Bent Håvard Hellum
About
Publications
2017
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Hellum, Bent Håvard.
(2017)
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product.
Pharmacology Research & Perspectives
Academic article
2016
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
European Journal of Clinical Pharmacology
Academic article
-
Thu, Ole Kristian Forstrønen;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products.
Pharmaceutical Biology
Academic article
-
Gustavsen, Marita;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Simultaneous determination of in vitro CYP-activities in human microsomes usin hops as a CYP trial inhibitor. A method development study.
NTNU
Master thesis
-
Syrstad, Ingvild Helø;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2016)
In vitro Inhibition of CYP3A4 by VitaePro.
Norges teknisk-naturvitenskapelige universitet
Master thesis
2015
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2015)
Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs.
Phytotherapy Research
Academic article
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard.
(2015)
Bruk av og holdninger til kommersielle naturprodukter hos medisin- og sykepleierstudenter.
NTNU-trykk
Master thesis
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg;
Spigset, Olav.
(2015)
Cytochrome P-450 (CYP) inhibition by commercial Rhodiola rosea products in vitro and in humans and the relevance of their constituents.
NTNU-trykk
Master thesis
2014
-
Bjørneboe, Lars H;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2014)
In vitro CYP3A4 inhibition by fractionated Rhodiola rosea extracts.
Drug metabolism reviews (Softcover ed.)
Conference abstract
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products.
Drug metabolism reviews (Softcover ed.)
Conference abstract
-
Djuv, Ane;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism.
Drug metabolism reviews (Softcover ed.)
Conference abstract
2013
-
Ystenæs, Charlotte;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2013)
A comparison of the in vitro inhibitory effect of ginger (Zingiber Officinale) on the CYP3A4 and CYP3A5 mediated metabolism of testosterone. Student thesis (hovedoppgave) in medicine.
NTNU-trykk
Master thesis
2012
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2012)
The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy Research
Academic article
-
Bjørnebo, Lars Henrik;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2012)
The Inhibitory Effect of Fractioned Rhodioala Rosea on CYP3A4 Mediated Metabolism-in Vitro. Student thesis in medicine.
NTNU trykk
Master thesis
2011
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2011)
Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje's cocktail.
Toxicology Letters
Conference abstract
2010
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2010)
Bioanalytical method validation for measuring Indinavir in plasma by LCMSMS.
NTH trykk
Research report
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2010)
Validation document of analytical assays used in the "Inje cocktail" for phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A.
NTNU TRYKK
Research report
-
Hellum, Bent Håvard;
Tøsse, Anita;
Høybakk, Kathrine;
Thomsen, Mette;
Rohloff, Jens;
Nilsen, Odd Georg.
(2010)
Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola rosea.
Planta Medica
Academic article
2009
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2009)
Trade Herbal Products and Induction of CYP2C19 and CYP2E1 in Cultured Human Hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
2008
-
Nilsen, Odd Georg;
Engdal, Silje;
Hellum, Bent Håvard.
(2008)
Farlige forbindelser.
Athene
Popular science article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
Urters virkning på omsetning av legemidler i kroppen.
Interaksjonsforskningsgruppen
Working paper
2007
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2007)
The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
DOKTORGRADSAVHANDLING: In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport.
Universitetsforlaget
Doctoral thesis
Journal publications
-
Nilsen, Odd Georg;
Engdal, Silje;
Hellum, Bent Håvard.
(2008)
Farlige forbindelser.
Athene
Popular science article
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
European Journal of Clinical Pharmacology
Academic article
-
Thu, Ole Kristian Forstrønen;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products.
Pharmaceutical Biology
Academic article
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2011)
Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje's cocktail.
Toxicology Letters
Conference abstract
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2009)
Trade Herbal Products and Induction of CYP2C19 and CYP2E1 in Cultured Human Hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2015)
Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs.
Phytotherapy Research
Academic article
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2012)
The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy Research
Academic article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2007)
The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.
Basic & Clinical Pharmacology & Toxicology
Academic article
-
Bjørneboe, Lars H;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2014)
In vitro CYP3A4 inhibition by fractionated Rhodiola rosea extracts.
Drug metabolism reviews (Softcover ed.)
Conference abstract
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Hellum, Bent Håvard.
(2017)
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product.
Pharmacology Research & Perspectives
Academic article
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products.
Drug metabolism reviews (Softcover ed.)
Conference abstract
-
Djuv, Ane;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism.
Drug metabolism reviews (Softcover ed.)
Conference abstract
-
Hellum, Bent Håvard;
Tøsse, Anita;
Høybakk, Kathrine;
Thomsen, Mette;
Rohloff, Jens;
Nilsen, Odd Georg.
(2010)
Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola rosea.
Planta Medica
Academic article
Report
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2010)
Bioanalytical method validation for measuring Indinavir in plasma by LCMSMS.
NTH trykk
Research report
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2010)
Validation document of analytical assays used in the "Inje cocktail" for phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A.
NTNU TRYKK
Research report
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
Urters virkning på omsetning av legemidler i kroppen.
Interaksjonsforskningsgruppen
Working paper
Student thesis or dissertation
-
Gustavsen, Marita;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Simultaneous determination of in vitro CYP-activities in human microsomes usin hops as a CYP trial inhibitor. A method development study.
NTNU
Master thesis
-
Ystenæs, Charlotte;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2013)
A comparison of the in vitro inhibitory effect of ginger (Zingiber Officinale) on the CYP3A4 and CYP3A5 mediated metabolism of testosterone. Student thesis (hovedoppgave) in medicine.
NTNU-trykk
Master thesis
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard.
(2015)
Bruk av og holdninger til kommersielle naturprodukter hos medisin- og sykepleierstudenter.
NTNU-trykk
Master thesis
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg;
Spigset, Olav.
(2015)
Cytochrome P-450 (CYP) inhibition by commercial Rhodiola rosea products in vitro and in humans and the relevance of their constituents.
NTNU-trykk
Master thesis
-
Syrstad, Ingvild Helø;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2016)
In vitro Inhibition of CYP3A4 by VitaePro.
Norges teknisk-naturvitenskapelige universitet
Master thesis
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
DOKTORGRADSAVHANDLING: In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport.
Universitetsforlaget
Doctoral thesis
-
Bjørnebo, Lars Henrik;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2012)
The Inhibitory Effect of Fractioned Rhodioala Rosea on CYP3A4 Mediated Metabolism-in Vitro. Student thesis in medicine.
NTNU trykk
Master thesis
Teaching
Courses
Outreach
2018
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Lecture
2017
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LectureHellum, Bent Håvard. (2017) Pille- og urtebruk, kan det kombineres?. Årsmøte Førde pensjonistforening
2016
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Conference lectureThu, Ole Kristian Forstrønen; Nilsen, Odd Georg; Spigset, Olav; Hellum, Bent Håvard. (2016) Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Annual Winter Meeting NSFT
-
Conference posterSyrstad, Ingvild Helø; Nilsen, Odd Georg; Hellum, Bent Håvard. (2016) In vitro inhibition of human CYP3A4 by VitaePro. Annual Winter Meeting NSFT
-
Conference posterGustavsen, Marita; Nilsen, Odd Georg; Hellum, Bent Håvard. (2016) In vitro inhibition of human CYP enzymes by hops (Humulus lupulus). A “cocktail” study. Annual Winter Meeting NSFT
2015
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LectureHellum, Bent Håvard. (2015) Pasienter og urtebruk: finnes det farlige legemiddel-urt kombinasjoner?. Vårmøte Brystkreftforeningen
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LectureHellum, Bent Håvard. (2015) Samvirkninger av kjemikalier i kroppen. Konferanse Norsk Yrkeshygienisk Forening
2013
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LectureNilsen, Odd Georg; Djuv, Ane; Langhammer, Astrid Jordet; Thu, Ole Kristian; Hellum, Bent Håvard. (2013) Possible significance of CYP inhibition for acetaminophen/other drugs toxicity and increase of clinical efficacy of indinavir in patients in and outside of general practice. Internal meeting at China Academy of Chinese Medical Sciences
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Conference posterThu, Ole Kristian F.; Hellum, Bent Håvard; Nilsen, Odd Georg. (2013) Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products. 10th International ISSX Meeting, Toronto
-
Conference posterDjuv, Ane; Hellum, Bent Håvard; Nilsen, Odd Georg. (2013) Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism. 10th International ISSX Meeting, Toronto
-
Conference posterBjørneboe, Lars H; Nilsen, Odd Georg; Hellum, Bent Håvard. (2013) In vitro CYP3A4 inhibition by fractionated Rhodeola rosea extracts. 10th International ISSX Meeting, Toronto
2011
-
Conference posterHellum, Bent Håvard; Nilsen, Odd Georg; Spigset, Olav. (2011) Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje’s cocktail. Eurotox 2011
2010
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Conference lectureHellum, Bent Håvard. (2010) An in vivo cocktail approach for evaluating herb-drug interactions -validation of bioanalytical methods. Monday meeting
2008
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Conference posterEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg. (2008) In Vitro Inhibition of CYP3A4 by Herbal Remedies. 15th North American Regional ISSX metting, San Diego
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Conference lectureHellum, Bent Håvard. (2008) Legemiddel-urt interaksjoner. Tirsdagsmøte for DMF, NTNU og St. Olavs Hospital
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Interview
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Lundh, Francis. (2008) Naturmedisin til kreftpasienter kan være farlig.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Brækhus, Leni Aurora. (2008) Naturmidler påvirker kreftbehandling.
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Conference posterHellum, Bent Håvard; Nilsen, Odd Georg. (2008) Comparison of the in vitro inhibition potential of six trade herbal products on CYP3A4 metabolism and P-glycoprotein efflux transport. Annual winter meeting NSFT
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Monsen, Tor Harald. (2008) Advarer mot urtemedisin.
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Moseng, Marianne. (2008) Advarer mot naturlegemidler- farlig i miks med medisiner.
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Conference posterHøybakk, Kathrine; Tøsse, Anita; Nilsen, T.; Engdal, Silje; Hellum, Bent Håvard; Rohloff, Jens; Thomsen, Mette; Nilsen, Odd Georg. (2008) Effect of Goldenroot (Rhodiola rosea) on P-glycoprotein and CYP3A4 in vitro. Annual Winter Meeting NSFT
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InterviewNilsen, Odd Georg; Hellum, Bent Håvard; Engdal, Silje; Steenstrup, Anne. (2008) Interesse for helsekostforskning.
2007
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg. (2007) Grapefrukt og viagra kan være livsfarlig.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Moseng, Marianne. (2007) Naturmidler kan forsterke medisiner.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Gråberg, Marte. (2007) Kreftmedisin og naturpreparater - en farlig kombinasjon?.
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Interview
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Tunstad, Hege J.. (2007) Farlige forbindelser.
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InterviewHellum, Bent Håvard; Engdal, Silje; Djuv, Ane; Nilsen, Odd Georg; Tilseth, Trond Ola. (2007) Viagra -og grapefruktjuice, potensielt farlig blanding av naturmedisin og legemiddel.
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Conference posterHellum, Bent Håvard; Nilsen, Odd Georg. (2007) CYP2D6 inhibition by herbal products. Pharmaceutical Science World Congress, Amsterdam.
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Conference posterHellum, Bent Håvard; Nilsen, Odd Georg. (2007) CYP2D6 inhibition by medicinal herbs. Annual Winter Meeting NSFT
2006
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Conference lecture
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Conference posterHellum, Bent Håvard; Nilsen, Odd Georg; Yang, Shu; Fang, Sishi; Mao, Yuchang; Tan, Jinxing; Yang, Youming; Hu, Zhuohan. (2006) An In Vitro Evaluation of the Inductive Potential of St. Johns Wort, Horse Chestnut, Common Sage, Gingko Biloba, Common Valerian and Echinacea Purpurea on Cytochrome P450 Activities in Human Primary Hepatocytes. 1st Asia/ Pacific International Society for the Study of Xenobiotics Meeting
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Conference posterHellum, Bent Håvard; Yang, Shu; Hu, Zhuohan; Nilsen, Odd Georg. (2006) The induction of CYP1A2 and 3A4 by six trade herbal products in primary human hepatocytes. Annual Meeting The Norwegian Society of Pharmacology and Toxicology, Beito
2005
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Conference lectureHellum, Bent Håvard; Yang, Shu; Fang, Sishi; Mao, Yuchang; Wang, Min; Hu, Zhuohan; Nilsen, Odd Georg. (2005) Inductive potentials of six natural products marked in Norway on CYP1A2, 2D6 and 3A4 by using human primary hepatocytes. III-International Conference on Drug Metabolism
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Conference posterHellum, Bent Håvard; Skålvoll, Anja Kristina; Nilsen, Odd Georg. (2005) In vitro cytochrome P-450 isoform assays for evaluation of drug-herb metabolic interactions. Annual Meeting The Norwegian Society of Pharmacology and Toxicology, Beito