Anna Mikalsen Kollstrøm
Research
I study the electrophysiological and molecular properties of patient-derived neurons aimed at understanding the key principles underlying optimal neural network behavior, and how this is compromised in neurodegenerative diseases. Combining methods such as extracellular recordings (micro-electrode arrays) with transcriptomics and proteomics, the overall aim is to identify the early structural alterations and functional responses to gradually progressive neurodegeneration.
Publications
2025
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Kollstrøm, Anna Mikalsen;
Sandvig, Ioanna;
Fiskum, Vegard;
Sandvig, Axel.
(2025)
Decoding neural adaptability in the face of adversity:Structural and functional dynamics of selforganized biological neural networks in response to neuropathology.
NTNU Norges teknisk-naturvitenskapelige universitet
NTNU Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
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Kollstrøm, Anna Mikalsen;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2025)
Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.
American Journal of Physiology - Cell Physiology
Academic article
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Kollstrøm, Anna Mikalsen;
Grønlie, Marthe Bendiksvoll;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2025)
Induced long-term potentiation improves synaptic stability and restores network function in ALS motor neurons.
Neurobiology of Disease
Academic article
2024
-
Kollstrøm, Anna Mikalsen;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2024)
Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.
BioRxiv
Academic article
Journal publications
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Kollstrøm, Anna Mikalsen;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2025)
Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.
American Journal of Physiology - Cell Physiology
Academic article
-
Kollstrøm, Anna Mikalsen;
Grønlie, Marthe Bendiksvoll;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2025)
Induced long-term potentiation improves synaptic stability and restores network function in ALS motor neurons.
Neurobiology of Disease
Academic article
-
Kollstrøm, Anna Mikalsen;
Christiansen, Nicholas;
Sandvig, Axel;
Sandvig, Ioanna.
(2024)
Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.
BioRxiv
Academic article
Report
-
Kollstrøm, Anna Mikalsen;
Sandvig, Ioanna;
Fiskum, Vegard;
Sandvig, Axel.
(2025)
Decoding neural adaptability in the face of adversity:Structural and functional dynamics of selforganized biological neural networks in response to neuropathology.
NTNU Norges teknisk-naturvitenskapelige universitet
NTNU Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
Outreach
2025
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PosterKollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna. (2025) Early synaptic dysfunction contributes to network-wide structural and functional disruptions in motor neurons derived from an ALS patient. FENS Regional Meeting 2025 , Oslo 2025-06-15 - 2025-11-18
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PosterGrønlie, Marthe Bendiksvoll; Kollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna. (2025) Synaptic Potentiation Stabilizes Structural and Functional Network Abnormalities in ALS Motor Neurons. FENS Regional Meeting 2025 , Oslo 2025-06-16 - 2025-06-19
2024
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PosterWinter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Fiskum, Vegard; Kollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel. (2024) Reverse engineered neural circuit motifs as computational substrates. The Brain Conference - Circuits for Movement , Rungstedgaard 2024-06-16 - 2024-06-19
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PosterKollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna. (2024) Longitudinal assessment of ALS patient-derived motor neurons reveals altered network dynamics and synaptic impairment. FENS Forum 2024 , Vienna, Austria 2024-06-25 - 2024-06-29
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PosterKollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna. (2024) Longitudinal assessment of ALS patient-derived motor neuron networks reveals structural and functional impairments. Nordic Neuroscience Meeting 2024 , Copenhagen, Denmark 2024-01-15 - 2024-01-17
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PosterGrønlie, Marthe Bendiksvoll; Kollstrøm, Anna Mikalsen; Christiansen, Nicholas; Røberg, Mari Susanne Ås; Sandvig, Axel; Sandvig, Ioanna. (2024) Advanced Cellular Models of Neurodegenerative Disease: Early Alterations in Neuronal Network Activity. National PhD Conference in Neuroscience 2024 , Jegtvolden Fjordhotell, Inderøy 2024-09-18 - 2024-09-20
2022
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PosterKollstrøm, Anna Mikalsen; Sandvig, Ioanna; Sandvig, Axel. (2022) Effects of early-onset ALS pathology on neural network dynamics. FENS Forum 2022 , Paris 2022-07-09 - 2022-07-13
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PosterKollstrøm, Anna Mikalsen; Sandvig, Ioanna; Sandvig, Axel. (2022) Effects of early-onset ALS pathology on neural network dynamics. NRSN National PhD Conference in Neuroscience 2022 , Stiklestad 2022-09-28 - 2022-09-30
2021
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PosterKollstrøm, Anna Mikalsen; Sandvig, Ioanna; Sandvig, Axel. (2021) Decoding motor neuron vulnerability and connectivity in ALS. NRSN National Neuroscience Symposium 2021-06-29 - 2021-07-01