Background and activities

Our research explores how genes and gene expression in IBD patients differ from healthy controls. We are interested in what gene variants and gene expression within the IBD patient cohort can tell us about each individual's disease prognosis and treatment response.

 

We perform large genome and gene expression analyses of patient samples and patient-derived cell cultures and correlate these results with clinical observations identifying genes and processes that can be used clinically for improved, more precise treatment and diagnosis. Identified processes and gene variants are followed up to better understand the mechanisms underlying the observed difference. All studies are performed in close collaboration with the other units within CAG-IBD, as well as the clinic.

Objectives for ongoing research activities:

  • Identify genetic variants that predispose to a complicated disease course and poor treatment outcomes in IBD.
  • Characterize the mechanisms underlying the effect of these genetic variants, for example through sequence variants in miRNA binding sites.
  • Evaluate if the identified genetic variants are efficient and reproducible biomarkers for use in the clinic.
  • Elucidate epithelial involvement in regulating the intestinal inflammation seen in IBD through gene expression analyses of epithelial cells from IBD patients and experiments in patient-derived epithelial cell lines.
  • Characterize the role of serotonin and epithelial serotonin reuptake transporter in intestinal fibrosis. 
  • It is our goal that our research should have a direct impact on IBD treatment and prognosis, either through the improvement of clinical practice or by ensuring a greater understanding of IBD pathophysiology.

    Scientific, academic and artistic work

    Displaying a selection of activities. See all publications in the database

    Journal publications