Hanne Hella
Publications
2025
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
BioRxiv
Academic article
2024
-
Nedal, Tonje Marie Vikene;
Moen, Siv Helen;
Roseth, Ingrid Aass;
Tryggestad, Synne Stokke;
Aass, Kristin Roseth;
Hov, Gunhild Garmo.
(2024)
Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma.
Scientific Reports
Academic article
-
Tryggestad, Synne Stokke;
Roseth, Ingrid Aass;
Aass, Kristin Roseth;
Ørning, Nadia Elise Helene;
Mjelle, Robin;
Hella, Hanne.
(2024)
Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
Frontiers in Immunology
Academic article
2023
-
Quist-Løkken, Ingrid;
Andersson-Rusch, Clara Leticia;
Kastnes, Martin Haugrud;
Kolos, Jürgen Markus;
Jatzlau, Jerome;
Hella, Hanne.
(2023)
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells.
Cell Communication and Signaling
Academic article
-
Andersson-Rusch, Clara Leticia;
Liu, Bin;
Quist-Løkken, Ingrid;
Upton, Paul D.;
Olsen, Oddrun Elise;
Hella, Hanne.
(2023)
High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells.
Scientific Reports
Academic article
2021
-
Håland, Erling;
Moen, Ingrid Nyhus;
Veidal, Elias;
Hella, Hanne;
Misund, Kristine;
Slørdahl, Tobias Schmidt.
(2021)
TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan.
OncoTarget
Academic article
2020
-
Olsen, Oddrun Elise;
Hella, Hanne;
Elsaadi, Samah;
Jacobi, Carsten;
Martinez-Hackert, Erik;
Holien, Toril.
(2020)
Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors.
Biomolecules
Academic article
-
Westhrin, Marita;
Holien, Toril;
Zahoor, Muhammad;
Moen, Siv Helen;
Buene, Glenn;
Størdal, Berit Fladvad.
(2020)
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone.
JBMR Plus
Academic article
2018
-
Olsen, Oddrun Elise;
Sankar, Meenu;
Elsaadi, Samah;
Hella, Hanne;
Buene, Glenn;
Darvekar, Sagar.
(2018)
BMPR2 inhibits activin and BMP signaling via wild-type ALK2.
Journal of Cell Science
Academic article
-
Holien, Toril;
Westhrin, Marita;
Moen, Siv Helen;
Zahoor, Muhammad;
Buene, Glenn;
Størdal, Berit Fladvad.
(2018)
BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone.
Blood
Abstract
2016
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Academic article
-
Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal
Academic article
2015
-
Olsen, Oddrun Elise;
Wader, Karin Fahl;
Hella, Hanne;
Mylin, Anne K.;
Turesson, Ingemar;
Nesthus, Ingerid.
(2015)
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
Cell Communication and Signaling
Academic article
2013
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Waage, Anders;
Sundan, Anders.
(2013)
Dependency on c-MYC in multiple myeloma.
Cancer Research
Abstract
-
Holien, Toril;
Olsen, Oddrun Elise;
Misund, Kristine;
Hella, Hanne;
Waage, Anders;
Rø, Torstein Baade.
(2013)
Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate.
European Journal of Haematology
Academic article
2012
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes.
(2012)
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC.
Leukemia
Academic article
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Waage, Anders;
Sundan, Anders.
(2012)
Addiction to c-MYC in multiple myeloma.
Blood
Academic article
2011
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes.
(2011)
BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC.
Haematologica
Abstract
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jönsson, S;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders.
(2011)
CpG-ODN inhibits Smad-dependent BMP signaling; Effects on myeloma cell apoptosis and in vitro osteoblastogenesis.
Bone
Abstract
2010
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jonsson, Sofia;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders.
(2010)
CpG-Oligodeoxynucleotide Inhibits Smad-Dependent Bone Morphogenetic Protein Signaling: Effects on Myeloma Cell Apoptosis and In Vitro Osteoblastogenesis.
Journal of Immunology
Academic article
2009
-
Brenne, Anne-Tove;
Fagerli, Unn Merete;
Shaughnessy, JD;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Hella, Hanne.
(2009)
High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis.
European Journal of Haematology
Academic article
2007
-
Hella, Hanne;
Krøkje, Åse.
(2007)
Fremstilling av monoklonale antistoffer mot myelomceller.
NTNU, Institutt for biologi
NTNU, Institutt for biologi
Masters thesis
2001
-
Lamvik, Jon;
Hella, Hanne;
Liabakk, Nina-Beate;
Halaas, Øyvind.
(2001)
Nonlabeled Secondary Antibodies Augment/Maintain the binding of Primarym Specific Antibodies to Cell Membrane Antigens.
Cytometry
Academic article
Journal publications
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
BioRxiv
Academic article
-
Nedal, Tonje Marie Vikene;
Moen, Siv Helen;
Roseth, Ingrid Aass;
Tryggestad, Synne Stokke;
Aass, Kristin Roseth;
Hov, Gunhild Garmo.
(2024)
Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma.
Scientific Reports
Academic article
-
Tryggestad, Synne Stokke;
Roseth, Ingrid Aass;
Aass, Kristin Roseth;
Ørning, Nadia Elise Helene;
Mjelle, Robin;
Hella, Hanne.
(2024)
Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
Frontiers in Immunology
Academic article
-
Quist-Løkken, Ingrid;
Andersson-Rusch, Clara Leticia;
Kastnes, Martin Haugrud;
Kolos, Jürgen Markus;
Jatzlau, Jerome;
Hella, Hanne.
(2023)
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells.
Cell Communication and Signaling
Academic article
-
Andersson-Rusch, Clara Leticia;
Liu, Bin;
Quist-Løkken, Ingrid;
Upton, Paul D.;
Olsen, Oddrun Elise;
Hella, Hanne.
(2023)
High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells.
Scientific Reports
Academic article
-
Håland, Erling;
Moen, Ingrid Nyhus;
Veidal, Elias;
Hella, Hanne;
Misund, Kristine;
Slørdahl, Tobias Schmidt.
(2021)
TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan.
OncoTarget
Academic article
-
Olsen, Oddrun Elise;
Hella, Hanne;
Elsaadi, Samah;
Jacobi, Carsten;
Martinez-Hackert, Erik;
Holien, Toril.
(2020)
Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors.
Biomolecules
Academic article
-
Westhrin, Marita;
Holien, Toril;
Zahoor, Muhammad;
Moen, Siv Helen;
Buene, Glenn;
Størdal, Berit Fladvad.
(2020)
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone.
JBMR Plus
Academic article
-
Olsen, Oddrun Elise;
Sankar, Meenu;
Elsaadi, Samah;
Hella, Hanne;
Buene, Glenn;
Darvekar, Sagar.
(2018)
BMPR2 inhibits activin and BMP signaling via wild-type ALK2.
Journal of Cell Science
Academic article
-
Holien, Toril;
Westhrin, Marita;
Moen, Siv Helen;
Zahoor, Muhammad;
Buene, Glenn;
Størdal, Berit Fladvad.
(2018)
BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone.
Blood
Abstract
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Academic article
-
Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal
Academic article
-
Olsen, Oddrun Elise;
Wader, Karin Fahl;
Hella, Hanne;
Mylin, Anne K.;
Turesson, Ingemar;
Nesthus, Ingerid.
(2015)
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
Cell Communication and Signaling
Academic article
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Waage, Anders;
Sundan, Anders.
(2013)
Dependency on c-MYC in multiple myeloma.
Cancer Research
Abstract
-
Holien, Toril;
Olsen, Oddrun Elise;
Misund, Kristine;
Hella, Hanne;
Waage, Anders;
Rø, Torstein Baade.
(2013)
Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate.
European Journal of Haematology
Academic article
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes.
(2012)
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC.
Leukemia
Academic article
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Waage, Anders;
Sundan, Anders.
(2012)
Addiction to c-MYC in multiple myeloma.
Blood
Academic article
-
Holien, Toril;
Våtsveen, Thea Kristin;
Hella, Hanne;
Rampa, Christoph Samuel;
Brede, Gaute;
Grøseth, Lill Anny Gunnes.
(2011)
BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC.
Haematologica
Abstract
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jönsson, S;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders.
(2011)
CpG-ODN inhibits Smad-dependent BMP signaling; Effects on myeloma cell apoptosis and in vitro osteoblastogenesis.
Bone
Abstract
-
Nørgaard, Nikolai Nordberg;
Holien, Toril;
Jonsson, Sofia;
Hella, Hanne;
Espevik, Terje;
Sundan, Anders.
(2010)
CpG-Oligodeoxynucleotide Inhibits Smad-Dependent Bone Morphogenetic Protein Signaling: Effects on Myeloma Cell Apoptosis and In Vitro Osteoblastogenesis.
Journal of Immunology
Academic article
-
Brenne, Anne-Tove;
Fagerli, Unn Merete;
Shaughnessy, JD;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Hella, Hanne.
(2009)
High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis.
European Journal of Haematology
Academic article
-
Lamvik, Jon;
Hella, Hanne;
Liabakk, Nina-Beate;
Halaas, Øyvind.
(2001)
Nonlabeled Secondary Antibodies Augment/Maintain the binding of Primarym Specific Antibodies to Cell Membrane Antigens.
Cytometry
Academic article
Report
-
Hella, Hanne;
Krøkje, Åse.
(2007)
Fremstilling av monoklonale antistoffer mot myelomceller.
NTNU, Institutt for biologi
NTNU, Institutt for biologi
Masters thesis
Outreach
2024
-
PosterMestvedt, Ingvild Bergdal; Yurchenko, Maria; Espevik, Terje; Standal, Therese; Wolowczyk, Camilla Izabel; Rasheed, Kashif. (2024) Exploring peptide derived from Signaling Lymphocytic Activation Molecule Family 1 as novel treatment for multiple myeloma. ENA 2024 Symposium on molecular targets and cancer therapeutics , Barcelona 2024-10-23 - 2024-10-25
-
Academic lectureRoseth, Ingrid Aass; Behsen, Alenka Djarmila; Moen, Siv Helen; Sponaas, Anne Marit; Aass, Kristin Roseth; Tryggestad, Synne Stokke. (2024) Mass cytometry of murine immune cell populations upon diet induced obesity and early stages of myeloma. Norwegian Flow Cytometry Meeting 2024 , Tromsø 2024-06-06 - 2024-06-07
2023
-
PosterMestvedt, Ingvild Bergdal; Yurchenko, Maria; Misund, Kristine; Hella, Hanne; Espevik, Terje; Slørdahl, Tobias Schmidt. (2023) SLAMF1-derived peptide P7N4-Pen as anti-myeloma treatment. 20th International Myeloma Society Annual Meeting , Athens 2023-09-27 - 2023-09-30
2022
-
Academic lectureQuist-Løkken, Ingrid; Andersson-Rusch, Clara; Kastnes, Martin Haugrud; Kolos, Jürgen M; Jatzlau, Jerome; Hella, Hanne. (2022) FKBP12 is a major regulator of ligand dependent ALK2 activity in multiple myeloma cells. The TGF-β Superfamily Conference: Signaling in Development and Disease , Malahide 2022-07-17 - 2022-07-21
-
PosterAndersson-Rusch, Clara; Liu, Bin; Quist-Løkken, Ingrid; Upton, Paul D.; Olsen, Oddrun Elise; Hella, Hanne. (2022) Soluble endoglin inhibits BMP9 signaling in non-endothelial cells. 13th International BMP Conference 2022-10-08 - 2022-10-12
-
Academic lectureQuist-Løkken, Ingrid; Andersson-Rusch, Clara; Kastnes, Martin Haugrud; Kolos, Jürgen M; Jatzlau, Jerome; Hella, Hanne. (2022) FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells. 13th International BMP Conference 2022-10-08 - 2022-10-12
-
PosterQuist-Løkken, Ingrid; Andersson-Rusch, Clara; Kastnes, Martin Haugrud; Kolos, Jürgen M; Jatzlau, Jerome; Hella, Hanne. (2022) FKBP12 regulates signal strength and specificity of bone morphogenetic protein activation via ALK2. 13th International BMP Conference 2022-10-08 - 2022-10-12
2019
-
Academic lectureHolien, Toril; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad. (2019) BMP4 gene therapy in mice inhibits myeloma tumor growth, but has a negative impact on bone. The TGF-β Superfamily: Signaling in Development and disease. , West Palm Beach, FL 2019-07-28 - 2019-08-02
-
PosterAass, Kristin Roseth; Mjelle, Robin; Westhrin, Marita; Zahoor, Muhammad; Yurchenko, Mariya; Buene, Glenn. (2019) IL-32 is a novel growth factor and metabolic regulator in multiple myeloma cells. The Second Conference on Molecular Mechanisms of Inflammation in Trondheim June 3-6, 2019. 2019-06-03 - 2019-06-06
-
PosterOlsen, Oddrun Elise; Elsaadi, Samah; Hella, Hanne; Holien, Toril. (2019) Activins as dual-specificity TGF-β family molecules: Activation of activin- and BMP-type I receptors. The TGF-β Superfamily: Signaling in Development and Disease , West Palm Beach, FL 2019-07-28 - 2019-08-02
-
PosterAass, Kristin Roseth; Mjelle, Robin; Zahoor, Muhammad; Yurchenko, Mariya; Westhrin, Marita; Buene, Glenn. (2019) IL-32 is a novel growth factor and metabolic regulator for multiple myeloma cells. Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment. , Florence 2019-03-15 - 2019-03-19
-
Academic lectureHolien, Toril; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad. (2019) BMP4 gene therapy in mice inhibits myeloma tumor growth, but has a negative impact on bone. BMP Signalling in Cancer II , Oxford 2019-04-01 - 2019-04-03
2018
-
PosterOlsen, Oddrun Elise; Sankar, Meenu; Elsaadi, Samah; Hella, Hanne; Darvekar, Sagar; Misund, Kristine. (2018) BMPR2 inhibits activin- and BMP-signaling via wild type ALK2. 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer: From diagnosis to immunotherapy – why is precision medicine so difficult? , Trondheim 2018-06-14 - 2018-06-15
-
PosterHolien, Toril; Westhrin, Marita; Moen, Siv Helen; Zahoor, Muhammad; Buene, Glenn; Størdal, Berit Fladvad. (2018) BMP4 gene therapy inhibits myeloma tumor growth, but has a negative impact on bone. 12th International BMP Conference , Tokyo 2018-10-24 - 2018-10-28
-
PosterHolien, Toril; Westhrin, Marita; Moen, Siv Helen; Zahoor, Muhammad; Buene, Glenn; Størdal, Berit Fladvad. (2018) BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone. ASH 2018 , San Diego 2018-12-01 - 2018-12-04
2017
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Academic lectureOlsen, Oddrun Elise; Sankar, Meenu; Elsaadi, Samah; Hella, Hanne; Darvekar, Sagar; Misund, Kristine. (2017) Activins induce apoptosis through wild type ALK2/ACVR1 and are counteracted by BMPR2. NMSG plenary meeting , Trondheim 2017-09-07 - 2017-09-08
2016
-
PosterOlsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Waage, Anders; Sundan, Anders; Holien, Toril. (2016) Activin A inhibits BMP-signalling by binding ACVR2A and ACVR2B. BMP Signalling in Cancer , Cambridge 2016-03-15 - 2016-03-17
2015
-
PosterOlsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Waage, Anders; Sundan, Anders; Holien, Toril. (2015) Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. The TGFb Superfamily: Signaling in Development and Disease 2015-07-12 - 2015-07-17
2013
-
PosterHolien, Toril; Våtsveen, Thea Kristin; Hella, Hanne; Waage, Anders; Sundan, Anders. (2013) Dependency on c-MYC in multiple myeloma. AACR Annual Meeting 2013 , Washington, D.C. 2013-04-06 - 2013-04-10
-
PosterMoen, Siv Helen; Nørgaard, Nikolai Nordberg; Westhrin, Marita; Størdal, Berit Fladvad; Hella, Hanne; Sundan, Anders. (2013) TLR agonists induce expression of cytokines in mesenchymal stem cells and pre-osteoblasts promoting osteoclast activation and MM-cell growth. International Myeloma Workshop 2013 2013-04-03 - 2013-04-07
2012
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Academic lectureHolien, Toril; Våtsveen, Thea Kristin; Hella, Hanne; Waage, Anders; Sundan, Anders. (2012) Dependency on c-MYC in multiple myeloma. BIT's 1st Annual International Symposium of Hematology (AISH-2012) , Beijing 2012-06-15 - 2012-06-17
2011
-
PosterHolien, Toril; Våtsveen, Thea Kristin; Hella, Hanne; Rampa, Christoph Samuel; Brede, Gaute; Grøseth, Lill Anny Gunnes. (2011) BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC. 13th Interntional Myeloma Workshop 2011-05-03 - 2011-05-06
2000
-
LectureLamvik, Jon; Hella, Hanne; Liabakk, Nina-Beate; Halaas, Øyvind. (2000) Non-labeled secondary antibodies augment the ability of primary, specific antibodies to be bound to cell membrane antigens. The Annual Meeting of the Norwegian Society of Immunology , Oslo, December 11, 2000