Trude Helen Flo
Background and activities
Co-Director Centre of Molecular Inflammation Research and Professor in Cell Biology at Dept of Cancer Research and Molecular Medicine, head of research group on Molecular Mechanisms of Mycobacterial Infections, teaching immunology, cell bio
Professor in Cell Biology at Dept. of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU,
Co-director of CEMIR : Centre of Molecular Inflammation Research, a center of excellence at the Faculty of Medicine, NTNU
Senior Research Scientist at Dept. of Cancer Research and Molecular Medicine, NTNU, 2004 - present
Associate Professor II in Immunology at Dept. of Laboratory Medicine, NTNU, 2011 - 2013
- Post doctoral position at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001-2002
PhD (Dr.Philos) in Immunology/Cell Biology at Dept. of Cancer Research and Molecular Medicine, NTNU, 2001
- MSc (sivilingeniør) in Biotechnology at The Norwegian Institute of Technology (NTH, later NTNU), 1995
Research activities and interests
My research is focused on host-pathogen interactions between innate immune cells and bacterial pathogens, e.g. mycobacteria and uropathogenic E. coli. The focus on mycobacteria comes from an interest in Global Health issues, in particular infectious diseases like tuberculosis where the world is in great need for new medications and vaccines, and where our basic research may contribute in revealing new therapeutic or vaccine targets. The macrophage is always in focus, but since the discovery of the anti-bacterial functions of lipocalin 2, I have initiated and contributed in projects exploring the role of lipocalin 2 in infectious diseases or use as a biomarker in diverse conditions.
My research group is part of a larger intitiative on molecular mechanisms of inflammation research, CEMIR.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2020) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency. Nature Communications. vol. 11.
- (2019) Global assessment of Mycobacterium avium subsp. hominissuis genetic requirement for growth and virulence. mSystems. vol. 4 (6).
- (2019) Genome-wide phenotypic profiling identifies and categorizes genes required for mycobacterial low iron fitness. Scientific Reports. vol. 9:11394.
- (2019) P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells. European Journal of Immunology. vol. 43.
- (2019) Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium. Infection and Immunity. vol. 87 (4).
- (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology. vol. 248.
- (2018) Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination. Frontiers in Immunology. vol. 9:650.
- (2018) Low lipocalin-2 in systemic lupus erythematosus pregnancies- a possible mechanism for loss of tolerance. Annals of the Rheumatic Diseases. vol. 77.
- (2018) A Sugar Rush for Innate Immunity. Cell Host and Microbe. vol. 24 (4).
- (2017) Molecular basis of mycobacterial survival in macrophages. Cellular and Molecular Life Sciences (CMLS).
- (2017) Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages. PLoS Pathogens. vol. 13 (8).
- (2017) N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy. vol. 13 (10).
- (2017) Cytokines and lipocalin-2 in pregnant women with rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases. vol. 76.
- (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology. vol. 32 (1).
- (2016) Low levels of short- and medium-chain acylcarnitines in HIV-infected patients. European Journal of Clinical Investigation. vol. 46 (5).
- (2015) Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proceedings of the National Academy of Sciences of the United States of America. vol. 112 (31).
- (2015) Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography. PLOS ONE. vol. 10:e0134644 (9).
- (2015) TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway. Journal of Immunology. vol. 195 (3).
- (2015) Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLOS ONE. vol. 10 (9).
- (2014) Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Journal of Immunology. vol. 193 (12).