Kaare Harald Bønaa

About

My research started in 1986 when professor Knut Westlund introduced me to cardiovascular epidemiology. He emphaziced that biology should be at the core of epidemiologic investigations. Following my PhD dissertation at the University of Tromsø in 1992, I was elected Principal Investigator (PI) of the large, population based Tromsø Heart Study which has been ongoing since 1974 and includes more than 50 000 persons. A main strategy as PI was to bring the clinical and the laboratory disciplines into epidemiologic investigations to integrate search for causal effects with the study of intermediary mechanisms. During 1994-95 we used ultrasound to study heart functions, atherosclerosis, and the abdominal aorta in a study of more than 6500 persons. I was the founder andhead of the Cardiovascular Research Group in Tromsø. This group was rated “Excellent” by the Research Council of Norway, and in 1999 qualified for the prestigious Top Research grant from the Research Council. Data from the Tromsø study has been used in more than 100 PhDs. I also contributed to the development and clinical documentation of the drug Omacor TM, the first therapeutic drug for humans developed on Norway, and hold a world-wide patent for Omacor TM together with industry researchers. In 2002 I published a new hypothesis explaining the sex contrast in the risk of acute myocardial infarction. Throughout my career my ambition has always been to conduct high quality research in the international front. I initiated and was the PI for three randomized clinical trials that were all successfully completed and published in the New England Journal of Medicine. I have published epidemiologicarticles in Circulation, BMJ, and JAMA. In total I have authored or co-authored more than 100 scientific papers published in peer reviewed journals. Research areas: 1. Omega-3 fatty acids, and interrelations between blood lipid levels and hemodynamics. We were the first to study the effects of highly purified omega-3 fatty acids on CVD risk factors, and found a significant blood pressure lowering effect in young patients with diastolic hypertension (NEJM 1990). During the work with my PhD I contributed to the development and clinical documentation of the drug Omacor ™, the first therapeutic drug for humans developed in Norway, and hold world-wide patents for Omacor™. We found interrelations between blood lipid levels and blood pressure and resting heart rate and observed that dietary n-3 fatty acids improves left ventricular function, and suggested potential mechanisms for these relations. 2. Use of ultrasound to study subclinical atherosclerosis, heart structure, and aneurysms We were among the first to use ultrasound in a large population – based surveys. We found that men had more atherosclerotic plaques than women, and were the first to demonstrate that men have more soft and lipid-laden carotid artery plaques than women. We observed that plaque morphology was a significant predictor for ischemic stroke. 3. Gender differences in cardiovascular risk factor levels and risk of coronary heart disease. The sex differences in coronary heart disease is surely one of the most interesting of all epidemiologicquestions, and has been focus for much of my research. We recently published data in JAMA showing that there is a life-long gender gap in risk of incident myocardial infarction - with no evidence of any attenuation of the sex contrast around the age for menopause. It is noteworthy that the determinant(s) of this gender contrast still remains unknown. I hypothesize that gender differences in plaque morphology, possibly related to testosterone and sex differences in atherogenic lipid levels, may contribute to the gender gap in risk for acute myocardial infarction, and published the hypothesis in 2002. 4. Determinants for trends in the incidence and case fatality of myocardial infarction. We found a significant fall in incidence of myocardial infarction during the last 20 years, and showed that about 60 % of this reduction is associated with trends in modifiable risk factors, and published our findings in Circulation in 2016. Our data indicate that a large proportion of incidence variations across time and geographic areas are due to modifiable risk factors. This is good news for prevention. 5. Multicentre randomized controlled clinical trials In recent years I was PI for two large multicentre randomized controlled clinical trials in secondary prevention and interventional cardiology, and I have spent much time to secure the successful completion of these large projects. The NORVIT study (NEJM 2016 tested the homocysteine hypothesis by randomizing 3749 CHD patients to treatment with B-vitamins. There was no benefit, and we concluded that such treatment should not be recommended. The NORSTENT study (NEJM 2016) compared long-term clinical effects of drug-eluting vs bare metal stents in 9013 patients. There were no significant differences between the two types of stent in mortality, MI, or quality of life, during 6 years of follow-up. In-stent restenosis was lower after drug-eluting stent. In Circulation paper published i 2017 we have discussed potential clinical implications of NORSTENT. Less than a year after publication, NORSTENT is referred to in international guidelines.

Publications

2020

Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Melvær, Giil Lasse; Wilsgaard, Tom; Wiseth, Rune. (2020) The effect of drug-eluting stents on target lesion revascularization in native coronary arteries: Results from the NORSTENT randomized study. Cardiology
Academic article
Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda. (2020) Employment status three years after percutaneous coronary intervention and predictors for being employed: A nationwide prospective cohort study. European Journal of Cardiovascular Nursing
Academic article
Kvåle, Rune; Bønaa, Kaare Harald; Forster, Rachel Bedenis; Gravningen, Kirsten Midttun; Juliusson, Pétur Benedikt; Myklebust, Tor Åge. (2020) Hva betyr tidligere hjerte- og karsykdom eller kreft for risiko for død etter påvist SARS-CoV-2?. Tidsskrift for Den norske legeforening
Academic article

2019

Dhar, Indu; Lysne, Vegard; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Gregory, Jesse F.; Bønaa, Kaare Harald. (2019) Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease. American Journal of Clinical Nutrition
Academic article
Piccolo, Raffaele; Bønaa, Kaare Harald; Efthimiou, Orestis; Varenne, Olivier; Baldo, Andrea; Urban, Philip. (2019) Drug-eluting or bare-metal stents for percutaneous coronary intervention: a systematic review and individual patient data meta-analysis of randomised clinical trials. The Lancet
Academic article
Arnesen, Julie Synnøve; Strøm, Knut Henrik; Bønaa, Kaare Harald; Wiseth, Rune. (2019) Behandling av hjerteinfarkt med ST-elevasjon – en observasjonsstudie. Tidsskrift for Den norske legeforening
Academic article

2018

Olsen, Siv Jorunn Storli; Schirmer, Henrik; Bønaa, Kaare; Hanssen, Tove Aminda. (2018) Cardiac rehabilitation after percutaneous coronary intervention: Results from a nationwide survey. European Journal of Cardiovascular Nursing
Academic article
Govatsmark, Ragna Elise Støre; Janszky, Imre; Slørdahl, Stig Arild; Ebbing, Marta; Wiseth, Rune; Grenne, Bjørnar. (2018) Completeness and correctness of acute myocardial infarction diagnoses in a medical quality register and an administrative health register. Scandinavian Journal of Public Health
Academic article
Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda. (2018) Cardiac rehabilitation and symptoms of anxiety and depression after percutaneous coronary intervention. European Journal of Preventive Cardiology (EJPC)
Academic article
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal. (2018) Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles. Journal of the American Heart Association (JAHA)
Academic article
Bønaa, Kaare; Steigen, Terje. (2018) K.H. Bønaa & T. Steigen svarer. Tidsskrift for Den norske legeforening
Letter to the editor
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; DeRatt, Barbara N.; Ulvik, Arve; Strand, Elin. (2018) Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: Results from two independent cohorts. International Journal of Cardiology
Academic article

2017

Bjørnestad, Espen Øglænd; Borsholm, Robert Andre; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Seifert, Reinhard; Midttun, Øivind. (2017) Neopterin as an effect modifier of the cardiovascular risk predicted by total homocysteine: A prospective 2-cohort study. Journal of the American Heart Association (JAHA)
Academic article
Garcia Lopez, Maria; Bønaa, Kaare; Ebbing, Marta; Eriksen, Erik Fink; Gjesdal, Clara Gram; Nygård, Ottar. (2017) B Vitamins and Hip Fracture: Secondary Analyses and Extended Follow-Up of Two Large Randomized Controlled Trials. Journal of Bone and Mineral Research
Academic article
Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger. (2017) Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979-2012. Atherosclerosis
Academic article
Varmdal, Torunn; Janszky, Imre; Bakken, Inger Johanne; Ellekjær, Hanne; Fjærtoft, Hild; Håberg, Siri Eldevik. (2017) Percutaneous coronary intervention as a trigger for stroke. American Journal of Cardiology
Academic article
Wiseth, Rune; Bønaa, Kaare Harald. (2017) Potential implications of NORSTENT (Norwegian coronary stent trial) in contemporary practice. Circulation
Letter to the editor
Bønaa, Kaare Harald; Steigen, Terje. (2017) Koronar angiografi ved akutt hjerteinfarkt uten ST-elevasjon - hvem og når?. Tidsskrift for Den norske legeforening
Feature article
Hopstock, Laila Arnesdatter; Bønaa, Kaare; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja-Lisa. (2017) Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016 . BMJ Open
Academic article
Albrektsen, Grethe; Bønaa, Kaare. (2017) Body Iron Stores and the Gender Gap in Risk of Incident Myocardial Infarction-Reply. JAMA Internal Medicine
Short communication
Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger. (2017) Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979-2012. Data in Brief
Academic article

2016

Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger. (2016) Lifelong gender gap in risk of incident myocardial infarction: The Tromsø study. JAMA Internal Medicine
Academic article
Nordrehaug, Jan Erik; Wiseth, Rune; Bønaa, Kaare. (2016) The authors reply. New England Journal of Medicine
Letter to the editor
Bønaa, Kaare; Wiseth, Rune; Nordrehaug, Jan Erik. (2016) Drug-eluting or bare-metal stents for coronary artery disease. New England Journal of Medicine
Reader opinion piece
Varmdal, Torunn; Bakken, Inger Johanne; Janszky, Imre; Wethal, Torgeir; Ellekjær, Hanne; Rohweder, Gitta. (2016) Comparison of the validity of stroke diagnoses in a medical quality register and an administrative health register. Scandinavian Journal of Public Health
Academic article
Govatsmark, Ragna Elise; Sneeggen, Sylvi Fredriksen; Karlsaune, Hanne Margrethe Thyrmer; Slørdahl, Stig Arild; Bønaa, Kaare. (2016) Interrater reliability of a national acute myocardial infarction register. Clinical Epidemiology
Academic article
Bønaa, Kaare; Mannsverk, Jan Torbjørn; Wiseth, Rune; Aaberge, Lars; Myreng, Yngvar; Nygård, Ottar. (2016) Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease . New England Journal of Medicine
Academic article
Mannsverk, Jan Torbjørn; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Rasmussen, Knut; Thelle, Dag Steinar. (2016) Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation
Academic article
Malmo, Vegard; Langhammer, Arnulf; Bønaa, Kaare; Loennechen, Jan Pål; Ellekjær, Hanne. (2016) Validation of self-reported and hospital-diagnosed atrial fibrillation: The HUNT study. Clinical Epidemiology
Academic article
Govatsmark, Ragna Elise Støre; Digre, Tormod Aarlott; Sneeggen, Sylvi Fredriksen; Karlsaune, Hanne Margrethe Thürmer; Bønaa, Kaare Harald. (2016) Årsrapport Norsk Hjerteinfarktregister, med plan for forbedringstiltak. St. Olav forlag St. Olav forlag
Report

2015

Varmdal, Torunn; Ellekjær, Hanne; Fjærtoft, Hild; Indredavik, Bent; Lydersen, Stian; Bønaa, Kaare Harald. (2015) Inter-rater reliability of a national acute stroke register. BMC Research Notes
Academic article
Wilsgaard, Tom; Mathiesen, Ellisiv B.; Patwardhan, Anil; Rowe, Michael W.; Schirmer, Henrik; Løchen, Maja-Lisa. (2015) Clinically significant novel biomarkers for prediction of first ever myocardial infarction: The Tromsø Study. Circulation: Cardiovascular Genetics
Academic article
Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Ueland, Per Magne; Pedersen, Eva Ringdal; Seifert, Reinhard; Ebbing, Marta. (2015) Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European Journal of Preventive Cardiology (EJPC)
Academic article
Wilsgaard, Tom; Loehr, LR; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Bønaa, Kaare Harald; Njølstad, Inger. (2015) Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study. BMC Public Health
Academic article
Hopstock, Laila Arnesdatter; Bønaa, Kaare Harald; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja-Lisa. (2015) Longitudinal and secular trends in blood pressure among women and men in birth cohorts born between 1905 and 1977. The Tromsø Study 1979-2008. Hypertension
Academic article
Karlsaune, Hanne Margrethe Thürmer; Digre, Tormod Aarlott; Sneeggen, Sylvi Fredriksen; Govatsmark, Ragna Elise Støre; Bønaa, Kaare Harald. (2015) Årsrapport Norsk Hjereinfarktregister 2015, med forbedringstiltak. St. Olav forlag St. Olav forlag
Magister thesis

2014

Karlsaune, Hanne Margrethe Thürmer; Digre, Tormod Aarlott; Sneeggen, Sylvi Fredriksen; Govatsmark, Ragna Elise Støre; Slørdahl, Stig Arild; Bønaa, Kaare Harald. (2014) Årsrapport Norskhjerteinfarktregister 2014, med plan for forbedringstiltak. St. Olav forlag St. Olav forlag
Report

2013

Bønaa, Kaare Harald. (2013) Mindre risiko for hjerteinfarkt.
Website (informational material)
Vollset, Stein Emil; Clarke, Robert; Lewington, Sarah; Ebbing, Marta; Halsey, Jim; Lonn, Eva. (2013) Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals. The Lancet
Academic article
Hopstock, Laila Arnesdatter; Barnett, Adrian Gerard; Bønaa, Kaare Harald; Mannsverk, Jan Torbjørn; Njølstad, Inger; Wilsgaard, Tom. (2013) Seasonal variation in cardiovascular disease risk factors in a subarctic population: the Tromsø Study 1979-2008. Journal of Epidemiology and Community Health
Academic article

2012

Mannsverk, Jan Torbjørn; Wilsgaard, Tom; Njølstad, Inger; Hopstock, Laila Arnesdatter; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.. (2012) Age and gender differences in incidence and case fatality trends for myocardial infarction: a 30-year follow-up. The Tromso Study. European Journal of Preventive Cardiology (EJPC)
Academic article
Hopstock, Laila Arnesdatter; Fors, Ane Schwenke; Bønaa, Kaare Harald; Mannsverk, Jan Torbjørn; Njølstad, Inger; Wilsgaard, Tom. (2012) The effect of daily weather conditions on myocardial infarction incidence in a subarctic population: the Tromso Study 1974-2004. Journal of Epidemiology and Community Health
Academic article

2011

Berntsen, Rolf Frank; Bønaa, Kaare Harald; Huikuri, Heikki V.; Rasmussen, knut. (2011) Determinants of cardiac vagal regulation: A cross-sectional study in a general population. Autonomic Neuroscience: Basic & Clinical
Academic article
Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Wilsgaard, Tom; Bønaa, Kaare Harald; Løchen, Maja-Lisa; Njølstad, Inger. (2011) Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke : a 10-year follow-up of 6584 men and women : The Tromsø Study. Stroke
Academic article
Hopstock, Laila Arnesdatter; Wilsgaard, Tom; Njølstad, Inger; Mannsverk, Jan Torbjørn; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa. (2011) Seasonal variation in incidence of acute myocardial infarction in a sub-Arctic population: the Tromsø Study 1974-2004. European Journal of Cardiovascular Prevention & Rehabilitation
Academic article

2010

Ebbing, M; Bønaa, Kaare Harald; Arnesen, E; Ueland, PM; Nordrehaug, Jan Erik; Rasmussen, K. (2010) Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. Journal of Internal Medicine
Academic article
Ulvik, Arve; Ebbing, Marta; Hustad, Steinar; Midttun, Øivind; Nygård, Ottar; Vollset, Stein Emil. (2010) Long- and short-term effects of tobacco smoking on circulating concentrations of B vitamins. Clinical Chemistry
Academic article
Collin, Simon M.; Metcalfe, Chris; Refsum, Helga; Lewis, Sarah J.; Zuccolo, Luisa; Smith, George Davey. (2010) Circulating folate, vitamin B-12, homocysteine, vitamin B-12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention
Academic literature review
Njølstad, Inger; Mathiesen, Ellisiv B.; Jacobsen, Bjarne K.; Eggen, Anne Elise; Løchen, Maja-Lisa; Bønaa, Kaare. (2010) Secular and life-time trends in blood pressure in a general population. The Tromsø study. Journal of Hypertension
Abstract
Clarke, Robert; Halsey, Jim; Lewington, Sarah; Lonn, Eva; Armitage, Jane; Manson, JoAnn E. (2010) Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific Mortality Meta-analysis of 8 Randomized Trials Involving 37 485 Individuals. Archives of Internal Medicine
Academic literature review

2009

Ebbing, Marta; Bønaa, Kaare Harald; Nygård, Ottar; Arnesen, Egil; Ueland, Per Magne; Nordrehaug, Jan Erik. (2009) Cancer incidence and mortality after treatment with folic acid and vitamin B12. Journal of the American Medical Association (JAMA)
Academic article

2006

Svartberg, J; Von Muhlen, D; Mathiesen, Ellisiv B.; Joakimsen, Oddmund; Bønaa, Kaare; Stensland-Bugge, Eva. (2006) Low testosterone levels are associated with carotid atherosclerosis in men. Journal of Internal Medicine
Academic article
Bønaa, Kaare; Njølstad, Inger. (2006) Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the randomized trials. American Heart Journal
Academic article
Bønaa, Kaare Harald; Njølstad, Inger; Ueland, Per Magne; Schirmer, Henrik; Tverdal, Aage; Steigen, Terje. (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. New England Journal of Medicine
Academic article
Bønaa, Kaare Harald; Bonaa, KH; Tverdal, Aage; Ueland, Per Magne. (2006) Homocysteine, B vitamins, and cardiovascular disease - Reply. New England Journal of Medicine
Reader opinion piece

2004

Vik-Mo, Harald; Bønaa, Kåre. (2004) Coronary stents reduce restenosis and repeat revascularizations and may also improve survival. Scandinavian Cardiovascular Journal
Academic literature review
Brodin, Elin; Borvik, T; Børvik , T; Sandset, PM; Bønaa, Kaare; Nordøy, Arne. (2004) Coagulation activation in young survivors of myocardial infarction (MI) - a population-based case-control study. Thrombosis and Haemostasis
Academic article
Mathiesen, Ellisiv B.; Waterloo, Knut K; Joakimsen, Oddmund; Bakke, Søren jacob; Jacobsen, Eva A; Bønaa, Kaare. (2004) Reduced neuropsychological test performance in asymptomatic carotid stenosis - The Tromso Study. Neurology
Academic article

2003

Singh, Kulbir; Jacobsen, Bjarne Koster; Solberg, Steinar; Bønaa, Kaare; Kumar, s; Bajic, R. (2003) Intra- and interobserver variablity in the measurements of abdominal aortic and common iliac artery diameter with computed tomography. The Tromsø Study. European Journal of Vascular and Endovascular Surgery
Academic article
Toft, Ingrid; Lindal, Sigurd; Bønaa, KH; Jenssen, Trond Geir. (2003) Quantitative measurement of muscle fibre composition in a normal population. Muscle and Nerve
Academic article
Svartberg, Johan; Jorde, Rolf; Sundsfjord, Johan A; Barrett-Connor, E; Bønaa, Kaare. (2003) Seasonal variation of ttestosterone and waist to hip ratio in men: The Tromsø Study. Journal of Clinical Endocrinology and Metabolism (JCEM)
Academic article
Svartberg, Johan; Midtby, Monica; Bønaa, Kaare; Sundsfjord, Johan A; Joakimsen, Ragnar M; Jorde, Rolf. (2003) The associations of age, life-style factors and chronic disease with testosterone in men. European Journal of Endocrinology (EJE)
Academic article

2002

Clarke, R; Collins, R; Lewington, S; Donald, A.; Alfthan, G; Tuomilehto, J. (2002) Homocysteine and risk of ischemic heart disease and stroke. A Meta-analysis. Journal of the American Medical Association (JAMA)
Academic literature review
Jacobsen, Bjarne K.; Bønaa, Kaare Harald; Njølstad, Inger. (2002) Cardiovascular risk factors, change in risk factors over 7 years, and the risk of clinical diabetes mellitus type 2 The Tromsø study. Clinical Epidemiology
Academic article
Mathiesen, Ellisiv B.; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2002) Cholesterol and Carotid Stenosis. Stroke
Letter to the editor
Toft, Ingrid; Bønaa, Kaare Harald; Eikrem, jorunn; Bendiksen, Åse Lund; Iversen, Hege; Jenssen, Trond. (2002) Microalbuminuria in hypertension is not a determinant of insulin resistance. Kidney International
Academic article

2001

Jorde, Rolf; Sundsfjord, J; Bønaa, Kaare Harald. (2001) Determinants of serum calcium in men and women. The Tromsø study. European Journal of Epidemiology (EJE)
Academic article
Mathiesen, Ellisiv B.; Joakimsen, Oddmund; Bønaa, Kaare Harald. (2001) Prevalence of and Risk Factors Associated with Carotid Artery Stenosis: The Tromsø Study. Cerebrovascular Diseases
Academic article
Mathiesen, Ellisiv B.; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2001) Echolucent Plaques Are Associated With High Risk of Ischemic Cerebrovascular Events in Carotid Stenosis The Tromsø Study. Circulation
Academic article
Mathiesen, Ellisiv B.; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2001) Low Levels of High-Density Lipoprotein Cholesterol Are Associated With Echolucent Carotid Artery Plaques: The Tromsø Study. Stroke
Academic article
Stensland-Bugge, Eva; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2001) Age and sex differences in the relationship between inherited and lifestyle risk factors and subclinical carotid atherosclerosis: the Tromsø study. Atherosclerosis
Academic article
Singh, K; Bønaa, Kaare; Jacobsen, Bjarne Koster; Bjørk, L; Solberg, Steinar. (2001) Prevalence of and risk factors for abdominal aortic aneurisms in a population-based study: The Tromsø Study. American Journal of Epidemiology
Academic article
Hansen, John-Bjarne; Grimsgaard, Sameline; Huseby, Nils-Erik; Sandset, Per Morten; Bønaa, Kåre H.. (2001) Serum lipids and regulation of tissue factor-induced coagulation in middle-aged men. Thrombosis Research
Academic article

2000

Joakimsen, Oddmund; Bønaa, Kaare Harald; Stensland-Bugge, Eva; Jacobsen, Bjarne K.. (2000) Population-based study of age at menopause and ultrasound assessed carotid atherosclerosis The Tromsø Study. Journal of Clinical Epidemiology
Academic article
Joakimsen, Oddmund; Bønaa, Kaare Harald; Mathiesen, Ellisiv B.; Stensland-Bugge, Eva; Arnesen, Egil. (2000) Prediction of Mortality by Ultrasound Screening of a General Population for Carotid Stenosis The Tromsø Study. Stroke
Academic article
Mathiesen, Ellisiv B.; Joakimsen, Oddmund; Bønaa, Kaare Harald. (2000) Intersonographer Reproducibility and Intermethod Variability of Ultrasound Measurements of Carotid Artery Stenosis:The Tromsø Study. Cerebrovascular Diseases
Academic article
Stensland-Bugge, Eva; Bønaa, Kaare Harald; Joakimsen, Oddmund; Njølstad, Inger. (2000) Sex Differences in the Relationship of Risk Factors to Subclinical Carotid Atherosclerosis Measured 15 Years Later: The Tromsø Study. Stroke
Academic article
Engstad, Torgeir; Bønaa, Kaare Harald; Viitanen, Matti. (2000) Validity of Self-Reported Stroke: The Tromsø Study. Stroke
Academic article
Jorde, Rolf; Bønaa, Kaare Harald. (2000) Calcium from dairy products, vitamin D intake, and blood pressure: the Tromsø study. American Journal of Clinical Nutrition
Academic article
Jorde, Rolf; Bønaa, Kaare Harald; Sundsfjord, Johan A.. (2000) Primary hyperparathyroidism detected in a health screening: The Tromsø Study. Journal of Clinical Epidemiology
Academic article
Nordøy, Arne; Bønaa, Kåre H.; Sandset, Per Morten; Hansen, J.B.; Nilsen, Harald. (2000) Effect of omega-3 Fatty Acids and Simvastatin on Hemostatic Risk Factors and Postprandial Hyperlipemia in Patients With Combined Hyperlipemia. Arteriosclerosis, Thrombosis and Vascular Biology
Academic article
Grimsgaard, Sameline; Bønaa, Kaare Harald; Bjerve, Kristian S. (2000) Fatty acid chain length and degree of unsaturation are inversely associated with serum triacylglycerol concentrations. Lipids
Academic article
Hansen, John-Bjarne; Grimsgaard, Sameline; Nordøy, Arne; Bønaa, Kaare Harald. (2000) Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. Thrombosis Research
Academic article
Grimsgaard, Sameline; Bønaa, Kåre H.; Bjerve, Kristian S. (2000) Fatty acid chain length and degree of unsaturation are inversely associated with serum triglycerides. Lipids
Academic article
Jorde, Rolf; Sundsfjord, J.A.; Haug, Egil; Bønaa, Kåre H.. (2000) Relation between low calcium intake, parathyroid hormone, and blood pressure. Hypertension
Academic article
Nordøy, Arne; Bønaa, Kåre H.; Sandset, Per Morten; Hansen, John-Bjarne; Nilsen, Harald. (2000) Relationship between apolipoprotein E polymorphism, postprandial hyperlipemia and hemostatic variables in patients with combined hyperlipemia. NMCD. Nutrition Metabolism and Cardiovascular Diseases
Academic article

1999

Jorde, Rolf; Sundsfjord, Johan; Fitzgerald, Patrick; Bønaa, Kaare Harald. (1999) Serum Calcium and Cardiovascular Risk Factors and Diseases The Tromsø Study. Hypertension
Academic article
Jorde, Rolf; Bønaa, Kaare Harald; Sundsfjord, Johan. (1999) Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromsø study. European Journal of Endocrinology (EJE)
Academic article
Delghandi, Madjid; Thangarajah, R; Nilsen, M; Grimsgaard, Sameline; Bønaa, Kaare Harald; Tonstad, Serena. (1999) DNA polymorphisms of the apolipoprotein B gene (XbaI, EcoRI, and MspIRFLPs) in Norwegians at risk of coronary artery disease and healthy controls. Acta Cardiologica
Academic article
Grimsgaard, Sameline; Bønaa, KH; Jacobsen, B. K.; Bjerve, Kristian S. (1999) Plasma saturated and linoleic fattty acids are independently associated with blood pressure. Hypertension
Academic article

1998

Nordøy, A.; Bønaa, K. H.; Nilsen, H.; Berge, Rolf Kristian; Hansen, J. B.; Ingebretsen, O. C.. (1998) Effects of Simvastatin and omega-3 fatty acids on plasma lipoproteins and lipid peroxidation in patients with combined hyperlipidaemia. Journal of Internal Medicine
Academic article
Hansen, J. B.; Berge, Rolf Kristian; Nordøy, A.; Bønaa, K. H.. (1998) Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after prolonged intake of highly purified eicosapentaenoic (EPA) or docosahecaenoic (DHA) acids. Lipids
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Lindal, Sigurd; Jenssen, Trond. (1998) Insulin Kinetics, Insulin Action, and Muscle Morphology in Lean or Slightly Overweight Persons With Impaired Glucose Tolerance. Metabolism: Clinical and Experimental
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Jenssen, Trond. (1998) Insulin Resistance in Hypertension Is Associated With Body Fat Rather Than Blood Pressure. Hypertension
Academic article
Grimsgaard, Sameline; Bønaa, Kaare Harald; Hansen, John-Bjarne; Myhre, Eivind S. P.. (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. American Journal of Clinical Nutrition
Academic article
Hansen, John-Bjarne; Grimsgaard, Sameline; Nilsen, Hugo; Nordøy, Arne; Bønaa, Kaare Harald. (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. Lipids
Academic article

1997

Toft, Ingrid; Bønaa, Kaare Harald; Ingebretsen, Ole C; NordØy, arne; Jenssen, Trond. (1997) Fibrinolytic Function After Dietary Supplementation With ω3 Polyunsaturated Fatty Acids. Arteriosclerosis, Thrombosis and Vascular Biology
Academic article
Tverdal, A; Åsberg, A; Bønaa, Kaare Harald; Stensvold, I.; Grudt, G; Ingebretsen, O.C.. (1997) Sammenligning av to blodprøver fra samme person analysert ved to laboratorier. Norsk Epidemiologi
Academic article
Halvorsen, Dag Seeger; Hansen, John-Bjarne; Grimsgaard, Sameline; Bønaa, Kaare Harald; Kierulf, Peter; Nordøy, Arne. (1997) The effect of highly purified Eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. Lipids
Academic article
Grimsgaard, Sameline; Bønaa, Kaare Harald; Hansen, John-Bjarne; Nordøy, Arne. (1997) Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol lowering effect but divergent effects on plasma fatty acids. American Journal of Clinical Nutrition
Academic article
Halvorsen, Dag S.; Hansen, J.B.; Grimsgaard, S.; Bønaa, Kåre H.; Kierulf, Peter; Nordøy, Arne. (1997) The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. Lipids
Academic article
Toft, Ingrid; Bønaa, Kåre H.; Ingebretsen, O.C.; Nordøy, Arne; Birkeland, Kåre I.; Jenssen, T.. (1997) Gender differences in the relationships between plasma plasminogen activator inhibitor-1 activity and factors linked to th insulin resistance syndrome in essential hypertension. Biol
Academic article

1995

Arnesen, Erik; Refsum, H.; Bønaa, K.H.; Ueland, P.M.; Førde, O.H.; Nordrehaug, J.E.. (1995) Serum total homocysteine and coronary heart disease. International Journal of Epidemiology
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Ingebretsen, Ole C; NordØy, arne; Jenssen, Trond. (1995) Effects of n-3 Polyunsaturated Fatty Acids on Glucose Homeostasis and Blood Pressure in Essential Hypertension A Randomized, Controlled Trial. Annals of Internal Medicine
Academic article

1992

Bønaa, K.H.; Bjerve, Kristian S; Nordøy, A.. (1992) Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoproteins in man. Arteriosclerosis and thrombosis
Academic article
Bønaa, K. H.; Bjerve, Kristian S; Nordøy, A.. (1992) Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Tromsø study. American Journal of Clinical Nutrition
Academic article
Bjerve, Kristian S; Thoresen, L.; Bønaa, KH; Vik, Torstein; Johnsen, Harald; Brubakk, Ann-Mari. (1992) Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. Nutrition - The International Journal of Applied and Basic Nutritional Sciences
Academic article

1991

Bønaa, Kaare Harald; Thelle, Dag Steinar. (1991) Association Between Blood Pressure and Serum Lipids in a Population. The Tromsø Study. Circulation
Academic article

1990

Bjerve, Kristian S; Bønaa, KH; Midthjell, Kristian; Fougner, Kristian J. (1990) Fatty Acids in Hypertension and Cardiovascular disease. Scandinavian Journal of Clinical and Laboratory Investigation
Academic literature review
Bønaa, KH; Bjerve, KS; Straume, Bjørn; Gram, Inger Torhild; Thelle, DS. (1990) Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. New England Journal of Medicine
Academic article

1989

Bjerve, Kristian S; Fougner, Kristian J; Midthjell, Kristian; Bønaa, K. H.. (1989) N-3 fatty acids in old age. Journal of Internal Medicine
Academic article

Journal publications

Kjellstadli, Camilla; Forster, Rachel Bedenis; Myklebust, Tor Åge; Bjørge, Tone; Bønaa, Kaare Harald; Helle, Svein Inge. (2023) Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study. Frontiers in Oncology
Academic article
Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd. (2023) Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study. Journal of Internal Medicine
Academic article
Albrektsen, Grethe; Wilsgaard, Tom; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Njølstad, Inger. (2023) Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016. Journal of the American Heart Association (JAHA)
Academic article
Piccolo, Raffaele; Bønaa, Kaare Harald; Efthimiou, Orestis; Varenne, Olivier; Baldo, Andrea; Urban, Philip. (2022) Individual Patient Data Meta-analysis of Drug-eluting Versus Bare-metal Stents for Percutaneous Coronary Intervention in Chronic Versus Acute Coronary Syndromes. American Journal of Cardiology
Academic article
Forster, Rachel Bedenis; Kjellstadli, Camilla; Myklebust, Tor Åge; Egeland, Grace M.; Sulo, Gerhard; Bjørge, Tone. (2022) Treatment and 30-Day Mortality after Myocardial Infarction in Prostate Cancer Patients: A Population-Based Study from Norway. Cardiology
Academic article
Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald. (2021) Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study. Cardiology
Academic article
Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Rotevatn, Svein. (2021) Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study. Cardiology
Academic article
Piccolo, Raffaele; Bonaa, Kaare H.; Efthimiou, Orestis; Varenne, Olivier; Urban, Philip; Kaiser, Christoph. (2021) Drug-eluting or bare-metal stents for left anterior descending or left main coronary artery revascularization. Journal of the American Heart Association (JAHA)
Academic article
Varmdal, Torunn; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Nyrnes, Audhild; Grimsgaard, Sameline. (2021) Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study. Clinical Epidemiology
Academic article
Løvsletten, Ola; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter; Jacobsen, Bjarne K.; Bønaa, Kaare Harald. (2021) Is the ongoing obesity epidemic partly explained by concurrent decline in cigarette smoking? Insights from a longitudinal population study. The Tromsø Study 1994–2016. Preventive Medicine
Academic article
Sen, Abhijit; Bakken, Inger Johanne Landsjøåsen; Govatsmark, Ragna Elise Støre; Varmdal, Torunn; Bønaa, Kaare Harald; Mukamal, Kenneth Jay. (2021) Influenza vaccination and risk for cardiovascular events: a nationwide self-controlled case series study. BMC Cardiovascular Disorders
Academic article
Borchgrevink, Petter Chr.; Glette, Mari; Woodhouse, Astrid; Butler, Stephen; Landmark, Tormod; Romundstad, Pål. (2021) A Clinical Description of Chronic Pain in a General Population Using ICD-10 and ICD-11 (The HUNT Pain Examination Study). Journal of Pain
Academic article
Samuelsen, Per-Jostein; Eggen, Anne Elise; Steigen, Terje; Wilsgaard, Tom; Kristensen, Andreas; Skogsholm, Anne. (2021) Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT). PLOS ONE
Academic article
Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Melvær, Giil Lasse; Wilsgaard, Tom; Wiseth, Rune. (2020) The effect of drug-eluting stents on target lesion revascularization in native coronary arteries: Results from the NORSTENT randomized study. Cardiology
Academic article
Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda. (2020) Employment status three years after percutaneous coronary intervention and predictors for being employed: A nationwide prospective cohort study. European Journal of Cardiovascular Nursing
Academic article
Kvåle, Rune; Bønaa, Kaare Harald; Forster, Rachel Bedenis; Gravningen, Kirsten Midttun; Juliusson, Pétur Benedikt; Myklebust, Tor Åge. (2020) Hva betyr tidligere hjerte- og karsykdom eller kreft for risiko for død etter påvist SARS-CoV-2?. Tidsskrift for Den norske legeforening
Academic article
Dhar, Indu; Lysne, Vegard; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Gregory, Jesse F.; Bønaa, Kaare Harald. (2019) Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease. American Journal of Clinical Nutrition
Academic article
Piccolo, Raffaele; Bønaa, Kaare Harald; Efthimiou, Orestis; Varenne, Olivier; Baldo, Andrea; Urban, Philip. (2019) Drug-eluting or bare-metal stents for percutaneous coronary intervention: a systematic review and individual patient data meta-analysis of randomised clinical trials. The Lancet
Academic article
Arnesen, Julie Synnøve; Strøm, Knut Henrik; Bønaa, Kaare Harald; Wiseth, Rune. (2019) Behandling av hjerteinfarkt med ST-elevasjon – en observasjonsstudie. Tidsskrift for Den norske legeforening
Academic article
Olsen, Siv Jorunn Storli; Schirmer, Henrik; Bønaa, Kaare; Hanssen, Tove Aminda. (2018) Cardiac rehabilitation after percutaneous coronary intervention: Results from a nationwide survey. European Journal of Cardiovascular Nursing
Academic article
Govatsmark, Ragna Elise Støre; Janszky, Imre; Slørdahl, Stig Arild; Ebbing, Marta; Wiseth, Rune; Grenne, Bjørnar. (2018) Completeness and correctness of acute myocardial infarction diagnoses in a medical quality register and an administrative health register. Scandinavian Journal of Public Health
Academic article
Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda. (2018) Cardiac rehabilitation and symptoms of anxiety and depression after percutaneous coronary intervention. European Journal of Preventive Cardiology (EJPC)
Academic article
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal. (2018) Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles. Journal of the American Heart Association (JAHA)
Academic article
Bønaa, Kaare; Steigen, Terje. (2018) K.H. Bønaa & T. Steigen svarer. Tidsskrift for Den norske legeforening
Letter to the editor
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; DeRatt, Barbara N.; Ulvik, Arve; Strand, Elin. (2018) Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: Results from two independent cohorts. International Journal of Cardiology
Academic article
Bjørnestad, Espen Øglænd; Borsholm, Robert Andre; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Seifert, Reinhard; Midttun, Øivind. (2017) Neopterin as an effect modifier of the cardiovascular risk predicted by total homocysteine: A prospective 2-cohort study. Journal of the American Heart Association (JAHA)
Academic article
Garcia Lopez, Maria; Bønaa, Kaare; Ebbing, Marta; Eriksen, Erik Fink; Gjesdal, Clara Gram; Nygård, Ottar. (2017) B Vitamins and Hip Fracture: Secondary Analyses and Extended Follow-Up of Two Large Randomized Controlled Trials. Journal of Bone and Mineral Research
Academic article
Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger. (2017) Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979-2012. Atherosclerosis
Academic article
Varmdal, Torunn; Janszky, Imre; Bakken, Inger Johanne; Ellekjær, Hanne; Fjærtoft, Hild; Håberg, Siri Eldevik. (2017) Percutaneous coronary intervention as a trigger for stroke. American Journal of Cardiology
Academic article
Wiseth, Rune; Bønaa, Kaare Harald. (2017) Potential implications of NORSTENT (Norwegian coronary stent trial) in contemporary practice. Circulation
Letter to the editor
Bønaa, Kaare Harald; Steigen, Terje. (2017) Koronar angiografi ved akutt hjerteinfarkt uten ST-elevasjon - hvem og når?. Tidsskrift for Den norske legeforening
Feature article
Hopstock, Laila Arnesdatter; Bønaa, Kaare; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja-Lisa. (2017) Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016 . BMJ Open
Academic article
Albrektsen, Grethe; Bønaa, Kaare. (2017) Body Iron Stores and the Gender Gap in Risk of Incident Myocardial Infarction-Reply. JAMA Internal Medicine
Short communication
Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger. (2017) Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979-2012. Data in Brief
Academic article
Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger. (2016) Lifelong gender gap in risk of incident myocardial infarction: The Tromsø study. JAMA Internal Medicine
Academic article
Nordrehaug, Jan Erik; Wiseth, Rune; Bønaa, Kaare. (2016) The authors reply. New England Journal of Medicine
Letter to the editor
Bønaa, Kaare; Wiseth, Rune; Nordrehaug, Jan Erik. (2016) Drug-eluting or bare-metal stents for coronary artery disease. New England Journal of Medicine
Reader opinion piece
Varmdal, Torunn; Bakken, Inger Johanne; Janszky, Imre; Wethal, Torgeir; Ellekjær, Hanne; Rohweder, Gitta. (2016) Comparison of the validity of stroke diagnoses in a medical quality register and an administrative health register. Scandinavian Journal of Public Health
Academic article
Govatsmark, Ragna Elise; Sneeggen, Sylvi Fredriksen; Karlsaune, Hanne Margrethe Thyrmer; Slørdahl, Stig Arild; Bønaa, Kaare. (2016) Interrater reliability of a national acute myocardial infarction register. Clinical Epidemiology
Academic article
Bønaa, Kaare; Mannsverk, Jan Torbjørn; Wiseth, Rune; Aaberge, Lars; Myreng, Yngvar; Nygård, Ottar. (2016) Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease . New England Journal of Medicine
Academic article
Mannsverk, Jan Torbjørn; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Rasmussen, Knut; Thelle, Dag Steinar. (2016) Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation
Academic article
Malmo, Vegard; Langhammer, Arnulf; Bønaa, Kaare; Loennechen, Jan Pål; Ellekjær, Hanne. (2016) Validation of self-reported and hospital-diagnosed atrial fibrillation: The HUNT study. Clinical Epidemiology
Academic article
Varmdal, Torunn; Ellekjær, Hanne; Fjærtoft, Hild; Indredavik, Bent; Lydersen, Stian; Bønaa, Kaare Harald. (2015) Inter-rater reliability of a national acute stroke register. BMC Research Notes
Academic article
Wilsgaard, Tom; Mathiesen, Ellisiv B.; Patwardhan, Anil; Rowe, Michael W.; Schirmer, Henrik; Løchen, Maja-Lisa. (2015) Clinically significant novel biomarkers for prediction of first ever myocardial infarction: The Tromsø Study. Circulation: Cardiovascular Genetics
Academic article
Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Ueland, Per Magne; Pedersen, Eva Ringdal; Seifert, Reinhard; Ebbing, Marta. (2015) Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European Journal of Preventive Cardiology (EJPC)
Academic article
Wilsgaard, Tom; Loehr, LR; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Bønaa, Kaare Harald; Njølstad, Inger. (2015) Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study. BMC Public Health
Academic article
Hopstock, Laila Arnesdatter; Bønaa, Kaare Harald; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja-Lisa. (2015) Longitudinal and secular trends in blood pressure among women and men in birth cohorts born between 1905 and 1977. The Tromsø Study 1979-2008. Hypertension
Academic article
Vollset, Stein Emil; Clarke, Robert; Lewington, Sarah; Ebbing, Marta; Halsey, Jim; Lonn, Eva. (2013) Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals. The Lancet
Academic article
Hopstock, Laila Arnesdatter; Barnett, Adrian Gerard; Bønaa, Kaare Harald; Mannsverk, Jan Torbjørn; Njølstad, Inger; Wilsgaard, Tom. (2013) Seasonal variation in cardiovascular disease risk factors in a subarctic population: the Tromsø Study 1979-2008. Journal of Epidemiology and Community Health
Academic article
Mannsverk, Jan Torbjørn; Wilsgaard, Tom; Njølstad, Inger; Hopstock, Laila Arnesdatter; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.. (2012) Age and gender differences in incidence and case fatality trends for myocardial infarction: a 30-year follow-up. The Tromso Study. European Journal of Preventive Cardiology (EJPC)
Academic article
Hopstock, Laila Arnesdatter; Fors, Ane Schwenke; Bønaa, Kaare Harald; Mannsverk, Jan Torbjørn; Njølstad, Inger; Wilsgaard, Tom. (2012) The effect of daily weather conditions on myocardial infarction incidence in a subarctic population: the Tromso Study 1974-2004. Journal of Epidemiology and Community Health
Academic article
Berntsen, Rolf Frank; Bønaa, Kaare Harald; Huikuri, Heikki V.; Rasmussen, knut. (2011) Determinants of cardiac vagal regulation: A cross-sectional study in a general population. Autonomic Neuroscience: Basic & Clinical
Academic article
Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Wilsgaard, Tom; Bønaa, Kaare Harald; Løchen, Maja-Lisa; Njølstad, Inger. (2011) Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke : a 10-year follow-up of 6584 men and women : The Tromsø Study. Stroke
Academic article
Hopstock, Laila Arnesdatter; Wilsgaard, Tom; Njølstad, Inger; Mannsverk, Jan Torbjørn; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa. (2011) Seasonal variation in incidence of acute myocardial infarction in a sub-Arctic population: the Tromsø Study 1974-2004. European Journal of Cardiovascular Prevention & Rehabilitation
Academic article
Ebbing, M; Bønaa, Kaare Harald; Arnesen, E; Ueland, PM; Nordrehaug, Jan Erik; Rasmussen, K. (2010) Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. Journal of Internal Medicine
Academic article
Ulvik, Arve; Ebbing, Marta; Hustad, Steinar; Midttun, Øivind; Nygård, Ottar; Vollset, Stein Emil. (2010) Long- and short-term effects of tobacco smoking on circulating concentrations of B vitamins. Clinical Chemistry
Academic article
Collin, Simon M.; Metcalfe, Chris; Refsum, Helga; Lewis, Sarah J.; Zuccolo, Luisa; Smith, George Davey. (2010) Circulating folate, vitamin B-12, homocysteine, vitamin B-12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention
Academic literature review
Njølstad, Inger; Mathiesen, Ellisiv B.; Jacobsen, Bjarne K.; Eggen, Anne Elise; Løchen, Maja-Lisa; Bønaa, Kaare. (2010) Secular and life-time trends in blood pressure in a general population. The Tromsø study. Journal of Hypertension
Abstract
Clarke, Robert; Halsey, Jim; Lewington, Sarah; Lonn, Eva; Armitage, Jane; Manson, JoAnn E. (2010) Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific Mortality Meta-analysis of 8 Randomized Trials Involving 37 485 Individuals. Archives of Internal Medicine
Academic literature review
Ebbing, Marta; Bønaa, Kaare Harald; Nygård, Ottar; Arnesen, Egil; Ueland, Per Magne; Nordrehaug, Jan Erik. (2009) Cancer incidence and mortality after treatment with folic acid and vitamin B12. Journal of the American Medical Association (JAMA)
Academic article
Svartberg, J; Von Muhlen, D; Mathiesen, Ellisiv B.; Joakimsen, Oddmund; Bønaa, Kaare; Stensland-Bugge, Eva. (2006) Low testosterone levels are associated with carotid atherosclerosis in men. Journal of Internal Medicine
Academic article
Bønaa, Kaare; Njølstad, Inger. (2006) Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the randomized trials. American Heart Journal
Academic article
Bønaa, Kaare Harald; Njølstad, Inger; Ueland, Per Magne; Schirmer, Henrik; Tverdal, Aage; Steigen, Terje. (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. New England Journal of Medicine
Academic article
Bønaa, Kaare Harald; Bonaa, KH; Tverdal, Aage; Ueland, Per Magne. (2006) Homocysteine, B vitamins, and cardiovascular disease - Reply. New England Journal of Medicine
Reader opinion piece
Vik-Mo, Harald; Bønaa, Kåre. (2004) Coronary stents reduce restenosis and repeat revascularizations and may also improve survival. Scandinavian Cardiovascular Journal
Academic literature review
Brodin, Elin; Borvik, T; Børvik , T; Sandset, PM; Bønaa, Kaare; Nordøy, Arne. (2004) Coagulation activation in young survivors of myocardial infarction (MI) - a population-based case-control study. Thrombosis and Haemostasis
Academic article
Mathiesen, Ellisiv B.; Waterloo, Knut K; Joakimsen, Oddmund; Bakke, Søren jacob; Jacobsen, Eva A; Bønaa, Kaare. (2004) Reduced neuropsychological test performance in asymptomatic carotid stenosis - The Tromso Study. Neurology
Academic article
Singh, Kulbir; Jacobsen, Bjarne Koster; Solberg, Steinar; Bønaa, Kaare; Kumar, s; Bajic, R. (2003) Intra- and interobserver variablity in the measurements of abdominal aortic and common iliac artery diameter with computed tomography. The Tromsø Study. European Journal of Vascular and Endovascular Surgery
Academic article
Toft, Ingrid; Lindal, Sigurd; Bønaa, KH; Jenssen, Trond Geir. (2003) Quantitative measurement of muscle fibre composition in a normal population. Muscle and Nerve
Academic article
Svartberg, Johan; Jorde, Rolf; Sundsfjord, Johan A; Barrett-Connor, E; Bønaa, Kaare. (2003) Seasonal variation of ttestosterone and waist to hip ratio in men: The Tromsø Study. Journal of Clinical Endocrinology and Metabolism (JCEM)
Academic article
Svartberg, Johan; Midtby, Monica; Bønaa, Kaare; Sundsfjord, Johan A; Joakimsen, Ragnar M; Jorde, Rolf. (2003) The associations of age, life-style factors and chronic disease with testosterone in men. European Journal of Endocrinology (EJE)
Academic article
Clarke, R; Collins, R; Lewington, S; Donald, A.; Alfthan, G; Tuomilehto, J. (2002) Homocysteine and risk of ischemic heart disease and stroke. A Meta-analysis. Journal of the American Medical Association (JAMA)
Academic literature review
Jacobsen, Bjarne K.; Bønaa, Kaare Harald; Njølstad, Inger. (2002) Cardiovascular risk factors, change in risk factors over 7 years, and the risk of clinical diabetes mellitus type 2 The Tromsø study. Clinical Epidemiology
Academic article
Mathiesen, Ellisiv B.; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2002) Cholesterol and Carotid Stenosis. Stroke
Letter to the editor
Toft, Ingrid; Bønaa, Kaare Harald; Eikrem, jorunn; Bendiksen, Åse Lund; Iversen, Hege; Jenssen, Trond. (2002) Microalbuminuria in hypertension is not a determinant of insulin resistance. Kidney International
Academic article
Jorde, Rolf; Sundsfjord, J; Bønaa, Kaare Harald. (2001) Determinants of serum calcium in men and women. The Tromsø study. European Journal of Epidemiology (EJE)
Academic article
Mathiesen, Ellisiv B.; Joakimsen, Oddmund; Bønaa, Kaare Harald. (2001) Prevalence of and Risk Factors Associated with Carotid Artery Stenosis: The Tromsø Study. Cerebrovascular Diseases
Academic article
Mathiesen, Ellisiv B.; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2001) Echolucent Plaques Are Associated With High Risk of Ischemic Cerebrovascular Events in Carotid Stenosis The Tromsø Study. Circulation
Academic article
Mathiesen, Ellisiv B.; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2001) Low Levels of High-Density Lipoprotein Cholesterol Are Associated With Echolucent Carotid Artery Plaques: The Tromsø Study. Stroke
Academic article
Stensland-Bugge, Eva; Bønaa, Kaare Harald; Joakimsen, Oddmund. (2001) Age and sex differences in the relationship between inherited and lifestyle risk factors and subclinical carotid atherosclerosis: the Tromsø study. Atherosclerosis
Academic article
Singh, K; Bønaa, Kaare; Jacobsen, Bjarne Koster; Bjørk, L; Solberg, Steinar. (2001) Prevalence of and risk factors for abdominal aortic aneurisms in a population-based study: The Tromsø Study. American Journal of Epidemiology
Academic article
Hansen, John-Bjarne; Grimsgaard, Sameline; Huseby, Nils-Erik; Sandset, Per Morten; Bønaa, Kåre H.. (2001) Serum lipids and regulation of tissue factor-induced coagulation in middle-aged men. Thrombosis Research
Academic article
Joakimsen, Oddmund; Bønaa, Kaare Harald; Stensland-Bugge, Eva; Jacobsen, Bjarne K.. (2000) Population-based study of age at menopause and ultrasound assessed carotid atherosclerosis The Tromsø Study. Journal of Clinical Epidemiology
Academic article
Joakimsen, Oddmund; Bønaa, Kaare Harald; Mathiesen, Ellisiv B.; Stensland-Bugge, Eva; Arnesen, Egil. (2000) Prediction of Mortality by Ultrasound Screening of a General Population for Carotid Stenosis The Tromsø Study. Stroke
Academic article
Mathiesen, Ellisiv B.; Joakimsen, Oddmund; Bønaa, Kaare Harald. (2000) Intersonographer Reproducibility and Intermethod Variability of Ultrasound Measurements of Carotid Artery Stenosis:The Tromsø Study. Cerebrovascular Diseases
Academic article
Stensland-Bugge, Eva; Bønaa, Kaare Harald; Joakimsen, Oddmund; Njølstad, Inger. (2000) Sex Differences in the Relationship of Risk Factors to Subclinical Carotid Atherosclerosis Measured 15 Years Later: The Tromsø Study. Stroke
Academic article
Engstad, Torgeir; Bønaa, Kaare Harald; Viitanen, Matti. (2000) Validity of Self-Reported Stroke: The Tromsø Study. Stroke
Academic article
Jorde, Rolf; Bønaa, Kaare Harald. (2000) Calcium from dairy products, vitamin D intake, and blood pressure: the Tromsø study. American Journal of Clinical Nutrition
Academic article
Jorde, Rolf; Bønaa, Kaare Harald; Sundsfjord, Johan A.. (2000) Primary hyperparathyroidism detected in a health screening: The Tromsø Study. Journal of Clinical Epidemiology
Academic article
Nordøy, Arne; Bønaa, Kåre H.; Sandset, Per Morten; Hansen, J.B.; Nilsen, Harald. (2000) Effect of omega-3 Fatty Acids and Simvastatin on Hemostatic Risk Factors and Postprandial Hyperlipemia in Patients With Combined Hyperlipemia. Arteriosclerosis, Thrombosis and Vascular Biology
Academic article
Grimsgaard, Sameline; Bønaa, Kaare Harald; Bjerve, Kristian S. (2000) Fatty acid chain length and degree of unsaturation are inversely associated with serum triacylglycerol concentrations. Lipids
Academic article
Hansen, John-Bjarne; Grimsgaard, Sameline; Nordøy, Arne; Bønaa, Kaare Harald. (2000) Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. Thrombosis Research
Academic article
Grimsgaard, Sameline; Bønaa, Kåre H.; Bjerve, Kristian S. (2000) Fatty acid chain length and degree of unsaturation are inversely associated with serum triglycerides. Lipids
Academic article
Jorde, Rolf; Sundsfjord, J.A.; Haug, Egil; Bønaa, Kåre H.. (2000) Relation between low calcium intake, parathyroid hormone, and blood pressure. Hypertension
Academic article
Nordøy, Arne; Bønaa, Kåre H.; Sandset, Per Morten; Hansen, John-Bjarne; Nilsen, Harald. (2000) Relationship between apolipoprotein E polymorphism, postprandial hyperlipemia and hemostatic variables in patients with combined hyperlipemia. NMCD. Nutrition Metabolism and Cardiovascular Diseases
Academic article
Jorde, Rolf; Sundsfjord, Johan; Fitzgerald, Patrick; Bønaa, Kaare Harald. (1999) Serum Calcium and Cardiovascular Risk Factors and Diseases The Tromsø Study. Hypertension
Academic article
Jorde, Rolf; Bønaa, Kaare Harald; Sundsfjord, Johan. (1999) Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromsø study. European Journal of Endocrinology (EJE)
Academic article
Delghandi, Madjid; Thangarajah, R; Nilsen, M; Grimsgaard, Sameline; Bønaa, Kaare Harald; Tonstad, Serena. (1999) DNA polymorphisms of the apolipoprotein B gene (XbaI, EcoRI, and MspIRFLPs) in Norwegians at risk of coronary artery disease and healthy controls. Acta Cardiologica
Academic article
Grimsgaard, Sameline; Bønaa, KH; Jacobsen, B. K.; Bjerve, Kristian S. (1999) Plasma saturated and linoleic fattty acids are independently associated with blood pressure. Hypertension
Academic article
Nordøy, A.; Bønaa, K. H.; Nilsen, H.; Berge, Rolf Kristian; Hansen, J. B.; Ingebretsen, O. C.. (1998) Effects of Simvastatin and omega-3 fatty acids on plasma lipoproteins and lipid peroxidation in patients with combined hyperlipidaemia. Journal of Internal Medicine
Academic article
Hansen, J. B.; Berge, Rolf Kristian; Nordøy, A.; Bønaa, K. H.. (1998) Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after prolonged intake of highly purified eicosapentaenoic (EPA) or docosahecaenoic (DHA) acids. Lipids
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Lindal, Sigurd; Jenssen, Trond. (1998) Insulin Kinetics, Insulin Action, and Muscle Morphology in Lean or Slightly Overweight Persons With Impaired Glucose Tolerance. Metabolism: Clinical and Experimental
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Jenssen, Trond. (1998) Insulin Resistance in Hypertension Is Associated With Body Fat Rather Than Blood Pressure. Hypertension
Academic article
Grimsgaard, Sameline; Bønaa, Kaare Harald; Hansen, John-Bjarne; Myhre, Eivind S. P.. (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. American Journal of Clinical Nutrition
Academic article
Hansen, John-Bjarne; Grimsgaard, Sameline; Nilsen, Hugo; Nordøy, Arne; Bønaa, Kaare Harald. (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. Lipids
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Ingebretsen, Ole C; NordØy, arne; Jenssen, Trond. (1997) Fibrinolytic Function After Dietary Supplementation With ω3 Polyunsaturated Fatty Acids. Arteriosclerosis, Thrombosis and Vascular Biology
Academic article
Tverdal, A; Åsberg, A; Bønaa, Kaare Harald; Stensvold, I.; Grudt, G; Ingebretsen, O.C.. (1997) Sammenligning av to blodprøver fra samme person analysert ved to laboratorier. Norsk Epidemiologi
Academic article
Halvorsen, Dag Seeger; Hansen, John-Bjarne; Grimsgaard, Sameline; Bønaa, Kaare Harald; Kierulf, Peter; Nordøy, Arne. (1997) The effect of highly purified Eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. Lipids
Academic article
Grimsgaard, Sameline; Bønaa, Kaare Harald; Hansen, John-Bjarne; Nordøy, Arne. (1997) Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol lowering effect but divergent effects on plasma fatty acids. American Journal of Clinical Nutrition
Academic article
Halvorsen, Dag S.; Hansen, J.B.; Grimsgaard, S.; Bønaa, Kåre H.; Kierulf, Peter; Nordøy, Arne. (1997) The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. Lipids
Academic article
Toft, Ingrid; Bønaa, Kåre H.; Ingebretsen, O.C.; Nordøy, Arne; Birkeland, Kåre I.; Jenssen, T.. (1997) Gender differences in the relationships between plasma plasminogen activator inhibitor-1 activity and factors linked to th insulin resistance syndrome in essential hypertension. Biol
Academic article
Arnesen, Erik; Refsum, H.; Bønaa, K.H.; Ueland, P.M.; Førde, O.H.; Nordrehaug, J.E.. (1995) Serum total homocysteine and coronary heart disease. International Journal of Epidemiology
Academic article
Toft, Ingrid; Bønaa, Kaare Harald; Ingebretsen, Ole C; NordØy, arne; Jenssen, Trond. (1995) Effects of n-3 Polyunsaturated Fatty Acids on Glucose Homeostasis and Blood Pressure in Essential Hypertension A Randomized, Controlled Trial. Annals of Internal Medicine
Academic article
Bønaa, K.H.; Bjerve, Kristian S; Nordøy, A.. (1992) Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoproteins in man. Arteriosclerosis and thrombosis
Academic article
Bønaa, K. H.; Bjerve, Kristian S; Nordøy, A.. (1992) Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Tromsø study. American Journal of Clinical Nutrition
Academic article
Bjerve, Kristian S; Thoresen, L.; Bønaa, KH; Vik, Torstein; Johnsen, Harald; Brubakk, Ann-Mari. (1992) Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. Nutrition - The International Journal of Applied and Basic Nutritional Sciences
Academic article
Bønaa, Kaare Harald; Thelle, Dag Steinar. (1991) Association Between Blood Pressure and Serum Lipids in a Population. The Tromsø Study. Circulation
Academic article
Bjerve, Kristian S; Bønaa, KH; Midthjell, Kristian; Fougner, Kristian J. (1990) Fatty Acids in Hypertension and Cardiovascular disease. Scandinavian Journal of Clinical and Laboratory Investigation
Academic literature review
Bønaa, KH; Bjerve, KS; Straume, Bjørn; Gram, Inger Torhild; Thelle, DS. (1990) Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. New England Journal of Medicine
Academic article
Bjerve, Kristian S; Fougner, Kristian J; Midthjell, Kristian; Bønaa, K. H.. (1989) N-3 fatty acids in old age. Journal of Internal Medicine
Academic article

Part of book/report

Karlsaune, Hanne Margrethe Thürmer; Digre, Tormod Aarlott; Sneeggen, Sylvi Fredriksen; Govatsmark, Ragna Elise Støre; Bønaa, Kaare Harald. (2015) Årsrapport Norsk Hjereinfarktregister 2015, med forbedringstiltak. St. Olav forlag St. Olav forlag
Magister thesis

Report

Govatsmark, Ragna Elise Støre; Digre, Tormod Aarlott; Sneeggen, Sylvi Fredriksen; Karlsaune, Hanne Margrethe Thürmer; Bønaa, Kaare Harald. (2016) Årsrapport Norsk Hjerteinfarktregister, med plan for forbedringstiltak. St. Olav forlag St. Olav forlag
Report
Karlsaune, Hanne Margrethe Thürmer; Digre, Tormod Aarlott; Sneeggen, Sylvi Fredriksen; Govatsmark, Ragna Elise Støre; Slørdahl, Stig Arild; Bønaa, Kaare Harald. (2014) Årsrapport Norskhjerteinfarktregister 2014, med plan for forbedringstiltak. St. Olav forlag St. Olav forlag
Report

INFORMASJONSMATR

Bønaa, Kaare Harald. (2013) Mindre risiko for hjerteinfarkt.
Website (informational material)

Media

2021

Academic lecture

Løvsletten, Ola; Njølstad, Inger; Bønaa, Kaare Harald; Eggen, Anne Elise; Furberg, Anne-Sofie; Grimsgaard, Sameline. (2021) Is the ongoing obesity epidemic partly explained by concurrent decline in cigarette smoking? Insights from a longitudinal population study. the Tromsø Study 1994-2016. Arctic Frontiers Arctic Frontiers conference 2021 , Digital/Tromsø 2021-02-01 - 2021-02-04