Jing Ye
About
Our research focuses on the epigenomic regulation of functionally specialized neuronal ensembles and neural circuits in the spatial memory coding system. Our projects are multidisciplinary, incorporating various sophisticated and advanced technologies in different research fields, e.g. neuroanatomy with high-quality imaging studies, in vivo / in vitro neuronal recording with behavior paradigms, transcriptomic and epigenomic sequencing and bioinformatic analysis, etc. Our work aims to link the epigenomic and transcriptional diversity to the functional complexity of neurons and neural networks beyond animals’ behavioral phenotypes. Uncovering novel molecular mechanisms underlying neural coding of the spatial navigation system will lay the foundation for understanding brain computations, resolving cognitive decline during normal and pathological aging, and for developing potential treatments for brain diseases.
Publications
2021
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Academic literature review
-
Kunath, Nicolas;
Bugaj, Anna Maria;
Bigonah, Pegah;
Fernandez Berrocal, Marion Silvana;
Bjørås, Magnar;
Ye, Jing.
(2021)
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons.
iScience
Academic article
2020
-
Rodriguez-Vargas, José-Manuel;
Martin-Hernandez, Kathline;
Wang, Wei;
Kunath, Nicolas;
Suganthan, Rajikala;
Amé, Jean-Christophe.
(2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.
Cell Death & Disease
Academic article
2018
-
Ye, Jing;
Witter, Menno;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2018)
Entorhinal fast-spiking speed cells project to the hippocampus.
Proceedings of the National Academy of Sciences of the United States of America
Academic article
2014
-
Zhang, Sheng Jia;
Ye, Jing;
Couey, Jonathan Jay;
Witter, Menno;
Moser, Edvard Ingjald;
Moser, May-Britt.
(2014)
Functional connectivity of the entorhinal - hippocampal space circuit.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
2013
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Tsao, Albert;
Cerniauskas, Ignas;
Ledergerber, Debora.
(2013)
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity.
Science
Academic article
-
Czajkowski, Rafal;
Sugar, Jørgen L;
Zhang, Sheng Jia;
Couey, Jonathan Jay;
Ye, Jing;
Witter, Menno.
(2013)
Superficially Projecting Principal Neurons in Layer V of Medial Entorhinal Cortex in the Rat Receive Excitatory Retrosplenial Input.
Journal of Neuroscience
Academic article
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Zheng, Kang;
Ye, Jing;
Dunn, Benjamin Adric.
(2013)
Recurrent inhibitory circuitry as a mechanism for grid formation.
Nature Neuroscience
Academic article
2012
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Czajkowski, Rafal;
Dunn, Benjamin Adric;
Ye, Jing.
(2012)
702.06/DDD22 - Medial entorhinal cortex layer ii stellate cells are embedded within a recurrent inhibitory network.
SFN Abstract Viewer/Itinerary Planner
Abstract
-
Ye, Jing;
Zhang, Sheng Jia;
Miao, Chenglin;
Tsao, Albert;
Ledergerber, Debora;
Moser, May-Britt.
(2012)
702.13/DDD29 - Optogenetic dissection of the entorhinal-hippocampal space circuit.
SFN Abstract Viewer/Itinerary Planner
Academic article
2010
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2010)
Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit.
Society for Neuroscience : Abstracts
Abstract
Journal publications
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology
Academic article
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Academic literature review
-
Kunath, Nicolas;
Bugaj, Anna Maria;
Bigonah, Pegah;
Fernandez Berrocal, Marion Silvana;
Bjørås, Magnar;
Ye, Jing.
(2021)
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons.
iScience
Academic article
-
Rodriguez-Vargas, José-Manuel;
Martin-Hernandez, Kathline;
Wang, Wei;
Kunath, Nicolas;
Suganthan, Rajikala;
Amé, Jean-Christophe.
(2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.
Cell Death & Disease
Academic article
-
Ye, Jing;
Witter, Menno;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2018)
Entorhinal fast-spiking speed cells project to the hippocampus.
Proceedings of the National Academy of Sciences of the United States of America
Academic article
-
Zhang, Sheng Jia;
Ye, Jing;
Couey, Jonathan Jay;
Witter, Menno;
Moser, Edvard Ingjald;
Moser, May-Britt.
(2014)
Functional connectivity of the entorhinal - hippocampal space circuit.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Academic literature review
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Tsao, Albert;
Cerniauskas, Ignas;
Ledergerber, Debora.
(2013)
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity.
Science
Academic article
-
Czajkowski, Rafal;
Sugar, Jørgen L;
Zhang, Sheng Jia;
Couey, Jonathan Jay;
Ye, Jing;
Witter, Menno.
(2013)
Superficially Projecting Principal Neurons in Layer V of Medial Entorhinal Cortex in the Rat Receive Excitatory Retrosplenial Input.
Journal of Neuroscience
Academic article
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Zheng, Kang;
Ye, Jing;
Dunn, Benjamin Adric.
(2013)
Recurrent inhibitory circuitry as a mechanism for grid formation.
Nature Neuroscience
Academic article
-
Couey, Jonathan Jay;
Witoelar, Aree Widya;
Zhang, Sheng Jia;
Czajkowski, Rafal;
Dunn, Benjamin Adric;
Ye, Jing.
(2012)
702.06/DDD22 - Medial entorhinal cortex layer ii stellate cells are embedded within a recurrent inhibitory network.
SFN Abstract Viewer/Itinerary Planner
Abstract
-
Ye, Jing;
Zhang, Sheng Jia;
Miao, Chenglin;
Tsao, Albert;
Ledergerber, Debora;
Moser, May-Britt.
(2012)
702.13/DDD29 - Optogenetic dissection of the entorhinal-hippocampal space circuit.
SFN Abstract Viewer/Itinerary Planner
Academic article
-
Zhang, Sheng Jia;
Ye, Jing;
Miao, Chenglin;
Moser, May-Britt;
Moser, Edvard Ingjald.
(2010)
Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit.
Society for Neuroscience : Abstracts
Abstract
Media
2013
-
PosterYe, Jing; Zhang, Sheng Jia; Cerniauskas, Ignas; Sørlie Wågan, R; Moser, May-Britt; Moser, Edvard Ingjald. (2013) Functional dissection of principal cell populations in layers II and III of medial entorhinal cortex. Society for Neuroscience 2013-11-13 -
2011
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PosterZhang, Sheng Jia; Ye, Jing; Miao, Chenglin; Tsao, Albert; Moser, May-Britt; Moser, Edvard Ingjald. (2011) Functional connectivity of the entorhinal-hippocampal space circuit. Soceiety for Neuroscience Society for Neuroscience 2011-11-12 - 2011-11-16
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PosterCzajkowski, Rafal; Couey, Jonathan Jay; Girao, Paulo Jorge Bettencourt; Zhang, Sheng Jia; Ye, Jing; Moser, May-Britt. (2011) Optogenetic mapping reveals a functional input from retrosplenial cortex. Society for Neuroscience 2011-11-12 - 2011-11-16
2010
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PosterZhang, Sheng Jia; Ye, Jing; Miao, Chenglin; Moser, May-Britt; Moser, Edvard Ingjald. (2010) Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit. SFN 2010-11-13 - 2010-11-17