Background and activities
Head of the research group “Women’s health and PCOS” at the Institute for Laboratory Medicine, Children’s and Women’s health, and at the Dept. of Obstetrics and Gynecology, St. Olav`s Hospital Trondheim, Norway
Principal investigator of the «Metformin treatment of pregnant PCOS women and prevention of preterm birth» (The PregMet2) study, a Nordic RCT, funded by the Norwegian Research Council.
Principal investigator of the “Intrauterine metformin exposure and long-term health of the children” (The PedMet1 study) a multicenter RCT, funded by the Norwegian Research Council, Novo Nordisk and The Joint Research Council at St.Olavs Hospital and The Faculty of Medicine, NTNU.
Principal investigator of the “Intrauterine metformin exposure and cognitive development in children born to PCOS mothers and control mothers” (The CogMet study) funded by Novo Nordisk and The Joint Research Council at St.Olavs Hospital and The Faculty of Medicine, NTNU.
We investigate polycystic ovary syndrome (PCOS) in both pregnant and non-pregnant women. Main focus is randomized clinical trials where the effect of metformin is explored. We follow up women before, during and after pregnancy and their children with somatic and cognitive examinations. Our aim is to survey long-term health of mothers with PCOS and their children. We explore possible consequences of PCOS and possible effects of metformin on hemodynamics, pharmacokinetics, weight development, body composition, hormones, metabolism and lung function.
Other area of interests is breastfeeding related to maternal and offspring long-term health, patient claims in gynecology, labour induction, breech deliveries and hyperemesis in pregnancy.
We have ongoing co-operation with the Dept. of Pediatrics, Dept. of Clinical Pharmacology, Inst. for Cancer Research and Molecular Biology; research group for “Inflammation and genetics in pregnancy” and research group «Excercise, cariometabolic health and reproduction».
We also have ongoing clinical and epidemiological studies and co-operation with established research groups in Bergen (Norway), Sweden, Finland, USA, Canada, and Australia where we explore different aspects of PCOS, obesity and breastfeeding.
Professor of Obstetrics and Gynecology at Institute of LBK/The Faculty of Medicine, Norwegian university of Science and Technology
Consultant at Dept. of Obstetrics and Gynecology, St. Olav\s Hospital, Trondheim, Norway.
1986 MD at the University of Linköping, Sweden
1995 Specialist in gynecologi and obstetrics,
2005 PhD thesis
2014 Professor at Institute for LBK, DMF, NTNU
Diabetes in pregnancy, obesity and life style in pregnancy, ante-natal and post-natal care in general practice.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2018) Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice. Clinical Endocrinology. vol. 88 (6).
- (2018) Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age: follow-up of two RCTs. Journal of Clinical Endocrinology and Metabolism. vol. 103 (4).
- (2018) Fetal growth and birth anthropometrics in metformin-exposed offspring born to mothers with PCOS. Journal of Clinical Endocrinology and Metabolism. vol. 103 (2).
- (2018) Polycystic ovary syndrome, body mass index and hypertensive disorders in pregnancy. Pregnancy Hypertension. vol. 11.
- (2017) Uterine artery doppler measurements during first and second trimesters of normal pregnancy. Acta Obstetricia et Gynecologica Scandinavica. vol. 96 (3).
- (2017) Racial and ethnic differences in the prevalence of metabolic syndrome and its components of metabolic syndrome in women with polycystic ovary syndrome: a regional cross-sectional study. American Journal of Obstetrics and Gynecology. vol. 217 (2).
- (2017) Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life. Fertility and Sterility. vol. 107 (3).
- (2016) Does AMH reflect follicle number similarly in women with and without PCOS?. PLoS ONE. vol. 11 (1).
- (2016) Changes in induction methods have not influenced cesarean section rates among women with induced labor. Acta Obstetricia et Gynecologica Scandinavica. vol. 95 (1).
- (2016) Obesity, polycystic ovary syndrome and breastfeeding: An observational study. Acta Obstetricia et Gynecologica Scandinavica. vol. 95 (4).
- (2016) Cervical length and androgens in pregnant women with polycystic ovary syndrome: Has metformin any effect?. Journal of Clinical Endocrinology and Metabolism. vol. 101 (6).
- (2016) Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women. Diabetology and Metabolic Syndrome. vol. 8 (43).
- (2016) Should we individualize lipid profiling in women with polycystic ovary syndrome?. Human Reproduction. vol. 31 (12).
- (2015) Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: A population-based cohort study. BJOG: an International Journal of Obstetrics and Gynaecology. vol. 122 (10).
- (2015) Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Human Reproduction. vol. 30 (3).
- (2015) HbA1c as screening for gestational diabetes mellitus in women with polycystic ovary syndrome. BMC Endocrine Disorders. vol. 15 (1).
- (2015) Androgen profile through life in women with polycystic ovary syndrome: A nordic multicenter collaboration study. Journal of Clinical Endocrinology and Metabolism. vol. 100 (9).
- (2014) The effect of exercise and metformin treatment on circulating free DNA in pregnancy. Placenta. vol. 35 (12).
- (2014) Androgens and hyperemesis gravidarum: A case-control study. European Journal of Obstetrics, Gynecology, and Reproductive Biology. vol. 175 (1).
- (2014) Maternal and fetal insulin levels at birth in women with polycystic ovary syndrome: Data from a randomized controlled study on metformin. European Journal of Endocrinology. vol. 170 (5).