Conference on Molecular Mechanisms of Inflammation

Conference on Molecular Mechanisms of Inflammation

– May 30 to June 2, 2016 in Trondheim, Norway

River Nidelva

The Centre of Molecular Inflammation Research, CEMIR was the organiser of an international conference about molecular mechanisms of inflammation, in May 2016.

The conference had a particular emphasis on the regulation of inflammation in sterile and infectious diseases. Experts from basic and clinical inflammation research were brought together to promote exchange across disciplines. The target group was scientists at the group leader, post-doc and PhD level.

Conference on Molecular Mechanisms of Inflammation 2016

The conference will focus on the molecular mechanisms of inflammation, with a particular emphasis on the regulation of inflammation in sterile and infectious diseases.

Inflammation is a host response that is triggered by noxious stimuli arising during infection and tissue injury. A controlled inflammatory response is needed to fight infections and to heal wounds, but can become detrimental if dysregulated. There is a growing understanding that some of the clinical manifestations are caused by common underlying inflammatory mechanisms instrumented by pattern recognition receptors.

Throughout the 1990s, researchers noticed that seemingly diverse diseases like atherosclerosis, type 2 diabetes, Alzheimer’s disease and some cancers, were characterized by an accumulation of immune cells at diseased sites. A prevailing hypothesis of today is that some of the clinical manifestations are caused by common underlying inflammatory mechanisms.

This conference will foster innovative research on molecular mechanisms and regulation of inflammation, and provide significant insight into common underlying processes of inflammatory disorders that can be translated to clinical settings.

Monday 30 May

16:00-18:00 Registration of participants at Kunnskapssenteret, St Olavs hospital
18:00-19:00 Symposium Opening
18:00-18:15 Opening remarks by Dean Björn Gustafsson and
CEMIR Director Professor Terje Espevik, NTNU
18:15-19:00 Keynote lecture: Harald Stenmark, University of Oslo and CEMIR, NTNU
19:30 Concert in the Nidaros Cathedral
20:00 Welcome Reception at 2 Tårn (drinks, snack food)      

» Detailed programme Monday 30 May

Tuesday 31 May

08:30-09:50  Systems Inflammation                                                                   
09:50-10:20 Coffee break
10:20-14:30 Innate Immunity of Infection (Lunch 12:00-13:30)
14:30-17:10 Trafficking and Compartmentalized Signaling
17:15-20:15 Poster Presentations /snack (warm and cold): MTFS                                  

» Detailed programme Tuesday 31 May

Wednesday 1 June

08:30-11:40    Intracellular Infections                                                                                   
11:40-13:00 Lunch
13:00-16:20 Chronic Inflammatory Diseases I
17:00 Optional activities (at own expense – need to sign up):
  • Ribtour on the Fjord
  • Canoe sightseeing
  • Fjordfishing
Adventure Trondheim tours and prices (pdf)                                                            

» Detailed programme Wednesday 1 June

Thursday 2 June

08:30-12:00 Cytosolic Signaling
12:00-13:30 Lunch
13:30-17:00 Chronic Inflammatory Diseases II
17:00-18:00 EMBO Keynote speaker: Luke O’Neill, Trinity College Dublin, Ireland    
20:00- Gala Dinner: Clarion Hotel & Congress Trondheim                                      

» Detailed programme Thursday 2 June

Detalied programme

Monday 30 May

16:00-18:00  Registration of participants at Kunnskapssenteret, St Olavs hospital

18:00-19:00  Symposium Opening

18:00-18:15  Opening remarks by Dean Björn Gustafsson and CEMIR Director Terje Espevik, NTNU

18:15-19:00  Keynote lecture: Harald Stenmark, Oslo University Hospital/ NTNU, Norway

Phosphoinositide-regulated membrane dynamics in cellular internalization and protrusion outgrowth.

Chair: Terje Espevik

19:30  Concert in Nidaros Cathedral

20:00  Welcome Reception at 2 Tårn (drinks, snack food)

Tuesday 31 May

08:30-09:50  Systems Inflammation

Chair: Trude Helen Flo

Adrem08:30-09:00  Alan Aderem, Seattle BioMed, USA

A Systems approach to dissecting Immunity

Kandasamy09:00-09:30  Richard Kumaran Kandasamy, NTNU, Norway

Global Phosphoproteomics Approaches for Studying Inflammation and Antiviral Signaling

09:30-09:50  Andrea Stutz, University of Bonn, Germany (Short presentation)

Post-translational modifications regulate the inflammasome component NLRP3

09:50-10:20  Coffee Break  

10:20-14:30  Innate Immunity of Infection

Chair: Kate Fitzgerald

10:20-10:50  David Underhill, Cedars-Sinai, USA

Innate recognition of S. aureus peptidoglycan

10:50-11:20  Lynda Stuart, Bill og Melinda Gates Foundation, USA

Self-defense: A new screening tool for identifying host resistance factors to pathogens

11:20-11:40  Jørgen Stenvik, NTNU, Norway (Short presentation)

TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFNb production via a TAK1–IKKb–IRF5 signaling pathway     

11:40-12:00  Meihong Deng, University of Pittsburgh, USA (Short presentation)

Caspase-11-mediated HMGB1 release from the liver drives immune cell pyroptosis in sepsis     

12:00-13:30  Lunch (Location: MTFS)   

13:30-14:00  Tom Eirik Mollnes, Oslo University Hospital / NTNU, Norway

Dual-blockade of complement and CD14 as a novel treatment approach for inflammation.

14:00-14:30  Egil Lien, University of Massachussets, USA/ NTNU, Norway

Bacterial activation and evasion of inflammasomes.

14:30-17:10  Trafficking and Compartmentalized Signaling

Chair: Harald Stenmark

14:30-15:00  Jonathan Kagan, Harvard Medical School, Boston, USA

Initiation and Regulation of Innate Immune Signal Transduction

15:00-15:30  Julie Blander, Mount Sinai Hospital, USA   

Detecting and Responding to Microbial Viability

15:30-16:00  Coffee Break   

16:00-16:30  Harald Husebye, NTNU, Norway

The TLR4 adaptor TRAM controls phagocytosis of Gram-negative bacteria through interaction with the Rab11-family interacting protein 2

16:30-16:50  Adriana Mantegazza, Children's Hospital of Philadelphia, USA (Short presentation)

Adaptor protein-3 (AP-3) links phagosome maturation to inflammasome activation in mouse dendritic cells

16:50-17:10  Lúcia Faccioli, Universidade de São Paulo, Brazil (Short presentation)

Scorpion venom induces lung edema and mortality by mechanism dependent on  IL-1β and eicosanoids release

17:15-20:15  Poster Presentations and snack (warm and cold)

(Location: MTFS)

Wednesday 1 June

08:30-11.40  Intracellular Infections

Chair: David Underhill

08:30-09:00  Stephanie Vogel, University of Maryland, USA

Targeting Innate Immune Responses to Influenza

09:00-09:30  Trude Flo, NTNU, Norway

The inner life of a mycobacterium-infected macrophage

09:30-09:50  Sylwia Tyrkalska, University of Murcia, IMIB-Arrixaca, Spain (Short presentation) 

Identification and functional characterization of an evolutionary conserved Ankyrin domain-containing protein which regulates inflammasome activation

09:50-10:20  Coffee Break   

10:20-10:50  Felix Randow, Cambridge Biomedical, UK

How cells defend their cytosol against bacterial invasion

10:50-11:20  EMBO Young Investigator Lecture: Petr Broz, University of Basel, Switzerland

ASC filament formation serves as a signal amplification mechanism for inflammasomes

11:20-11:40  Ashley Mansell, Hudson Institute of Medical Research, Australia (Short presentation)

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection: Good Cop, Bad Cop

11:40-13:00  Lunch (Location: MTFS)

13:00-16:20  Chronic Inflammatory Diseases I

Chair: Arne Sandvik

13:00-13:30  Paul Hertzog, University of Monash, Australia

Mechanisms to modulate a cell's response to type I interferons

Richard Flavell13:30-14:00  Richard Flavell, Yale School of Medicine, USA

Long non-coding RNAs in the regulation of inflammation

14:00-14:20  Lars Vereecke, Gent University, Belgium (Short presentation)

A20/TNFAIP3: Master regulator of intestinal immune homeostasis

14:20-14:50  Coffee Break    

14:50-15:20  Claudia Kemper, King's College London, UK

The force from within: Unexpected roles for intracellular complement in Th1 regulation

15:20-15:40  Jonathan Schmid-Burgk, University of Bonn, Germany (Short presentation)

A forward genetic CRISPR screen identifies NEK7 as a novel component of NLRP3 inflammasome activation

15:40-16:00  Marlene Balbach, University of Tuebingen, Germany (Short presentation)

Induction of myeloid-derived suppressor cells in cryopyrin-associated periodic syndromes

16:00-16:20  Menno Oudhoff, NTNU, Norway (Short presentation)

Intestinal Epithelial Cell-Intrinsic Delition of Setd7 Identifies Crucial Roles for Development Pathways in Immunity against Parasitic Infections

17:00 Optional activities (own expense – need to sign up):

  • Ribtour on the Fjord
  • Canoe sightseeing
  • Fjordfishing

Adventure Trondheim tours and prices (pdf)

Thursday 2 June

08:30-12:00  Cytosolic Signaling

Chair: Egil Lien

08:30-09:00  Kate Fitzgerald, University of Massachussets, USA / NTNU, Norway

Negative regulation on Immune Gene expression by long non-coding RNAs

09:00-09:30  Kim Newton, Genentech, USA

RIPK1 and RIPK3: regulators of cell death and inflammation

09:30-09:50  Moritz Gaidt, Ludwig-Maximilians-University Munich, Germany (Short presentation)

Human monocytes engage an alternative inflammasome pathway

09:50-10:20  Coffee Break

10:20-10:50  Alan Sher, National Institute of Allergy and Infectious Diseases, Maryland, USA

Role of NOD signaling in steady-state hematopoiesis

10:50-11:20  Alexander Poltorak, Tufts University, USA

Evolutionary balance between response to infection and the risk of inflammatory disease

11:20-11:40  Pedro Saavedra, Zwijnaarde, Belgium (Short presentation)

Microtubule dynamics are critical for Clostridium difficile-induced Pyrin inflammasome activation

11:40-12:00  Ingvild Bjellmo Johnsen, NTNU, Norway (Short presentation)

The innate immune kinase TBK1 controls ULK1 and autophagy induction in response to paramyxovirus infection

12:00-13:30  Lunch (Location: MTFS)

13:30-17:00  Chronic Inflammatory Diseases II

Chair: Therese Standal

13:30-14:00  Göran Hansson, Karolinska Institutet, Sweden

Immunometabolic interactions – role in lipoprotein metabolism and atherosclerosis

14:00-14:30  Terje Espevik, NTNU, Norway

Cholesterol crystal-induced inflammation in atherogenesis

14:30-14:50  Mieke Louwe, Oslo University Hospital, Norway (Short presentation)

NLRP3 aggravates survival but not cardiac remodeling after myocardial infarction in mice

14:50-15:20  Coffee Break

15:20-15:50  Douglas Golenbock, University of Massachussets, USA

Alzheimer's Disease and IL-18

15:50-16:20  Ann-Charlotte Iversen, NTNU, Norway

Danger response by fetal trophoblasts in the inflammatory pregnancy disorder preeclampsia

16:20-16:40  Thomas Zillinger, University of Bonn, Germany (Short presentation)

A minimal RNA secondary structure motif mediates potent and selective activation of TLR7

16:40-17:00  Coffee Break

17:00-18:00  The EMBO Keynote Lecture: Luke O’Neill, Trinity College Dublin, Ireland

Metabolic reprogramming in innate immunity and inflammation

Chair: Douglas Golenbock

20:00 Gala Dinner: Clarion Hotel & Congress Trondheim

  1. Alan Aderem 
  2. Julie Blander
  3. Petr Broz
  4. Terje Espevik
  5. Kate Fitzgerald    
  6. Richard Flavell    
  7. Trude Helen Flo
  8. Douglas Golenbock    
  9. Göran Hansson  
  10. Paul Hertzog
  11. Harald Husebye
  12. Jonathan Kagan    
  13. Richard Kandasamy
  14. Claudia Kemper
  15. Egil Lien
  16. Tom Eirik Mollnes
  17. Kim Newton
  18. Luke O’Neill
  19. Alexander Poltorak
  20. Felix Randow
  21. Alan Sher
  22. Harald Stenmark
  23. Lynda Stuart
  24. David Underhill
  25. Stephanie Vogel

Conference venue

The conference will be held in the Kunnskapssenteret at the Norwegian University of Science and Technology (NTNU) / St.Olavs Hospital - Trondheim Universtity Hospital. Kunnskapssenteret is part of the new hospital area in Trondheim, chosen as the winner of the “Attractive City” award in 2015. More about Trondheim

Knowledge Centre


Conference secretariat

The secretariat will be open for registration and questions (Kunnskapssenteret, 1st floor):

  • Monday May 30th, 16:00-18:00
  • Tuesday May 31st , 08:00-10:30
  • Wednesday June 1st, 11:30-13:00

Optional social activites

In the evening 1 June you can choose between activities arranged by Trondheim Adventure. Read more about the options: Adventure Trondheim tours and prices (pdf)

Please, sign up for social activities when registering for the conference.


The conference participants will be staying at the Comfort Hotel Park, which is located in the city centre and in walking distance to the conference venue. There is free WiFi and parking at the hotel. Guests may also enjoy the relaxation area with sauna, gym and view over the rooftops of Trondheim.

Please note: Hotel reservations are made via the conference registration form only


Registration fee for regular delegates

  • Early fee (before 1 March 2016): NOK 5500
  • Regular fee: NOK 6500

Registration fee for PhD students

  • Early fee (before 1 March 2016): NOK 4000
  • Regular fee: NOK 4500

Registration closes on 13 May 2016

Registration fee includes

  • Access to all scientific lectures and poster session
  • Access to Opening session including reception and concert in Nidarosdomen
  • Lunches and coffee/tea during breaks
  • Galla dinner 2 June at Clarion Hotel Trondheim

Maximum number of conference praticipants: 25


Abstracts will be presented as posters or orals presentations, forming part of the official congress scientific programme. A committee will review all abstracts and decide who will be invited to give an oral presentation, and who will be invited to give a poster presentation. Authors will be notified (via email) about the Scientific Committee decision in due time.

Abstracts will not be edited in any way after submission. Deadline for submission was: 15 April 2016.


The poster size should be vertical and no larger than A0 (841 x 1189 mm).

During the conference there will be two possibilities to place your posters on boards:

  • Monday, May 30th 16:00-18:00
  • Tuesday, may 31st 12:00-13:30

The conference secretariat (Kunnskapssenteret 1st floor) will guide you to the right location.

For questions regarding the posters and the poster session, please contact Trine Strand,

Those who are selected for short talk has been notified.

Award for best poster and oral presentation

As a way to encourage scientist to publicly present their novel findings, the best poster presentation and oral presentation will be awarded

The conference is sponsored by:



Logo GenentechGenentech


Ortomedic logoOrtomedic

Leica logoLeica



Zeiss logoZeiss





Nature Revews Immunology


The BIOTEK2021 programme – The Research Council of Norway’s research initiative in the field of biotechnology.

NBS logo
Norsk Biokjemisk Selskap (NBS)

Embo logoEmbo
Young Investigator Lecture Grant
Embo Key Lecture

Sponsorship CEMIR conference 2016

This conference is an excellent opportunity for companies to promote themselves to scientists from basic and clinical inflammation research. The conference will focus on the molecular mechanisms of inflammation, with a particular emphasis on the regulation of inflammation in sterile and infectious diseases. World leading experts in the field will present cutting-edge research.

We expect up to 250 participants from many different countries and fields of research. Several possibilities exist for presentation of your products and services:

General sponsorship

General sponsorship includes:

  • Company logo with link on meeting web site
  • Advert in conference programme
  • Inserts/material in lecture hall
  • Company name and logo in abstract book/programme
  • Company logo on conference bag
  • Company logo on screen between lectures
  • Possibility to provide the participants’ Congress bags, including a company promotion material.
    (Please note that the material should be approved by the Organizing Committee)
  • One free participation at the conference

Price: 3500 Euro

Company promotion material/brochure in congress bag

  • Company logo with link on meeting web site
  • Company name and logo in abstract book/program

Price: 700 Euro


Space for exhibitors will be allocated in the area outside the conference hall, in the lunch area and at the poster session. Please contact Kjartan Egeberg, email:, to discuss possibilities for exhibition.

We will do our best to maximize exhibitors’ exposure to the conference delegates.

Additional benefits for exhibitors:

  • Exhibitors logo with hyperlink on Congress website
  • Company name and logo in abstract book/programme
  • One free participation at the conference.

Price: 2000 Euro

Sponsor of award for best abstract and oral presentation

Would you like to sponsor the conference awards? The best poster presentation and oral presentation will be awarded, and this is a good opportunity for sponsors to be exposed. The winners will be announced at the gala dinner June 2nd and the sponsors will be acknowledged.

Speaker’s sponsorship

This sponsorship covers travel, registration and accommodation of one or more speakers. The speakers will be informed about the sponsorship. Sponsorship includes acknowledgement in the program, at the sessions, and logo/link at the conference website.

Price: 2000 Euro

Discuss options with us

Please contact Centre of Molecular Inflammation Research, CEMIR by email if your company would like to discuss these or other sponsorship possibilities.

The conference is hosted by Centre of Molecular Inflammation Research, CEMIR. CEMIR is a Centre of Excellence funded by the Research Council of Norway.


Phone: +47 7282 5337

If you have questions regarding registration, accomodation or other practical information, please contact NTNU VIDERE:

Organising Committee

Trude Helen Flo

Trude Helen Flo,
Norwegian University of Science and Technology, NTNU



Terje Espevik

Terje Espevik
Norwegian University of Science and Technology, NTNU



Egil Lien

Egil Lien,
University of Massachusetts



Kate Fitzgerald

Katherine Fitzgerald,
University of Massachusetts



Harald Stenmark

Harald Stenmark,
University of Oslo



Conference host

Conference host

Centre of Molecular Inflammation Research (CEMIR). CEMIR is a Centre of Excellence funded by the Research Council of Norway.

Report from the Conference