Trude Helen Flo
Trude Helen Flo
Professor in Cell Biology and Co-director of CEMIR
Department of Clinical and Molecular Medicine Faculty of Medicine and Health SciencesBackground and activities
Co-Director Centre of Molecular Inflammation Research and Professor in Cell Biology at Dept. of Clinical and Molecular Medicine. Head of research group on Mycobacteria and HIV. Teaching immunology and cell biology.
Curriculum
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Professor in Cell Biology at Dept. of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU,
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Co-director of CEMIR : Centre of Molecular Inflammation Research, a center of excellence at the Faculty of Medicine, NTNU
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Researcher at Dept. of Cancer Research and Molecular Medicine, NTNU, 2004 - 2014
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Associate Professor II in Immunology at Dept. of Laboratory Medicine, NTNU, 2011 - 2013
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Visiting post doc in Alan Aderems lab, Institute for Systems Biology, Seattle, USA, 2002-2003
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PhD (Dr.Philos) in Immunology/Cell Biology at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001
- MSc (sivilingeniør) in Biotechnology at The Norwegian Institute of Technology (NTH, later NTNU), 1995
Research activities and interests
My research is focused on host-pathogen interactions between innate immune cells and pathogens, e.g. mycobacteria, HIV and lately also SARS-CoV2. Infectious diseases still represents a threath to global health and the world is in great need for new medications and vaccines. Our basic research may contribute in revealing new therapeutic or vaccine targets. The macrophage is always in focus, but we are currently establishing multicellular ex vivo infection models to study how cellular cross-talk shapes the resulting immune response. Since the discovery of the anti-bacterial functions of lipocalin 2, I have also initiated and contributed in projects exploring the role of lipocalin 2 in infectious diseases or use as a biomarker in diverse conditions.
My research group is part of a larger intitiative on molecular mechanisms of inflammation research, CEMIR.
Publications
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
Journal publications
- (2020) Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection. Nature Communications. vol. 11.
- (2020) Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium. Frontiers in Immunology. vol. 11.
- (2020) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency. Nature Communications. vol. 11.
- (2019) Global assessment of Mycobacterium avium subsp. hominissuis genetic requirement for growth and virulence. mSystems. vol. 4 (6).
- (2019) Genome-wide phenotypic profiling identifies and categorizes genes required for mycobacterial low iron fitness. Scientific Reports. vol. 9:11394.
- (2019) P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells. European Journal of Immunology. vol. 43.
- (2019) Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium. Infection and Immunity. vol. 87 (4).
- (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology. vol. 248.
- (2018) Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination. Frontiers in Immunology. vol. 9:650.
- (2018) Low lipocalin-2 in systemic lupus erythematosus pregnancies- a possible mechanism for loss of tolerance. Annals of the Rheumatic Diseases. vol. 77.
- (2018) A Sugar Rush for Innate Immunity. Cell Host and Microbe. vol. 24 (4).
- (2017) Molecular basis of mycobacterial survival in macrophages. Cellular and Molecular Life Sciences (CMLS).
- (2017) Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages. PLoS Pathogens. vol. 13 (8).
- (2017) N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy. vol. 13 (10).
- (2017) Cytokines and lipocalin-2 in pregnant women with rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases. vol. 76.
- (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology. vol. 32 (1).
- (2016) Low levels of short- and medium-chain acylcarnitines in HIV-infected patients. European Journal of Clinical Investigation. vol. 46 (5).
- (2015) Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proceedings of the National Academy of Sciences of the United States of America. vol. 112 (31).
- (2015) Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography. PLOS ONE. vol. 10:e0134644 (9).
- (2015) TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway. Journal of Immunology. vol. 195 (3).