Andreas Abentung
About
Research Interests
One of the most fascinating properties of the mammalian brain is its plasticity: the capacity to modify neuronal circuit function and thereby incorporate transient experiences into persistent memory traces. The ability to encode, consolidate and retrieve memories is a prerequisite for any organism`s behavioral adaptation to environmental changes. How the brain achieves such remarkable tasks is still one of the greatest remaining mysteries of our time.
Over the last years it has become evident that activity-dependent gene expression plays an essential role in controlling memory persistence. However, how exactly neuronal gene expression affecting cognition and behavior is orchestrated is not fully understood. Deciphering the molecular mechanisms that affect epigenetic modifications and chromatin architecture in neurons will help to better understand how gene expression is maintained in neurons. In addition, those findings could help to unravel potential drug targets for a variety of neurodegenerative diseases in the near future.
Competencies
Publications
2025
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Abentung, Andreas;
Sakshaug, Teri;
Dumaru, Rabina;
Liabakk, Nina-Beate;
Yang, Mingyi;
Wang, Junbai.
(2025)
DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition.
Cellular and Molecular Life Sciences (CMLS)
Academic article
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Berrocal, Marion Silvana Fernández;
Reis, Amilcar;
Rolseth, Veslemøy;
Suganthan, Rajikala;
Kusnierczyk, Anna;
França, Arthur.
(2025)
NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling.
Cellular and Molecular Life Sciences (CMLS)
Academic article
2024
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Obermann, Tobias;
Sakshaug, Teri Shearer;
Kanagaraj, Vishnu Vignesh;
Abentung, Andreas;
Sousa, Mirta Mittelstedt Leal de;
Hagen, Lars.
(2024)
Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH.
Redox Biology
Academic article
-
Egiazarian, Milena Armenovna;
Abentung, Andreas;
Sakshaug, Teri;
Karabeika, Emily;
Hanumaihgari, Priyanka Reddy;
Grøntvedt, Gøril Rolfseng.
(2024)
The role of impaired oxidative base lesion repair in Alzheimer’s disease.
Alzheimer's & Dementia
Abstract
Journal publications
-
Abentung, Andreas;
Sakshaug, Teri;
Dumaru, Rabina;
Liabakk, Nina-Beate;
Yang, Mingyi;
Wang, Junbai.
(2025)
DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition.
Cellular and Molecular Life Sciences (CMLS)
Academic article
-
Berrocal, Marion Silvana Fernández;
Reis, Amilcar;
Rolseth, Veslemøy;
Suganthan, Rajikala;
Kusnierczyk, Anna;
França, Arthur.
(2025)
NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling.
Cellular and Molecular Life Sciences (CMLS)
Academic article
-
Obermann, Tobias;
Sakshaug, Teri Shearer;
Kanagaraj, Vishnu Vignesh;
Abentung, Andreas;
Sousa, Mirta Mittelstedt Leal de;
Hagen, Lars.
(2024)
Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH.
Redox Biology
Academic article
-
Egiazarian, Milena Armenovna;
Abentung, Andreas;
Sakshaug, Teri;
Karabeika, Emily;
Hanumaihgari, Priyanka Reddy;
Grøntvedt, Gøril Rolfseng.
(2024)
The role of impaired oxidative base lesion repair in Alzheimer’s disease.
Alzheimer's & Dementia
Abstract
Outreach
2024
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PosterEgiazarian, Milena Armenovna; Abentung, Andreas; Karabeika, Emily; Hanumaihgari, Priyanka; Schnur, Paulina; Hovland, Oline Øie. (2024) The role of impaired oxidative base lesion repair in Alzheimer's disease. Alzheimer's Association International Conference 2024-07-28 - 2024-08-01