Ann-Charlotte Iversen

About

Group Leader Inflammation in Pregnancy Research Group / Theme Leader in CEMIR

My main research focus is to utilize knowledge from basic molecular immunity into clinical research on the major human inflammatory diseases; cardiovascular disease and preeclampsia. Use of new knowledge on molecular inflammation to approach inflammatory diseases with new hypotheses of underlying abnormal immune mechanisms, provides a more solid foundation for the search for new therapeutic approaches and biomarkers. The field of danger signal induced inflammation has revealed a common set of inflammatory mechanisms that underlie a wide variety of diseases, both induced by environmental factors, like pathogens, and by abnormal endogenous inflammatory response. Thus, the combined look at related major inflammatory diseases is of particular importance. My motivation for this translational approach is further strengthened by the need for gender-specific knowledge to address the “female way” of developing cardiovascular diseases, and the up to eight-fold increase in risk for later-life cardiovascular disease following a preeclamptic pregnancy.

Publications

2021

Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte. (2021) Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies. Placenta. volum 105.

2020

Gierman, Lobke; Silva, Gabriela; Pervaiz, Zahra; Rakner, Johanne Johnsen; Mundal, Siv Boon; Thaning, Astrid Josefin; Nervik, Ingunn; Elschot, Mattijs; Mathew, Seema; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte. (2020) TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies. Journal of Leukocyte Biology.
Silva, Gabriela; Gierman, Lobke; Rakner, Johanne Johnsen; Stødle, Guro; Thaning, Astrid Josefin; Mundal, Siv Boon; Sporsheim, Bjørnar; Elschot, Mattijs; Collett, Karin; Bjørge, Line; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Iversen, Ann-Charlotte. (2020) Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies. Frontiers in Immunology. volum 11:564712.
Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda. (2020) Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications. volum 11.

2019

Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte. (2019) Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity. Hypertension. volum 74 (5).
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Egeland, Grace M.; Nygård, Ottar; Selmer, Randi Marie; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti. (2019) Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors. International Journal of Cardiology. volum 282.
Stokkeland, Live Marie Tobiesen; Giskeødegård, Guro F.; Stridsklev, Solhild; Ryan, Liv; Steinkjer, Bjørg; Tangerås, Line Haugstad; Vanky, Eszter; Iversen, Ann-Charlotte. (2019) Serum cytokine patterns in first half of pregnancy. Cytokine. volum 119.

2018

Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti. (2018) Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women. Journal of the American Heart Association (JAHA). volum 7 (10).
Stødle, Guro; Silva, Gabriela; Tangerås, Line Haugstad; Gierman, Lobke; Nervik, Ingunn; Dahlberg, Unn; Sun, Chen; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte. (2018) Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. Clinical and Experimental Immunology. volum 193 (1).
Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte. (2018) Placental inflammation by HMGB1 activation of TLR4 at the syncytium. Placenta. volum 72-73.

2017

McGinnis, Ralph; Steinthorsdottir, Valgerdur; Williams, Nicholas O.; Thorleifsson, Gudmar; Shooter, Scott; Hjartardóttir, Sigrún; Bumpstead, Suzannah; Stefánsdóttir, Lilja; Hildyard, Lucy; Sigurdsson, Jon K.; Kemp, John P.; Silva, Gabriela; Thomsen, Liv Cecilie Vestrheim; Jääskeläinen, Tiina; Kajantie, Eero; Chappell, Sally; Kalsheker, Noor; Moffett, Ashley; Hiby, Susan; Lee, Wai Kwong; Padmanabhan, Sandosh; Simpson, Nigel A.B.; Dolby, Vivien A.; Staines-Urias, Eleonora; Engel, Stephanie M.; Haugan, Anita; Trogstad, Lill; Svyatova, Gulnara; Zakhidova, Nodira; Najmutdinova, Dilbar; Dominiczak, Anna F.; Gjessing, Håkon K.; Casas, Juan P.; Dudbridge, Frank; Walker, James J.; Pipkin, Fiona Broughton; Thorsteinsdóttir, Unnur; Geirsson, Reynir Tõmas; Lawlor, Debbie A.; Iversen, Ann-Charlotte; Magnus, Per; Laivuori, Hannele; Stefánsson, Kári; Morgan, Linda. (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nature Genetics. volum 49 (8).
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Iversen, Ann-Charlotte; Austgulen, Rigmor; Daltveit, Anne Kjersti. (2017) Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity. Journal of the American Heart Association (JAHA). volum 6 (3).

2016

Thomsen, Liv Cecilie Vestrheim; McCarthy, Nina; Melton, Philip E.; Cadby, Gemma; Austgulen, Rigmor; Nygård, Ottar; Johnson, Matthew P; Brennecke, Shaun P.; Moses, Eric K; Bjørge, Line; Iversen, Ann-Charlotte. (2016) The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia. Journal of Hypertension. volum 35.

2015

Austdal, Marie; Tangerås, Line Haugstad; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost. (2015) First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study. International Journal of Molecular Sciences. volum 16 (9).
Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte. (2015) Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics. Placenta. volum 36 (12).
Gierman, Lobke; Stødle, Guro; Tangerås, Line Haugstad; Austdal, Marie; Olsen, Guro Dalheim; Follestad, Turid; Skei, Bente; Rian, Kristin; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte. (2015) Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts. Placenta. volum 36 (11).
Pabalan, Noel; Jarjanazi, H; Sun, Chen; Iversen, Ann-Charlotte. (2015) Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia. Tissue Antigens. volum 86 (3).
Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte. (2015) Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia. Arteriosclerosis, Thrombosis and Vascular Biology. volum 35 (11).
Thomsen, Liv Cecilie Vestrheim; Melton, Philip E.; Tollaksen, Kjersti; Lyslo, Ingvill; Roten, Linda Tømmerdal; Odland, Maria Lisa; Strand, Kristin Melheim; Nygård, Ottar; Sun, Chen; Iversen, Ann-Charlotte; Austgulen, Rigmor; Moses, Eric; Bjørge, Line. (2015) Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort. Journal of Hypertension. volum 33 (11).

2014

Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost. (2014) Metabolomic biomarkers in serum and urine in women with preeclampsia. PLOS ONE. volum 9 (3:e91923).
Løset, Mari; Johnson, Matthew P.; Melton, Philip E.; Ang, Wei; Huang, Rae-Chi; Mori, Trevor; Beilin, Lawrence J.; Pennell, Craig E.; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, Christine E.; Blangero, John; Brennecke, Shaun P.; Moses, Eric K. (2014) Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy Hypertension. volum 4 (2).
Morgan, Linda; McGinnis, Ralph; Steinthorsdottir, Valgerdur; Syvatova, Gulnara; Zakhidova, Nodira; Lee, Wai Kwong; Iversen, Ann-Charlotte; Magnus, Per; Walker, James; Casas, Juan Pablo; Sultanov, Saidazim; Laivuori, Hannele. (2014) InterPregGen: Genetic studies of pre-eclampsia in three continents. Norsk Epidemiologi. volum 24 (1-2).
Tangerås, Line; Stødle, Guro; Olsen, Guro Dalheim; Leknes, Ann-Helen; Gundersen, Astrid; Skei, Bente; Vikdal, Anne Jorunn; Ryan, Liv; Steinkjer, Bjørg; Myklebost, Merete; Langaas, Mette; Austgulen, Rigmor; Iversen, Ann-Charlotte. (2014) Functional Toll-like receptors in primary first-trimester trophoblasts. Journal of Reproductive Immunology. volum 106.

2013

Odland, Maria Lisa; Strand, Kristin Melheim; Nordbø, Svein Arne; Forsmo, Siri; Ausgtulen, Rigmor; Iversen, Ann-Charlotte. (2013) Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study. BMJ Open. volum 3.
Strand, Kristin Melheim; Heimstad, Runa Kristine; Iversen, Ann-Charlotte; Austgulen, Rigmor; Lydersen, Stian; Andersen, Guro Lillemoen; Irgens, Lorentz M.; Vik, Torstein. (2013) Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study. BMJ. British Medical Journal.

2012

Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K. (2012) Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. PLOS ONE. volum 7 (3).
Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann-Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor. (2012) Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway. BJOG: An International Journal of Obstetrics and Gynaecology. volum 119 (11).

2009

Iversen, Ann-Charlotte; Steinkjer, Bjørg; Nilsen, Nadra; Bohnhorst, Janne Øvrebø; Moen, Siv Helen; Vik, Randi; Stephens, Phil; Thomas, DW; Benedict, Chris A.; Espevik, Terje. (2009) A proviral role for CpG in cytomegalovirus infection. Journal of Immunology. volum 182 (9).
Sandanger, O; Sandanger, Øystein; Ryan, Liv; Bohnhorst, Janne Øvrebø; Iversen, AC; Iversen, Ann-Charlotte; Husebye, Harald; Halaas, O; Halaas, Øyvind; Landrø, Linn; Aukrust, Pål; Frøland, Stig S.; Elson, Greg; Visintin, Alberto; Øktedalen, Olav; Damås, Jan Kristian; Damas, JK; Sundan, Anders; Golenbock, Douglas T.; Espevik, Terje. (2009) IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients. Journal of Immunology. volum 182 (1).

2006

Eide, Irina P.; Isaksen, Christina Vogt; Salvesen, Kjell Å; Langaas, Mette; Gunther, Clara-Cecilie; Iversen, Ann-Charlotte; Austgulen, Rigmor. (2006) Fetal growth restriction is associated with reduced FasL expression by decidual cells. American Journal of Reproductive Immunology.
Iversen, Ann-Charlotte; Tømmerdal, Linda Føll; Nguyen, Olav Toai Duc; Landsem, Veslemøy Malm; Acar, Nuray; Eide, Irina P.; Klungland, Helge; Austgulen, Rigmor. (2006) Fetal HLA-G 14bp gene polymorphism is associated with expression of three different variants of HLA-G mRNA in decidual tissues, as studied in abnormal (PE/FGR) and healthy pregnancies. Tissue Antigens. volum 68.

2005

Iversen, Ann-Charlotte; Norris, Paula S; Ware, Carl F; Benedict, Christopher A. (2005) Human NK cells inhibit CMV replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of interferon-beta. Journal of Immunology. volum 175.
Øren, Anita; Husebø, Christina Aspaas; Iversen, Ann-Charlotte; Austgulen, Rigmor. (2005) A comparative study of immunomagnetic methods used for separation of human natural killer cells from peripheral blood. JIM - Journal of Immunological Methods. volum 303.

1999

Haux, Johan; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Steinkjer, Bjørg; Egeberg, Kjartan Wøllo; Sundan, Anders; Espevik, Terje. (1999) The role of IL-2 in regulating the sensitivity of NK cells for Fas-mediated apoptosis. Cancer Immunology and Immunotherapy. volum 48.
Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte. (1999) TNF-related death receptors - characterization of mechanisms of NK cell cytotoxicity. 1999. ISBN 82-7861-190-4.
Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Haux, Johan; Steinkjer, Bjørg; Nonstad, Unni; Egeberg, Kjartan Wøllo; Sundan, Anders; Ashkenazi, Avi; Espevik, Terje. (1999) Regulation of Apo-2 Ligand/Trail expression in NK cells - Involvement in NK cell mediated cytotoxicity. Cytokine. volum 11 (9).

1995

Lien, Egil; Liabakk, Nina-Beate; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Nonstad, Unni; Sundan, Anders; Espevik, Terje. (1995) Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells. European Journal of Immunology. volum 25.

1993

Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte. (1993) Etablering av RT-PCR og en undersøkelse av variasjoner i cytokin-genekspresjon i natural killer celler stimulert med IL-2, IL-7 og IL-12. 1993.
Naume, Bjørn; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Espevik, Terje; Sundan, Anders. (1993) Gene expression and secretion of cytokines and cytokine receptors from hihgly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12. European Journal of Immunology. volum 23.

Journal publications

Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte. (2021) Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies. Placenta. volum 105.
Gierman, Lobke; Silva, Gabriela; Pervaiz, Zahra; Rakner, Johanne Johnsen; Mundal, Siv Boon; Thaning, Astrid Josefin; Nervik, Ingunn; Elschot, Mattijs; Mathew, Seema; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte. (2020) TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies. Journal of Leukocyte Biology.
Silva, Gabriela; Gierman, Lobke; Rakner, Johanne Johnsen; Stødle, Guro; Thaning, Astrid Josefin; Mundal, Siv Boon; Sporsheim, Bjørnar; Elschot, Mattijs; Collett, Karin; Bjørge, Line; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Iversen, Ann-Charlotte. (2020) Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies. Frontiers in Immunology. volum 11:564712.
Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda. (2020) Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications. volum 11.
Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte. (2019) Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity. Hypertension. volum 74 (5).
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Egeland, Grace M.; Nygård, Ottar; Selmer, Randi Marie; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti. (2019) Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors. International Journal of Cardiology. volum 282.
Stokkeland, Live Marie Tobiesen; Giskeødegård, Guro F.; Stridsklev, Solhild; Ryan, Liv; Steinkjer, Bjørg; Tangerås, Line Haugstad; Vanky, Eszter; Iversen, Ann-Charlotte. (2019) Serum cytokine patterns in first half of pregnancy. Cytokine. volum 119.
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti. (2018) Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women. Journal of the American Heart Association (JAHA). volum 7 (10).
Stødle, Guro; Silva, Gabriela; Tangerås, Line Haugstad; Gierman, Lobke; Nervik, Ingunn; Dahlberg, Unn; Sun, Chen; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte. (2018) Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. Clinical and Experimental Immunology. volum 193 (1).
Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte. (2018) Placental inflammation by HMGB1 activation of TLR4 at the syncytium. Placenta. volum 72-73.
McGinnis, Ralph; Steinthorsdottir, Valgerdur; Williams, Nicholas O.; Thorleifsson, Gudmar; Shooter, Scott; Hjartardóttir, Sigrún; Bumpstead, Suzannah; Stefánsdóttir, Lilja; Hildyard, Lucy; Sigurdsson, Jon K.; Kemp, John P.; Silva, Gabriela; Thomsen, Liv Cecilie Vestrheim; Jääskeläinen, Tiina; Kajantie, Eero; Chappell, Sally; Kalsheker, Noor; Moffett, Ashley; Hiby, Susan; Lee, Wai Kwong; Padmanabhan, Sandosh; Simpson, Nigel A.B.; Dolby, Vivien A.; Staines-Urias, Eleonora; Engel, Stephanie M.; Haugan, Anita; Trogstad, Lill; Svyatova, Gulnara; Zakhidova, Nodira; Najmutdinova, Dilbar; Dominiczak, Anna F.; Gjessing, Håkon K.; Casas, Juan P.; Dudbridge, Frank; Walker, James J.; Pipkin, Fiona Broughton; Thorsteinsdóttir, Unnur; Geirsson, Reynir Tõmas; Lawlor, Debbie A.; Iversen, Ann-Charlotte; Magnus, Per; Laivuori, Hannele; Stefánsson, Kári; Morgan, Linda. (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nature Genetics. volum 49 (8).
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Iversen, Ann-Charlotte; Austgulen, Rigmor; Daltveit, Anne Kjersti. (2017) Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity. Journal of the American Heart Association (JAHA). volum 6 (3).
Thomsen, Liv Cecilie Vestrheim; McCarthy, Nina; Melton, Philip E.; Cadby, Gemma; Austgulen, Rigmor; Nygård, Ottar; Johnson, Matthew P; Brennecke, Shaun P.; Moses, Eric K; Bjørge, Line; Iversen, Ann-Charlotte. (2016) The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia. Journal of Hypertension. volum 35.
Austdal, Marie; Tangerås, Line Haugstad; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost. (2015) First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study. International Journal of Molecular Sciences. volum 16 (9).
Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte. (2015) Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics. Placenta. volum 36 (12).
Gierman, Lobke; Stødle, Guro; Tangerås, Line Haugstad; Austdal, Marie; Olsen, Guro Dalheim; Follestad, Turid; Skei, Bente; Rian, Kristin; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte. (2015) Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts. Placenta. volum 36 (11).
Pabalan, Noel; Jarjanazi, H; Sun, Chen; Iversen, Ann-Charlotte. (2015) Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia. Tissue Antigens. volum 86 (3).
Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte. (2015) Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia. Arteriosclerosis, Thrombosis and Vascular Biology. volum 35 (11).
Thomsen, Liv Cecilie Vestrheim; Melton, Philip E.; Tollaksen, Kjersti; Lyslo, Ingvill; Roten, Linda Tømmerdal; Odland, Maria Lisa; Strand, Kristin Melheim; Nygård, Ottar; Sun, Chen; Iversen, Ann-Charlotte; Austgulen, Rigmor; Moses, Eric; Bjørge, Line. (2015) Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort. Journal of Hypertension. volum 33 (11).
Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost. (2014) Metabolomic biomarkers in serum and urine in women with preeclampsia. PLOS ONE. volum 9 (3:e91923).
Løset, Mari; Johnson, Matthew P.; Melton, Philip E.; Ang, Wei; Huang, Rae-Chi; Mori, Trevor; Beilin, Lawrence J.; Pennell, Craig E.; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, Christine E.; Blangero, John; Brennecke, Shaun P.; Moses, Eric K. (2014) Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy Hypertension. volum 4 (2).
Morgan, Linda; McGinnis, Ralph; Steinthorsdottir, Valgerdur; Syvatova, Gulnara; Zakhidova, Nodira; Lee, Wai Kwong; Iversen, Ann-Charlotte; Magnus, Per; Walker, James; Casas, Juan Pablo; Sultanov, Saidazim; Laivuori, Hannele. (2014) InterPregGen: Genetic studies of pre-eclampsia in three continents. Norsk Epidemiologi. volum 24 (1-2).
Tangerås, Line; Stødle, Guro; Olsen, Guro Dalheim; Leknes, Ann-Helen; Gundersen, Astrid; Skei, Bente; Vikdal, Anne Jorunn; Ryan, Liv; Steinkjer, Bjørg; Myklebost, Merete; Langaas, Mette; Austgulen, Rigmor; Iversen, Ann-Charlotte. (2014) Functional Toll-like receptors in primary first-trimester trophoblasts. Journal of Reproductive Immunology. volum 106.
Odland, Maria Lisa; Strand, Kristin Melheim; Nordbø, Svein Arne; Forsmo, Siri; Ausgtulen, Rigmor; Iversen, Ann-Charlotte. (2013) Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study. BMJ Open. volum 3.
Strand, Kristin Melheim; Heimstad, Runa Kristine; Iversen, Ann-Charlotte; Austgulen, Rigmor; Lydersen, Stian; Andersen, Guro Lillemoen; Irgens, Lorentz M.; Vik, Torstein. (2013) Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study. BMJ. British Medical Journal.
Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K. (2012) Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. PLOS ONE. volum 7 (3).
Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann-Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor. (2012) Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway. BJOG: An International Journal of Obstetrics and Gynaecology. volum 119 (11).
Iversen, Ann-Charlotte; Steinkjer, Bjørg; Nilsen, Nadra; Bohnhorst, Janne Øvrebø; Moen, Siv Helen; Vik, Randi; Stephens, Phil; Thomas, DW; Benedict, Chris A.; Espevik, Terje. (2009) A proviral role for CpG in cytomegalovirus infection. Journal of Immunology. volum 182 (9).
Sandanger, O; Sandanger, Øystein; Ryan, Liv; Bohnhorst, Janne Øvrebø; Iversen, AC; Iversen, Ann-Charlotte; Husebye, Harald; Halaas, O; Halaas, Øyvind; Landrø, Linn; Aukrust, Pål; Frøland, Stig S.; Elson, Greg; Visintin, Alberto; Øktedalen, Olav; Damås, Jan Kristian; Damas, JK; Sundan, Anders; Golenbock, Douglas T.; Espevik, Terje. (2009) IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients. Journal of Immunology. volum 182 (1).
Eide, Irina P.; Isaksen, Christina Vogt; Salvesen, Kjell Å; Langaas, Mette; Gunther, Clara-Cecilie; Iversen, Ann-Charlotte; Austgulen, Rigmor. (2006) Fetal growth restriction is associated with reduced FasL expression by decidual cells. American Journal of Reproductive Immunology.
Iversen, Ann-Charlotte; Tømmerdal, Linda Føll; Nguyen, Olav Toai Duc; Landsem, Veslemøy Malm; Acar, Nuray; Eide, Irina P.; Klungland, Helge; Austgulen, Rigmor. (2006) Fetal HLA-G 14bp gene polymorphism is associated with expression of three different variants of HLA-G mRNA in decidual tissues, as studied in abnormal (PE/FGR) and healthy pregnancies. Tissue Antigens. volum 68.
Iversen, Ann-Charlotte; Norris, Paula S; Ware, Carl F; Benedict, Christopher A. (2005) Human NK cells inhibit CMV replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of interferon-beta. Journal of Immunology. volum 175.
Øren, Anita; Husebø, Christina Aspaas; Iversen, Ann-Charlotte; Austgulen, Rigmor. (2005) A comparative study of immunomagnetic methods used for separation of human natural killer cells from peripheral blood. JIM - Journal of Immunological Methods. volum 303.
Haux, Johan; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Steinkjer, Bjørg; Egeberg, Kjartan Wøllo; Sundan, Anders; Espevik, Terje. (1999) The role of IL-2 in regulating the sensitivity of NK cells for Fas-mediated apoptosis. Cancer Immunology and Immunotherapy. volum 48.
Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Haux, Johan; Steinkjer, Bjørg; Nonstad, Unni; Egeberg, Kjartan Wøllo; Sundan, Anders; Ashkenazi, Avi; Espevik, Terje. (1999) Regulation of Apo-2 Ligand/Trail expression in NK cells - Involvement in NK cell mediated cytotoxicity. Cytokine. volum 11 (9).
Lien, Egil; Liabakk, Nina-Beate; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Nonstad, Unni; Sundan, Anders; Espevik, Terje. (1995) Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells. European Journal of Immunology. volum 25.
Naume, Bjørn; Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte; Espevik, Terje; Sundan, Anders. (1993) Gene expression and secretion of cytokines and cytokine receptors from hihgly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12. European Journal of Immunology. volum 23.

Report/dissertation

Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte. (1999) TNF-related death receptors - characterization of mechanisms of NK cell cytotoxicity. 1999. ISBN 82-7861-190-4.
Iversen, Ann-Charlotte; Johnsen, Ann-Charlotte. (1993) Etablering av RT-PCR og en undersøkelse av variasjoner i cytokin-genekspresjon i natural killer celler stimulert med IL-2, IL-7 og IL-12. 1993.

Språkvelger

Ann-Charlotte Iversen