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Avneesh Jain

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Avneesh Jain

Phd Candidate : Brain MRS
Department of Neuromedicine and Movement Science

avneesh.jain@ntnu.no
NFNEVBIO 130 Nevrosenteret Øya, Trondheim
About Research Publications Outreach

About

PhD student at the Department of Neuromedicine and Movement Science (INB), and a part of the Norwegian Centre for Headache Research (NorHead) and St. Olav's University Hospital. In our study, we investigate cortical hyperexcitability in primary headache disorders: Chronic migraine and chronic cluster headache or "suicide headache" with MR spectroscopy using an ultrahigh-field 7T MR scanner.

Previously worked as a research associate at NorHead and K.G. Jebsen Centre for Alzheimer’s Disease (JCA) on 1H MRS, 31P MRS, and CEST imaging scan protocol, optimization, and piloting in patient groups for chronic cluster headache (thalamus and hypothalamus); transient global amnesia (TGA; medial temporal lobe) and characterization of macromolecular changes linked to aging and Alzheimer’s disease (Hippocampus).  

Competencies

  • Aging and emotions neuroscience
  • Alzheimer's Disease
  • Magnetic Resonance Imaging
  • Magnetic Resonance Physics
  • Magnetic Resonance Spectroscopy
  • Neurometabolism
  • Primary headache disorders
  • Ultrahigh Field 7-Tesla

Research

  • NorHead

HYPE : Cortical hyperexcitability in Chronic Migraine

This study is aimed to enhance our understanding of cortical hyperexcitability in Chronic Migraine (with and without aura) and to provide metrics (primarily the T2 of Glu) for developing targeted therapeutic interventions.

Dynamic MRS : REPRO

The aim of this study is to set up a multi Echo time (TE) experiment, in order to provide a reliable and robust measurement of the T2 relaxation of metabolites, with a specific interest for the T2 of Glutamate for detecting neurotransmission impairments.

Implementation of advanced 7T MR methods in personalization of the treatment of brain disorders

This project was aimed to develop a research platform for advanced in vivo magnetic resonance spectroscopy (MRS) methods at NTNU and St Olav university hospital.

Aging & Resilience Study

To unravel neurobiological mechanisms underlying emotional responses to ultimately design effective interventions that help prevention and treatment of psychiatric symptoms, such as depression and anxiety, across ageing. (Previous work)

Publications

Resilience-driven neural synchrony during naturalistic movie watching: an ultra-high field fMRI study

Sharing others’ emotional states may facilitate the understanding of their well-being characteristics, such as resilience (Under peer-review)
  • Chronological
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  • All publications registered in NVA

Outreach

Scientific Lecture : European Headache Congress, Lisbon, 2025

Evidence of mitochondrial dysfunction and disrupted neuronal energy metabolism in hypothalamic neurons in Chronic Cluster Headache: A 7-Tesla ¹H MR Spectroscopy Study.

Migrene i et livsløpsperspektiv, Hodepineaften, Trondheim, 2025

Presenterer vår nye forskningsstudie om Kronisk Migrene og hypereksitabilitet ved bruk av 7T 1H-MRS

Proffered Abstract : Center for Magnetic Resonance Research, Minneapolis, Minnesota, 2025

Towards reliable Glutamate T2 quantification at 7T: Role of macromolecules and model choice. To investigate the Influence of macromolecular background on the evaluation of glutamate (Glu) transverse relaxation time (T₂).

Lecture : European Headache Congress, Rotterdam 2024

Studying the metabolic profile of chronic cluster headache (cCH) in pain perception-related areas could provide novel, useful clinical information

Scientific talk : European Society for Magnetic Resonance in Medicine, Barcelona, 2024.

Higher thalamic myo-Inositol measured at 7T suggests novel mechanisms in chronic cluster headaches.

2024

  • Poster
    Jain, Avneesh; Rørnes, Anna Xiu; Farestveit, Anne; Grinde, Maria; Nyman, Axel Karl Gottfrid; Sitter, Beathe. (2024) Higher thalamic myo-Inositol measured at 7T using 1H-MR spectroscopy suggests novel mechanisms in chronic cluster headaches. 18th European Headache Concgress 2024-12-04 - 2024-12-07
  • Academic lecture
    Jain, Avneesh; Rørnes, Anna Xiu; Farestveit, Anne; Grinde, Maria; Nyman, Axel Karl Gottfrid; Sitter, Beathe. (2024) Higher thalamic myo-Inositol measured at 7Tesla suggests novel mechanisms in chronic cluster headaches. European Society for Magnetic Resonance in Medicine and Biology 40th Annual Scientific Meeting 2024-10-02 - 2024-10-05

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