Kristin Roseth Aass

About

My research is focused on Multiple Myeloma, a hematologic cancer of terminally differentiated plasma cells in the bone marrow. Myeloma is an heterogenous and incurable disease, and the ultimate aim is, through translational research, identify new treatment targets and develop efficient individualized therapy strategies for patients. In my current main research project I study the role of the cytokine IL-32, a biomarker for poor prognosis-patients. In addition, a side project has focused on the role of miRNA as predictors of prognosis in myeloma.

Previously, I studied Biotechnology at Department of Biotechnology and Food Science, NTNU, for three years before I completed my MSc in Molecular Medicine at Department of Clinical and Molecular Medicine, NTNU. I finished my PhD in 2020 at Therese Standal´s group and have continued at a Cancer Society funded post doc on the same group, where I follow up the research findings from my PhD.

Supervision:

2017-2018

M.Sc supervision

2018-2019

2019

Alex Waters, Fulbrigth fellowship

Tonje Marie Vikene Nedal

Luca van den Brink

2019-2020

Synne Stokke Tryggestad

Ongoing PhD supervision

2020-

Martin H. Kastnes

Synne Stokke Tryggestad

Publications

2024

Tryggestad, Synne Stokke; Roseth, Ingrid Aass; Aass, Kristin Roseth; Ørning, Nadia Elise Helene; Mjelle, Robin; Hella, Hanne. (2024) Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen. Frontiers in Immunology
Academic article
Nedal, Tonje Marie Vikene; Moen, Siv Helen; Roseth, Ingrid Aass; Tryggestad, Synne Stokke; Aass, Kristin Roseth; Hov, Gunhild Garmo. (2024) Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma. Scientific Reports
Academic article

2023

Aass, Kristin Roseth; Tryggestad, Synne Stokke; Mjelle, Robin; Kastnes, Martin Haugrud; Nedal, Tonje Marie Vikene; Misund, Kristine. (2023) IL-32 is induced by activation of toll-like receptors in multiple myeloma cells. Frontiers in Immunology
Academic article
Kastnes, Martin Haugrud; Aass, Kristin Roseth; Bouma, Siri Anshushaug; Årseth, Charlotte; Zahoor, Muhammad; Yurchenko, Mariya. (2023) The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes. Frontiers in Oncology
Academic article

2022

Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Bouma, Siri Anshushaug; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt. (2022) Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival. British Journal of Cancer
Academic article
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders. (2022) Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma. Scientific Reports
Academic article

2021

Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca Mare; Roseth, Ingrid Aass. (2021) Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. iScience
Academic article

2020

Standal, Therese; Aass, Kristin Roseth. (2020) The role IL-32 in multiple myeloma. NTNU Open
Doctoral dissertation
Mjelle, Robin; Aass, Kristin Roseth; Sjursen, Wenche; Hofsli, Eva; Sætrom, Pål. (2020) sMETASeq: combined profiling of microbiota and host small RNAs. iScience
Academic article
Aass, Kristin Roseth; Kastnes, Martin; Standal, Therese. (2020) Molecular interactions and functions of IL-32. Journal of Leukocyte Biology
Academic article

2017

Zahoor, Muhammad; Westhrin, Marita; Aass, Kristin Roseth; Moen, Siv Helen; Misund, Kristine; Psonka-Antonczyk, Katarzyna Maria. (2017) Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss. Blood Advances
Academic article

Journal publications

Tryggestad, Synne Stokke; Roseth, Ingrid Aass; Aass, Kristin Roseth; Ørning, Nadia Elise Helene; Mjelle, Robin; Hella, Hanne. (2024) Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen. Frontiers in Immunology
Academic article
Nedal, Tonje Marie Vikene; Moen, Siv Helen; Roseth, Ingrid Aass; Tryggestad, Synne Stokke; Aass, Kristin Roseth; Hov, Gunhild Garmo. (2024) Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma. Scientific Reports
Academic article
Aass, Kristin Roseth; Tryggestad, Synne Stokke; Mjelle, Robin; Kastnes, Martin Haugrud; Nedal, Tonje Marie Vikene; Misund, Kristine. (2023) IL-32 is induced by activation of toll-like receptors in multiple myeloma cells. Frontiers in Immunology
Academic article
Kastnes, Martin Haugrud; Aass, Kristin Roseth; Bouma, Siri Anshushaug; Årseth, Charlotte; Zahoor, Muhammad; Yurchenko, Mariya. (2023) The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes. Frontiers in Oncology
Academic article
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Bouma, Siri Anshushaug; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt. (2022) Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival. British Journal of Cancer
Academic article
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders. (2022) Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma. Scientific Reports
Academic article
Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca Mare; Roseth, Ingrid Aass. (2021) Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. iScience
Academic article
Mjelle, Robin; Aass, Kristin Roseth; Sjursen, Wenche; Hofsli, Eva; Sætrom, Pål. (2020) sMETASeq: combined profiling of microbiota and host small RNAs. iScience
Academic article
Aass, Kristin Roseth; Kastnes, Martin; Standal, Therese. (2020) Molecular interactions and functions of IL-32. Journal of Leukocyte Biology
Academic article
Zahoor, Muhammad; Westhrin, Marita; Aass, Kristin Roseth; Moen, Siv Helen; Misund, Kristine; Psonka-Antonczyk, Katarzyna Maria. (2017) Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss. Blood Advances
Academic article

Report

Standal, Therese; Aass, Kristin Roseth. (2020) The role IL-32 in multiple myeloma. NTNU Open
Doctoral dissertation

Knowledge Transfer