Bent Håvard Hellum
About
Publications
2017
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Hellum, Bent Håvard.
(2017)
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product.
Pharmacology Research & Perspectives.
volum 5 (4).
Academic article
2016
-
Thu, Ole Kristian Forstrønen;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products.
Pharmaceutical Biology.
volum 54 (12).
Academic article
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
European Journal of Clinical Pharmacology.
volum 72 (3).
Academic article
2015
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2015)
Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs.
Phytotherapy Research.
volum 29 (6).
Academic article
2014
-
Bjørneboe, Lars H;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2014)
In vitro CYP3A4 inhibition by fractionated Rhodiola rosea extracts.
Drug metabolism reviews (Softcover ed.).
volum 45 (S1).
Abstract
-
Djuv, Ane;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism.
Drug metabolism reviews (Softcover ed.).
volum 45 (S1).
Abstract
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products.
Drug metabolism reviews (Softcover ed.).
volum 45 (S1).
Abstract
2012
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2012)
The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy Research.
volum 26 (2).
Academic article
2011
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2011)
Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje's cocktail.
Toxicology Letters.
volum 205.
Abstract
2010
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2010)
Validation document of analytical assays used in the "Inje cocktail" for phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A.
2010.
Report
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2010)
Bioanalytical method validation for measuring Indinavir in plasma by LCMSMS.
2010.
Report
-
Hellum, Bent Håvard;
Tøsse, Anita;
Høybakk, Kathrine;
Thomsen, Mette;
Rohloff, Jens;
Nilsen, Odd Georg.
(2010)
Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola rosea.
Planta Medica.
volum 76 (4).
Academic article
2009
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2009)
Trade Herbal Products and Induction of CYP2C19 and CYP2E1 in Cultured Human Hepatocytes.
Basic & Clinical Pharmacology & Toxicology.
volum 105 (1).
Academic article
2008
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.
Basic & Clinical Pharmacology & Toxicology.
volum 102 (5).
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
Urters virkning på omsetning av legemidler i kroppen.
2008.
Compendium
-
Nilsen, Odd Georg;
Engdal, Silje;
Hellum, Bent Håvard.
(2008)
Farlige forbindelser.
Athene.
Popular scientific article
2007
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2007)
The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes.
Basic & Clinical Pharmacology & Toxicology.
volum 100.
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
DOKTORGRADSAVHANDLING: In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport.
2007. ISBN 978-82-471-5711-4.
Doctoral dissertation
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
Basic & Clinical Pharmacology & Toxicology.
volum 101 (5).
Academic article
Journal publications
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Hellum, Bent Håvard.
(2017)
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product.
Pharmacology Research & Perspectives.
volum 5 (4).
Academic article
-
Thu, Ole Kristian Forstrønen;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products.
Pharmaceutical Biology.
volum 54 (12).
Academic article
-
Thu, Ole Kristian Forstrønen;
Spigset, Olav;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2016)
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
European Journal of Clinical Pharmacology.
volum 72 (3).
Academic article
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2015)
Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs.
Phytotherapy Research.
volum 29 (6).
Academic article
-
Bjørneboe, Lars H;
Nilsen, Odd Georg;
Hellum, Bent Håvard.
(2014)
In vitro CYP3A4 inhibition by fractionated Rhodiola rosea extracts.
Drug metabolism reviews (Softcover ed.).
volum 45 (S1).
Abstract
-
Djuv, Ane;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism.
Drug metabolism reviews (Softcover ed.).
volum 45 (S1).
Abstract
-
Thu, Ole Kristian Forstrønen;
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2014)
Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products.
Drug metabolism reviews (Softcover ed.).
volum 45 (S1).
Abstract
-
Zhao, Yong;
Hellum, Bent Håvard;
Liang, Aihua;
Nilsen, Odd Georg.
(2012)
The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy Research.
volum 26 (2).
Academic article
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2011)
Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje's cocktail.
Toxicology Letters.
volum 205.
Abstract
-
Hellum, Bent Håvard;
Tøsse, Anita;
Høybakk, Kathrine;
Thomsen, Mette;
Rohloff, Jens;
Nilsen, Odd Georg.
(2010)
Potent in vitro Inhibition of CYP3A4 and P-Glycoprotein by Rhodiola rosea.
Planta Medica.
volum 76 (4).
Academic article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2009)
Trade Herbal Products and Induction of CYP2C19 and CYP2E1 in Cultured Human Hepatocytes.
Basic & Clinical Pharmacology & Toxicology.
volum 105 (1).
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.
Basic & Clinical Pharmacology & Toxicology.
volum 102 (5).
Academic article
-
Nilsen, Odd Georg;
Engdal, Silje;
Hellum, Bent Håvard.
(2008)
Farlige forbindelser.
Athene.
Popular scientific article
-
Hellum, Bent Håvard;
Hu, Zhuohan;
Nilsen, Odd Georg.
(2007)
The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes.
Basic & Clinical Pharmacology & Toxicology.
volum 100.
Academic article
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
Basic & Clinical Pharmacology & Toxicology.
volum 101 (5).
Academic article
Report
-
Hellum, Bent Håvard;
Spigset, Olav;
Nilsen, Odd Georg.
(2010)
Validation document of analytical assays used in the "Inje cocktail" for phenotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A.
2010.
Report
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2010)
Bioanalytical method validation for measuring Indinavir in plasma by LCMSMS.
2010.
Report
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2008)
Urters virkning på omsetning av legemidler i kroppen.
2008.
Compendium
-
Hellum, Bent Håvard;
Nilsen, Odd Georg.
(2007)
DOKTORGRADSAVHANDLING: In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport.
2007. ISBN 978-82-471-5711-4.
Doctoral dissertation
Teaching
Courses
Media
2018
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LectureHellum, Bent Håvard. (2018) How can TADM be utilized. User meeting Hamilton Robotics . Hamilton Robotics; Copenhagen. 2018-05-14 - 2018-05-15.
2017
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LectureHellum, Bent Håvard. (2017) Pille- og urtebruk, kan det kombineres?. Årsmøte Førde pensjonistforening . Førde pensjonistforening; Førde. 2017-02-15 - 2017-02-15.
2016
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PosterGustavsen, Marita; Nilsen, Odd Georg; Hellum, Bent Håvard. (2016) In vitro inhibition of human CYP enzymes by hops (Humulus lupulus). A “cocktail” study. Annual Winter Meeting NSFT . Norwegian Society for Pharmacology and Toxicology; Beitostølen. 2016-01-28 - 2016-01-31.
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PosterSyrstad, Ingvild Helø; Nilsen, Odd Georg; Hellum, Bent Håvard. (2016) In vitro inhibition of human CYP3A4 by VitaePro. Annual Winter Meeting NSFT . Norwegian Society for Pharmacology and Toxicology; Beitostølen. 2016-01-28 - 2016-01-31.
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Academic lectureThu, Ole Kristian Forstrønen; Nilsen, Odd Georg; Spigset, Olav; Hellum, Bent Håvard. (2016) Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Annual Winter Meeting NSFT . Norwegian Society for Pharmacology and Toxicology; Beitostølen. 2016-01-28 - 2016-01-31.
2015
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LectureHellum, Bent Håvard. (2015) Pasienter og urtebruk: finnes det farlige legemiddel-urt kombinasjoner?. Vårmøte Brystkreftforeningen . Kreftforeningen; Bærum. 2015-04-14 - 2015-04-14.
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LectureHellum, Bent Håvard. (2015) Samvirkninger av kjemikalier i kroppen. Konferanse Norsk Yrkeshygienisk Forening . Norsk Yrkeshygienisk Forening; Trondheim. 2015-10-31 - 2015-10-31.
2013
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PosterBjørneboe, Lars H; Nilsen, Odd Georg; Hellum, Bent Håvard. (2013) In vitro CYP3A4 inhibition by fractionated Rhodeola rosea extracts. 10th International ISSX Meeting, Toronto . International Society for the Study on Xenobiotics; Toronto. 2013-09-29 - 2013-10-03.
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PosterDjuv, Ane; Hellum, Bent Håvard; Nilsen, Odd Georg. (2013) Impact of Aloe vera juice on in vitro P-gp transport and CYP3A4 metabolism. 10th International ISSX Meeting, Toronto . International Society for the Study of Xenobiotics; Toronto. 2013-09-29 - 2013-10-03.
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LectureNilsen, Odd Georg; Djuv, Ane; Langhammer, Astrid Jordet; Thu, Ole Kristian; Hellum, Bent Håvard. (2013) Possible significance of CYP inhibition for acetaminophen/other drugs toxicity and increase of clinical efficacy of indinavir in patients in and outside of general practice. Internal meeting at China Academy of Chinese Medical Sciences ; Beijing. 2013-12-10 - 2013-12-10.
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PosterThu, Ole Kristian F.; Hellum, Bent Håvard; Nilsen, Odd Georg. (2013) Variation in the in vitro inhibition of CYP3A4, CYP2D6 and CYP1A2 by different commercial Rhodiola rosea products. 10th International ISSX Meeting, Toronto . International Society for the Study of Xenobiotics; Toronto. 2013-09-29 - 2013-10-03.
2011
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PosterHellum, Bent Håvard; Nilsen, Odd Georg; Spigset, Olav. (2011) Bioanalytical method validation of LC-MSMS, GC-MS and HPLC assays used for analyzing substrates and metabolites included in Inje’s cocktail. Eurotox 2011 . European Societies of Toxicology; Paris. 2011-08-28 - 2011-08-31.
2010
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Academic lectureHellum, Bent Håvard. (2010) An in vivo cocktail approach for evaluating herb-drug interactions -validation of bioanalytical methods. Monday meeting . Research group for molecular biology; Trondheim. 2010-10-18 - 2010-10-18.
2008
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PosterEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg. (2008) In Vitro Inhibition of CYP3A4 by Herbal Remedies. 15th North American Regional ISSX metting, San Diego . International Society for the Study of Xenobiotics; San Diego. 2008-10-12 - 2008-10-16.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Brækhus, Leni Aurora. (2008) Naturmidler påvirker kreftbehandling. ABC Nyheter [Internett]. 2008-10-02.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Lundh, Francis. (2008) Naturmedisin til kreftpasienter kan være farlig. VG [Internett]. 2008-10-02.
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DocumentaryEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Steenstrup, Anne. (2008) Intervju med IKM stipendiat om naturmidler og kreftbehandling. Innsida, Det medisinske fakultet [Internett]. 2008-10-02.
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Academic lectureHellum, Bent Håvard. (2008) Legemiddel-urt interaksjoner. Tirsdagsmøte for DMF, NTNU og St. Olavs Hospital . IKM; Trondheim. 2008-04-22.
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Monsen, Tor Harald. (2008) Advarer mot urtemedisin. www.forskning.no [Internett]. 2008-02-15.
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Moseng, Marianne. (2008) Advarer mot naturlegemidler- farlig i miks med medisiner. Dagbladet [Avis]. 2008-02-15.
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PosterHellum, Bent Håvard; Nilsen, Odd Georg. (2008) Comparison of the in vitro inhibition potential of six trade herbal products on CYP3A4 metabolism and P-glycoprotein efflux transport. Annual winter meeting NSFT . Norwegian Society for Pharmacology and Toxicology; Beitostølen. 2008-01-24 - 2008-01-27.
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PosterHøybakk, Kathrine; Tøsse, Anita; Nilsen, T.; Engdal, Silje; Hellum, Bent Håvard; Rohloff, Jens; Thomsen, Mette; Nilsen, Odd Georg. (2008) Effect of Goldenroot (Rhodiola rosea) on P-glycoprotein and CYP3A4 in vitro. Annual Winter Meeting NSFT . Norwegian Society for Pharmacology and Toxicology; Beitostølen. 2008-01-24 - 2008-01-27.
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InterviewNilsen, Odd Georg; Engdal, Silje; Hellum, Bent Håvard; Hasle, Inger. (2008) Farlige forbindelser. www.ffb.no [Internett]. 2008-12-11.
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InterviewNilsen, Odd Georg; Hellum, Bent Håvard; Engdal, Silje; Steenstrup, Anne. (2008) Interesse for helsekostforskning. Innsida DMF [Internett]. 2008-12-19.
2007
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg. (2007) Grapefrukt og viagra kan være livsfarlig. NTB [Internett]. 2007-06-18.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Gråberg, Marte. (2007) Kreftmedisin og naturpreparater - en farlig kombinasjon?. Kreftforeningen.no [Internett]. 2007-06-29.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Moseng, Marianne. (2007) Naturmidler kan forsterke medisiner. Dagbladet [Avis]. 2007-05-25.
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InterviewEngdal, Silje; Hellum, Bent Håvard; Nilsen, Odd Georg; Tunstad, Hege J.. (2007) Farlige forbindelser. GEMINI [Avis]. 2007-05-01.
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InterviewHellum, Bent Håvard; Engdal, Silje; Djuv, Ane; Nilsen, Odd Georg; Tilseth, Trond Ola. (2007) Viagra -og grapefruktjuice, potensielt farlig blanding av naturmedisin og legemiddel. Adresseavisen [Avis]. 2007-07-11.
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InterviewHellum, Bent Håvard; Engdal, Silje; Nilsen, Odd Georg; Solberg, Dag. (2007) Advarer mot sex-miks. Cupido [Avis]. 2007-07-15.
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PosterHellum, Bent Håvard; Nilsen, Odd Georg. (2007) CYP2D6 inhibition by herbal products. Pharmaceutical Science World Congress, Amsterdam. . International Pharmaceutical Federation; Amsterdam. 2007-04-22 - 2007-04-25.
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PosterHellum, Bent Håvard; Nilsen, Odd Georg. (2007) CYP2D6 inhibition by medicinal herbs. Annual Winter Meeting NSFT . Norwegian Society of Pharmaciology and Toxicology; Beitostølen. 2007-01-25 - 2007-01-28.
2006
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Academic lectureHellum, Bent Håvard. (2006) Cytochrome P450 forskning i Trondheim. Seminar Statens legemiddelverk . Statens legemiddelverk og prosjektfaggruppe; Oslo. 2006-10-12 - 2006-10-12.
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PosterHellum, Bent Håvard; Nilsen, Odd Georg; Yang, Shu; Fang, Sishi; Mao, Yuchang; Tan, Jinxing; Yang, Youming; Hu, Zhuohan. (2006) An In Vitro Evaluation of the Inductive Potential of St. Johns Wort, Horse Chestnut, Common Sage, Gingko Biloba, Common Valerian and Echinacea Purpurea on Cytochrome P450 Activities in Human Primary Hepatocytes. 1st Asia/ Pacific International Society for the Study of Xenobiotics Meeting . International Society for the Study of Xenobiotics (ISSX); Jeju Island. 2006-05-24 - 2006-05-27.
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PosterHellum, Bent Håvard; Yang, Shu; Hu, Zhuohan; Nilsen, Odd Georg. (2006) The induction of CYP1A2 and 3A4 by six trade herbal products in primary human hepatocytes. Annual Meeting The Norwegian Society of Pharmacology and Toxicology, Beito . NSFT; Beito. 2006-01-26 - 2006-01-29.
2005
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PosterHellum, Bent Håvard; Skålvoll, Anja Kristina; Nilsen, Odd Georg. (2005) In vitro cytochrome P-450 isoform assays for evaluation of drug-herb metabolic interactions. Annual Meeting The Norwegian Society of Pharmacology and Toxicology, Beito . Norwegian society of pharmacology and toxicology; Beitostølen. 2005-01-27 - 2005-01-29.
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Academic lectureHellum, Bent Håvard; Yang, Shu; Fang, Sishi; Mao, Yuchang; Wang, Min; Hu, Zhuohan; Nilsen, Odd Georg. (2005) Inductive potentials of six natural products marked in Norway on CYP1A2, 2D6 and 3A4 by using human primary hepatocytes. III-International Conference on Drug Metabolism . ISSX and China Pharmacology Society; Hangzhou. 2005-10-17 - 2005-10-20.