Atle van Beelen Granlund

About

Our research explores how genes and gene expression in IBD patients differ from healthy controls. We are interested in what gene variants and gene expression within the IBD patient cohort can tell us about each individual's disease prognosis and treatment response.

We perform large genome and gene expression analyses of patient samples and patient-derived cell cultures and correlate these results with clinical observations identifying genes and processes that can be used clinically for improved, more precise treatment and diagnosis. Identified processes and gene variants are followed up to better understand the mechanisms underlying the observed difference. All studies are performed in close collaboration with the other units within CAG-IBD, as well as the clinic.

Objectives for ongoing research activities:

Identify genetic variants that predispose to a complicated disease course and poor treatment outcomes in IBD.

Characterize the mechanisms underlying the effect of these genetic variants, for example through sequence variants in miRNA binding sites.

Evaluate if the identified genetic variants are efficient and reproducible biomarkers for use in the clinic.

Elucidate epithelial involvement in regulating the intestinal inflammation seen in IBD through gene expression analyses of epithelial cells from IBD patients and experiments in patient-derived epithelial cell lines.

Characterize the role of serotonin and epithelial serotonin reuptake transporter in intestinal fibrosis.

It is our goal that our research should have a direct impact on IBD treatment and prognosis, either through the improvement of clinical practice or by ensuring a greater understanding of IBD pathophysiology.

Publications

2026

Walaas, Gunnar Andreas Enerhaug; Sridhar, Arun; Kuraas, Lusie Frostvoll; Sæterstad, Siri; Schioldborg, Amanda Yin; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Østvik, Ann Elisabeth; Bakke, Ingunn; Bruland, Torunn. (2026) Patient-matched transcriptomics of in vivo and in vitro colonic epithelium substantiate organoids as a translational model for ulcerative colitis. Scientific Reports
Academic article
Hjelle, Heidi; Myklebust, Tor Åge; Granlund, Atle van Beelen; Østvik, Ann Elisabeth; Ness-Jensen, Eivind. (2026) Long-term changes in disease extent and severity in ulcerative colitis: a population-based cohort from the Norwegian HUNT study, (2002–2024). Scandinavian Journal of Gastroenterology
Academic article

2025

Hjelle, Heidi; Myklebust, Tor Åge; Granlund, Atle van Beelen; Østvik, Ann Elisabeth; Ness-Jensen, Eivind. (2025) Changes in prevalence and incidence of inflammatory bowel disease over 30 years: a population-based cohort study, the HUNT study. Scandinavian Journal of Gastroenterology
Academic article

2024

Campo, Martin; Hjelle, Heidi; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Ness-Jensen, Eivind. (2024) The relationship between weight change and inflammatory bowel disease. A population-based cohort study, the HUNT study. Scandinavian Journal of Gastroenterology
Academic article
Sæterstad, Siri; Østvik, Ann Elisabeth; Hansen, Marianne Dore; Bruland, Torunn; Granlund, Atle van Beelen. (2024) The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response. Journal of Translational Medicine
Academic article
Sæterstad, Siri; Østvik, Ann Elisabeth; Hansen, Marianne Dore; Bruland, Torunn; Granlund, Atle van Beelen. (2024) Correction to: The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response(Journal of Translational Medicine, (2024), 22, 1, (750), 10.1186/s12967-024-05532-w). Journal of Translational Medicine
Corrigendum

2023

Catalan-Serra, Ignacio; Thorsvik, Silje; Beisvag, Vidar; Bruland, Torunn; Underhill, David; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2023) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course. Inflammatory Bowel Diseases
Academic article
Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn. (2023) Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids. Frontiers in Immunology
Academic article
Balderramo, Domingo C.; Romagnoli, Pablo Alberto; Granlund, Atle van Beelen; Catalan-Serra, Ignacio. (2023) Fecal Fungal Microbiota (Mycobiome) Study as a Potential Tool for Precision Medicine in Inflammatory Bowel Disease. Gut and Liver
Academic literature review

2022

Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar. (2022) The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course. Frontiers in Medicine
Academic article
Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn. (2022) Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium. Frontiers in Immunology
Academic article
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2022) Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease. PLOS ONE
Academic article

2021

Escudero-Hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Münch, Andreas. (2021) Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH)
Academic article
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet. (2021) Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis. Journal of gastroenterology
Academic article
Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias; Thorsvik, Silje; Flatberg, Arnar; Sporsheim, Bjørnar; Ostrop, Jenny. (2021) Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration. Frontiers in Pharmacology
Academic article

2020

Olaisen, Maya; Flatberg, Arnar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Martinsen, Tom Christian; Sandvik, Arne Kristian; Fossmark, Reidar. (2020) Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease. Inflammatory Bowel Diseases
Academic article
Escudero-Hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Münch, Andreas. (2020) Whole-genome RNA sequencing in collagenous colitis: a subgroup analysis. Journal of Crohn`s and Colitis
Conference abstract
Sæterstad, Siri; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2020) Gene expression landscape of epithelial monolayer in inflammatory bowel disease. Journal of Crohn`s and Colitis
Conference abstract
Bakke, Ingunn; Bruland, Torunn; Eriksen, Kaja Sørgård; Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Thorsvik, Silje; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Østvik, Ann Elisabet. (2020) Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease. Journal of Crohn`s and Colitis
Conference abstract
Walaas, Gunnar Andreas; Bakke, Ingunn; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Bruland, Torunn; Røyset, Elin Synnøve; Thorsvik, Silje; Münch, Andreas; Østvik, Ann Elisabet; Sandvik, Arne Kristian. (2020) Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker in collagenous colitis. Journal of Crohn`s and Colitis
Conference abstract
Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan. (2020) The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis. Journal of Crohn's and Colitis
Academic article
Jørandli, Jonas Woll; Thorsvik, Silje; Skovdahl, Helene Kolstad; Kornfeld, Benedikt; Sæterstad, Siri; Gustafsson, Björn; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2020) The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik. (2020) Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease. Journal of Crohn's and Colitis
Academic article
Olaisen, Maya; Flatberg, Arnar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Martinsen, Tom Christian; Sandvik, Arne Kristian; Fossmark, Reidar. (2020) P833 Bacterial mucosa-associated microbiome in inflamed and proximal non-inflamed ileum of patients with Crohn’s disease. Journal of Crohn's and Colitis
Conference abstract

2019

Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian. (2019) Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis. Alimentary Pharmacology and Therapeutics
Academic article
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian. (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology
Academic article

2018

Thorsvik, Silje; Bakke, Ingunn; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Damås, Jan Kristian; Østvik, Ann Elisabeth; Sandvik, Arne Kristian. (2018) Expression of neutrophil gelatinase-associated lipocalin (NGAL) in the gut in Crohn's disease. Cell and Tissue Research
Academic article
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Skovdahl, Helene Kolstad; Mollnes, Tom Eirik; Gustafsson, Björn. (2018) Tu1753 - type 1 Interferon Signaling in Intestinal Epithelial Cells During Active Inflammatory Bowel Disease. Gastroenterology
Conference abstract
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian. (2018) C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release. International Journal of Molecular Sciences
Academic article

2017

Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian. (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology
Academic article

2015

Goll, Rasmus; Granlund, Atle Van Beelen. (2015) Intestinal barrier homeostasis in inflammatory bowel disease. Scandinavian Journal of Gastroenterology
Academic literature review
Granlund, Atle Van Beelen. (2015) Den intentinale barriærefunksjon og dets rolle i inflammatorisk tarmsykdom. BestPractice Gastroenterologi
Professional article
Granlund, Atle Van Beelen. (2015) RNA sequencing of laser microdissected tissue - Towards resolving the complex tissue problem. NBS-nytt
Professional article
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bruland, Torunn; Bakke, Ingunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian. (2015) Expression of CCL20 and its corresponding receptor CCR6 is enhanced in active inflammatory bowel disease, and TLR3 mediates CCL20 expression in colonic epithelial cells. PLOS ONE
Academic article
Brenna, Øystein; Bruland, Torunn; Furnes, Marianne Waldum; Granlund, Atle Van Beelen; Drozdov, Ignat; Emgård, Johanna; Brønstad, Gunnar; Kidd, Mark; Sandvik, Arne Kristian; Gustafsson, Björn. (2015) The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease. Scandinavian Journal of Gastroenterology
Academic article

2014

Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Gustafsson, Björn; Torp, Sverre Helge; Espevik, Terje; Mollnes, Tom Eirik; Damås, Jan Kristian; Sandvik, Arne Kristian. (2014) Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease. Inflammatory Bowel Diseases
Academic article

2013

Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Flatberg, Arnar; Sandvik, Arne Kristian; Zwiggelaar, Rosalie; Mårvik, Ronald; Nordrum, Ivar Skjåk; Kidd, Mark. (2013) Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Historical and Transcripttomic Characterization and Correlation to IBD. PLOS ONE
Academic article
Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Svendsen, Tarjei D.; Jørandli, Jonas W.; Flatberg, Arnar; Zwiggelaar, Rosalie; Nordrum, Ivar Skjåk; Sandvik, Arne. (2013) Su1771 Reduced Guanylate Cyclase C Signaling in IBD May Sustain Inflammation, Epithelial Barrier Dysfunction and Increase Cancer Risk in IBD. Gastroenterology
Conference abstract
Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Brenna, Øystein; Torp, Sverre Helge; Gustafsson, Björn; Sandvik, Arne Kristian. (2013) REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation. Cell and Tissue Research
Academic article
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian. (2013) Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation. Inflammatory Bowel Diseases
Academic article
Granlund, Atle Van Beelen. (2013) Nye doktorgrader - Atle van Beelen Granlund. NBS-nytt
Conference abstract
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian. (2013) Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis. PLOS ONE
Academic article
Granlund, Atle Van Beelen. (2013) Colonic mucosal gene expression in inflammatory bowel disease. NTNU
Doctoral thesis
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology
Academic article

2012

Chin, A; Svejda, B; Gustafsson, Björn; Granlund, Atle Van Beelen; Sandvik, Arne Kristian; Timberlake, Alan; Sumpio, B; Pfragner, R; Modlin, IM; Kidd, M. (2012) The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Brenna, Øystein; Furnes, Marianne Waldum; Granlund, Atle; Flatberg, Arnar; Drozdov, Ignat; Sandvik, Arne Kristian; Zwiggelaar, Rosalie; Mårvik, Ronald; Nordrum, Ivar Skjåk; Kidd, Mark. (2012) Tu1912 Endoscopic, Histological and Transcriptomic Characterization of TNBS-Colitis in Rats, a Model for IBD. Gastroenterology
Conference abstract
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Waldum, Helge; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2012) Induction of Lipocalin-2 in Colonic Epithelial Cells in Inflammatory Bowel Disease. Inflammatory Bowel Diseases
Conference abstract
Østvik, Ann Elisabet; Nilsen, Nadra; Granlund, Atle; Torp, Sverre Helge; Flatberg, Arnar; Waldum, Helge; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2012) Enhanced expression of CXCL10 in inflammatory bowel disease-role of mucosal TLR3 stimulation. Journal of Crohn’s and Coltis Supplements
Conference abstract
Granlund, Atle; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, I; Gustafsson, Björn; Kidd, M; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian. (2012) Dissecting the IBD Transcriptome. Inflammatory Bowel Diseases
Conference abstract

2011

Granlund, Atle Van Beelen; Beisvag, Vidar; Torp, Sverre Helge; Flatberg, Arnar; Kleveland, Per Martin; Østvik, Ann Elisabet; Waldum, Helge; Sandvik, Arne Kristian. (2011) Activation of REG family proteins in colitis. Scandinavian Journal of Gastroenterology
Academic article

2005

Granlund, Atle van Beelen; Johansen, Berit. (2005) The development of a method for the study of gastrin induced cell responses using MALDI-TOF mass spectrometry and chemometrics. NTNU, Institutt for biologi
Master thesis

Journal publications

Walaas, Gunnar Andreas Enerhaug; Sridhar, Arun; Kuraas, Lusie Frostvoll; Sæterstad, Siri; Schioldborg, Amanda Yin; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Østvik, Ann Elisabeth; Bakke, Ingunn; Bruland, Torunn. (2026) Patient-matched transcriptomics of in vivo and in vitro colonic epithelium substantiate organoids as a translational model for ulcerative colitis. Scientific Reports
Academic article
Hjelle, Heidi; Myklebust, Tor Åge; Granlund, Atle van Beelen; Østvik, Ann Elisabeth; Ness-Jensen, Eivind. (2026) Long-term changes in disease extent and severity in ulcerative colitis: a population-based cohort from the Norwegian HUNT study, (2002–2024). Scandinavian Journal of Gastroenterology
Academic article
Hjelle, Heidi; Myklebust, Tor Åge; Granlund, Atle van Beelen; Østvik, Ann Elisabeth; Ness-Jensen, Eivind. (2025) Changes in prevalence and incidence of inflammatory bowel disease over 30 years: a population-based cohort study, the HUNT study. Scandinavian Journal of Gastroenterology
Academic article
Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian. (2017) Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. Journal of Gastroenterology and Hepatology
Academic article
Chin, A; Svejda, B; Gustafsson, Björn; Granlund, Atle Van Beelen; Sandvik, Arne Kristian; Timberlake, Alan; Sumpio, B; Pfragner, R; Modlin, IM; Kidd, M. (2012) The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Flatberg, Arnar; Sandvik, Arne Kristian; Zwiggelaar, Rosalie; Mårvik, Ronald; Nordrum, Ivar Skjåk; Kidd, Mark. (2013) Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Historical and Transcripttomic Characterization and Correlation to IBD. PLOS ONE
Academic article
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian. (2019) Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis. Alimentary Pharmacology and Therapeutics
Academic article
Escudero-Hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Münch, Andreas. (2021) Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH)
Academic article
Brenna, Øystein; Furnes, Marianne Waldum; Drozdov, Ignat; Granlund, Atle Van Beelen; Svendsen, Tarjei D.; Jørandli, Jonas W.; Flatberg, Arnar; Zwiggelaar, Rosalie; Nordrum, Ivar Skjåk; Sandvik, Arne. (2013) Su1771 Reduced Guanylate Cyclase C Signaling in IBD May Sustain Inflammation, Epithelial Barrier Dysfunction and Increase Cancer Risk in IBD. Gastroenterology
Conference abstract
Brenna, Øystein; Furnes, Marianne Waldum; Granlund, Atle; Flatberg, Arnar; Drozdov, Ignat; Sandvik, Arne Kristian; Zwiggelaar, Rosalie; Mårvik, Ronald; Nordrum, Ivar Skjåk; Kidd, Mark. (2012) Tu1912 Endoscopic, Histological and Transcriptomic Characterization of TNBS-Colitis in Rats, a Model for IBD. Gastroenterology
Conference abstract
Thorsvik, Silje; Bakke, Ingunn; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Damås, Jan Kristian; Østvik, Ann Elisabeth; Sandvik, Arne Kristian. (2018) Expression of neutrophil gelatinase-associated lipocalin (NGAL) in the gut in Crohn's disease. Cell and Tissue Research
Academic article
Olaisen, Maya; Flatberg, Arnar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Martinsen, Tom Christian; Sandvik, Arne Kristian; Fossmark, Reidar. (2020) Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease. Inflammatory Bowel Diseases
Academic article
Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Brenna, Øystein; Torp, Sverre Helge; Gustafsson, Björn; Sandvik, Arne Kristian. (2013) REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation. Cell and Tissue Research
Academic article
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Waldum, Helge; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2012) Induction of Lipocalin-2 in Colonic Epithelial Cells in Inflammatory Bowel Disease. Inflammatory Bowel Diseases
Conference abstract
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Skovdahl, Helene Kolstad; Mollnes, Tom Eirik; Gustafsson, Björn. (2018) Tu1753 - type 1 Interferon Signaling in Intestinal Epithelial Cells During Active Inflammatory Bowel Disease. Gastroenterology
Conference abstract
Østvik, Ann Elisabet; Nilsen, Nadra; Granlund, Atle; Torp, Sverre Helge; Flatberg, Arnar; Waldum, Helge; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2012) Enhanced expression of CXCL10 in inflammatory bowel disease-role of mucosal TLR3 stimulation. Journal of Crohn’s and Coltis Supplements
Conference abstract
Campo, Martin; Hjelle, Heidi; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Ness-Jensen, Eivind. (2024) The relationship between weight change and inflammatory bowel disease. A population-based cohort study, the HUNT study. Scandinavian Journal of Gastroenterology
Academic article
Sæterstad, Siri; Østvik, Ann Elisabeth; Hansen, Marianne Dore; Bruland, Torunn; Granlund, Atle van Beelen. (2024) The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response. Journal of Translational Medicine
Academic article
Catalan-Serra, Ignacio; Thorsvik, Silje; Beisvag, Vidar; Bruland, Torunn; Underhill, David; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2023) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course. Inflammatory Bowel Diseases
Academic article
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet. (2021) Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis. Journal of gastroenterology
Academic article
Escudero-Hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Münch, Andreas. (2020) Whole-genome RNA sequencing in collagenous colitis: a subgroup analysis. Journal of Crohn`s and Colitis
Conference abstract
Sæterstad, Siri; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2020) Gene expression landscape of epithelial monolayer in inflammatory bowel disease. Journal of Crohn`s and Colitis
Conference abstract
Bakke, Ingunn; Bruland, Torunn; Eriksen, Kaja Sørgård; Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Thorsvik, Silje; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Østvik, Ann Elisabet. (2020) Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease. Journal of Crohn`s and Colitis
Conference abstract
Walaas, Gunnar Andreas; Bakke, Ingunn; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Bruland, Torunn; Røyset, Elin Synnøve; Thorsvik, Silje; Münch, Andreas; Østvik, Ann Elisabet; Sandvik, Arne Kristian. (2020) Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker in collagenous colitis. Journal of Crohn`s and Colitis
Conference abstract
Granlund, Atle Van Beelen; Beisvag, Vidar; Torp, Sverre Helge; Flatberg, Arnar; Kleveland, Per Martin; Østvik, Ann Elisabet; Waldum, Helge; Sandvik, Arne Kristian. (2011) Activation of REG family proteins in colitis. Scandinavian Journal of Gastroenterology
Academic article
Goll, Rasmus; Granlund, Atle Van Beelen. (2015) Intestinal barrier homeostasis in inflammatory bowel disease. Scandinavian Journal of Gastroenterology
Academic literature review
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian. (2013) Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation. Inflammatory Bowel Diseases
Academic article
Granlund, Atle; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, I; Gustafsson, Björn; Kidd, M; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian. (2012) Dissecting the IBD Transcriptome. Inflammatory Bowel Diseases
Conference abstract
Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan. (2020) The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis. Journal of Crohn's and Colitis
Academic article
Granlund, Atle Van Beelen. (2013) Nye doktorgrader - Atle van Beelen Granlund. NBS-nytt
Conference abstract
Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar. (2022) The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course. Frontiers in Medicine
Academic article
Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn. (2023) Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids. Frontiers in Immunology
Academic article
Granlund, Atle Van Beelen. (2015) Den intentinale barriærefunksjon og dets rolle i inflammatorisk tarmsykdom. BestPractice Gastroenterologi
Professional article
Granlund, Atle Van Beelen. (2015) RNA sequencing of laser microdissected tissue - Towards resolving the complex tissue problem. NBS-nytt
Professional article
Balderramo, Domingo C.; Romagnoli, Pablo Alberto; Granlund, Atle van Beelen; Catalan-Serra, Ignacio. (2023) Fecal Fungal Microbiota (Mycobiome) Study as a Potential Tool for Precision Medicine in Inflammatory Bowel Disease. Gut and Liver
Academic literature review
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bruland, Torunn; Bakke, Ingunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian. (2015) Expression of CCL20 and its corresponding receptor CCR6 is enhanced in active inflammatory bowel disease, and TLR3 mediates CCL20 expression in colonic epithelial cells. PLOS ONE
Academic article
Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn. (2022) Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium. Frontiers in Immunology
Academic article
Sæterstad, Siri; Østvik, Ann Elisabeth; Hansen, Marianne Dore; Bruland, Torunn; Granlund, Atle van Beelen. (2024) Correction to: The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response(Journal of Translational Medicine, (2024), 22, 1, (750), 10.1186/s12967-024-05532-w). Journal of Translational Medicine
Corrigendum
Brenna, Øystein; Bruland, Torunn; Furnes, Marianne Waldum; Granlund, Atle Van Beelen; Drozdov, Ignat; Emgård, Johanna; Brønstad, Gunnar; Kidd, Mark; Sandvik, Arne Kristian; Gustafsson, Björn. (2015) The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease. Scandinavian Journal of Gastroenterology
Academic article
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Gustafsson, Björn; Torp, Sverre Helge; Espevik, Terje; Mollnes, Tom Eirik; Damås, Jan Kristian; Sandvik, Arne Kristian. (2014) Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease. Inflammatory Bowel Diseases
Academic article
Jørandli, Jonas Woll; Thorsvik, Silje; Skovdahl, Helene Kolstad; Kornfeld, Benedikt; Sæterstad, Siri; Gustafsson, Björn; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2020) The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian. (2018) C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release. International Journal of Molecular Sciences
Academic article
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik. (2020) Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease. Journal of Crohn's and Colitis
Academic article
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian. (2013) Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis. PLOS ONE
Academic article
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian. (2019) Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels. Journal of Pathology
Academic article
Olaisen, Maya; Flatberg, Arnar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Martinsen, Tom Christian; Sandvik, Arne Kristian; Fossmark, Reidar. (2020) P833 Bacterial mucosa-associated microbiome in inflamed and proximal non-inflamed ileum of patients with Crohn’s disease. Journal of Crohn's and Colitis
Conference abstract
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen. (2022) Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease. PLOS ONE
Academic article
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian. (2013) Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clinical and Experimental Immunology
Academic article
Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias; Thorsvik, Silje; Flatberg, Arnar; Sporsheim, Bjørnar; Ostrop, Jenny. (2021) Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration. Frontiers in Pharmacology
Academic article

Student thesis or dissertation

Granlund, Atle van Beelen; Johansen, Berit. (2005) The development of a method for the study of gastrin induced cell responses using MALDI-TOF mass spectrometry and chemometrics. NTNU, Institutt for biologi
Master thesis
Granlund, Atle Van Beelen. (2013) Colonic mucosal gene expression in inflammatory bowel disease. NTNU
Doctoral thesis

Outreach