Jing Ye
Background and activities
Our research focuses on epigenomic regulation of functionally specialized neuronal ensembles and neural circuits in the spatial memory coding system. Our projects are multidisciplinary, incorporating various sophisticated and advanced technologies in different research fields, e.g. neuroanatomy with high-quality imaging studies, in vivo / in vitro neuronal recording with behavior paradigms, transcriptomic and epigenomic sequencing and bioinformatic analysis, and etc. Our work aims to link the epigenomic and transcriptional diversity to the functional complexity of neurons and neural networks beyond animals’ behavioral phenotypes. Uncovering novel molecular mechanisms underlying neural coding of the spatial navigation system will lay the foundation for understanding brain computations, for resolving cognitive decline during normal and/or pathological aging, and for developing potential treatments of brain diseases.
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
Journal publications
- (2021) NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Communications Biology. vol. 4.
- (2021) DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons. iScience. vol. 24 (12).
- (2021) Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction. International Journal of Molecular Sciences. vol. 22 (23).
- (2020) Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation. Cell Death & Disease. vol. 11 (11).
- (2018) Entorhinal fast-spiking speed cells project to the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol. 115 (7).
- (2014) Functional connectivity of the entorhinal - hippocampal space circuit. Philosophical Transactions of the Royal Society of London. Biological Sciences. vol. 369 (1635).
- (2013) Recurrent inhibitory circuitry as a mechanism for grid formation. Nature Neuroscience. vol. 16 (3).
- (2013) Superficially Projecting Principal Neurons in Layer V of Medial Entorhinal Cortex in the Rat Receive Excitatory Retrosplenial Input. Journal of Neuroscience. vol. 33 (40).
- (2013) Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity. Science. vol. 340 (6128).
- (2012) 702.06/DDD22 - Medial entorhinal cortex layer ii stellate cells are embedded within a recurrent inhibitory network. SFN Abstract Viewer/Itinerary Planner.
- (2012) 702.13/DDD29 - Optogenetic dissection of the entorhinal-hippocampal space circuit. SFN Abstract Viewer/Itinerary Planner.
- (2010) Optogenetic dissection of the entorhinal-hippocampal spatial representation circuit. Society for Neuroscience : Abstracts.