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Katrine Sjaastad Hanssen

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Katrine Sjaastad Hanssen

Researcher
Department of Neuromedicine and Movement Science

katrine.s.hanssen@ntnu.no
+4790705845 Nevro øst, Edvard Griegs gate 8, 7030 Trondheim
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About Research Publications Teaching Outreach

About

CV

Researcher in The Sandvig Integrative Neuroscience Group, Department of Neuromedicine and Movement Science, NTNU. During my PhD, I worked on integrating advanced neural network models relevant for Alzheimer's disease. In my current researcher position I am working with both basic reasearch and clinical research within Alzheimer's disease. 

Research focus:

1) Inflammatory response and pathology at early disease stages of Alzheimer's.
2) Critical time points for structural and functional alterations in Alzheimer's neural networks. 

Clinical research: 
1) To better understand the stages of Alzheimer’s disease and their association with semantic memory networks.

More information about our MemAD-study can be found here: MemAD-study - Research in fight against Alzheimer's.

Methods:
Main methods and tools applied include in vitro neuron-, disease-, and patient-specific modelling, electrophysiology, selective manipulation of neuronal assemblies in vitro using designer chemogenetic tools, clinical neuroimaging, and computational modelling focused on connectomics.

Outreach activities: 
Alongside lab work, writing articles and lecturing I have a great passion for outreach activities for dementia and Alzheimer's disease to the public. I have been holding talks to patients and next-of-kin at unions, resource centre for dementia and several local dementia units. 

Background: 
2019-2023: Ph.d. in Medicine og Health Sciences, KISN/INB, NTNU
2017-2019: M.Sc. in Neuroscience, KISN, NTNU
2014-2017: B.Sc. in Human Movement Science, NTNU/Aarhus University 

 

Competencies

  • Alzheimer's Disease
  • Microeletrode Arrays
  • Microfluidic devices
  • Neural Networks

Research

  • Sandvig Group for Integrative Neuroscience

Publications

Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice

To enable culturing of neurons and networks more relevant for the initiating stages of AD, we used adult APP/PS1 mice and dissected tissue from the lateralmost domain of LEC, aiming for the Re+ lLEC-LII-neurons

Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction

In the present study, we demonstrate reverse engineering of anatomically relevant biological neural networks, including networks of layer specific neurons derived from adult AD model animals, using custom-designed microfluidic MEA interfaces

Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation

Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.
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2024

  • Weir, Janelle Shari; Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Sandvig, Ioanna. (2024) Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation. European Journal of Neuroscience
    Academic article
  • Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2024) Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction. Scientific Reports
    Academic article

2023

  • Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling. bioRxiv
    Academic article
  • Hanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Witter, Menno Peter. (2023) Dissecting the complexities of Alzheimer's disease. Engineering selectively vulnerable neural networks in vitro. Norges teknisk-naturvitenskapelige universitet Doctoral theses at NTNU (365)
    Doctoral dissertation
  • Hanssen, Katrine Sjaastad; Witter, Menno Peter; Sandvig, Axel; Sandvig, Ioanna; Kobro-Flatmoen, Asgeir. (2023) Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice. Journal of Neuroscience Methods
    Academic article
  • Weir, Janelle Shari; Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Sandvig, Ioanna. (2023) Altered structural organization and functional connectivity in feedforward neural networks after induced perturbation. bioRxiv
    Academic article

Journal publications

  • Weir, Janelle Shari; Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Sandvig, Ioanna. (2024) Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation. European Journal of Neuroscience
    Academic article
  • Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2024) Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction. Scientific Reports
    Academic article
  • Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling. bioRxiv
    Academic article
  • Hanssen, Katrine Sjaastad; Witter, Menno Peter; Sandvig, Axel; Sandvig, Ioanna; Kobro-Flatmoen, Asgeir. (2023) Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice. Journal of Neuroscience Methods
    Academic article
  • Weir, Janelle Shari; Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Sandvig, Ioanna. (2023) Altered structural organization and functional connectivity in feedforward neural networks after induced perturbation. bioRxiv
    Academic article

Report

  • Hanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Witter, Menno Peter. (2023) Dissecting the complexities of Alzheimer's disease. Engineering selectively vulnerable neural networks in vitro. Norges teknisk-naturvitenskapelige universitet Doctoral theses at NTNU (365)
    Doctoral dissertation

Teaching

Courses

  • NEVR3001 - Cellular and Systems Neuroscience

Supervision

Supervision of current and previous students:

2023 - today: 

  • PhD candidate -  Marthe B. Grønli 
  • MSc student - Nurinissa Ece Erik  
  • MSc student - Maya Louise Atieno Ibenfeldt
  • MSc student - Trym Herre 

2020 - 2021: 

  • Salome Nora Niethammer - "Extraction and culturing of adult hippocampal and entorhinal neurons from Alzheimer model-animals"
  • Emily Karabeika - "Co-culture of humanized Apolipoprotein E astrocytes with primary entorhinal cortex neurons from adult mice and hippocampal neurons from embryonic rats"

Outreach

Katrine (30) med fersk doktorgrad om Alzheimer

Litt om prosjektarbeidet i løpet av min doktorgrad.

Doktorpromosjonen vår 2024 ved NTNU

Blant de som mottok diplom for avlagt doktorgrad var Katrine Sjaastad Hanssen, for sin forskning på nye metoder for å studere nevrale nettverk i tidlige fase av Alzheimers sykdom.

Nasjonalforeningen for folkehelsen - Trøndelag

Åpent møte om demens i regi Nasjonalforeningen Grong demensforening Tema var Alzheimer med Grong "sin egen" hjerneforsker Katrine, samt hvilke tilbud som finnes for pårørende ved daglig leder i Nasjonalforeningen Trøndelag.

Investigating Neural Networks Through Microfluidics

Here we show how the directional flow of information can be successfully mimicked using ‘microfluidic platforms’ developed at NTNU NanoLab, which feature microscopic networks of channels and chambers.

2024

  • Popular scientific lecture
    Hanssen, Katrine Sjaastad. (2024) Demens og Alzheimer sykdom - Hva er det som skjer i hjernen? . Ressurssenter for Demens og Kavli Insitituttet Alzheimer med Katrine S.Hanssen og Trd.Kommune Ressurssenter , Fred Kavli Bygget, Øya, Trondheim 2024-04-25 - 2024-04-25
  • Academic lecture
    Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems Maxwell Summit 2024 , Zürich 2024-04-08 - 2024-04-10
  • Poster
    Winter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks . Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich 2024-04-08 - 2024-04-10
  • Poster
    Winter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Fiskum, Vegard; Kollstrøm, Anna Mikalsen; Christiansen, Nicholas; Sandvig, Axel. (2024) Reverse engineered neural circuit motifs as computational substrates. FENS & Lundbeck Foundation The Brain Conference - Circuits for Movement , Rungstedgaard 2024-06-16 - 2024-06-19
  • Lecture
    Hanssen, Katrine Sjaastad. (2024) Demens - Forløp, sykdomsprosesser og diagnose. Stjørdal Kommune Foredrag , Stjørdal Bosenter 2024-08-21 - 2024-08-21
  • Academic lecture
    Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
  • Popular scientific lecture
    Hanssen, Katrine Sjaastad. (2024) Alzheimer sykdom - Hva er det som skjer i hjernen?. Nasjonalforeningen Grong Demensforening Åpent møte om Demens , Grong Hotell 2024-04-11 - 2024-04-11
  • Poster
    Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
  • Academic lecture
    Winter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Maxwell Biosystems 4th In-Vitro 2D & 3D Neuronal Networks Summit , Zürich, Switzerland 2024-04-08 - 2024-04-10
  • Poster
    Winter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Nordic NanoLab Network Nordic NanoLab User Meeting 2024 , Oslo 2024-06-03 - 2024-06-04
  • Poster
    Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Research School for Training the Next Generation of Micro- and Nanotechnology Researchers in Norway TNNN Conference 2024 , Oslo, Norway 2024-06-06 - 2024-06-08
  • Poster
    Hanssen, Katrine Sjaastad; Klausen, Kasper; Tomren, Åste Brune; Normann, Amund Stensrud; Sandvig, Axel; Sikorski, Pawel Tadeusz. (2024) Advanced Interfaces for Investigating the Impact of Topology on the Functional Dynamics of Engineered Neural Networks. Nordic Nanolab Network Nordic NanoLab User Meeting 2024 , Oslo, Norway 2024-06-03 - 2024-06-04

2023

  • Academic lecture
    Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Sandvig, Axel. (2023) Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling. Norwegian Research School in Neuroscience (NRSN) NRSN Norwegian Research School for Neuroscience 10th NRSN Conference , Egersund 2023-09-27 - 2023-09-29
  • Poster
    Winter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Tomren, Åste Brune; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2023) Engineered Multi-Nodal Neuronal Networks with Predefined Afferent-Efferent Connectivity for Advanced Modelling of Network Function and Dysfunction. European Biophysical Societies' Association 14th EBSA Congress , Stockholm 2023-07-31 - 2023-08-04
  • Academic lecture
    Winter-Hjelm, Nicolai; Hanssen, Katrine Sjaastad; Sikorski, Pawel; Sandvig, Axel; Sandvig, Ioanna. (2023) Advanced Engineering Approaches for Recapitulating Structure-Function Dynamics of Neuronal Networks In Vitro . YROCK & NeuroSYS NeuroSYS 2023 2023-04-06 - 2023-04-06
  • Popular scientific lecture
    Hanssen, Katrine Sjaastad. (2023) Alzheimer sykdom . Parat, NTNU Årsmøte Parat , Digitalt 2023-03-22 - 2023-03-22
  • Popular scientific lecture
    Hanssen, Katrine Sjaastad. (2023) Demens; Alzheimer sykdom . Nordland Teater Vinterlysfestivalen 2023 , Mo I Rana 2023-02-15 - 2023-02-15
  • Popular scientific lecture
    Hanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir. (2023) Leve bedre med Alzheimer?. Kavli Insituttet, NTNU Medisin og helse Brain Awareness Week , Trondheim 2023-03-16 - 2023-03-16
  • Academic lecture
    Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) Reverse Engineering of Feedforward ​ Cortical-Hippocampal Neural Networks ​ Relevant for Preclinical Disease Modelling ​. Norwegian Research School in Neuroscience (NRSN) 10th Annual PhD Conference in Neuroscience , Egersund, Stavanger, Norway 2023-09-27 - 2023-09-29
  • Poster
    Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Niethammer, Salome Nora; Witter, Menno Peter; Kobro-Flatmoen, Asgeir; Sandvig, Axel. (2023) An in vitro platform to study entorhinal-hippocampal neuronal networks. AD/PD kenes 17th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD) , Gothenburg, Sweden 2023-03-28 - 2023-04-01

2022

  • Academic lecture
    Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study entorhinal-hippocampal neural networks . Norwegian Research School for Neuroscience 9th NRSN Conference , Stiklestad 2022-09-28 - 2022-09-30
  • Poster
    Hanssen, Katrine Sjaastad; Winter-Hjelm, Nicolai; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna. (2022) An in vitro platform to study adult entorhinal entorhinal-hippocampal neuronal circuits in early Alzheimer's disease. NTNU, Kyoto University JANUBET Symposiym , Kyoto 2022-09-20 - 2022-09-24
  • Poster
    Hanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2022) An in vitro platform to study adult entorhinal networks in Alzheimer's disease. AD/PD 2022 , Barcelona 2022-03-15 - 2022-03-20

2021

  • Poster
    Hanssen, Katrine Sjaastad; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno; Kobro-Flatmoen, Asgeir. (2021) An in vitro platform to study entorhinal networks in Alzheimer’s disease. NRSN NRSN National Neuroscience Symposium 2021-06-29 - 2021-07-01

2020

  • Poster
    Hanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2020) Developing a novel in vitro platform to study neuronal networks relevant to Alzheimer’s disease. FENS FENS Forum 2020 , Glasgow/Virtual Forum 2020-07-11 - 2020-07-15

2019

  • Poster
    Hanssen, Katrine Sjaastad; Kobro-Flatmoen, Asgeir; Sandvig, Ioanna; Sandvig, Axel; Witter, Menno. (2019) Establishing entorhinal cortex layer II neuron cultures as a tool for the investigation of early Alzheimer's disease related changes. Nordic Neuroscience 3rd Nordic Neuroscience Meeting 2019 , Helsinki 2019-06-12 - 2019-06-14

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