Background and activities
Head of the research group “Women’s health and PCOS” at the Institute for Laboratory Medicine, Children’s and Women’s health, and at the Dept. of Obstetrics and Gynecology, St. Olav`s Hospital Trondheim, Norway
Principal investigator of the «Metformin treatment of pregnant PCOS women and prevention of preterm birth» (The PregMet2) study, a Nordic RCT, funded by the Norwegian Research Council.
Principal investigator of the “Intrauterine metformin exposure and long-term health of the children” (The PedMet1 study) a multicenter RCT, funded by the Norwegian Research Council, Novo Nordisk and The Joint Research Council at St.Olavs Hospital and The Faculty of Medicine, NTNU.
Principal investigator of the “Intrauterine metformin exposure and cognitive development in children born to PCOS mothers and control mothers” (The CogMet study) funded by Novo Nordisk and The Joint Research Council at St.Olavs Hospital and The Faculty of Medicine, NTNU.
We investigate polycystic ovary syndrome (PCOS) in both pregnant and non-pregnant women. Main focus is randomized clinical trials where the effect of metformin is explored. We follow up women before, during and after pregnancy and their children with somatic and cognitive examinations. Our aim is to survey long-term health of mothers with PCOS and their children. We explore possible consequences of PCOS and possible effects of metformin on hemodynamics, pharmacokinetics, weight development, body composition, hormones, metabolism and lung function.
Other area of interests is breastfeeding related to maternal and offspring long-term health, patient claims in gynecology, labour induction, breech deliveries and hyperemesis in pregnancy.
We have ongoing co-operation with the Dept. of Pediatrics, Dept. of Clinical Pharmacology, Inst. for Cancer Research and Molecular Biology; research group for “Inflammation and genetics in pregnancy” and research group «Excercise, cariometabolic health and reproduction».
We also have ongoing clinical and epidemiological studies and co-operation with established research groups in Bergen (Norway), Sweden, Finland, USA, Canada, and Australia where we explore different aspects of PCOS, obesity and breastfeeding.
Professor of Obstetrics and Gynecology at Institute of LBK/The Faculty of Medicine, Norwegian university of Science and Technology
Consultant at Dept. of Obstetrics and Gynecology, St. Olav\s Hospital, Trondheim, Norway.
1986 MD at the University of Linköping, Sweden
1995 Specialist in gynecologi and obstetrics,
2005 PhD thesis
2014 Professor at Institute for LBK, DMF, NTNU
Diabetes in pregnancy, obesity and life style in pregnancy, ante-natal and post-natal care in general practice.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2021) No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used. PLOS ONE.
- (2021) Systemic immunological perturbations and placental pathology in preeclampsia. Placenta. vol. 112.
- (2021) Longitudinal serum cytokine profiles in gestational hypertension and preeclampsia. Pregnancy Hypertension. vol. 25.
- (2021) Higher blood pressure in normal weight women with pcos compared to controls. Endocrine Connections. vol. 10 (2).
- (2021) Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study. PLOS ONE. vol. 16 (2).
- (2020) Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus. Journal of Clinical Endocrinology and Metabolism.
- (2020) Proactive versus standard support of labour in nulliparous women; study protocol for a randomized, controlled trial. Trials.
- (2020) Cognitive function in metformin exposed children, born to mothers with PCOS – follow-up of an RCT. BMC Pediatrics. vol. 20 (60).
- (2020) Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial. BMJ Open. vol. 10:e0344733 (2).
- (2020) Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training. Frontiers in Physiology. vol. 11.
- (2020) Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis. BMJ Open.
- (2020) Claims for compensation from women with cervical cancer in Norway-A retrospective, descriptive study of a 12-year period. Acta Obstetricia et Gynecologica Scandinavica. vol. 99 (11).
- (2020) Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study. Journal of Clinical Endocrinology and Metabolism. vol. 105 (1).
- (2020) Polycystic ovary syndrome and pregnancy - From a clinical perspective. Current Opinion in Endocrine and Metabolic Research. vol. 12.
- (2019) A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome. Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG). vol. 59 (6).
- (2019) Intrauterine metformin exposure and offspring cardiometabolic risk factors (PedMet study): a 5-10 year follow-up of the PregMet randomised controlled trial. The Lancet Child and Adolescent Health. vol. 3 (3).
- (2019) Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. The Lancet Diabetes and Endocrinology. vol. 7 (4).
- (2019) Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe. PLOS ONE. vol. 14:e0226074 (12).
- (2019) Approved claims for compensation from gynecological patients in Norway?What characterizes the cases? A 14-year nationwide study. Acta Obstetricia et Gynecologica Scandinavica. vol. 98 (8).
- (2019) Serum cytokine patterns in first half of pregnancy. Cytokine. vol. 119.