for the search for new therapeutic approaches and biomarkers. The field of danger signal induced inflammation has revealed a common set of inflammatory mechanisms that underlie a wide variety of diseases, both induced by environmental factors, like pathogens, and by abnormal endogenous inflammatory response. Thus, the combined look at related major inflammatory diseases is of particular importance. My motivation for this translational approach is further strengthened by the need for gender-specific knowledge to address the “female way” of developing cardiovascular diseases, and the up to eight-fold increase in risk for later-life cardiovascular disease following a preeclamptic pregnancy.
Scientific, academic and artistic work
Displaying a selection of activities. See all publications in the database
- (2021) Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies. Placenta. vol. 105.
- (2020) TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies. Journal of Leukocyte Biology.
- (2020) Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies. Frontiers in Immunology. vol. 11:564712.
- (2020) Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications. vol. 11.
- (2019) Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity. Hypertension. vol. 74 (5).
- (2019) Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors. International Journal of Cardiology. vol. 282.
- (2019) Serum cytokine patterns in first half of pregnancy. Cytokine. vol. 119.
- (2018) Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women. Journal of the American Heart Association (JAHA). vol. 7 (10).
- (2018) Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. Clinical and Experimental Immunology. vol. 193 (1).
- (2018) Placental inflammation by HMGB1 activation of TLR4 at the syncytium. Placenta. vol. 72-73.
- (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nature Genetics. vol. 49 (8).
- (2017) Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity. Journal of the American Heart Association (JAHA). vol. 6 (3).
- (2016) The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia. Journal of Hypertension. vol. 35.
- (2015) First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study. International Journal of Molecular Sciences. vol. 16 (9).
- (2015) Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics. Placenta. vol. 36 (12).
- (2015) Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts. Placenta. vol. 36 (11).
- (2015) Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia. Tissue Antigens. vol. 86 (3).
- (2015) Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia. Arteriosclerosis, Thrombosis and Vascular Biology. vol. 35 (11).
- (2015) Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort. Journal of Hypertension. vol. 33 (11).
- (2014) Metabolomic biomarkers in serum and urine in women with preeclampsia. PLOS ONE. vol. 9 (3:e91923).
- (2014) Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy Hypertension. vol. 4 (2).
- (2014) InterPregGen: Genetic studies of pre-eclampsia in three continents. Norsk Epidemiologi. vol. 24 (1-2).
- (2014) Functional Toll-like receptors in primary first-trimester trophoblasts. Journal of Reproductive Immunology. vol. 106.
- (2013) Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study. BMJ Open. vol. 3.
- (2013) Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study. BMJ. British Medical Journal.
- (2012) Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. PLOS ONE. vol. 7 (3).
- (2012) Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway. BJOG: An International Journal of Obstetrics and Gynaecology. vol. 119 (11).
- (2009) A proviral role for CpG in cytomegalovirus infection. Journal of Immunology. vol. 182 (9).
- (2009) IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients. Journal of Immunology. vol. 182 (1).
- (2006) Fetal growth restriction is associated with reduced FasL expression by decidual cells. American Journal of Reproductive Immunology.
- (2006) Fetal HLA-G 14bp gene polymorphism is associated with expression of three different variants of HLA-G mRNA in decidual tissues, as studied in abnormal (PE/FGR) and healthy pregnancies. Tissue Antigens. vol. 68.
- (2005) Human NK cells inhibit CMV replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of interferon-beta. Journal of Immunology. vol. 175.
- (2005) A comparative study of immunomagnetic methods used for separation of human natural killer cells from peripheral blood. JIM - Journal of Immunological Methods. vol. 303.
- (1999) The role of IL-2 in regulating the sensitivity of NK cells for Fas-mediated apoptosis. Cancer Immunology and Immunotherapy. vol. 48.
- (1999) Regulation of Apo-2 Ligand/Trail expression in NK cells - Involvement in NK cell mediated cytotoxicity. Cytokine. vol. 11 (9).
- (1995) Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells. European Journal of Immunology. vol. 25.
- (1993) Gene expression and secretion of cytokines and cytokine receptors from hihgly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12. European Journal of Immunology. vol. 23.
- (1999) TNF-related death receptors - characterization of mechanisms of NK cell cytotoxicity. 1999. ISBN 82-7861-190-4.
- (1993) Etablering av RT-PCR og en undersøkelse av variasjoner i cytokin-genekspresjon i natural killer celler stimulert med IL-2, IL-7 og IL-12. 1993.