Jing Ye
+4773598433
+4745676009
Laboratoriesenteret, Øya
About
Research: DNA-methylome dynamics in cognition and brain diseases
The dynamics of DNA methylation landscapes (the DNA methylome) is one of the important epigenetic mechanisms regulating the neural basis of cognition and the progression of brain diseases. It is achieved through a cyclic enzymatic cascade comprised of (i) methylation of cytosines (mC) by DNA methyltransferases (DNMTs), (ii) iterative oxidation of the methyl group to hydroxymethyl cytosine (hmC), formylcytosine (fC), and carboxylcytosine (caC) by TET dioxygenases, and (iii) restoration of unmodified cytosines by DNA glycosylase-initiated base excision repair (BER). Our research focus is to decipher the distinct patterns of DNA methylation and mC derivatives underlying the cognitive brain function (e.g., learning and memory) and the development of brain cancer (e.g., glioblastoma).
We offer interdisciplinary research projects, involving transgenic mouse models, rAAV viral tools, diverse molecular techniques, cutting-edge single-cell transcriptome and epigenome sequencing technologies, functional neural anatomy, neurophysiological and animal behavioral studies, as well as 2D/3D human disease models of brain tumors. Distinct tasks and objectives will be assigned based on the student’s interests and backgrounds.
Publications
2025
-
Fernández Berrocal, Marion Silvana;
Reis, Amilcar;
Rolseth, Veslemøy;
Suganthan, Rajikala;
Kusnierczyk, Anna;
França, Arthur.
(2025)
NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling.
Cellular and Molecular Life Sciences (CMLS)
Academic article
-
Ianevski, Aleksandr;
Camara Quilez, Maria;
Suganthan, Rajikala;
Hildrestrand, Gunn Annette;
Grini, Jonas Viken;
Døskeland, Dagny Sanden.
(2025)
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Academic article
-
Fernández Berrocal, Marion Silvana;
Ye, Jing;
Bjørås, Magnar;
Døskeland, Dagny Sanden.
(2025)
Direct and bisulfite-free 5-methylcytosine and 5-hydroxymethylcytosine sequencing at single-cell resolution with scTAPS and scCAPS + .
Genome Biology
Academic article
2024
-
Bugaj, Anna Maria;
Kunath, Nicolas;
Saasen, Vidar Langseth;
Fernández Berrocal, Marion Silvana;
Vankova, Ana;
Sætrom, Pål.
(2024)
Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.
Progress in Neurobiology
Academic article
2023
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Academic article
2021
-
Kunath, Nicolas;
Bugaj, Anna Maria;
Bigonah, Pegah;
Fernandez Berrocal, Marion Silvana;
Bjørås, Magnar;
Ye, Jing.
(2021)
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons.
iScience
Academic article
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Academic literature review
2020
-
Rodriguez-Vargas, José-Manuel;
Martin-Hernandez, Kathline;
Wang, Wei;
Kunath, Nicolas;
Suganthan, Rajikala;
Amé, Jean-Christophe.
(2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.
Cell Death & Disease
Academic article
2018
-
Ye, Jing;
Witter, Menno;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2018)
Entorhinal fast-spiking speed cells project to the hippocampus.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Academic article
2014
-
Zhang, Sheng Jia;
Ye, Jing;
Couey, Jonathan Jay;
Witter, Menno;
Moser, Edvard Ingjald;
Moser, May-Britt.
(2014)
Functional connectivity of the entorhinal - hippocampal space circuit.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
2013
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Zheng, Kang;
Ye, Jing;
Dunn, Benjamin Adric.
(2013)
Recurrent inhibitory circuitry as a mechanism for grid formation.
Nature Neuroscience
Academic article
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Tsao, Albert;
Cerniauskas, Ignas;
Ledergerber, Debora.
(2013)
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity.
Science
Academic article
-
Czajkowski, Rafal;
Sugar, Jørgen L;
Zhang, Sheng Jia;
Couey, Jonathan Jay;
Ye, Jing;
Witter, Menno.
(2013)
Superficially Projecting Principal Neurons in Layer V of Medial Entorhinal Cortex in the Rat Receive Excitatory Retrosplenial Input.
Journal of Neuroscience
Academic article
2012
-
Ye, Jing;
Zhang, Sheng Jia;
Miao, Chenglin;
Tsao, Albert;
Ledergerber, Debora;
Moser, May-Britt.
(2012)
702.13/DDD29 - Optogenetic dissection of the entorhinal-hippocampal space circuit.
SFN Abstract Viewer/Itinerary Planner
Academic article
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Czajkowski, Rafal;
Dunn, Benjamin Adric;
Ye, Jing.
(2012)
702.06/DDD22 - Medial entorhinal cortex layer ii stellate cells are embedded within a recurrent inhibitory network.
SFN Abstract Viewer/Itinerary Planner
Abstract
2010
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2010)
Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit.
Society for Neuroscience : Abstracts
Abstract
Journal publications
-
Fernández Berrocal, Marion Silvana;
Reis, Amilcar;
Rolseth, Veslemøy;
Suganthan, Rajikala;
Kusnierczyk, Anna;
França, Arthur.
(2025)
NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling.
Cellular and Molecular Life Sciences (CMLS)
Academic article
-
Ianevski, Aleksandr;
Camara Quilez, Maria;
Suganthan, Rajikala;
Hildrestrand, Gunn Annette;
Grini, Jonas Viken;
Døskeland, Dagny Sanden.
(2025)
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Academic article
-
Fernández Berrocal, Marion Silvana;
Ye, Jing;
Bjørås, Magnar;
Døskeland, Dagny Sanden.
(2025)
Direct and bisulfite-free 5-methylcytosine and 5-hydroxymethylcytosine sequencing at single-cell resolution with scTAPS and scCAPS + .
Genome Biology
Academic article
-
Bugaj, Anna Maria;
Kunath, Nicolas;
Saasen, Vidar Langseth;
Fernández Berrocal, Marion Silvana;
Vankova, Ana;
Sætrom, Pål.
(2024)
Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion.
Progress in Neurobiology
Academic article
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Academic article
-
Kunath, Nicolas;
Bugaj, Anna Maria;
Bigonah, Pegah;
Fernandez Berrocal, Marion Silvana;
Bjørås, Magnar;
Ye, Jing.
(2021)
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons.
iScience
Academic article
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Academic literature review
-
Rodriguez-Vargas, José-Manuel;
Martin-Hernandez, Kathline;
Wang, Wei;
Kunath, Nicolas;
Suganthan, Rajikala;
Amé, Jean-Christophe.
(2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.
Cell Death & Disease
Academic article
-
Ye, Jing;
Witter, Menno;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2018)
Entorhinal fast-spiking speed cells project to the hippocampus.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Academic article
-
Zhang, Sheng Jia;
Ye, Jing;
Couey, Jonathan Jay;
Witter, Menno;
Moser, Edvard Ingjald;
Moser, May-Britt.
(2014)
Functional connectivity of the entorhinal - hippocampal space circuit.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Zheng, Kang;
Ye, Jing;
Dunn, Benjamin Adric.
(2013)
Recurrent inhibitory circuitry as a mechanism for grid formation.
Nature Neuroscience
Academic article
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Tsao, Albert;
Cerniauskas, Ignas;
Ledergerber, Debora.
(2013)
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity.
Science
Academic article
-
Czajkowski, Rafal;
Sugar, Jørgen L;
Zhang, Sheng Jia;
Couey, Jonathan Jay;
Ye, Jing;
Witter, Menno.
(2013)
Superficially Projecting Principal Neurons in Layer V of Medial Entorhinal Cortex in the Rat Receive Excitatory Retrosplenial Input.
Journal of Neuroscience
Academic article
-
Ye, Jing;
Zhang, Sheng Jia;
Miao, Chenglin;
Tsao, Albert;
Ledergerber, Debora;
Moser, May-Britt.
(2012)
702.13/DDD29 - Optogenetic dissection of the entorhinal-hippocampal space circuit.
SFN Abstract Viewer/Itinerary Planner
Academic article
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Czajkowski, Rafal;
Dunn, Benjamin Adric;
Ye, Jing.
(2012)
702.06/DDD22 - Medial entorhinal cortex layer ii stellate cells are embedded within a recurrent inhibitory network.
SFN Abstract Viewer/Itinerary Planner
Abstract
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2010)
Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit.
Society for Neuroscience : Abstracts
Abstract
Outreach
2024
-
PosterDøskeland, Dagny Sanden; Saasen, Vidar Langseth; Grini, Jonas Viken; Ye, Jing; Bjørås, Magnar. (2024) The Role of TDG-Mediated DNA Demethylation in Spatial Cognition. Federation of European Neuroscience Societies (FENS) FENS Forum 2024 , Wien 2024-06-19 - 2024-06-23
2013
-
PosterYe, Jing; Zhang, Sheng Jia; Cerniauskas, Ignas; Sørlie Wågan, R; Moser, May-Britt; Moser, Edvard Ingjald. (2013) Functional dissection of principal cell populations in layers II and III of medial entorhinal cortex. Society for Neuroscience 2013-11-13 -
2011
-
PosterZhang, Sheng Jia; Ye, Jing; Miao, Chenglin; Tsao, Albert; Moser, May-Britt; Moser, Edvard Ingjald. (2011) Functional connectivity of the entorhinal-hippocampal space circuit. Soceiety for Neuroscience Society for Neuroscience 2011-11-12 - 2011-11-16
-
PosterCzajkowski, Rafal; Couey, Jonathan Jay; Girao, Paulo Jorge Bettencourt; Zhang, Sheng Jia; Ye, Jing; Moser, May-Britt. (2011) Optogenetic mapping reveals a functional input from retrosplenial cortex. Society for Neuroscience 2011-11-12 - 2011-11-16
2010
-
PosterZhang, Sheng Jia; Ye, Jing; Miao, Chenglin; Moser, May-Britt; Moser, Edvard Ingjald. (2010) Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit. SFN 2010-11-13 - 2010-11-17