Atle van Beelen Granlund

About

Our research explores how genes and gene expression in IBD patients differ from healthy controls. We are interested in what gene variants and gene expression within the IBD patient cohort can tell us about each individual's disease prognosis and treatment response.

We perform large genome and gene expression analyses of patient samples and patient-derived cell cultures and correlate these results with clinical observations identifying genes and processes that can be used clinically for improved, more precise treatment and diagnosis. Identified processes and gene variants are followed up to better understand the mechanisms underlying the observed difference. All studies are performed in close collaboration with the other units within CAG-IBD, as well as the clinic.

Objectives for ongoing research activities:

Identify genetic variants that predispose to a complicated disease course and poor treatment outcomes in IBD.

Characterize the mechanisms underlying the effect of these genetic variants, for example through sequence variants in miRNA binding sites.

Evaluate if the identified genetic variants are efficient and reproducible biomarkers for use in the clinic.

Elucidate epithelial involvement in regulating the intestinal inflammation seen in IBD through gene expression analyses of epithelial cells from IBD patients and experiments in patient-derived epithelial cell lines.

Characterize the role of serotonin and epithelial serotonin reuptake transporter in intestinal fibrosis.

It is our goal that our research should have a direct impact on IBD treatment and prognosis, either through the improvement of clinical practice or by ensuring a greater understanding of IBD pathophysiology.

Publications

2021

Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias. (2021) Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration. Frontiers in Pharmacology
Academic article
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia. (2021) Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis . Journal of gastroenterology
Academic article
Escudero-Hernandez, Celia; van Beelen Granlund, Atle; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet. (2021) Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH)
Academic article

2020

Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn. (2020) Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease. Journal of Crohn's and Colitis
Academic article
Olaisen, Maya; Flatberg, Arnar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Martinsen, Tom Christian; Sandvik, Arne Kristian. (2020) Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease. Inflammatory Bowel Diseases
Academic article
Jørandli, Jonas Woll; Thorsvik, Silje; Skovdahl, Helene Kolstad; Kornfeld, Benedikt; Sæterstad, Siri; Gustafsson, Björn. (2020) The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan. (2020) The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis. Journal of Crohn's and Colitis
Academic article
Escudero-Hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet. (2020) Whole-genome RNA sequencing in collagenous colitis: a subgroup analysis. Journal of Crohn`s and Colitis
Abstract
Bakke, Ingunn; Bruland, Torunn; Eriksen, Kaja Sørgård; Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Thorsvik, Silje. (2020) Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease. Journal of Crohn`s and Colitis
Abstract

2019

Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen. (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology
Academic article
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe. (2019) Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis. Alimentary Pharmacology and Therapeutics
Academic article

2018

Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn. (2018) C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release. International Journal of Molecular Sciences
Academic article
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Bakke, Ingunn; Thorsvik, Silje. (2018) Tu1753 - type 1 Interferon Signaling in Intestinal Epithelial Cells During Active Inflammatory Bowel Disease. Gastroenterology
Abstract
Thorsvik, Silje; Bakke, Ingunn; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Damås, Jan Kristian; Østvik, Ann Elisabeth. (2018) Expression of neutrophil gelatinase-associated lipocalin (NGAL) in the gut in Crohn's disease. Cell and Tissue Research
Academic article

2017

Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet. (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology
Academic article

2015

Brenna, Øystein; Bruland, Torunn; Furnes, Marianne Waldum; Granlund, Atle Van Beelen; Drozdov, Ignat; Emgård, Johanna. (2015) The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease. Scandinavian Journal of Gastroenterology
Academic article
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bruland, Torunn; Bakke, Ingunn; Torp, Sverre Helge. (2015) Expression of CCL20 and its corresponding receptor CCR6 is enhanced in active inflammatory bowel disease, and TLR3 mediates CCL20 expression in colonic epithelial cells. PLOS ONE
Academic article

2014

Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Gustafsson, Björn; Torp, Sverre Helge; Espevik, Terje; Mollnes, Tom Eirik. (2014) Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease. Inflammatory Bowel Diseases
Academic article

2013

Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge. (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology
Academic article
Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Brenna, Øystein; Torp, Sverre Helge; Gustafsson, Björn; Sandvik, Arne Kristian. (2013) REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation. Cell and Tissue Research
Academic article
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge. (2013) Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation. Inflammatory Bowel Diseases
Academic article
Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Flatberg, Arnar; Sandvik, Arne Kristian. (2013) Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Historical and Transcripttomic Characterization and Correlation to IBD. PLOS ONE
Academic article
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark. (2013) Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis. PLOS ONE
Academic article

2012

Chin, A; Svejda, B; Gustafsson, Björn; Granlund, Atle Van Beelen; Sandvik, Arne Kristian; Timberlake, Alan. (2012) The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article

2011

Granlund, Atle Van Beelen; Beisvag, Vidar; Torp, Sverre Helge; Flatberg, Arnar; Kleveland, Per Martin; Østvik, Ann Elisabet. (2011) Activation of REG family proteins in colitis. Scandinavian Journal of Gastroenterology
Academic article

Journal publications

Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias. (2021) Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration. Frontiers in Pharmacology
Academic article
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia. (2021) Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis . Journal of gastroenterology
Academic article
Escudero-Hernandez, Celia; van Beelen Granlund, Atle; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet. (2021) Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH)
Academic article
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn. (2020) Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease. Journal of Crohn's and Colitis
Academic article
Olaisen, Maya; Flatberg, Arnar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Martinsen, Tom Christian; Sandvik, Arne Kristian. (2020) Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease. Inflammatory Bowel Diseases
Academic article
Jørandli, Jonas Woll; Thorsvik, Silje; Skovdahl, Helene Kolstad; Kornfeld, Benedikt; Sæterstad, Siri; Gustafsson, Björn. (2020) The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan. (2020) The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis. Journal of Crohn's and Colitis
Academic article
Escudero-Hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet. (2020) Whole-genome RNA sequencing in collagenous colitis: a subgroup analysis. Journal of Crohn`s and Colitis
Abstract
Bakke, Ingunn; Bruland, Torunn; Eriksen, Kaja Sørgård; Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Thorsvik, Silje. (2020) Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease. Journal of Crohn`s and Colitis
Abstract
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen. (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology
Academic article
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe. (2019) Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis. Alimentary Pharmacology and Therapeutics
Academic article
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn. (2018) C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release. International Journal of Molecular Sciences
Academic article
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Bakke, Ingunn; Thorsvik, Silje. (2018) Tu1753 - type 1 Interferon Signaling in Intestinal Epithelial Cells During Active Inflammatory Bowel Disease. Gastroenterology
Abstract
Thorsvik, Silje; Bakke, Ingunn; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Damås, Jan Kristian; Østvik, Ann Elisabeth. (2018) Expression of neutrophil gelatinase-associated lipocalin (NGAL) in the gut in Crohn's disease. Cell and Tissue Research
Academic article
Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet. (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology
Academic article
Brenna, Øystein; Bruland, Torunn; Furnes, Marianne Waldum; Granlund, Atle Van Beelen; Drozdov, Ignat; Emgård, Johanna. (2015) The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease. Scandinavian Journal of Gastroenterology
Academic article
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bruland, Torunn; Bakke, Ingunn; Torp, Sverre Helge. (2015) Expression of CCL20 and its corresponding receptor CCR6 is enhanced in active inflammatory bowel disease, and TLR3 mediates CCL20 expression in colonic epithelial cells. PLOS ONE
Academic article
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Gustafsson, Björn; Torp, Sverre Helge; Espevik, Terje; Mollnes, Tom Eirik. (2014) Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease. Inflammatory Bowel Diseases
Academic article
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge. (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology
Academic article
Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Brenna, Øystein; Torp, Sverre Helge; Gustafsson, Björn; Sandvik, Arne Kristian. (2013) REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation. Cell and Tissue Research
Academic article
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge. (2013) Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation. Inflammatory Bowel Diseases
Academic article
Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Flatberg, Arnar; Sandvik, Arne Kristian. (2013) Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Historical and Transcripttomic Characterization and Correlation to IBD. PLOS ONE
Academic article
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark. (2013) Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis. PLOS ONE
Academic article
Chin, A; Svejda, B; Gustafsson, Björn; Granlund, Atle Van Beelen; Sandvik, Arne Kristian; Timberlake, Alan. (2012) The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Granlund, Atle Van Beelen; Beisvag, Vidar; Torp, Sverre Helge; Flatberg, Arnar; Kleveland, Per Martin; Østvik, Ann Elisabet. (2011) Activation of REG family proteins in colitis. Scandinavian Journal of Gastroenterology
Academic article

Språkvelger

Atle van Beelen Granlund