Ann-Charlotte Iversen
About
Group Leader Inflammation in Pregnancy Research Group / Theme Leader in CEMIR
My main research focus is to utilize knowledge from basic molecular immunity into clinical research on the major human inflammatory diseases; cardiovascular disease and preeclampsia. Use of new knowledge on molecular inflammation to approach inflammatory diseases with new hypotheses of underlying abnormal immune mechanisms, provides a more solid foundation for the search for new therapeutic approaches and biomarkers. The field of danger signal induced inflammation has revealed a common set of inflammatory mechanisms that underlie a wide variety of diseases, both induced by environmental factors, like pathogens, and by abnormal endogenous inflammatory response. Thus, the combined look at related major inflammatory diseases is of particular importance. My motivation for this translational approach is further strengthened by the need for gender-specific knowledge to address the “female way” of developing cardiovascular diseases, and the up to eight-fold increase in risk for later-life cardiovascular disease following a preeclamptic pregnancy.
Publications
2021
-
Rakner, Johanne Johnsen;
Silva, Gabriela;
Mundal, Siv Boon;
Thaning, Astrid Josefin;
Elschot, Mattijs;
Ostrop, Jenny;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Gierman, Lobke;
Iversen, Ann-Charlotte.
(2021)
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies.
Placenta.
volum 105.
Academic article
2020
-
Gierman, Lobke;
Silva, Gabriela;
Pervaiz, Zahra;
Rakner, Johanne Johnsen;
Mundal, Siv Boon;
Thaning, Astrid Josefin;
Nervik, Ingunn;
Elschot, Mattijs;
Mathew, Seema;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2020)
TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies.
Journal of Leukocyte Biology.
Academic literature review
-
Silva, Gabriela;
Gierman, Lobke;
Rakner, Johanne Johnsen;
Stødle, Guro;
Thaning, Astrid Josefin;
Mundal, Siv Boon;
Sporsheim, Bjørnar;
Elschot, Mattijs;
Collett, Karin;
Bjørge, Line;
Aune, Marie Hjelmseth;
Thomsen, Liv Cecilie Vestrheim;
Iversen, Ann-Charlotte.
(2020)
Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies.
Frontiers in Immunology.
volum 11:564712.
Academic article
-
Steinthorsdottir, Valgerdur;
McGinnis, Ralph;
Williams, Nicholas O.;
Stefánsdóttir, Lilja;
Thorleifsson, Gudmar;
Shooter, Scott;
Fadista, João;
Sigurdsson, Jon K.;
Auro, Kirsi;
Berezina, Galina;
Borges, Maria-Carolina;
Bumpstead, Suzannah;
Bybjerg-Grauholm, Jonas;
Colgiu, Irina;
Dolby, Vivien A.;
Dudbridge, Frank;
Engel, Stephanie M.;
Franklin, Christopher S.;
Frigge, Michael L;
Frisbaek, Yr;
Geirsson, Reynir T.;
Geller, Frank;
Gretarsdottir, Solveig;
Gudbjartsson, Daniel F.;
Harmon, Quaker;
Hougaard, David Michael;
Hegay, Tatyana;
Helgadottir, Anna;
Hjartardóttir, Sigrún;
Jääskeläinen, Tiina;
Johannsdottir, Hrefna;
Jonsdottir, Ingileif;
Juliusdottir, Thorhildur;
Kalsheker, Noor;
Kasimov, Abdumadjit;
Kemp, John P.;
Kivinen, Katja;
Klungsøyr, Kari;
Lee, Wai K;
Melbye, Mads;
Miedzybrodska, Zosia;
Moffett, Ashley;
Najmutdinova, Dilbar;
Nishanova, Firuza;
Olafsdottir, Thorunn;
Perola, Markus;
Pipkin, Fiona Broughton;
Poston, Lucilla;
Prescott, Gordon;
Saevarsdottir, Saedis;
Salimbayeva, Damilya;
Scaife, Paula Juliet;
Skotte, Line;
Staines-Urias, Eleonora;
Stefansson, Olafur A.;
Sørensen, Karina Meden;
Thomsen, Liv Cecilie Vestrheim;
Tragante, Vinicius;
Trogstad, Lill;
Simpson, Nigel A.B.;
Aripova, Tamara;
Casas, Juan P;
Dominiczak, Anna F;
Walker, James J.;
Thorsteinsdottir, Unnur;
Iversen, Ann-Charlotte;
Feenstra, Bjarke;
Lawlor, Deborah A.;
Boyd, Heather Allison;
Magnus, Per;
Laivuori, Hannele;
Zakhidova, Nodira;
Syvatova, Gulnara;
Stefansson, Kari;
Morgan, Linda.
(2020)
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.
Nature Communications.
volum 11.
Academic article
2019
-
Austdal, Marie;
Silva, Gabriela;
Bowe, Sophie;
Thomsen, Liv Cecilie Vestrheim;
Tangerås, Line Haugstad;
Bjørge, Line;
Bathen, Tone Frost;
Iversen, Ann-Charlotte.
(2019)
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity.
Hypertension.
volum 74 (5).
Academic article
-
Riise, Hilde Kristin Refvik;
Sulo, Gerhard;
Tell, Grethe S.;
Igland, Jannicke;
Egeland, Grace M.;
Nygård, Ottar;
Selmer, Randi Marie;
Iversen, Ann-Charlotte;
Daltveit, Anne Kjersti.
(2019)
Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors.
International Journal of Cardiology.
volum 282.
Academic article
-
Stokkeland, Live Marie Tobiesen;
Giskeødegård, Guro F.;
Stridsklev, Solhild;
Ryan, Liv;
Steinkjer, Bjørg;
Tangerås, Line Haugstad;
Vanky, Eszter;
Iversen, Ann-Charlotte.
(2019)
Serum cytokine patterns in first half of pregnancy.
Cytokine.
volum 119.
Academic article
2018
-
Riise, Hilde Kristin Refvik;
Sulo, Gerhard;
Tell, Grethe S.;
Igland, Jannicke;
Nygård, Ottar;
Iversen, Ann-Charlotte;
Daltveit, Anne Kjersti.
(2018)
Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women.
Journal of the American Heart Association (JAHA).
volum 7 (10).
Academic article
-
Stødle, Guro;
Silva, Gabriela;
Tangerås, Line Haugstad;
Gierman, Lobke;
Nervik, Ingunn;
Dahlberg, Unn;
Sun, Chen;
Aune, Marie Hjelmseth;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2018)
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts.
Clinical and Experimental Immunology.
volum 193 (1).
Academic article
-
Tangerås, Line Haugstad;
Silva, Gabriela;
Stødle, Guro;
Gierman, Lobke;
Skei, Bente;
Collett, Karin;
Beversmark, Anne Lise;
Skråstad, Ragnhild Bergene;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2018)
Placental inflammation by HMGB1 activation of TLR4 at the syncytium.
Placenta.
volum 72-73.
Academic article
2017
-
McGinnis, Ralph;
Steinthorsdottir, Valgerdur;
Williams, Nicholas O.;
Thorleifsson, Gudmar;
Shooter, Scott;
Hjartardóttir, Sigrún;
Bumpstead, Suzannah;
Stefánsdóttir, Lilja;
Hildyard, Lucy;
Sigurdsson, Jon K.;
Kemp, John P.;
Silva, Gabriela;
Thomsen, Liv Cecilie Vestrheim;
Jääskeläinen, Tiina;
Kajantie, Eero;
Chappell, Sally;
Kalsheker, Noor;
Moffett, Ashley;
Hiby, Susan;
Lee, Wai Kwong;
Padmanabhan, Sandosh;
Simpson, Nigel A.B.;
Dolby, Vivien A.;
Staines-Urias, Eleonora;
Engel, Stephanie M.;
Haugan, Anita;
Trogstad, Lill;
Svyatova, Gulnara;
Zakhidova, Nodira;
Najmutdinova, Dilbar;
Dominiczak, Anna F.;
Gjessing, Håkon K.;
Casas, Juan P.;
Dudbridge, Frank;
Walker, James J.;
Pipkin, Fiona Broughton;
Thorsteinsdóttir, Unnur;
Geirsson, Reynir Tõmas;
Lawlor, Debbie A.;
Iversen, Ann-Charlotte;
Magnus, Per;
Laivuori, Hannele;
Stefánsson, Kári;
Morgan, Linda.
(2017)
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.
Nature Genetics.
volum 49 (8).
Academic article
-
Riise, Hilde Kristin Refvik;
Sulo, Gerhard;
Tell, Grethe S.;
Igland, Jannicke;
Nygård, Ottar;
Vollset, Stein Emil;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
Daltveit, Anne Kjersti.
(2017)
Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity.
Journal of the American Heart Association (JAHA).
volum 6 (3).
Academic article
2016
-
Thomsen, Liv Cecilie Vestrheim;
McCarthy, Nina;
Melton, Philip E.;
Cadby, Gemma;
Austgulen, Rigmor;
Nygård, Ottar;
Johnson, Matthew P;
Brennecke, Shaun P.;
Moses, Eric K;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2016)
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.
Journal of Hypertension.
volum 35.
Academic article
2015
-
Austdal, Marie;
Tangerås, Line Haugstad;
Skråstad, Ragnhild;
Salvesen, Kjell Å;
Austgulen, Rigmor;
Iversen, Ann-Charlotte;
Bathen, Tone Frost.
(2015)
First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study.
International Journal of Molecular Sciences.
volum 16 (9).
Academic article
-
Austdal, Marie;
Thomsen, Liv Cecilie Vestrheim;
Tangerås, Line Haugstad;
Skei, Bente;
Mathew, Seema;
Bjørge, Line;
Austgulen, Rigmor;
Bathen, Tone Frost;
Iversen, Ann-Charlotte.
(2015)
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics.
Placenta.
volum 36 (12).
Academic article
-
Gierman, Lobke;
Stødle, Guro;
Tangerås, Line Haugstad;
Austdal, Marie;
Olsen, Guro Dalheim;
Follestad, Turid;
Skei, Bente;
Rian, Kristin;
Gundersen, Astrid;
Austgulen, Rigmor;
Iversen, Ann-Charlotte.
(2015)
Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts.
Placenta.
volum 36 (11).
Academic article
-
Pabalan, Noel;
Jarjanazi, H;
Sun, Chen;
Iversen, Ann-Charlotte.
(2015)
Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia.
Tissue Antigens.
volum 86 (3).
Academic article
-
Tangerås, Line Haugstad;
Austdal, Marie;
Skråstad, Ragnhild;
Salvesen, Kjell Å;
Austgulen, Rigmor;
Bathen, Tone Frost;
Iversen, Ann-Charlotte.
(2015)
Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia.
Arteriosclerosis, Thrombosis and Vascular Biology.
volum 35 (11).
Academic article
-
Thomsen, Liv Cecilie Vestrheim;
Melton, Philip E.;
Tollaksen, Kjersti;
Lyslo, Ingvill;
Roten, Linda Tømmerdal;
Odland, Maria Lisa;
Strand, Kristin Melheim;
Nygård, Ottar;
Sun, Chen;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
Moses, Eric;
Bjørge, Line.
(2015)
Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort.
Journal of Hypertension.
volum 33 (11).
Academic article
2014
-
Austdal, Marie;
Skråstad, Ragnhild;
Gundersen, Astrid;
Austgulen, Rigmor;
Iversen, Ann-Charlotte;
Bathen, Tone Frost.
(2014)
Metabolomic biomarkers in serum and urine in women with preeclampsia.
PLOS ONE.
volum 9 (3:e91923).
Academic article
-
Løset, Mari;
Johnson, Matthew P.;
Melton, Philip E.;
Ang, Wei;
Huang, Rae-Chi;
Mori, Trevor;
Beilin, Lawrence J.;
Pennell, Craig E.;
Roten, Linda Tømmerdal;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
East, Christine E.;
Blangero, John;
Brennecke, Shaun P.;
Moses, Eric K.
(2014)
Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22.
Pregnancy Hypertension.
volum 4 (2).
Academic article
-
Morgan, Linda;
McGinnis, Ralph;
Steinthorsdottir, Valgerdur;
Syvatova, Gulnara;
Zakhidova, Nodira;
Lee, Wai Kwong;
Iversen, Ann-Charlotte;
Magnus, Per;
Walker, James;
Casas, Juan Pablo;
Sultanov, Saidazim;
Laivuori, Hannele.
(2014)
InterPregGen: Genetic studies of pre-eclampsia in three continents.
Norsk Epidemiologi.
volum 24 (1-2).
Academic article
-
Tangerås, Line;
Stødle, Guro;
Olsen, Guro Dalheim;
Leknes, Ann-Helen;
Gundersen, Astrid;
Skei, Bente;
Vikdal, Anne Jorunn;
Ryan, Liv;
Steinkjer, Bjørg;
Myklebost, Merete;
Langaas, Mette;
Austgulen, Rigmor;
Iversen, Ann-Charlotte.
(2014)
Functional Toll-like receptors in primary first-trimester trophoblasts.
Journal of Reproductive Immunology.
volum 106.
Academic article
2013
-
Odland, Maria Lisa;
Strand, Kristin Melheim;
Nordbø, Svein Arne;
Forsmo, Siri;
Ausgtulen, Rigmor;
Iversen, Ann-Charlotte.
(2013)
Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study.
BMJ Open.
volum 3.
Academic article
-
Strand, Kristin Melheim;
Heimstad, Runa Kristine;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
Lydersen, Stian;
Andersen, Guro Lillemoen;
Irgens, Lorentz M.;
Vik, Torstein.
(2013)
Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study.
BMJ. British Medical Journal.
Academic article
2012
-
Johnson, Matthew P;
Brennecke, Shaun P.;
East, Christine;
Göring, Harald H H;
Kent, Jack W;
Dyer, Thomas D.;
Said, Joanne M;
Roten, Linda Tømmerdal;
Iversen, Ann-Charlotte;
Abraham, Lawrence J;
Heinonen, Seppo;
Kajantie, Eero;
Kere, Juha;
Kivinen, Katja;
Pouta, Anneli;
Laivuori, Hannele;
Austgulen, Rigmor;
Blangero, John;
Moses, Eric K.
(2012)
Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.
PLOS ONE.
volum 7 (3).
Academic article
-
Strand, Kristin Melheim;
Odland, Maria Lisa;
Iversen, Ann-Charlotte;
Nordbø, Svein Arne;
Vik, Torstein;
Austgulen, Rigmor.
(2012)
Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway.
BJOG: An International Journal of Obstetrics and Gynaecology.
volum 119 (11).
Academic article
2009
-
Iversen, Ann-Charlotte;
Steinkjer, Bjørg;
Nilsen, Nadra;
Bohnhorst, Janne Øvrebø;
Moen, Siv Helen;
Vik, Randi;
Stephens, Phil;
Thomas, DW;
Benedict, Chris A.;
Espevik, Terje.
(2009)
A proviral role for CpG in cytomegalovirus infection.
Journal of Immunology.
volum 182 (9).
Academic article
-
Sandanger, O;
Sandanger, Øystein;
Ryan, Liv;
Bohnhorst, Janne Øvrebø;
Iversen, AC;
Iversen, Ann-Charlotte;
Husebye, Harald;
Halaas, O;
Halaas, Øyvind;
Landrø, Linn;
Aukrust, Pål;
Frøland, Stig S.;
Elson, Greg;
Visintin, Alberto;
Øktedalen, Olav;
Damås, Jan Kristian;
Damas, JK;
Sundan, Anders;
Golenbock, Douglas T.;
Espevik, Terje.
(2009)
IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients.
Journal of Immunology.
volum 182 (1).
Academic article
2006
-
Eide, Irina P.;
Isaksen, Christina Vogt;
Salvesen, Kjell Å;
Langaas, Mette;
Gunther, Clara-Cecilie;
Iversen, Ann-Charlotte;
Austgulen, Rigmor.
(2006)
Fetal growth restriction is associated with reduced FasL expression by decidual cells.
American Journal of Reproductive Immunology.
Academic article
-
Iversen, Ann-Charlotte;
Tømmerdal, Linda Føll;
Nguyen, Olav Toai Duc;
Landsem, Veslemøy Malm;
Acar, Nuray;
Eide, Irina P.;
Klungland, Helge;
Austgulen, Rigmor.
(2006)
Fetal HLA-G 14bp gene polymorphism is associated with expression of three different variants of HLA-G mRNA in decidual tissues, as studied in abnormal (PE/FGR) and healthy pregnancies.
Tissue Antigens.
volum 68.
Abstract
2005
-
Iversen, Ann-Charlotte;
Norris, Paula S;
Ware, Carl F;
Benedict, Christopher A.
(2005)
Human NK cells inhibit CMV replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of interferon-beta.
Journal of Immunology.
volum 175.
Academic article
-
Øren, Anita;
Husebø, Christina Aspaas;
Iversen, Ann-Charlotte;
Austgulen, Rigmor.
(2005)
A comparative study of immunomagnetic methods used for separation of human natural killer cells from peripheral blood.
JIM - Journal of Immunological Methods.
volum 303.
Academic article
1999
-
Haux, Johan;
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Steinkjer, Bjørg;
Egeberg, Kjartan Wøllo;
Sundan, Anders;
Espevik, Terje.
(1999)
The role of IL-2 in regulating the sensitivity of NK cells for Fas-mediated apoptosis.
Cancer Immunology and Immunotherapy.
volum 48.
Academic article
-
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte.
(1999)
TNF-related death receptors - characterization of mechanisms of NK cell cytotoxicity.
1999. ISBN 82-7861-190-4.
Doctoral dissertation
-
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Haux, Johan;
Steinkjer, Bjørg;
Nonstad, Unni;
Egeberg, Kjartan Wøllo;
Sundan, Anders;
Ashkenazi, Avi;
Espevik, Terje.
(1999)
Regulation of Apo-2 Ligand/Trail expression in NK cells - Involvement in NK cell mediated cytotoxicity.
Cytokine.
volum 11 (9).
Academic article
1995
-
Lien, Egil;
Liabakk, Nina-Beate;
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Nonstad, Unni;
Sundan, Anders;
Espevik, Terje.
(1995)
Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells.
European Journal of Immunology.
volum 25.
Academic article
1993
-
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte.
(1993)
Etablering av RT-PCR og en undersøkelse av variasjoner i cytokin-genekspresjon i natural killer celler stimulert med IL-2, IL-7 og IL-12.
1993.
Thesis at a second degree level
-
Naume, Bjørn;
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Espevik, Terje;
Sundan, Anders.
(1993)
Gene expression and secretion of cytokines and cytokine receptors from hihgly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12.
European Journal of Immunology.
volum 23.
Academic article
Journal publications
-
Rakner, Johanne Johnsen;
Silva, Gabriela;
Mundal, Siv Boon;
Thaning, Astrid Josefin;
Elschot, Mattijs;
Ostrop, Jenny;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Gierman, Lobke;
Iversen, Ann-Charlotte.
(2021)
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies.
Placenta.
volum 105.
Academic article
-
Gierman, Lobke;
Silva, Gabriela;
Pervaiz, Zahra;
Rakner, Johanne Johnsen;
Mundal, Siv Boon;
Thaning, Astrid Josefin;
Nervik, Ingunn;
Elschot, Mattijs;
Mathew, Seema;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2020)
TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies.
Journal of Leukocyte Biology.
Academic literature review
-
Silva, Gabriela;
Gierman, Lobke;
Rakner, Johanne Johnsen;
Stødle, Guro;
Thaning, Astrid Josefin;
Mundal, Siv Boon;
Sporsheim, Bjørnar;
Elschot, Mattijs;
Collett, Karin;
Bjørge, Line;
Aune, Marie Hjelmseth;
Thomsen, Liv Cecilie Vestrheim;
Iversen, Ann-Charlotte.
(2020)
Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies.
Frontiers in Immunology.
volum 11:564712.
Academic article
-
Steinthorsdottir, Valgerdur;
McGinnis, Ralph;
Williams, Nicholas O.;
Stefánsdóttir, Lilja;
Thorleifsson, Gudmar;
Shooter, Scott;
Fadista, João;
Sigurdsson, Jon K.;
Auro, Kirsi;
Berezina, Galina;
Borges, Maria-Carolina;
Bumpstead, Suzannah;
Bybjerg-Grauholm, Jonas;
Colgiu, Irina;
Dolby, Vivien A.;
Dudbridge, Frank;
Engel, Stephanie M.;
Franklin, Christopher S.;
Frigge, Michael L;
Frisbaek, Yr;
Geirsson, Reynir T.;
Geller, Frank;
Gretarsdottir, Solveig;
Gudbjartsson, Daniel F.;
Harmon, Quaker;
Hougaard, David Michael;
Hegay, Tatyana;
Helgadottir, Anna;
Hjartardóttir, Sigrún;
Jääskeläinen, Tiina;
Johannsdottir, Hrefna;
Jonsdottir, Ingileif;
Juliusdottir, Thorhildur;
Kalsheker, Noor;
Kasimov, Abdumadjit;
Kemp, John P.;
Kivinen, Katja;
Klungsøyr, Kari;
Lee, Wai K;
Melbye, Mads;
Miedzybrodska, Zosia;
Moffett, Ashley;
Najmutdinova, Dilbar;
Nishanova, Firuza;
Olafsdottir, Thorunn;
Perola, Markus;
Pipkin, Fiona Broughton;
Poston, Lucilla;
Prescott, Gordon;
Saevarsdottir, Saedis;
Salimbayeva, Damilya;
Scaife, Paula Juliet;
Skotte, Line;
Staines-Urias, Eleonora;
Stefansson, Olafur A.;
Sørensen, Karina Meden;
Thomsen, Liv Cecilie Vestrheim;
Tragante, Vinicius;
Trogstad, Lill;
Simpson, Nigel A.B.;
Aripova, Tamara;
Casas, Juan P;
Dominiczak, Anna F;
Walker, James J.;
Thorsteinsdottir, Unnur;
Iversen, Ann-Charlotte;
Feenstra, Bjarke;
Lawlor, Deborah A.;
Boyd, Heather Allison;
Magnus, Per;
Laivuori, Hannele;
Zakhidova, Nodira;
Syvatova, Gulnara;
Stefansson, Kari;
Morgan, Linda.
(2020)
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.
Nature Communications.
volum 11.
Academic article
-
Austdal, Marie;
Silva, Gabriela;
Bowe, Sophie;
Thomsen, Liv Cecilie Vestrheim;
Tangerås, Line Haugstad;
Bjørge, Line;
Bathen, Tone Frost;
Iversen, Ann-Charlotte.
(2019)
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity.
Hypertension.
volum 74 (5).
Academic article
-
Riise, Hilde Kristin Refvik;
Sulo, Gerhard;
Tell, Grethe S.;
Igland, Jannicke;
Egeland, Grace M.;
Nygård, Ottar;
Selmer, Randi Marie;
Iversen, Ann-Charlotte;
Daltveit, Anne Kjersti.
(2019)
Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors.
International Journal of Cardiology.
volum 282.
Academic article
-
Stokkeland, Live Marie Tobiesen;
Giskeødegård, Guro F.;
Stridsklev, Solhild;
Ryan, Liv;
Steinkjer, Bjørg;
Tangerås, Line Haugstad;
Vanky, Eszter;
Iversen, Ann-Charlotte.
(2019)
Serum cytokine patterns in first half of pregnancy.
Cytokine.
volum 119.
Academic article
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Riise, Hilde Kristin Refvik;
Sulo, Gerhard;
Tell, Grethe S.;
Igland, Jannicke;
Nygård, Ottar;
Iversen, Ann-Charlotte;
Daltveit, Anne Kjersti.
(2018)
Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women.
Journal of the American Heart Association (JAHA).
volum 7 (10).
Academic article
-
Stødle, Guro;
Silva, Gabriela;
Tangerås, Line Haugstad;
Gierman, Lobke;
Nervik, Ingunn;
Dahlberg, Unn;
Sun, Chen;
Aune, Marie Hjelmseth;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2018)
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts.
Clinical and Experimental Immunology.
volum 193 (1).
Academic article
-
Tangerås, Line Haugstad;
Silva, Gabriela;
Stødle, Guro;
Gierman, Lobke;
Skei, Bente;
Collett, Karin;
Beversmark, Anne Lise;
Skråstad, Ragnhild Bergene;
Thomsen, Liv Cecilie Vestrheim;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2018)
Placental inflammation by HMGB1 activation of TLR4 at the syncytium.
Placenta.
volum 72-73.
Academic article
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McGinnis, Ralph;
Steinthorsdottir, Valgerdur;
Williams, Nicholas O.;
Thorleifsson, Gudmar;
Shooter, Scott;
Hjartardóttir, Sigrún;
Bumpstead, Suzannah;
Stefánsdóttir, Lilja;
Hildyard, Lucy;
Sigurdsson, Jon K.;
Kemp, John P.;
Silva, Gabriela;
Thomsen, Liv Cecilie Vestrheim;
Jääskeläinen, Tiina;
Kajantie, Eero;
Chappell, Sally;
Kalsheker, Noor;
Moffett, Ashley;
Hiby, Susan;
Lee, Wai Kwong;
Padmanabhan, Sandosh;
Simpson, Nigel A.B.;
Dolby, Vivien A.;
Staines-Urias, Eleonora;
Engel, Stephanie M.;
Haugan, Anita;
Trogstad, Lill;
Svyatova, Gulnara;
Zakhidova, Nodira;
Najmutdinova, Dilbar;
Dominiczak, Anna F.;
Gjessing, Håkon K.;
Casas, Juan P.;
Dudbridge, Frank;
Walker, James J.;
Pipkin, Fiona Broughton;
Thorsteinsdóttir, Unnur;
Geirsson, Reynir Tõmas;
Lawlor, Debbie A.;
Iversen, Ann-Charlotte;
Magnus, Per;
Laivuori, Hannele;
Stefánsson, Kári;
Morgan, Linda.
(2017)
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.
Nature Genetics.
volum 49 (8).
Academic article
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Riise, Hilde Kristin Refvik;
Sulo, Gerhard;
Tell, Grethe S.;
Igland, Jannicke;
Nygård, Ottar;
Vollset, Stein Emil;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
Daltveit, Anne Kjersti.
(2017)
Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity.
Journal of the American Heart Association (JAHA).
volum 6 (3).
Academic article
-
Thomsen, Liv Cecilie Vestrheim;
McCarthy, Nina;
Melton, Philip E.;
Cadby, Gemma;
Austgulen, Rigmor;
Nygård, Ottar;
Johnson, Matthew P;
Brennecke, Shaun P.;
Moses, Eric K;
Bjørge, Line;
Iversen, Ann-Charlotte.
(2016)
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.
Journal of Hypertension.
volum 35.
Academic article
-
Austdal, Marie;
Tangerås, Line Haugstad;
Skråstad, Ragnhild;
Salvesen, Kjell Å;
Austgulen, Rigmor;
Iversen, Ann-Charlotte;
Bathen, Tone Frost.
(2015)
First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study.
International Journal of Molecular Sciences.
volum 16 (9).
Academic article
-
Austdal, Marie;
Thomsen, Liv Cecilie Vestrheim;
Tangerås, Line Haugstad;
Skei, Bente;
Mathew, Seema;
Bjørge, Line;
Austgulen, Rigmor;
Bathen, Tone Frost;
Iversen, Ann-Charlotte.
(2015)
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics.
Placenta.
volum 36 (12).
Academic article
-
Gierman, Lobke;
Stødle, Guro;
Tangerås, Line Haugstad;
Austdal, Marie;
Olsen, Guro Dalheim;
Follestad, Turid;
Skei, Bente;
Rian, Kristin;
Gundersen, Astrid;
Austgulen, Rigmor;
Iversen, Ann-Charlotte.
(2015)
Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts.
Placenta.
volum 36 (11).
Academic article
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Pabalan, Noel;
Jarjanazi, H;
Sun, Chen;
Iversen, Ann-Charlotte.
(2015)
Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia.
Tissue Antigens.
volum 86 (3).
Academic article
-
Tangerås, Line Haugstad;
Austdal, Marie;
Skråstad, Ragnhild;
Salvesen, Kjell Å;
Austgulen, Rigmor;
Bathen, Tone Frost;
Iversen, Ann-Charlotte.
(2015)
Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia.
Arteriosclerosis, Thrombosis and Vascular Biology.
volum 35 (11).
Academic article
-
Thomsen, Liv Cecilie Vestrheim;
Melton, Philip E.;
Tollaksen, Kjersti;
Lyslo, Ingvill;
Roten, Linda Tømmerdal;
Odland, Maria Lisa;
Strand, Kristin Melheim;
Nygård, Ottar;
Sun, Chen;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
Moses, Eric;
Bjørge, Line.
(2015)
Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort.
Journal of Hypertension.
volum 33 (11).
Academic article
-
Austdal, Marie;
Skråstad, Ragnhild;
Gundersen, Astrid;
Austgulen, Rigmor;
Iversen, Ann-Charlotte;
Bathen, Tone Frost.
(2014)
Metabolomic biomarkers in serum and urine in women with preeclampsia.
PLOS ONE.
volum 9 (3:e91923).
Academic article
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Løset, Mari;
Johnson, Matthew P.;
Melton, Philip E.;
Ang, Wei;
Huang, Rae-Chi;
Mori, Trevor;
Beilin, Lawrence J.;
Pennell, Craig E.;
Roten, Linda Tømmerdal;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
East, Christine E.;
Blangero, John;
Brennecke, Shaun P.;
Moses, Eric K.
(2014)
Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22.
Pregnancy Hypertension.
volum 4 (2).
Academic article
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Morgan, Linda;
McGinnis, Ralph;
Steinthorsdottir, Valgerdur;
Syvatova, Gulnara;
Zakhidova, Nodira;
Lee, Wai Kwong;
Iversen, Ann-Charlotte;
Magnus, Per;
Walker, James;
Casas, Juan Pablo;
Sultanov, Saidazim;
Laivuori, Hannele.
(2014)
InterPregGen: Genetic studies of pre-eclampsia in three continents.
Norsk Epidemiologi.
volum 24 (1-2).
Academic article
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Tangerås, Line;
Stødle, Guro;
Olsen, Guro Dalheim;
Leknes, Ann-Helen;
Gundersen, Astrid;
Skei, Bente;
Vikdal, Anne Jorunn;
Ryan, Liv;
Steinkjer, Bjørg;
Myklebost, Merete;
Langaas, Mette;
Austgulen, Rigmor;
Iversen, Ann-Charlotte.
(2014)
Functional Toll-like receptors in primary first-trimester trophoblasts.
Journal of Reproductive Immunology.
volum 106.
Academic article
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Odland, Maria Lisa;
Strand, Kristin Melheim;
Nordbø, Svein Arne;
Forsmo, Siri;
Ausgtulen, Rigmor;
Iversen, Ann-Charlotte.
(2013)
Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study.
BMJ Open.
volum 3.
Academic article
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Strand, Kristin Melheim;
Heimstad, Runa Kristine;
Iversen, Ann-Charlotte;
Austgulen, Rigmor;
Lydersen, Stian;
Andersen, Guro Lillemoen;
Irgens, Lorentz M.;
Vik, Torstein.
(2013)
Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study.
BMJ. British Medical Journal.
Academic article
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Johnson, Matthew P;
Brennecke, Shaun P.;
East, Christine;
Göring, Harald H H;
Kent, Jack W;
Dyer, Thomas D.;
Said, Joanne M;
Roten, Linda Tømmerdal;
Iversen, Ann-Charlotte;
Abraham, Lawrence J;
Heinonen, Seppo;
Kajantie, Eero;
Kere, Juha;
Kivinen, Katja;
Pouta, Anneli;
Laivuori, Hannele;
Austgulen, Rigmor;
Blangero, John;
Moses, Eric K.
(2012)
Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.
PLOS ONE.
volum 7 (3).
Academic article
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Strand, Kristin Melheim;
Odland, Maria Lisa;
Iversen, Ann-Charlotte;
Nordbø, Svein Arne;
Vik, Torstein;
Austgulen, Rigmor.
(2012)
Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway.
BJOG: An International Journal of Obstetrics and Gynaecology.
volum 119 (11).
Academic article
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Iversen, Ann-Charlotte;
Steinkjer, Bjørg;
Nilsen, Nadra;
Bohnhorst, Janne Øvrebø;
Moen, Siv Helen;
Vik, Randi;
Stephens, Phil;
Thomas, DW;
Benedict, Chris A.;
Espevik, Terje.
(2009)
A proviral role for CpG in cytomegalovirus infection.
Journal of Immunology.
volum 182 (9).
Academic article
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Sandanger, O;
Sandanger, Øystein;
Ryan, Liv;
Bohnhorst, Janne Øvrebø;
Iversen, AC;
Iversen, Ann-Charlotte;
Husebye, Harald;
Halaas, O;
Halaas, Øyvind;
Landrø, Linn;
Aukrust, Pål;
Frøland, Stig S.;
Elson, Greg;
Visintin, Alberto;
Øktedalen, Olav;
Damås, Jan Kristian;
Damas, JK;
Sundan, Anders;
Golenbock, Douglas T.;
Espevik, Terje.
(2009)
IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients.
Journal of Immunology.
volum 182 (1).
Academic article
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Eide, Irina P.;
Isaksen, Christina Vogt;
Salvesen, Kjell Å;
Langaas, Mette;
Gunther, Clara-Cecilie;
Iversen, Ann-Charlotte;
Austgulen, Rigmor.
(2006)
Fetal growth restriction is associated with reduced FasL expression by decidual cells.
American Journal of Reproductive Immunology.
Academic article
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Iversen, Ann-Charlotte;
Tømmerdal, Linda Føll;
Nguyen, Olav Toai Duc;
Landsem, Veslemøy Malm;
Acar, Nuray;
Eide, Irina P.;
Klungland, Helge;
Austgulen, Rigmor.
(2006)
Fetal HLA-G 14bp gene polymorphism is associated with expression of three different variants of HLA-G mRNA in decidual tissues, as studied in abnormal (PE/FGR) and healthy pregnancies.
Tissue Antigens.
volum 68.
Abstract
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Iversen, Ann-Charlotte;
Norris, Paula S;
Ware, Carl F;
Benedict, Christopher A.
(2005)
Human NK cells inhibit CMV replication through a noncytolytic mechanism involving lymphotoxin-dependent induction of interferon-beta.
Journal of Immunology.
volum 175.
Academic article
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Øren, Anita;
Husebø, Christina Aspaas;
Iversen, Ann-Charlotte;
Austgulen, Rigmor.
(2005)
A comparative study of immunomagnetic methods used for separation of human natural killer cells from peripheral blood.
JIM - Journal of Immunological Methods.
volum 303.
Academic article
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Haux, Johan;
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Steinkjer, Bjørg;
Egeberg, Kjartan Wøllo;
Sundan, Anders;
Espevik, Terje.
(1999)
The role of IL-2 in regulating the sensitivity of NK cells for Fas-mediated apoptosis.
Cancer Immunology and Immunotherapy.
volum 48.
Academic article
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Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Haux, Johan;
Steinkjer, Bjørg;
Nonstad, Unni;
Egeberg, Kjartan Wøllo;
Sundan, Anders;
Ashkenazi, Avi;
Espevik, Terje.
(1999)
Regulation of Apo-2 Ligand/Trail expression in NK cells - Involvement in NK cell mediated cytotoxicity.
Cytokine.
volum 11 (9).
Academic article
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Lien, Egil;
Liabakk, Nina-Beate;
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Nonstad, Unni;
Sundan, Anders;
Espevik, Terje.
(1995)
Polymorphonuclear granulocytes enhance lipopolysaccharide-induced p75 tumor necrosis factor receptor release from mononuclear cells.
European Journal of Immunology.
volum 25.
Academic article
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Naume, Bjørn;
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte;
Espevik, Terje;
Sundan, Anders.
(1993)
Gene expression and secretion of cytokines and cytokine receptors from hihgly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12.
European Journal of Immunology.
volum 23.
Academic article
Report
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Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte.
(1999)
TNF-related death receptors - characterization of mechanisms of NK cell cytotoxicity.
1999. ISBN 82-7861-190-4.
Doctoral dissertation
-
Iversen, Ann-Charlotte;
Johnsen, Ann-Charlotte.
(1993)
Etablering av RT-PCR og en undersøkelse av variasjoner i cytokin-genekspresjon i natural killer celler stimulert med IL-2, IL-7 og IL-12.
1993.
Thesis at a second degree level