Background and activities
Head of the research group “Women’s health and PCOS” at the Institute for Laboratory Medicine, Children’s and Women’s health, and at the Dept. of Obstetrics and Gynecology, St. Olav`s Hospital Trondheim, Norway
Principal investigator of the «Metformin treatment of pregnant PCOS women and prevention of preterm birth» (The PregMet2) study, a Nordic RCT, funded by the Norwegian Research Council.
Principal investigator of the “Intrauterine metformin exposure and long-term health of the children” (The PedMet1 study) a multicenter RCT, funded by the Norwegian Research Council, Novo Nordisk and The Joint Research Council at St.Olavs Hospital and The Faculty of Medicine, NTNU.
Principal investigator of the “Intrauterine metformin exposure and cognitive development in children born to PCOS mothers and control mothers” (The CogMet study) funded by Novo Nordisk and The Joint Research Council at St.Olavs Hospital and The Faculty of Medicine, NTNU.
We investigate polycystic ovary syndrome (PCOS) in both pregnant and non-pregnant women. Main focus is randomized clinical trials where the effect of metformin is explored. We follow up women before, during and after pregnancy and their children with somatic and cognitive examinations. Our aim is to survey long-term health of mothers with PCOS and their children. We explore possible consequences of PCOS and possible effects of metformin on hemodynamics, pharmacokinetics, weight development, body composition, hormones, metabolism and lung function.
Other area of interests is breastfeeding related to maternal and offspring long-term health, patient claims in gynecology, labour induction, breech deliveries and hyperemesis in pregnancy.
We have ongoing co-operation with the Dept. of Pediatrics, Dept. of Clinical Pharmacology, Inst. for Cancer Research and Molecular Biology; research group for “Inflammation and genetics in pregnancy” and research group «Excercise, cariometabolic health and reproduction».
We also have ongoing clinical and epidemiological studies and co-operation with established research groups in Bergen (Norway), Sweden, Finland, USA, Canada, and Australia where we explore different aspects of PCOS, obesity and breastfeeding.
Professor of Obstetrics and Gynecology at Institute of LBK/The Faculty of Medicine, Norwegian university of Science and Technology
Consultant at Dept. of Obstetrics and Gynecology, St. Olav\s Hospital, Trondheim, Norway.
1986 MD at the University of Linköping, Sweden
1995 Specialist in gynecologi and obstetrics,
2005 PhD thesis
2014 Professor at Institute for LBK, DMF, NTNU
Diabetes in pregnancy, obesity and life style in pregnancy, ante-natal and post-natal care in general practice.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2020) Proactive versus standard support of labour in nulliparous women; study protocol for a randomized, controlled trial. BMC Pregnancy and Childbirth. vol. 21 (358).
- (2020) Cognitive function in metformin exposed children, born to mothers with PCOS – follow-up of an RCT. BMC Pediatrics. vol. 20 (60).
- (2020) Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial. BMJ Open.
- (2020) Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training. Frontiers in Physiology.
- (2020) Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study. Journal of Clinical Endocrinology and Metabolism. vol. 105 (1).
- (2020) Polycystic ovary syndrome and pregnancy - From a clinical perspective. Current Opinion in Endocrine and Metabolic Research. vol. 12.
- (2019) A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome. Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG). vol. 59 (6).
- (2019) Intrauterine metformin exposure and offspring cardiometabolic risk factors (PedMet study): a 5-10 year follow-up of the PregMet randomised controlled trial. The Lancet Child and Adolescent Health. vol. 3 (3).
- (2019) Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. The Lancet Diabetes and Endocrinology. vol. 7 (4).
- (2019) Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe. PLOS ONE. vol. 14:e0226074 (12).
- (2019) Approved claims for compensation from gynecological patients in Norway?What characterizes the cases? A 14-year nationwide study. Acta Obstetricia et Gynecologica Scandinavica. vol. 98 (8).
- (2019) Serum cytokine patterns in first half of pregnancy. Cytokine. vol. 119.
- (2019) Prolactin and breast increase during pregnancy in PCOS: linked to long-term metabolic health?. European Journal of Endocrinology. vol. 180 (6).
- (2019) Children born to women with polycystic ovary syndrome - short- and long-term impacts on health and development. Fertility and Sterility. vol. 111 (6).
- (2018) Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice. Clinical Endocrinology. vol. 88 (6).
- (2018) Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age: follow-up of two RCTs. Journal of Clinical Endocrinology and Metabolism. vol. 103 (4).
- (2018) Fetal growth and birth anthropometrics in metformin-exposed offspring born to mothers with PCOS. Journal of Clinical Endocrinology and Metabolism. vol. 103 (2).
- (2018) Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy. Pregnancy Hypertension. vol. 11.
- (2018) Uterine artery Doppler in pregnancy: Women with PCOS compared to healthy controls. International Journal of Endocrinology. vol. 2018.
- (2018) Does Metformin Treatment during Pregnancy Modify the Future Metabolic Profile in Women with PCOS?. Journal of Clinical Endocrinology and Metabolism. vol. 103 (6).