Trude Helen Flo
+4773598498
+4791897796
Kunnskapssenteret, 424.04.035, Øya
About
Co-Director Centre of Molecular Inflammation Research and Professor in Cell Biology at Dept. of Clinical and Molecular Medicine. Head of research group on Mycobacteria and HIV. Teaching immunology and cell biology. Researcher unique identifier(s): E-1311-2013
Curriculum
- Professor in Cell Biology at Dept. of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU,
- Co-director of CEMIR : Centre of Molecular Inflammation Research, a center of excellence at the Faculty of Medicine, NTNU
- Researcher at Dept. of Cancer Research and Molecular Medicine, NTNU, 2004 - 2014
- Associate Professor II in Immunology at Dept. of Laboratory Medicine, NTNU, 2011 - 2013
- Visiting post doc in Alan Aderems lab, Institute for Systems Biology, Seattle, USA, 2002-2003
- PhD (Dr.Philos) in Immunology/Cell Biology at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001
- MSc (sivilingeniør) in Biotechnology at The Norwegian Institute of Technology (NTH, later NTNU), 1995
Research activities and interests
My research is focused on host-pathogen interactions between innate immune cells and pathogens, e.g. mycobacteria, HIV and lately also SARS-CoV2. Infectious diseases still represents a threath to global health and the world is in great need for new medications and vaccines. Our basic research may contribute in revealing new therapeutic or vaccine targets. We have a BSL3 lab with a Leica SP8 confocal microscope where we investigate host-pathogen relations in M. tuberculosis infected macrophages, HIV and SARS-CoV2 infection and we have established methods for correlative imaging at an ultra-high resolution and in 3D using FIB-SEM together with fluorescence microscopy. Intracellular trafficking, compartmentalized receptor signaling and pathogen-induced host-cell death are investigated in our lab. We are currently establishing multicellular ex vivo infection models to study how cellular cross-talk shapes the resulting immune response. Since the discovery of the anti-bacterial functions of lipocalin 2, I have also initiated and contributed in projects exploring the role of lipocalin 2 in infectious diseases or use as a biomarker in diverse conditions.
My research group is part of a larger intitiative on molecular mechanisms of inflammation research, CEMIR.
Publications
Competencies
Publications
2022
- Røst, Lisa M.; Louet, Claire; Bruheim, Per; Flo, Trude Helen; Gidon, Alexandre. (2022) Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages. Frontiers in Immunology. volum 13.
2021
- Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna. (2021) In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology. Journal of Alzheimer's Disease. volum 84 (4).
- Gidon, Alexandre; Louet, Claire; Røst, Lisa M.; Bruheim, Per; Flo, Trude Helen. (2021) The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages. mBio. volum 12 (5).
- Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud Khaled; Abdoli, Asghar; Abudu, Yakubu Princely; Birgisdottir, Åsa Birna; Bjørkøy, Geir; Calbet, Jose Antonio Lopez; Chica-Balaguera, Nathalia; Engedal, Nikolai; Engelsen, Agnete; Enserink, Jorrit M.; Fang, Evandro Fei; Flo, Trude Helen; Gupta, Swapnil; Johansen, Terje; Knævelsrud, Helene; Korsnes, Monica Suarez; Lamark, Trond; Lindner, Paula Maria; Llorente, Alicia; Luhr, Morten; Mejlvang, Jakob; Lystad, Alf Håkon Lohsen; Morales-Alamo, David; Orellana Munoz, Sara; Petrovski, Goran; Seglen, Per O.; Stefan, Katja; Stefan, Sven Marcel; Stenmark, Harald; Takats, Szabolcs; Torgersen, Maria Lyngaas; Øynebråten, Inger; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H.; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E.; Adeli, Khosrow; Adolph, Timon E.; Adornetto, Annagrazia; Aflaki, Elma; Agarwal, Anupam; Agam, Galila; Aggarwal, Bharat B.; Agnello, Maria; Agostinis, Patrizia; Agrewala, Javed N.. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. volum 17 (1).
- Rex, D.A.B.; Deepak, K.; Vaid, Neelanchal; Dagamajalu, Shobha; Kandasamy, Richard Kumaran; Flo, Trude Helen; Keshava Prasad, Prasad. (2021) A modular map of Bradykinin-mediated inflammatory signaling network. Journal of cell communication and signaling.
2020
- Bazilchuk, Nancy Reney; Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) New mechanism allows the immune system to detect and respond to HIV. Norwegian SciTech News.
- Bazilchuk, Nancy Reney; Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) Vil lure HIV-virus ut av gjemmestedene. Gemini.no.
- Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Kim, Hae Lin; Marstad, Anne; Åsberg, Signe Elisabeth; Strand, Trine Aakvik; Haug, Markus; Niederweis, Michael; Stenmark, Harald Alfred; Flo, Trude Helen. (2020) Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection. Nature Communications. volum 11:2270.
- Flo, Trude Helen; Meås, Hany Zakaria; Damås, Jan Kristian; Haug, Markus. (2020) Forskere: Slik kan vi lure hivviruset til å avsløre seg selv. Aftenposten Viten.
- Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) Hvordan vi oppdaget en ny mekanisme i immunceller for å vekke HIV virus som ligger i dvale.
- Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) Smoking HIV out of dormancy. EurekAlert!.
- Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) Wie man das HI-Virus aufscheucht. Wissenschaft.de.
- Kannan, Nisha; Haug, Markus; Steigedal, Magnus; Flo, Trude Helen. (2020) Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium. Frontiers in Immunology. volum 11.
- Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Zhenyi; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, Hang; Damås, Jan Kristian; Flo, Trude Helen. (2020) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency. Nature Communications. volum 11:147.
- Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) A newly discovered mechanism allows the immune system to detect and respond to HIV. Medical Xpress.
- Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) HIV entry into the wrong T cell: not a “dead-end” but a “highway” for viral spread.
- Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) Smoking dormant HIV virus out into the open to develop a cure. News Medical Life Sciences.
- Midling, Anne Sliper; Flo, Trude Helen. (2020) Verdenspremiere på døden i en celle med tuberkulose World film premiere: watch cell infected with tuberculosis die. Gemini.
- Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran. (2020) The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function. International Journal of Molecular Sciences. volum 22 (1).
- Åsberg, Signe Elisabeth; Mediaas, Sindre Dahl; Marstad, Anne; Ryan, Liv; Louet, Claire; Sporsheim, Bjørnar; Beckwith, Kai Sandvold; Underhill, David; Gidon, Alexandre; Flo, Trude Helen. (2020) Antibiotic treatment routes Mycobacterium avium to phagolysosomes without triggering proinflammatory cytokine production in human Mϕs. Journal of Leukocyte Biology.
2019
- Dragset, Marte Singsås; Ioerger, Thomas R.; Loevenich, Maja; Haug, Markus; Sivakumar, Niruja; Marstad, Anne; Cardona, Pere-Joan; Klinkenberg, Geir; Rubin, Eric J.; Steigedal, Magnus; Flo, Trude Helen. (2019) Global assessment of Mycobacterium avium subsp. hominissuis genetic requirement for growth and virulence. mSystems. volum 4 (6).
- Dragset, Marte Singsås; Ioerger, Thomas R.; Zhang, Yanjia; Mærk, Mali; Ginbot, Zekarias; Sacchettini, James C.; Flo, Trude Helen; Rubin, Eric J; Steigedal, Magnus. (2019) Genome-wide phenotypic profiling identifies and categorizes genes required for mycobacterial low iron fitness. Scientific Reports. volum 9:11394.
- Flo, Trude Helen; Moen, Vegard; Aksnes, Beret. (2019) Antibiotikaresistens, foredrag som supplement til utstillingen av Aksnes og Moen om samme tema. NTNU Big Challenge Vitenfestival - The Micro Challenge [Kunstnerisk og museal presentasjon] . NTNU; Trondheim. 2019-06-17 - 2019-06-17.
- Haug, Markus; Meås, Hany Zakaria; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Z.; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, H. H.; Damås, Jan Kristian; Flo, Trude Helen. (2019) P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells. European Journal of Immunology. volum 43.
- Kannan, Nisha; Lai, Yi-Pin; Haug, Markus; Lilleness, Mary Kathleen; Bakke, Siril Skaret; Marstad, Anne; Hov, Håkon; Naustdal, Thor; Afset, Jan Egil; Ioerger, Thomas R.; Flo, Trude Helen; Steigedal, Magnus. (2019) Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium. Infection and Immunity. volum 87 (4).
- Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian. (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology. volum 248.
2018
- Awuh, Jane Atesoh; Flo, Trude Helen. (2018) Erratum to: Molecular basis of mycobacterial survival in macrophages (Cellular and Molecular Life Sciences, (2017), 74, 9, (1625-1648), 10.1007/s00018-016-2422-8). Cellular and Molecular Life Sciences (CMLS). volum 75 (1).
- Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete Gargul; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind. (2018) Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination. Frontiers in Immunology. volum 9:650.
- Pedersen, Tina Therese; Fenstad, Mona H.; Jakobsen, Bente; Koksvik, Hege; Moksnes, Tone; Wallenius, Marianne; Flo, Trude Helen; Haug, Markus. (2018) Low lipocalin-2 in systemic lupus erythematosus pregnancies- a possible mechanism for loss of tolerance. Annals of the Rheumatic Diseases. volum 77.
- Ørning, Mathias Pontus Andreas; Flo, Trude Helen; Lien, Egil. (2018) A Sugar Rush for Innate Immunity. Cell Host and Microbe. volum 24 (4).
2017
- Awuh, Jane Atesoh; Flo, Trude Helen. (2017) Molecular basis of mycobacterial survival in macrophages. Cellular and Molecular Life Sciences (CMLS).
- Gidon, Alexandre; Åsberg, Signe; Louet, Claire; Ryan, Liv; Haug, Markus; Flo, Trude Helen. (2017) Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages. PLoS Pathogens. volum 13 (8).
- Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir. (2017) N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy. volum 13 (10).
- Pedersen, Tina Therese; Fenstad, Mona H.; Moksnes, Tone; Wallenius, Marianne; Flo, Trude Helen; Haug, Markus. (2017) Cytokines and lipocalin-2 in pregnant women with rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases. volum 76.
- Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian. (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology. volum 32 (1).
2016
- Waagsbø, Bjørn; Svardal, Asbjørn M.; Ueland, Thor; Landrø, Linn Aina Ysland; Øktedalen, Olav; Berge, Rolf Kristian; Flo, Trude Helen; Aukrust, Pål; Damås, Jan Kristian. (2016) Low levels of short- and medium-chain acylcarnitines in HIV-infected patients. European Journal of Clinical Investigation. volum 46 (5).
2015
- Awuh, Jane Atesoh; Haug, Markus; Mildenberger, Jennifer; Marstad, Anne; Chau, Do Ngoc Phuc; Louet, Claire; Stenvik, Jørgen; Steigedal, Magnus; Damås, Jan Kristian; Halaas, Øyvind; Flo, Trude Helen. (2015) Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proceedings of the National Academy of Sciences of the United States of America. volum 112 (31).
- Bazilchuk, Nancy Reney; Flo, Trude Helen. (2015) Uncovering the secrets of immune system invaders. Gemini (English edition).
- Beckwith, Marianne; Beckwith, Kai Sandvold; Sikorski, Pawel; Skogaker, Nan Elisabeth Tostrup; Flo, Trude Helen; Halaas, Øyvind. (2015) Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography. PLOS ONE. volum 10:e0134644 (9).
- Bergstrøm, Bjarte; Aune, Marie Hjelmseth; Awuh, Jane Atesoh; Kojen, June Frengen; Blix, Kjetil Jordahl; Ryan, Liv; Flo, Trude Helen; Mollnes, Tom Eirik; Espevik, Terje; Stenvik, Jørgen. (2015) TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway. Journal of Immunology. volum 195 (3).
- Buset, Karen Johanne; Kvam, Anne Mari Selven; Nordrum, Ivar Skjåk; Strypet, Hanne; Sylvester, Morten; Ødegården, Mona; Aadahl, Petter; Selvaag, Elisabeth; Flo, Trude Helen. (2015) UNG HELSE. UNG HELSE [Kunstnerisk og museal presentasjon] . Medisinsk Museumsutvalg StOH og DMF-NTNU; Kunnskapssenteret. 2015-12-01.
- Dragset, Marte Singsås; Barczak, Amy K.; Kannan, Nisha; Mærk, Mali; Flo, Trude Helen; Valla, Svein; Rubin, Eric J.; Steigedal, Magnus. (2015) Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLOS ONE. volum 10 (9).
2014
- Flo, Trude Helen. (2014) 24. mars er Verdens tuberkulosedag.
- Steigedal, Magnus; Marstad, Anne; Haug, Markus; Damås, Jan Kristian; Strong, Roland K.; Roberts, Pacita L.; Himpsl, Stephanie D.; Stapleton, Ann; Hooton, Thomas M.; Mobley, Harry L.T.; Hawn, Thomas R.; Flo, Trude Helen. (2014) Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Journal of Immunology. volum 193 (12).
2013
- Flo, Trude Helen. (2013) Hva har betennelse med global helse å gjøre?.
- Flo, Trude Helen. (2013) What does inflammation have to do with global health?.
- Haug, Markus; Awuh, Jane Atesoh; Steigedal, Magnus; Kojen, June Frengen; Marstad, Anne; Nordrum, Ivar Skjåk; Halaas, Øyvind; Flo, Trude Helen. (2013) Dynamics of immune effector mechanisms during infection with Mycobacterium aviumin C57BL/6 mice. Immunology. volum 140 (2).
- Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology. volum 173 (3).
2012
- Damås, Jan Kristian; Bækken, Morten; Ueland, Thor; MANNER, INGJERD W; Os, Ingrid; Yndestad, Arne; Flo, Trude Helen; Øktedalen, Olav; Aukrust, Pål. (2012) Serum Levels of Neutrophil Gelatinase-Associated Lipocalin Are Associated With Microalbuminuria in HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes. volum 59 (2).
- Damås, Jan Kristian; Øktedalen, Olav; Ueland, Thor; Landrø, Linn Aina Ysland; Barstad, Johannes; Müller, Fredrik; Frøland, Stig Sophus; Flo, Trude Helen; Aukrust, Pål. (2012) Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS). Clinical and Experimental Immunology. volum 167 (3).
- Nymo, Ståle Haugset; Ueland, Thor; Askevold, Erik Tandberg; Flo, Trude Helen; Kjekshus, John; Hulthe, Johannes; Wikstrand, John; McMurray, J; Van Veldhuisen, D J; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne. (2012) The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA. Journal of Internal Medicine. volum 271 (5).
- Pathak, Sharad; Awuh, Jane Atesoh; Leversen, Nils Anders; Flo, Trude Helen; Åsjø, Birgitta. (2012) Counting mycobacteria in infected human cells and mouse tissue: a comparison between qPCR and CFU. PLOS ONE. volum 7 (4).
2010
- Halaas, Øyvind; Steigedal, Magnus; Haug, Markus; Awuh, Jane Atesoh; Ryan, Liv; Brech, Andreas; Sato, S; Husebye, Harald; Cangelosi, Gerard; Akira, Shizuo; Strong, Roland; Espevik, Terje; Flo, Trude Helen. (2010) Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway. Journal of Infectious Diseases. volum 201 (5).
- Pukstad, Brita; Ryan, Liv; Flo, Trude Helen; Stenvik, Jørgen; Moseley, Ryan; Harding, Keith; Thomas, David W.; Espevik, Terje. (2010) Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of dermatological science (Amsterdam). volum 59 (2).
2009
- Damås, Jan Kristian; Davi, Giovanni; Jensenius, M; Santilli, F; Otterdal, K; Ueland, T; Flo, Trude Helen; Lien, E; Espevik, Terje; Frøland, Stig S; Vitale, G; Raoult, D; Aukrust, P. (2009) Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. Journal of Infection. volum 58 (1).
- Yndestad, A; Landrø, Linn; Ueland, Thor; Dahl, CP; Flo, Trude Helen; Vinge, Leif Erik; Espevik, Terje; Frøland, Stig S; Husberg, Cathrine; Christensen, Geir; Dickstein, K; Kjekshus, John; Øie, Erik; Gullestad, Lars; Aukrust, Pål. (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. European Heart Journal. volum 30 (10).
2008
- Landrø, Linn Aina Ysland; Landro, L; Damås, Jan Kristian; Damas, JK; Flo, Trude Helen; Heggelund, L; Ueland, T; Tjonnfjord, GE; Tjønnfjord, Geir Erland; Espevik, Terje; Aukrust, P; Frøland, Stig Sophus; Froland, SS. (2008) Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy. Clinical and Experimental Immunology. volum 152 (1).
2004
- Heggelund, L; Flo, Trude Helen; Berg, K.; Lien, E; Espevik, Terje. (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 3 (18).
- Heggelund, Lars; Flo, T; Berg, K; Lien, T; Mollnes, TE; Ueland, Thor; Aukrust, Pål; Espevik, T; Frøland, Stig Sophus. (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 18.
- Flo, Trude Helen; Smith, KD; Sato, S; Rodriguez, DJ; Holmes, MA; Strong, RK; Akira, S; Aderem, A. (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. volum 432.
2003
- Schjetne, KW; Thompson, Keith; Fleckenstein, Burkhard; Aarvak, Tanja; Flo, T. H.; Iversen, Jens Gustav; Espevik, T; Bogen, Bjarne. (2003) Cutting edge: Link between innate and adaptive immunity: toll like receptor 2 (TLR 2) captures antigen for MHC class II presentation to CD4+ T cell responses. Journal of Immunology. volum 171.
- Schjetne, KW; Thompson, KM; Nilsen, Nadra; Flo, Trude Helen; Fleckenstein, B; Iversen, JG; Espevik, Terje; Bogen, B. (2003) Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. Journal of Immunology. volum 171 (1).
2002
- Dybdahl, Brit; Lien, Egil; Flo, Trude Helen; Espevik, Terje; Sundan, Anders; Wahba, Alexander; Sellevold, Olav F Münter. (2002) Heat Shock Proteins and Endotoxin Combined as a Trigger for Inflammatory Cytokine Release During Cardiopulmonary Bypass: A Possible Third Way? Letter til artikkel. Circulation. volum 106.
- Dybdahl, Brit; Wahba, Alexander; Lien, Egil; Flo, Trude Helen; Waage, Anders; Sellevold, Olav F Münter; Espevik, Terje; Sundan, Anders; Qureshi, Nilofer. (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation. volum 105 (6).
- Ellingsen, E.A.; Morath, S; Flo, Trude Helen; Schromm, Andra; Hartung, T; Thiemermann, C; Espevik, Terje; Golenbock, Douglas T.; Foster, D; Solberg, R.; Aasen, A; Wang, J. (2002) Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. Medical Science Monitor. volum 8 (5).
- Flo, Trude Helen; Ryan, Liv; Latz, Eicke; Takeuchi, Osamu; Monks, Brian G.; Lien, Egil; Halaas, Øyvind; Akira, Shizuo; Skjåk-Bræk, Gudmund; Golenbock, Douglas T.; Espevik, Terje. (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. Journal of Biological Chemistry. volum 277 (38).
2001
- Flo, Trude Helen. (2001) Receptors involved in cell activation by defined uronic acid polymers and bacterial components. 2001. ISBN 82-471-5053-0.
- Flo, Trude Helen; Halaas, Øyvind; Torp, Sverre Helge; Ryan, Liv; Lien, Egil; Dybdahl, Brit; Sundan, Anders; Espevik, Terje. (2001) Differential expression of Toll-like receptor 2 in human cells. Journal of Leukocyte Biology. volum 69.
- Flo, Trude Helen; Ryan, Liv; Kilaas, L; Skjåk-Bræk, Gudmund; Ingalls, Robin; Sundan, Anders; Golenbock, D; Espevik, Terje. (2001) The involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infection and Immunity. volum 68.
- Wang, J; Warris, A; Ellingsen, E.A.; Jorgensen, P.F.; Flo, Trude Helen; Espevik, Terje; Solberg, R.; Verweij, P.E.; Aasen, A. O.. (2001) Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infection and Immunity. volum 69 (4).
2000
- Cuzzola, M.; Mancuso, G.; Beninati, C.; Biondo, C.; Genovese, F.; Tomasello, F.; Flo, Trude Helen; Espevik, Terje; Teti, G.. (2000) _B2 integrins are involved in cytokine responses to whole gram-positive bacteria. Journal of Immunology. volum 164.
- Cuzzola, Maria; Mancuso, Guiseppe; Beninati, Concetta; Biondo, Carmelo; von Hunolstein, Christina; Orefici, Graziella; Espevik, Terje; Flo, Trude Helen; Teti, Guisseppe. (2000) Human monocyte receptors involved in tumor necrosis factor responses to group B streptococcal products. Infection and Immunity. volum 68.
- Flo, T.H.; Ryan, L.; Kilaas, L.; Skjåk-Bræk, Gudmund; Ingalls, R.R.; Sundan, A.; Golenbock, D.T.; Espevik, Terje. (2000) Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infection and Immunity. volum 68 (12).
- Flo, Trude Helen; Halaas, Øyvind; Lien, Egil; Ryan, Liv; Teti, Guiseppe; Golenbock, Douglas T.; Sundan, Anders; Espevik, Terje. (2000) Human Toll-like Receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. Journal of Immunology. volum 164.
- Flo, Trude Helen; Ryan, Liv; Kilaas, Lars; Skjåk-Bræk, Gudmund; Ingalls, Robin R.A; Sundan, Anders; Golenbock, Douglas T.; Espevik, Terje. (2000) Involvement of CD14 and _B2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infection and Immunity. volum 68 (12).
- Skjåk-Bræk, Gudmund; Flo, Trude Helen; Halaas, Øyvind; Espevik, Terje. (2000) Immune stimulating properties of di-equatorially beta(1->4) linked poly-uronides. Proceedings of the Phytochemical Society of Europe. volum 44.
1999
- Lien, Egil; Sellati, Timothy J.; Yoshimura, Atsutosi; Flo, Trude Helen; Rawadi, Georges; Finberg, Robert W.; Caroll, J.David; Espevik, Terje; Ingalls, Robin R; Radolf, Justin D.; Golenbock, Douglas T.. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. Journal of Biological Chemistry. volum 274 (47).
1998
- Berntzen, G.; Flo, T; Medvedev, A; Kilaas, L; Skjåk-Bræk, Gudmund; Sundan, A; Espevik, Terje. (1998) The tumor necrosis factor-inducing potency of lipopolysaccharide and uronic acid polymers is increased when they are covalently linked to particles. Clinical and Vaccine Immunology.
- Berntzen, Gøril; Flo, Trude Helen; Medvedev, Andrei E.; Skjåk-Bræk, Gudmund. (1998) The tumor necrosis factor-inducing potency of lipopolysacharide and uronic acid polymers is increased when they are covalently linked to particles. Clinical and Laboratory Immunology. volum 5/1998 (3).
- Medvedev, AE; Flo, T; Vogel, SN; Robin, R; Golenbock, DT; Teti, G; Espevik, Terje. (1998) Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. Journal of Immunology.
UTSTILLING
- Flo, Trude Helen; Moen, Vegard; Aksnes, Beret. (2019) Antibiotikaresistens, foredrag som supplement til utstillingen av Aksnes og Moen om samme tema. NTNU Big Challenge Vitenfestival - The Micro Challenge [Kunstnerisk og museal presentasjon] . NTNU; Trondheim. 2019-06-17 - 2019-06-17.
- Buset, Karen Johanne; Kvam, Anne Mari Selven; Nordrum, Ivar Skjåk; Strypet, Hanne; Sylvester, Morten; Ødegården, Mona; Aadahl, Petter; Selvaag, Elisabeth; Flo, Trude Helen. (2015) UNG HELSE. UNG HELSE [Kunstnerisk og museal presentasjon] . Medisinsk Museumsutvalg StOH og DMF-NTNU; Kunnskapssenteret. 2015-12-01.
Journal publications
- Røst, Lisa M.; Louet, Claire; Bruheim, Per; Flo, Trude Helen; Gidon, Alexandre. (2022) Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages. Frontiers in Immunology. volum 13.
- Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna. (2021) In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology. Journal of Alzheimer's Disease. volum 84 (4).
- Gidon, Alexandre; Louet, Claire; Røst, Lisa M.; Bruheim, Per; Flo, Trude Helen. (2021) The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages. mBio. volum 12 (5).
- Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud Khaled; Abdoli, Asghar; Abudu, Yakubu Princely; Birgisdottir, Åsa Birna; Bjørkøy, Geir; Calbet, Jose Antonio Lopez; Chica-Balaguera, Nathalia; Engedal, Nikolai; Engelsen, Agnete; Enserink, Jorrit M.; Fang, Evandro Fei; Flo, Trude Helen; Gupta, Swapnil; Johansen, Terje; Knævelsrud, Helene; Korsnes, Monica Suarez; Lamark, Trond; Lindner, Paula Maria; Llorente, Alicia; Luhr, Morten; Mejlvang, Jakob; Lystad, Alf Håkon Lohsen; Morales-Alamo, David; Orellana Munoz, Sara; Petrovski, Goran; Seglen, Per O.; Stefan, Katja; Stefan, Sven Marcel; Stenmark, Harald; Takats, Szabolcs; Torgersen, Maria Lyngaas; Øynebråten, Inger; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H.; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E.; Adeli, Khosrow; Adolph, Timon E.; Adornetto, Annagrazia; Aflaki, Elma; Agarwal, Anupam; Agam, Galila; Aggarwal, Bharat B.; Agnello, Maria; Agostinis, Patrizia; Agrewala, Javed N.. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. volum 17 (1).
- Rex, D.A.B.; Deepak, K.; Vaid, Neelanchal; Dagamajalu, Shobha; Kandasamy, Richard Kumaran; Flo, Trude Helen; Keshava Prasad, Prasad. (2021) A modular map of Bradykinin-mediated inflammatory signaling network. Journal of cell communication and signaling.
- Bazilchuk, Nancy Reney; Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) New mechanism allows the immune system to detect and respond to HIV. Norwegian SciTech News.
- Bazilchuk, Nancy Reney; Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) Vil lure HIV-virus ut av gjemmestedene. Gemini.no.
- Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Kim, Hae Lin; Marstad, Anne; Åsberg, Signe Elisabeth; Strand, Trine Aakvik; Haug, Markus; Niederweis, Michael; Stenmark, Harald Alfred; Flo, Trude Helen. (2020) Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection. Nature Communications. volum 11:2270.
- Flo, Trude Helen; Meås, Hany Zakaria; Damås, Jan Kristian; Haug, Markus. (2020) Forskere: Slik kan vi lure hivviruset til å avsløre seg selv. Aftenposten Viten.
- Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) Smoking HIV out of dormancy. EurekAlert!.
- Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) Wie man das HI-Virus aufscheucht. Wissenschaft.de.
- Kannan, Nisha; Haug, Markus; Steigedal, Magnus; Flo, Trude Helen. (2020) Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium. Frontiers in Immunology. volum 11.
- Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Zhenyi; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, Hang; Damås, Jan Kristian; Flo, Trude Helen. (2020) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency. Nature Communications. volum 11:147.
- Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) A newly discovered mechanism allows the immune system to detect and respond to HIV. Medical Xpress.
- Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) Smoking dormant HIV virus out into the open to develop a cure. News Medical Life Sciences.
- Midling, Anne Sliper; Flo, Trude Helen. (2020) Verdenspremiere på døden i en celle med tuberkulose World film premiere: watch cell infected with tuberculosis die. Gemini.
- Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran. (2020) The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function. International Journal of Molecular Sciences. volum 22 (1).
- Åsberg, Signe Elisabeth; Mediaas, Sindre Dahl; Marstad, Anne; Ryan, Liv; Louet, Claire; Sporsheim, Bjørnar; Beckwith, Kai Sandvold; Underhill, David; Gidon, Alexandre; Flo, Trude Helen. (2020) Antibiotic treatment routes Mycobacterium avium to phagolysosomes without triggering proinflammatory cytokine production in human Mϕs. Journal of Leukocyte Biology.
- Dragset, Marte Singsås; Ioerger, Thomas R.; Loevenich, Maja; Haug, Markus; Sivakumar, Niruja; Marstad, Anne; Cardona, Pere-Joan; Klinkenberg, Geir; Rubin, Eric J.; Steigedal, Magnus; Flo, Trude Helen. (2019) Global assessment of Mycobacterium avium subsp. hominissuis genetic requirement for growth and virulence. mSystems. volum 4 (6).
- Dragset, Marte Singsås; Ioerger, Thomas R.; Zhang, Yanjia; Mærk, Mali; Ginbot, Zekarias; Sacchettini, James C.; Flo, Trude Helen; Rubin, Eric J; Steigedal, Magnus. (2019) Genome-wide phenotypic profiling identifies and categorizes genes required for mycobacterial low iron fitness. Scientific Reports. volum 9:11394.
- Haug, Markus; Meås, Hany Zakaria; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Z.; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, H. H.; Damås, Jan Kristian; Flo, Trude Helen. (2019) P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells. European Journal of Immunology. volum 43.
- Kannan, Nisha; Lai, Yi-Pin; Haug, Markus; Lilleness, Mary Kathleen; Bakke, Siril Skaret; Marstad, Anne; Hov, Håkon; Naustdal, Thor; Afset, Jan Egil; Ioerger, Thomas R.; Flo, Trude Helen; Steigedal, Magnus. (2019) Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium. Infection and Immunity. volum 87 (4).
- Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian. (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology. volum 248.
- Awuh, Jane Atesoh; Flo, Trude Helen. (2018) Erratum to: Molecular basis of mycobacterial survival in macrophages (Cellular and Molecular Life Sciences, (2017), 74, 9, (1625-1648), 10.1007/s00018-016-2422-8). Cellular and Molecular Life Sciences (CMLS). volum 75 (1).
- Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete Gargul; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind. (2018) Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination. Frontiers in Immunology. volum 9:650.
- Pedersen, Tina Therese; Fenstad, Mona H.; Jakobsen, Bente; Koksvik, Hege; Moksnes, Tone; Wallenius, Marianne; Flo, Trude Helen; Haug, Markus. (2018) Low lipocalin-2 in systemic lupus erythematosus pregnancies- a possible mechanism for loss of tolerance. Annals of the Rheumatic Diseases. volum 77.
- Ørning, Mathias Pontus Andreas; Flo, Trude Helen; Lien, Egil. (2018) A Sugar Rush for Innate Immunity. Cell Host and Microbe. volum 24 (4).
- Awuh, Jane Atesoh; Flo, Trude Helen. (2017) Molecular basis of mycobacterial survival in macrophages. Cellular and Molecular Life Sciences (CMLS).
- Gidon, Alexandre; Åsberg, Signe; Louet, Claire; Ryan, Liv; Haug, Markus; Flo, Trude Helen. (2017) Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages. PLoS Pathogens. volum 13 (8).
- Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir. (2017) N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy. volum 13 (10).
- Pedersen, Tina Therese; Fenstad, Mona H.; Moksnes, Tone; Wallenius, Marianne; Flo, Trude Helen; Haug, Markus. (2017) Cytokines and lipocalin-2 in pregnant women with rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases. volum 76.
- Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian. (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology. volum 32 (1).
- Waagsbø, Bjørn; Svardal, Asbjørn M.; Ueland, Thor; Landrø, Linn Aina Ysland; Øktedalen, Olav; Berge, Rolf Kristian; Flo, Trude Helen; Aukrust, Pål; Damås, Jan Kristian. (2016) Low levels of short- and medium-chain acylcarnitines in HIV-infected patients. European Journal of Clinical Investigation. volum 46 (5).
- Awuh, Jane Atesoh; Haug, Markus; Mildenberger, Jennifer; Marstad, Anne; Chau, Do Ngoc Phuc; Louet, Claire; Stenvik, Jørgen; Steigedal, Magnus; Damås, Jan Kristian; Halaas, Øyvind; Flo, Trude Helen. (2015) Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proceedings of the National Academy of Sciences of the United States of America. volum 112 (31).
- Bazilchuk, Nancy Reney; Flo, Trude Helen. (2015) Uncovering the secrets of immune system invaders. Gemini (English edition).
- Beckwith, Marianne; Beckwith, Kai Sandvold; Sikorski, Pawel; Skogaker, Nan Elisabeth Tostrup; Flo, Trude Helen; Halaas, Øyvind. (2015) Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography. PLOS ONE. volum 10:e0134644 (9).
- Bergstrøm, Bjarte; Aune, Marie Hjelmseth; Awuh, Jane Atesoh; Kojen, June Frengen; Blix, Kjetil Jordahl; Ryan, Liv; Flo, Trude Helen; Mollnes, Tom Eirik; Espevik, Terje; Stenvik, Jørgen. (2015) TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway. Journal of Immunology. volum 195 (3).
- Dragset, Marte Singsås; Barczak, Amy K.; Kannan, Nisha; Mærk, Mali; Flo, Trude Helen; Valla, Svein; Rubin, Eric J.; Steigedal, Magnus. (2015) Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLOS ONE. volum 10 (9).
- Steigedal, Magnus; Marstad, Anne; Haug, Markus; Damås, Jan Kristian; Strong, Roland K.; Roberts, Pacita L.; Himpsl, Stephanie D.; Stapleton, Ann; Hooton, Thomas M.; Mobley, Harry L.T.; Hawn, Thomas R.; Flo, Trude Helen. (2014) Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Journal of Immunology. volum 193 (12).
- Haug, Markus; Awuh, Jane Atesoh; Steigedal, Magnus; Kojen, June Frengen; Marstad, Anne; Nordrum, Ivar Skjåk; Halaas, Øyvind; Flo, Trude Helen. (2013) Dynamics of immune effector mechanisms during infection with Mycobacterium aviumin C57BL/6 mice. Immunology. volum 140 (2).
- Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology. volum 173 (3).
- Damås, Jan Kristian; Bækken, Morten; Ueland, Thor; MANNER, INGJERD W; Os, Ingrid; Yndestad, Arne; Flo, Trude Helen; Øktedalen, Olav; Aukrust, Pål. (2012) Serum Levels of Neutrophil Gelatinase-Associated Lipocalin Are Associated With Microalbuminuria in HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes. volum 59 (2).
- Damås, Jan Kristian; Øktedalen, Olav; Ueland, Thor; Landrø, Linn Aina Ysland; Barstad, Johannes; Müller, Fredrik; Frøland, Stig Sophus; Flo, Trude Helen; Aukrust, Pål. (2012) Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS). Clinical and Experimental Immunology. volum 167 (3).
- Nymo, Ståle Haugset; Ueland, Thor; Askevold, Erik Tandberg; Flo, Trude Helen; Kjekshus, John; Hulthe, Johannes; Wikstrand, John; McMurray, J; Van Veldhuisen, D J; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne. (2012) The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA. Journal of Internal Medicine. volum 271 (5).
- Pathak, Sharad; Awuh, Jane Atesoh; Leversen, Nils Anders; Flo, Trude Helen; Åsjø, Birgitta. (2012) Counting mycobacteria in infected human cells and mouse tissue: a comparison between qPCR and CFU. PLOS ONE. volum 7 (4).
- Halaas, Øyvind; Steigedal, Magnus; Haug, Markus; Awuh, Jane Atesoh; Ryan, Liv; Brech, Andreas; Sato, S; Husebye, Harald; Cangelosi, Gerard; Akira, Shizuo; Strong, Roland; Espevik, Terje; Flo, Trude Helen. (2010) Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway. Journal of Infectious Diseases. volum 201 (5).
- Pukstad, Brita; Ryan, Liv; Flo, Trude Helen; Stenvik, Jørgen; Moseley, Ryan; Harding, Keith; Thomas, David W.; Espevik, Terje. (2010) Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of dermatological science (Amsterdam). volum 59 (2).
- Damås, Jan Kristian; Davi, Giovanni; Jensenius, M; Santilli, F; Otterdal, K; Ueland, T; Flo, Trude Helen; Lien, E; Espevik, Terje; Frøland, Stig S; Vitale, G; Raoult, D; Aukrust, P. (2009) Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. Journal of Infection. volum 58 (1).
- Yndestad, A; Landrø, Linn; Ueland, Thor; Dahl, CP; Flo, Trude Helen; Vinge, Leif Erik; Espevik, Terje; Frøland, Stig S; Husberg, Cathrine; Christensen, Geir; Dickstein, K; Kjekshus, John; Øie, Erik; Gullestad, Lars; Aukrust, Pål. (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. European Heart Journal. volum 30 (10).
- Landrø, Linn Aina Ysland; Landro, L; Damås, Jan Kristian; Damas, JK; Flo, Trude Helen; Heggelund, L; Ueland, T; Tjonnfjord, GE; Tjønnfjord, Geir Erland; Espevik, Terje; Aukrust, P; Frøland, Stig Sophus; Froland, SS. (2008) Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy. Clinical and Experimental Immunology. volum 152 (1).
- Heggelund, L; Flo, Trude Helen; Berg, K.; Lien, E; Espevik, Terje. (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 3 (18).
- Heggelund, Lars; Flo, T; Berg, K; Lien, T; Mollnes, TE; Ueland, Thor; Aukrust, Pål; Espevik, T; Frøland, Stig Sophus. (2004) Soluble toll-like receptor 2 in HIV infection: association with disease progression. AIDS (London). volum 18.
- Flo, Trude Helen; Smith, KD; Sato, S; Rodriguez, DJ; Holmes, MA; Strong, RK; Akira, S; Aderem, A. (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. volum 432.
- Schjetne, KW; Thompson, Keith; Fleckenstein, Burkhard; Aarvak, Tanja; Flo, T. H.; Iversen, Jens Gustav; Espevik, T; Bogen, Bjarne. (2003) Cutting edge: Link between innate and adaptive immunity: toll like receptor 2 (TLR 2) captures antigen for MHC class II presentation to CD4+ T cell responses. Journal of Immunology. volum 171.
- Schjetne, KW; Thompson, KM; Nilsen, Nadra; Flo, Trude Helen; Fleckenstein, B; Iversen, JG; Espevik, Terje; Bogen, B. (2003) Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. Journal of Immunology. volum 171 (1).
- Dybdahl, Brit; Lien, Egil; Flo, Trude Helen; Espevik, Terje; Sundan, Anders; Wahba, Alexander; Sellevold, Olav F Münter. (2002) Heat Shock Proteins and Endotoxin Combined as a Trigger for Inflammatory Cytokine Release During Cardiopulmonary Bypass: A Possible Third Way? Letter til artikkel. Circulation. volum 106.
- Dybdahl, Brit; Wahba, Alexander; Lien, Egil; Flo, Trude Helen; Waage, Anders; Sellevold, Olav F Münter; Espevik, Terje; Sundan, Anders; Qureshi, Nilofer. (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation. volum 105 (6).
- Ellingsen, E.A.; Morath, S; Flo, Trude Helen; Schromm, Andra; Hartung, T; Thiemermann, C; Espevik, Terje; Golenbock, Douglas T.; Foster, D; Solberg, R.; Aasen, A; Wang, J. (2002) Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. Medical Science Monitor. volum 8 (5).
- Flo, Trude Helen; Ryan, Liv; Latz, Eicke; Takeuchi, Osamu; Monks, Brian G.; Lien, Egil; Halaas, Øyvind; Akira, Shizuo; Skjåk-Bræk, Gudmund; Golenbock, Douglas T.; Espevik, Terje. (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. Journal of Biological Chemistry. volum 277 (38).
- Flo, Trude Helen; Halaas, Øyvind; Torp, Sverre Helge; Ryan, Liv; Lien, Egil; Dybdahl, Brit; Sundan, Anders; Espevik, Terje. (2001) Differential expression of Toll-like receptor 2 in human cells. Journal of Leukocyte Biology. volum 69.
- Flo, Trude Helen; Ryan, Liv; Kilaas, L; Skjåk-Bræk, Gudmund; Ingalls, Robin; Sundan, Anders; Golenbock, D; Espevik, Terje. (2001) The involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infection and Immunity. volum 68.
- Wang, J; Warris, A; Ellingsen, E.A.; Jorgensen, P.F.; Flo, Trude Helen; Espevik, Terje; Solberg, R.; Verweij, P.E.; Aasen, A. O.. (2001) Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infection and Immunity. volum 69 (4).
- Cuzzola, M.; Mancuso, G.; Beninati, C.; Biondo, C.; Genovese, F.; Tomasello, F.; Flo, Trude Helen; Espevik, Terje; Teti, G.. (2000) _B2 integrins are involved in cytokine responses to whole gram-positive bacteria. Journal of Immunology. volum 164.
- Cuzzola, Maria; Mancuso, Guiseppe; Beninati, Concetta; Biondo, Carmelo; von Hunolstein, Christina; Orefici, Graziella; Espevik, Terje; Flo, Trude Helen; Teti, Guisseppe. (2000) Human monocyte receptors involved in tumor necrosis factor responses to group B streptococcal products. Infection and Immunity. volum 68.
- Flo, T.H.; Ryan, L.; Kilaas, L.; Skjåk-Bræk, Gudmund; Ingalls, R.R.; Sundan, A.; Golenbock, D.T.; Espevik, Terje. (2000) Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infection and Immunity. volum 68 (12).
- Flo, Trude Helen; Halaas, Øyvind; Lien, Egil; Ryan, Liv; Teti, Guiseppe; Golenbock, Douglas T.; Sundan, Anders; Espevik, Terje. (2000) Human Toll-like Receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. Journal of Immunology. volum 164.
- Flo, Trude Helen; Ryan, Liv; Kilaas, Lars; Skjåk-Bræk, Gudmund; Ingalls, Robin R.A; Sundan, Anders; Golenbock, Douglas T.; Espevik, Terje. (2000) Involvement of CD14 and _B2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infection and Immunity. volum 68 (12).
- Skjåk-Bræk, Gudmund; Flo, Trude Helen; Halaas, Øyvind; Espevik, Terje. (2000) Immune stimulating properties of di-equatorially beta(1->4) linked poly-uronides. Proceedings of the Phytochemical Society of Europe. volum 44.
- Lien, Egil; Sellati, Timothy J.; Yoshimura, Atsutosi; Flo, Trude Helen; Rawadi, Georges; Finberg, Robert W.; Caroll, J.David; Espevik, Terje; Ingalls, Robin R; Radolf, Justin D.; Golenbock, Douglas T.. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. Journal of Biological Chemistry. volum 274 (47).
- Berntzen, G.; Flo, T; Medvedev, A; Kilaas, L; Skjåk-Bræk, Gudmund; Sundan, A; Espevik, Terje. (1998) The tumor necrosis factor-inducing potency of lipopolysaccharide and uronic acid polymers is increased when they are covalently linked to particles. Clinical and Vaccine Immunology.
- Berntzen, Gøril; Flo, Trude Helen; Medvedev, Andrei E.; Skjåk-Bræk, Gudmund. (1998) The tumor necrosis factor-inducing potency of lipopolysacharide and uronic acid polymers is increased when they are covalently linked to particles. Clinical and Laboratory Immunology. volum 5/1998 (3).
- Medvedev, AE; Flo, T; Vogel, SN; Robin, R; Golenbock, DT; Teti, G; Espevik, Terje. (1998) Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. Journal of Immunology.
Report/dissertation
- Flo, Trude Helen. (2001) Receptors involved in cell activation by defined uronic acid polymers and bacterial components. 2001. ISBN 82-471-5053-0.
INFORMASJONSMATR
- Haug, Markus; Meås, Hany Zakaria; Flo, Trude Helen. (2020) Hvordan vi oppdaget en ny mekanisme i immunceller for å vekke HIV virus som ligger i dvale.
- Meås, Hany Zakaria; Haug, Markus; Flo, Trude Helen. (2020) HIV entry into the wrong T cell: not a “dead-end” but a “highway” for viral spread.
- Flo, Trude Helen. (2014) 24. mars er Verdens tuberkulosedag.
- Flo, Trude Helen. (2013) Hva har betennelse med global helse å gjøre?.
- Flo, Trude Helen. (2013) What does inflammation have to do with global health?.
Teaching
Courses
Media
2022
- Flem, Sofie Svanes; Spurkland, Anne; Flo, Trude Helen. (2022) Norsk Facebook-post om korona gikk viralt – men påstanden er feil. Faktisk.no [Internett]. 2022-05-18.
2021
- Flo, Trude Helen; Olsen, Emilie Sofie. (2021) Slik fungerer koronavaksinen: - Må en lokal betennelse til for at vaksinen skal virke. Adresseavisen [Avis]. 2021-01-20.
2020
- Flo, Trude Helen. (2020) Ny kunnskap om tuberkulosebakterien. NRK Midtnytt [TV]. 2020-07-02.
- Ness, Kaja Kristin; Flo, Trude Helen. (2020) Nye funn: Slik dreper tuberkulosebakteriene. NRK Viten [Internett]. 2020-07-02.
2019
- Flo, Trude Helen; Espevik, Terje. (2019) Betennelse – et tveegget sverd for helse og sykdom. Adresseavisa [Avis]. 2019-06-05.
- Flo, Trude Helen; Karlsen, Morten. (2019) Inflammasjon - betennelse. NRK Trøndelag radio [Radio]. 2019-05-31.
- Flo, Trude Helen; Mcdonagh, Kirsten Eileen Hjelmeland. (2019) Podcast "Diagnose" - om antibiotikaresistens. Podcast [Internett]. 2019-10-24.
2018
- Flo, Trude Helen; Bergesen, Norunn. (2018) Ti millioner til NTNU-forsker. Adresseavisen [Avis]. 2018-01-11.
- Flo, Trude Helen; Børstad, Johannes. (2018) God Ettermiddag Trøndelag Forskerprat: Tuberkulose - tildeling av FriMedBio forskerprosjekt. NRK radio [Radio]. 2018-12-07.
- Tveter, Nina Elisabeth; Flo, Trude Helen. (2018) Ti millioner til NTNU-forsker. GEMINI [Fagblad]. 2018-01-11.
2017
- Brandslet, Steinar; Flo, Trude Helen. (2017) Sånn skjuler tuberkulose seg i kroppen. Gemini [Fagblad]. 2017-09-11.
2016
- Flo, Trude Helen. (2016) Årstiden du føder kan påvirke barnets helse. abcnyheter.no [Internett]. 2016-06-13.
- NRK, Schrödingers katt; Flo, Trude Helen; Steigedal, Magnus. (2016) Antibiotikaresistens. NRK, Schrödingers katt [TV]. 2016-03-03.
2015
- Flo, Trude Helen. (2015) Fant protein som hindrer immunforsvaret å løpe løpsk. Adresseavisen [Avis]. 2015-08-10.
- Flo, Trude Helen. (2015) Newton - hva er vaksine?. NRK Newton [TV]. 2015-01-25.
- Flo, Trude Helen; Awuh, Jane A; Stenvik, Jørgen. (2015) Slik lurer bakterier immunsystemet. forskning.no [Internett]. 2015-07-25.
- Flo, Trude Helen; Dale, Åsta. (2015) Er det riktig å gi antibiotika mot lungebetennelse?. Forskning.no [Internett]. 2015-09-21.
- Spilde, Ingrid; Flo, Trude Helen. (2015) Blir immunforsvaret sterkere etter sykdom?. Forskning.no [Internett]. 2015-03-04.
- Spilde, Ingrid; Flo, Trude Helen. (2015) E. coli-bakterie hjalp syke mus. Forskning.no [Internett]. 2015-11-02.
- Steigedal, Magnus; Flo, Trude Helen. (2015) Ingen vil ta regningen for nye antibiotika. Gemini [Tidsskrift]. 2015-03-25.
- Steigedal, Magnus; Flo, Trude Helen. (2015) Nobody wants to foot the bill for new antibiotics. alphagalileo.org [Internett]. 2015-05-07.
- Weisser, Agnethe; Flo, Trude Helen. (2015) Slik løper immunforsvaret løpsk. Adressa [Avis]. 2015-08-07.
2014
- Flo, Trude Helen. (2014) Norske babyer får ny vaksine - den ellevte i rekken: - Forstår at foreldre er skeptiske. VG [Avis]. 2014-10-10.
- Flo, Trude Helen. (2014) VAKSINELANDET Nå skal babyer få enda en vaksine Vil at barn skal ta totalt 11 vaksiner. VG [Avis]. 2014-10-10.
2013
- Flo, Trude Helen; ntnuinfo, ntnuinfo. (2013) Mycobacteria. null [Internett]. 2013-07-03.
- Jakobsen, Siw Ellen; Espevik, Terje; Flo, Trude Helen. (2013) Når forsvarerne blir fienden. Bladet Forskning [Fagblad]. 2013-09-01.
- Monsen, Tor; Flo, Trude Helen. (2013) Leter etter ny vaksine. Universitetsavisa [Avis]. 2013-12-18.
- Weisser, Agnethe; Espevik, Terje; Flo, Trude Helen. (2013) Se krigercellene gå til angrep. Adressa [Avis]. 2013-03-15.