Kristine Misund
About
Research Scientist at Centre of Myeloma Research the Department of Clinical and Molecular Medicine.
My research group studies a blood cancer called Multiple Myeloma, a cancer arising in the antibody producing plasma cells in the bone marrow. This cancer is a relatively rare cancer diagnosed in approximately 400 people each year in Norway. Unfortunately, this cancer can be quite aggressive, and multiple myeloma is still an incurable disease, although the introduction of new drugs the two last decades have increased the median survivalfrom 3 to 6 years. Drug resistance is a major and unsolved problem in myeloma. The primary focus of our research is to understand the genetic and molecular events that occur from the time of diagnosis and to the development of a tumor later in the disease stage which is refractory to therapy. We use novel methods, such as next-generation sequencing (NGS) analysis of both tumor cells and cell free DNA, as well as well-established cell biology methods.
Publications
2025
-
Roseth, Ingrid Aass;
Standahl, Therese;
Misund, Kristine;
Hov, Håkon;
Moen, Siv Helen.
(2025)
Multiple myeloma: the role of the bone marrow microenvironment in tumor progression.
NTNU Norges teknisk-naturvitenskapelige universitet
NTNU Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
-
Våtsveen, Thea Kristin;
Giliberto, Mariaserena;
Bjornsdottir, Valgerdur;
Centonze, Federica Grazia;
Besse, Andrej;
Frey, Yannick.
(2025)
Targeting proteostasis in multiple myeloma through inhibition of LTK.
Leukemia
Academic article
-
Behsen, Alenka Djarmila;
Vandsemb, Esten Nymoen;
Slørdahl, Tobias Schmidt;
Dybkær, Karen;
Jakobsen, Maja Zimmer;
Kashif, Muhammad.
(2025)
T cell phenotype and clonality changes in myeloma patients with short overall survival.
JCI Insight
Academic article
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
BioRxiv
Academic article
2024
-
Behsen, Alenka Djarmila;
Holien, Toril;
Micci, Francesca;
Rye, Morten Beck;
Rasmussen, Jenny Malm;
Andersen, Kristin.
(2024)
Cell surface marker heterogeneity in human myeloma cell lines for modeling of disease and therapy.
Scientific Reports
Academic article
-
Jakobsen, Theresa;
Pløen, Gro Grunnet;
Behsen, Alenka Djarmila;
Møller, Holger Jon;
Plesner, Torben;
Dybkær, Karen.
(2024)
The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.
Journal of Cellular and Molecular Medicine
Academic article
-
Berg, Sigrid Ravn;
Demirovic, Aida;
Sharma, Animesh;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Zatula, Alexey.
(2024)
Progression of monoclonal gammopathy of undetermined significance to multiple myeloma is associated with enhanced translational quality control and overall loss of surface antigens.
Journal of Translational Medicine
Academic article
2023
-
Aass, Kristin Roseth;
Tryggestad, Synne Stokke;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Nedal, Tonje Marie Vikene;
Misund, Kristine.
(2023)
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells.
Frontiers in Immunology
Academic article
-
Behsen, Alenka Djarmila;
Vandsemb, Esten Nymoen;
Slørdahl, Tobias Schmidt;
Hjorth-Hansen, Henrik;
Quist-Paulsen, Petter;
Misund, Kristine.
(2023)
A patient with minimal myeloma treatment who survived for 20 years.
Haematologica
Academic article
2022
-
Steiro, Ida Johnsen;
Vandsemb, Esten Nymoen;
Elsaadi, Samah;
Misund, Kristine;
Sponaas, Anne-Marit;
Børset, Magne.
(2022)
The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells.
OncoTarget
Academic article
-
Misund, Kristine;
Bruinink, Davine Hofste op;
Coward, Eivind;
Hoogenboezem, Remco M.;
Rustad, Even Holth;
Sanders, Mathijs A..
(2022)
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence.
Leukemia
Academic article
-
Giliberto, Mariaserena;
Santana, Leonardo Miranda;
Holien, Toril;
Misund, Kristine;
Nakken, Sigve;
Vodak, Daniel.
(2022)
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines.
Frontiers in Oncology
Academic article
2021
-
Håland, Erling;
Moen, Ingrid Nyhus;
Veidal, Elias;
Hella, Hanne;
Misund, Kristine;
Slørdahl, Tobias Schmidt.
(2021)
TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan.
OncoTarget
Academic article
-
Sponaas, Anne-Marit;
Waage, Anders;
Vandsemb, Esten;
Misund, Kristine;
Børset, Magne;
Sundan, Anders.
(2021)
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?.
Frontiers in Immunology
Academic literature review
-
Aass, Kristin Roseth;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Tryggestad, Synne Stokke;
Brink, Luca Mare van den;
Roseth, Ingrid Aass.
(2021)
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells.
iScience
Academic article
-
Abdollahi, Pegah;
Vandsemb, Esten;
Elsaadi, Samah;
Røst, Lisa Marie;
Yang, Rui;
Hjort, Magnus Aassved.
(2021)
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma.
The FASEB Journal
Academic article
2020
-
Yang, Rui;
Elsaadi, Samah;
Misund, Kristine;
Abdollahi, Pegah;
Vandsemb, Esten;
Moen, Siv Helen.
(2020)
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade.
Journal for ImmunoTherapy of Cancer (JITC)
Academic article
-
Westhrin, Marita;
Kovcic, Vlado;
Zejian, Zhang;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene;
Bondt, Albert.
(2020)
Monoclonal immunoglobulins promote bone loss in multiple myeloma.
Blood
Academic article
2019
-
Rustad, Even Holth;
Misund, Kristine;
Bernard, Elsa;
Coward, Eivind;
Yellapantula, Venkata D;
Hultcrantz, Malin.
(2019)
Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma.
American Journal of Hematology
Academic article
-
Misund, Kristine.
(2019)
Forekomst og betydning av MYC-translokasjoner i sykdomsforløpet ved myelomatose.
Bestpractice Onkologi/Hematologi
Article in business/trade/industry journal
-
Misund, Kristine;
Keane, Niamh;
Stein, Caleb;
Asmann, Yan;
Day, Grady;
Welsh, Seth.
(2019)
MYC dysregulation in the progression of multiple myeloma.
Leukemia
Academic article
2018
-
Olsen, Oddrun Elise;
Sankar, Meenu;
Elsaadi, Samah;
Hella, Hanne;
Buene, Glenn;
Darvekar, Sagar.
(2018)
BMPR2 inhibits activin and BMP signaling via wild-type ALK2.
Journal of Cell Science
Academic article
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Academic article
-
Holien, Toril;
Misund, Kristine;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Buene, Glenn;
Børset, Magne.
(2018)
Correction: MYC amplifications in myeloma cell lines: correlation
with MYC-inhibitor efficacy.
OncoTarget
Errata
-
Misund, Kristine;
Bruinink, Davine Hofste op;
Coward, Eivind;
Hoogenboezem, Remco;
Rustad, Even Holth;
Hovig, Eivind.
(2018)
Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse.
Blood
Abstract
2017
-
Rustad, Even Holth;
Coward, Eivind;
Skytøen, Emilie R;
Misund, Kristine;
Holien, Toril;
Standal, Therese.
(2017)
Monitoring multiple myeloma by quantification of recurrent mutations in serum.
Haematologica
Academic article
-
Zahoor, Muhammad;
Westhrin, Marita;
Aass, Kristin Roseth;
Moen, Siv Helen;
Misund, Kristine;
Psonka-Antonczyk, Katarzyna Maria.
(2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss.
Blood Advances
Academic article
-
Tangen, Jon-Magnus;
Holien, Toril;
Mirlashari, Mohammad Reza;
Misund, Kristine;
Hetland, Geir.
(2017)
Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™.
BioMed Research International
Academic article
2016
-
Baranowska, Katarzyna Anna;
Misund, Kristine;
Starheim, Kristian K.;
Holien, Toril;
Johansson, Ida;
Darvekar, Sagar.
(2016)
Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.
OncoTarget
Academic article
-
Abdollahi, Pegah;
Vandsemb, Esten Nymoen;
Hjort, Magnus Aassved;
Misund, Kristine;
Holien, Toril;
Sponaas, Anne-Marit.
(2016)
Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3.
Molecular Cancer Research
Academic article
-
Slørdahl, Tobias Schmidt;
Abdollahi, Pegah;
Vandsemb, Esten Nymoen;
Rampa, Christoph Samuel;
Misund, Kristine;
Baranowska, Katarzyna Anna.
(2016)
The phosphatase of regenerating liver-3 (PRL-3) is importantfor IL-6-mediated survival of myeloma cells.
OncoTarget
Academic article
-
Våtsveen, Thea Kristin;
Sponaas, Anne Marit;
Tian, Erming;
Zhang, Qing;
Misund, Kristine;
Sundan, Anders.
(2016)
Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro.
Journal of Hematology & Oncology
Academic article
-
Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal
Academic article
-
Misund, Kristine;
Keane, Niamh;
Asmann, Yan;
Wier, Scott Von;
Riggs, Daniel;
Ahmann, Gregory.
(2016)
Complementary Activation of CCND, MYC, RAS and NFkB by Mutations in Multiple Myeloma.
Blood
Abstract
2015
-
Rustad, Even Holth;
Dai, Hong Yan;
Hov, Håkon;
Coward, Eivind;
Beisvag, Vidar;
Myklebost, Ola.
(2015)
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis.
Blood Cancer Journal
Academic article
-
Follin-Arbelet, Virginie;
Misund, Kristine;
Naderi, Elin Hallan;
Ugland, Hege Katrin;
Sundan, Anders;
Blomhoff, Heidi Kiil.
(2015)
The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM.
Scientific Reports
Academic article
-
Holien, Toril;
Misund, Kristine;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Buene, Glenn;
Børset, Magne.
(2015)
MYC amplifications in myeloma cell lines: Correlation with MYC-inhibitor efficacy.
OncoTarget
Academic article
-
Rustad, Even Holth;
Dai, Hong Yan;
Coward, Eivind;
Misund, Kristine;
Sundan, Anders;
Waage, Anders.
(2015)
Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients By Digital PCR of Circulating DNA.
Blood
Abstract
-
Johansson, Ida;
Monsen, Vivi Anita Talstad;
Pettersen, Kristine;
Mildenberger, Jennifer;
Misund, Kristine;
Kaarniranta, Kai.
(2015)
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells.
Autophagy
Academic article
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Starheim, Kristian K.;
Johansson, Ida;
Buene, Glenn.
(2015)
Chloroquine potentiates Carfilzomib but not Bortezomib effects on myeloma cells.
Cancer Research
Abstract
-
Wang, Huabo;
Teriete, Peter;
Hu, Angela;
Raveendra-Panickar, Dhanya;
Pendelton, Kelsey;
Lazo, John S.
(2015)
Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.
OncoTarget
Academic article
2014
-
Olsen, Oddrun Elise;
Wader, Karin Fahl;
Misund, Kristine;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Mylin, Anne K..
(2014)
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
Blood Cancer Journal
Academic article
-
Holien, Toril;
Misund, Kristine;
Buene, Glenn;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Waage, Anders.
(2014)
MYC gene copy number determine MYC expression and sensitivity to a MYC-inhibitor in multiple myeloma cells.
Cancer Research
Abstract
-
Selvik, Linn-Karina M.;
Rao, Shalini;
Steigedal, Tonje;
Haltbakk, Ildri;
Misund, Kristine;
Bruland, Torunn.
(2014)
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells.
PLOS ONE
Academic article
-
Rø, Torstein Baade;
Slørdahl, Tobias Schmidt;
Abdollahi, Pegah;
Vansemb, Esten;
Hagen, Lars;
Baranowska, Katarzyna Anna.
(2014)
PRL-3 Mediates Survival of Primary Myeloma Cells.
Blood
Abstract
2013
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Rampa, Christoph Samuel;
Klein, Dionne;
Børset, Magne.
(2013)
A method for measurement of drug sensitivity of myeloma cells co-cultured with bone marrow stromal cells.
Journal of Biomolecular Screening
Academic article
-
Selvik, Linn-Karina M.;
Fjeldbo, Christina Sæten;
Flatberg, Arnar;
Steigedal, Tonje;
Misund, Kristine;
Anderssen, Endre.
(2013)
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis.
BMC Genomics
Academic article
-
Misund, Kristine;
Selvik, Linn-Karina M.;
Rao, Shalini;
Nørsett, Kristin Gabestad;
Bakke, Ingunn;
Sandvik, Arne.
(2013)
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells.
PLOS ONE
Academic article
-
Follin-Arbelet, Virginie;
Torgersen, Maria Lyngaas;
Naderi, Elin Hallan;
Misund, Kristine;
Sundan, Anders;
Blomhoff, Heidi Kiil.
(2013)
Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway.
Cancer Letters
Academic article
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE
Academic article
-
Holien, Toril;
Olsen, Oddrun Elise;
Misund, Kristine;
Hella, Hanne;
Waage, Anders;
Rø, Torstein Baade.
(2013)
Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate.
European Journal of Haematology
Academic article
-
Rø, Torstein Baade;
Holien, Toril;
Fagerli, Unn-Merete;
Hov, Håkon;
Misund, Kristine;
Waage, Anders.
(2013)
HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase.
Experimental Hematology
Academic article
2012
-
Slørdahl, Tobias Schmidt;
Misund, Kristine;
Rø, Torstein Baade;
Børset, Magne.
(2012)
PRL-3 Regulates Myeloma Cell Survival, Proliferation, Adhesion and Migration.
Blood
Abstract
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Rampa, Christoph Samuel;
Klein, Dionne;
Børset, Magne.
(2012)
A Method for Measurement of Drug Sensitivity of Myeloma Cells Co-Cultured with Bone Marrow Stromal Cells.
Blood
Abstract
2010
-
Fjeldbo, Christina Sæten;
Misund, Kristine;
Günther, Clara-Cecilie;
Langaas, Mette;
Steigedal, Tonje;
Thommesen, Liv.
(2010)
Functional studies on RNA-transfected cell microarrays.
Methods in molecular biology
Academic article
2008
-
Fjeldbo, Christina Sæten;
Misund, Kristine;
Gunther, Clara-Cecilie;
Langaas, Mette;
Steigedal, Tonje;
Thommesen, Liv.
(2008)
Functional studies on transfected cell microarray analysed by linear regression modelling.
Nucleic Acids Research (NAR)
Academic article
-
Fjeldbo, Christina Sæten;
Misund, Kristine;
Günther, Clara-Cecilie;
Langaas, Mette;
Steigedal, Tonje Strømmen;
Thommesen, Liv.
(2008)
Functional studies on transfected cell microarray analysed by linear regression modelling.
Nucleic Acids Research (NAR)
Academic article
2007
-
Misund, Kristine;
Steigedal, Tonje Strømmen;
Lægreid, Astrid;
Thommesen, Liv.
(2007)
Inducible cAMP early repressor splice variants ICER I and IIgamma both repress transcription of c-fos and chromogranin A.
Journal of Cellular Biochemistry
Academic article
-
Sætre, Rune;
Ranang, Martin Thorsen;
Steigedal, Tonje Strømmen;
Stunes, Kamilla;
Misund, Kristine;
Thommesen, Liv.
(2007)
Webprot : online mining and annotation of biomedical literature using Google.
Academic chapter/article/Conference paper
-
Misund, Kristine;
Steigedal, Tonje;
Lægreid, Astrid;
Thommesen, Liv.
(2007)
Inducible cAMP early repressor splice variants ICER I and II gamma both repress transcription of c-fos and chromogranin A.
Journal of Cellular Biochemistry
Academic article
-
Steigedal, Tonje;
Bruland, Torunn;
Misund, Kristine;
Thommesen, Liv;
Lægreid, Astrid.
(2007)
Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression.
American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
-
Steigedal, Tonje Strømmen;
Bruland, Torunn;
Misund, Kristine;
Thommesen, Liv;
Lægreid, Astrid.
(2007)
Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression.
American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
2003
-
Misund, Kristine.
(2003)
Studier av transkripsjonsrepressoren ICER sin funksjon i regulering av CRE-styrt genuttrykk.
[Mangler utgivernavn]
[Mangler utgivernavn]
Masters thesis
Journal publications
-
Våtsveen, Thea Kristin;
Giliberto, Mariaserena;
Bjornsdottir, Valgerdur;
Centonze, Federica Grazia;
Besse, Andrej;
Frey, Yannick.
(2025)
Targeting proteostasis in multiple myeloma through inhibition of LTK.
Leukemia
Academic article
-
Behsen, Alenka Djarmila;
Vandsemb, Esten Nymoen;
Slørdahl, Tobias Schmidt;
Dybkær, Karen;
Jakobsen, Maja Zimmer;
Kashif, Muhammad.
(2025)
T cell phenotype and clonality changes in myeloma patients with short overall survival.
JCI Insight
Academic article
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
BioRxiv
Academic article
-
Behsen, Alenka Djarmila;
Holien, Toril;
Micci, Francesca;
Rye, Morten Beck;
Rasmussen, Jenny Malm;
Andersen, Kristin.
(2024)
Cell surface marker heterogeneity in human myeloma cell lines for modeling of disease and therapy.
Scientific Reports
Academic article
-
Jakobsen, Theresa;
Pløen, Gro Grunnet;
Behsen, Alenka Djarmila;
Møller, Holger Jon;
Plesner, Torben;
Dybkær, Karen.
(2024)
The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.
Journal of Cellular and Molecular Medicine
Academic article
-
Berg, Sigrid Ravn;
Demirovic, Aida;
Sharma, Animesh;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Zatula, Alexey.
(2024)
Progression of monoclonal gammopathy of undetermined significance to multiple myeloma is associated with enhanced translational quality control and overall loss of surface antigens.
Journal of Translational Medicine
Academic article
-
Aass, Kristin Roseth;
Tryggestad, Synne Stokke;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Nedal, Tonje Marie Vikene;
Misund, Kristine.
(2023)
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells.
Frontiers in Immunology
Academic article
-
Behsen, Alenka Djarmila;
Vandsemb, Esten Nymoen;
Slørdahl, Tobias Schmidt;
Hjorth-Hansen, Henrik;
Quist-Paulsen, Petter;
Misund, Kristine.
(2023)
A patient with minimal myeloma treatment who survived for 20 years.
Haematologica
Academic article
-
Steiro, Ida Johnsen;
Vandsemb, Esten Nymoen;
Elsaadi, Samah;
Misund, Kristine;
Sponaas, Anne-Marit;
Børset, Magne.
(2022)
The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells.
OncoTarget
Academic article
-
Misund, Kristine;
Bruinink, Davine Hofste op;
Coward, Eivind;
Hoogenboezem, Remco M.;
Rustad, Even Holth;
Sanders, Mathijs A..
(2022)
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence.
Leukemia
Academic article
-
Giliberto, Mariaserena;
Santana, Leonardo Miranda;
Holien, Toril;
Misund, Kristine;
Nakken, Sigve;
Vodak, Daniel.
(2022)
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines.
Frontiers in Oncology
Academic article
-
Håland, Erling;
Moen, Ingrid Nyhus;
Veidal, Elias;
Hella, Hanne;
Misund, Kristine;
Slørdahl, Tobias Schmidt.
(2021)
TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan.
OncoTarget
Academic article
-
Sponaas, Anne-Marit;
Waage, Anders;
Vandsemb, Esten;
Misund, Kristine;
Børset, Magne;
Sundan, Anders.
(2021)
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?.
Frontiers in Immunology
Academic literature review
-
Aass, Kristin Roseth;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Tryggestad, Synne Stokke;
Brink, Luca Mare van den;
Roseth, Ingrid Aass.
(2021)
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells.
iScience
Academic article
-
Abdollahi, Pegah;
Vandsemb, Esten;
Elsaadi, Samah;
Røst, Lisa Marie;
Yang, Rui;
Hjort, Magnus Aassved.
(2021)
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma.
The FASEB Journal
Academic article
-
Yang, Rui;
Elsaadi, Samah;
Misund, Kristine;
Abdollahi, Pegah;
Vandsemb, Esten;
Moen, Siv Helen.
(2020)
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade.
Journal for ImmunoTherapy of Cancer (JITC)
Academic article
-
Westhrin, Marita;
Kovcic, Vlado;
Zejian, Zhang;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene;
Bondt, Albert.
(2020)
Monoclonal immunoglobulins promote bone loss in multiple myeloma.
Blood
Academic article
-
Rustad, Even Holth;
Misund, Kristine;
Bernard, Elsa;
Coward, Eivind;
Yellapantula, Venkata D;
Hultcrantz, Malin.
(2019)
Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma.
American Journal of Hematology
Academic article
-
Misund, Kristine.
(2019)
Forekomst og betydning av MYC-translokasjoner i sykdomsforløpet ved myelomatose.
Bestpractice Onkologi/Hematologi
Article in business/trade/industry journal
-
Misund, Kristine;
Keane, Niamh;
Stein, Caleb;
Asmann, Yan;
Day, Grady;
Welsh, Seth.
(2019)
MYC dysregulation in the progression of multiple myeloma.
Leukemia
Academic article
-
Olsen, Oddrun Elise;
Sankar, Meenu;
Elsaadi, Samah;
Hella, Hanne;
Buene, Glenn;
Darvekar, Sagar.
(2018)
BMPR2 inhibits activin and BMP signaling via wild-type ALK2.
Journal of Cell Science
Academic article
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Academic article
-
Holien, Toril;
Misund, Kristine;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Buene, Glenn;
Børset, Magne.
(2018)
Correction: MYC amplifications in myeloma cell lines: correlation
with MYC-inhibitor efficacy.
OncoTarget
Errata
-
Misund, Kristine;
Bruinink, Davine Hofste op;
Coward, Eivind;
Hoogenboezem, Remco;
Rustad, Even Holth;
Hovig, Eivind.
(2018)
Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse.
Blood
Abstract
-
Rustad, Even Holth;
Coward, Eivind;
Skytøen, Emilie R;
Misund, Kristine;
Holien, Toril;
Standal, Therese.
(2017)
Monitoring multiple myeloma by quantification of recurrent mutations in serum.
Haematologica
Academic article
-
Zahoor, Muhammad;
Westhrin, Marita;
Aass, Kristin Roseth;
Moen, Siv Helen;
Misund, Kristine;
Psonka-Antonczyk, Katarzyna Maria.
(2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss.
Blood Advances
Academic article
-
Tangen, Jon-Magnus;
Holien, Toril;
Mirlashari, Mohammad Reza;
Misund, Kristine;
Hetland, Geir.
(2017)
Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™.
BioMed Research International
Academic article
-
Baranowska, Katarzyna Anna;
Misund, Kristine;
Starheim, Kristian K.;
Holien, Toril;
Johansson, Ida;
Darvekar, Sagar.
(2016)
Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.
OncoTarget
Academic article
-
Abdollahi, Pegah;
Vandsemb, Esten Nymoen;
Hjort, Magnus Aassved;
Misund, Kristine;
Holien, Toril;
Sponaas, Anne-Marit.
(2016)
Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3.
Molecular Cancer Research
Academic article
-
Slørdahl, Tobias Schmidt;
Abdollahi, Pegah;
Vandsemb, Esten Nymoen;
Rampa, Christoph Samuel;
Misund, Kristine;
Baranowska, Katarzyna Anna.
(2016)
The phosphatase of regenerating liver-3 (PRL-3) is importantfor IL-6-mediated survival of myeloma cells.
OncoTarget
Academic article
-
Våtsveen, Thea Kristin;
Sponaas, Anne Marit;
Tian, Erming;
Zhang, Qing;
Misund, Kristine;
Sundan, Anders.
(2016)
Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro.
Journal of Hematology & Oncology
Academic article
-
Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal
Academic article
-
Misund, Kristine;
Keane, Niamh;
Asmann, Yan;
Wier, Scott Von;
Riggs, Daniel;
Ahmann, Gregory.
(2016)
Complementary Activation of CCND, MYC, RAS and NFkB by Mutations in Multiple Myeloma.
Blood
Abstract
-
Rustad, Even Holth;
Dai, Hong Yan;
Hov, Håkon;
Coward, Eivind;
Beisvag, Vidar;
Myklebost, Ola.
(2015)
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis.
Blood Cancer Journal
Academic article
-
Follin-Arbelet, Virginie;
Misund, Kristine;
Naderi, Elin Hallan;
Ugland, Hege Katrin;
Sundan, Anders;
Blomhoff, Heidi Kiil.
(2015)
The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM.
Scientific Reports
Academic article
-
Holien, Toril;
Misund, Kristine;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Buene, Glenn;
Børset, Magne.
(2015)
MYC amplifications in myeloma cell lines: Correlation with MYC-inhibitor efficacy.
OncoTarget
Academic article
-
Rustad, Even Holth;
Dai, Hong Yan;
Coward, Eivind;
Misund, Kristine;
Sundan, Anders;
Waage, Anders.
(2015)
Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients By Digital PCR of Circulating DNA.
Blood
Abstract
-
Johansson, Ida;
Monsen, Vivi Anita Talstad;
Pettersen, Kristine;
Mildenberger, Jennifer;
Misund, Kristine;
Kaarniranta, Kai.
(2015)
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells.
Autophagy
Academic article
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Starheim, Kristian K.;
Johansson, Ida;
Buene, Glenn.
(2015)
Chloroquine potentiates Carfilzomib but not Bortezomib effects on myeloma cells.
Cancer Research
Abstract
-
Wang, Huabo;
Teriete, Peter;
Hu, Angela;
Raveendra-Panickar, Dhanya;
Pendelton, Kelsey;
Lazo, John S.
(2015)
Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.
OncoTarget
Academic article
-
Olsen, Oddrun Elise;
Wader, Karin Fahl;
Misund, Kristine;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Mylin, Anne K..
(2014)
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
Blood Cancer Journal
Academic article
-
Holien, Toril;
Misund, Kristine;
Buene, Glenn;
Olsen, Oddrun Elise;
Baranowska, Katarzyna Anna;
Waage, Anders.
(2014)
MYC gene copy number determine MYC expression and sensitivity to a MYC-inhibitor in multiple myeloma cells.
Cancer Research
Abstract
-
Selvik, Linn-Karina M.;
Rao, Shalini;
Steigedal, Tonje;
Haltbakk, Ildri;
Misund, Kristine;
Bruland, Torunn.
(2014)
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells.
PLOS ONE
Academic article
-
Rø, Torstein Baade;
Slørdahl, Tobias Schmidt;
Abdollahi, Pegah;
Vansemb, Esten;
Hagen, Lars;
Baranowska, Katarzyna Anna.
(2014)
PRL-3 Mediates Survival of Primary Myeloma Cells.
Blood
Abstract
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Rampa, Christoph Samuel;
Klein, Dionne;
Børset, Magne.
(2013)
A method for measurement of drug sensitivity of myeloma cells co-cultured with bone marrow stromal cells.
Journal of Biomolecular Screening
Academic article
-
Selvik, Linn-Karina M.;
Fjeldbo, Christina Sæten;
Flatberg, Arnar;
Steigedal, Tonje;
Misund, Kristine;
Anderssen, Endre.
(2013)
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis.
BMC Genomics
Academic article
-
Misund, Kristine;
Selvik, Linn-Karina M.;
Rao, Shalini;
Nørsett, Kristin Gabestad;
Bakke, Ingunn;
Sandvik, Arne.
(2013)
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells.
PLOS ONE
Academic article
-
Follin-Arbelet, Virginie;
Torgersen, Maria Lyngaas;
Naderi, Elin Hallan;
Misund, Kristine;
Sundan, Anders;
Blomhoff, Heidi Kiil.
(2013)
Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway.
Cancer Letters
Academic article
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE
Academic article
-
Holien, Toril;
Olsen, Oddrun Elise;
Misund, Kristine;
Hella, Hanne;
Waage, Anders;
Rø, Torstein Baade.
(2013)
Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate.
European Journal of Haematology
Academic article
-
Rø, Torstein Baade;
Holien, Toril;
Fagerli, Unn-Merete;
Hov, Håkon;
Misund, Kristine;
Waage, Anders.
(2013)
HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase.
Experimental Hematology
Academic article
-
Slørdahl, Tobias Schmidt;
Misund, Kristine;
Rø, Torstein Baade;
Børset, Magne.
(2012)
PRL-3 Regulates Myeloma Cell Survival, Proliferation, Adhesion and Migration.
Blood
Abstract
-
Misund, Kristine;
Baranowska, Katarzyna Anna;
Holien, Toril;
Rampa, Christoph Samuel;
Klein, Dionne;
Børset, Magne.
(2012)
A Method for Measurement of Drug Sensitivity of Myeloma Cells Co-Cultured with Bone Marrow Stromal Cells.
Blood
Abstract
-
Fjeldbo, Christina Sæten;
Misund, Kristine;
Günther, Clara-Cecilie;
Langaas, Mette;
Steigedal, Tonje;
Thommesen, Liv.
(2010)
Functional studies on RNA-transfected cell microarrays.
Methods in molecular biology
Academic article
-
Fjeldbo, Christina Sæten;
Misund, Kristine;
Gunther, Clara-Cecilie;
Langaas, Mette;
Steigedal, Tonje;
Thommesen, Liv.
(2008)
Functional studies on transfected cell microarray analysed by linear regression modelling.
Nucleic Acids Research (NAR)
Academic article
-
Fjeldbo, Christina Sæten;
Misund, Kristine;
Günther, Clara-Cecilie;
Langaas, Mette;
Steigedal, Tonje Strømmen;
Thommesen, Liv.
(2008)
Functional studies on transfected cell microarray analysed by linear regression modelling.
Nucleic Acids Research (NAR)
Academic article
-
Misund, Kristine;
Steigedal, Tonje Strømmen;
Lægreid, Astrid;
Thommesen, Liv.
(2007)
Inducible cAMP early repressor splice variants ICER I and IIgamma both repress transcription of c-fos and chromogranin A.
Journal of Cellular Biochemistry
Academic article
-
Misund, Kristine;
Steigedal, Tonje;
Lægreid, Astrid;
Thommesen, Liv.
(2007)
Inducible cAMP early repressor splice variants ICER I and II gamma both repress transcription of c-fos and chromogranin A.
Journal of Cellular Biochemistry
Academic article
-
Steigedal, Tonje;
Bruland, Torunn;
Misund, Kristine;
Thommesen, Liv;
Lægreid, Astrid.
(2007)
Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression.
American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
-
Steigedal, Tonje Strømmen;
Bruland, Torunn;
Misund, Kristine;
Thommesen, Liv;
Lægreid, Astrid.
(2007)
Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression.
American Journal of Physiology - Gastrointestinal and Liver Physiology
Academic article
Part of book/report
-
Sætre, Rune;
Ranang, Martin Thorsen;
Steigedal, Tonje Strømmen;
Stunes, Kamilla;
Misund, Kristine;
Thommesen, Liv.
(2007)
Webprot : online mining and annotation of biomedical literature using Google.
Academic chapter/article/Conference paper
Report
-
Roseth, Ingrid Aass;
Standahl, Therese;
Misund, Kristine;
Hov, Håkon;
Moen, Siv Helen.
(2025)
Multiple myeloma: the role of the bone marrow microenvironment in tumor progression.
NTNU Norges teknisk-naturvitenskapelige universitet
NTNU Norges teknisk-naturvitenskapelige universitet
Doctoral dissertation
-
Misund, Kristine.
(2003)
Studier av transkripsjonsrepressoren ICER sin funksjon i regulering av CRE-styrt genuttrykk.
[Mangler utgivernavn]
[Mangler utgivernavn]
Masters thesis
Teaching
Courses
Outreach
2024
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PosterMestvedt, Ingvild Bergdal; Yurchenko, Maria; Espevik, Terje; Standal, Therese; Wolowczyk, Camilla Izabel; Rasheed, Kashif. (2024) Exploring peptide derived from Signaling Lymphocytic Activation Molecule Family 1 as novel treatment for multiple myeloma. ENA 2024 Symposium on molecular targets and cancer therapeutics , Barcelona 2024-10-23 - 2024-10-25
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PosterAndersson-Rusch, Clara; Quist-Løkken, Ingrid; Sætrom, Pål; Hanif, Md Abu; Rolinski, Milosz; Møen, Johanna. (2024) Whole genome CRISPR knockout screen reveals key function for ID3 in regulating myeloma cell survival via TCF3 and c-MYC. TGF-β Superfamily , Niagara Falls, NY 2024-07-21 - 2024-07-25
2023
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PosterAndersson-Rusch, Clara Leticia; Quist-Løkken, Ingrid; Sætrom, Pål; Beisvag, Vidar; Rolinski, Milosz; Møen, Johanna. (2023) Genome-Wide CRISPR/Cas9 Knock-out Screen Identifies Apoptosis-Relevant Genes in Multiple Myeloma. 65th ASH Annual Meeting and Exposition 2023-12-09 - 2023-12-12
2022
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Academic lectureBehsen, Alenka Djarmila; Vandsemb, Esten Nymoen; Waage, Anders; Slørdahl, Tobias Schmidt; Sponaas, Anne Marit; Misund, Kristine. (2022) Altered composition of CD8 T cell subsets over time in the bone marrow of multiple myeloma patients with long- and short-term disease control. International Myeloma Society Annual Meeting , Los Angeles, CA, USA 2022-08-25 - 2022-08-27
2021
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Academic lectureBehsen, Alenka Djarmila; Vandsemb, Esten Nymoen; Waage, Anders; Slørdahl, Tobias Schmidt; Sponaas, Anne-Marit; Misund, Kristine. (2021) Altered composition of CD8 T cells subsets over time in the bone marrow of multiple myeloma patients with long-term disease control and short-term disease control. NMSG Meeting , Stockholm 2021-09-16 - 2021-09-17
2018
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PosterOlsen, Oddrun Elise; Sankar, Meenu; Elsaadi, Samah; Hella, Hanne; Darvekar, Sagar; Misund, Kristine. (2018) BMPR2 inhibits activin- and BMP-signaling via wild type ALK2. 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer: From diagnosis to immunotherapy – why is precision medicine so difficult? , Trondheim 2018-06-14 - 2018-06-15
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Academic lectureMisund, Kristine; Bruinink, Davine Hofste op; Coward, Eivind; Hoogenboezem, Remco; Rustad, Even Holth; Hovig, Eivind. (2018) Clonal Evolution of Multiple Myeloma After Treatment with Novel Agents. 2nd. International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer 2018-06-14 - 2018-06-15
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PosterMisund, Kristine; Bruinink, Davine Hofste op; Coward, Eivind; Hoogenboezem, Remco; Rustad, Even Holth; Hovig, Eivind. (2018) Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse. American Society of Hematology (ASH) 2018 2018-12-01 - 2018-12-04
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PosterYang, Rui; Elsaadi, Samah; Misund, Kristine; Slupphaug, Geir; Menu, Eline; Hay, Carl. (2018) Role of ectoenzymes CD39 and CD73 in the immune response to multiple myeloma. Annual Meeting of the American Association for Cancer Research , Chicago 2018-04-14 - 2018-04-18
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Academic lectureMisund, Kristine. (2018) Next-generation sequencing - Status og Nyheter. Nyheter inom myelom med ett multidisciplinärt fokus – Ny diagnostik, next generation sequenzing, högrisk myelom, uppdaterat vårdprogram, motivering av patienten etc. 2018-09-18 -
2017
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Academic lectureMisund, Kristine; Bruinink, Davine Hofste op; Coward, Eivind; Hoogenboezem, Remco; Rustad, Even Holth; Hovig, Eivind. (2017) Detection of mutations in Multiple Myeloma during different stages of disease. NMSG plenary meeting , Trondheim 2017-09-07 - 2017-09-08
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Academic lectureOlsen, Oddrun Elise; Sankar, Meenu; Darvekar, Sagar; Misund, Kristine; Sundan, Anders; Holien, Toril. (2017) Activins induce apoptosis through wild type ALK2/ACVR1 and are counteracted by BMPR2. The TGFb Superfamily: Signaling in Development and Disease , Lisboa 2017-07-09 - 2017-07-14
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Academic lectureKeane, Niamh; Stein, Caleb; Angelov, Daniel; Tian, Shulan; Wiswanatha, David; Kumar, Shaji K.. (2017) MYC Translocations Identified By Sequencing Panel in Smoldering Multiple Myeloma Strongly Predict for Rapid Progression to Multiple Myeloma. American Society of Hematology 2017 , Atlanta 2017-12-09 - 2017-12-12
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Academic lectureOlsen, Oddrun Elise; Sankar, Meenu; Elsaadi, Samah; Hella, Hanne; Darvekar, Sagar; Misund, Kristine. (2017) Activins induce apoptosis through wild type ALK2/ACVR1 and are counteracted by BMPR2. NMSG plenary meeting , Trondheim 2017-09-07 - 2017-09-08
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PosterCoward, Eivind; Misund, Kristine; Bruinink, Davine Hofste op; Hoogenboezem, Remco; Rustad, Even Holth; Myklebost, Ola. (2017) Exome sequencing of multiple myeloma at sequential time points. Trondheim - Oslo Genome Dynamics Workshop , Trondheim 2017-06-15 - 2017-06-16
2016
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PosterRustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese. (2016) Circulating Tumor DNA in Multiple Myeloma. European Hematology Association 21th Congress , Copenhagen 2016-06-09 - 2016-06-12
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Academic lectureMisund, Kristine; Keane, Niamh; Asmann, Yan; Wier, Scott Van; Riggs, Daniel; Ahmann, Gregory. (2016) Complementary Activation of CCND, MYC, RAS and NFkB by Mutations in Multiple Myeloma. 58th ASH Annual Meeting and Exposition , San Diego 2016-12-02 - 2016-12-06
2015
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LectureMisund, Kristine; Grøseth, Lill Anny Gunnes; Holien, Toril. (2015) Forskning på myelomatose. Klassebesøk, 3. trinn v.g.s. med fordypning i biologi 2015-03-18 - 2015-03-18
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PosterAbdollahi, Pegah; Vandsemb, Esten Nymoen; Hjort, Magnus Aassved; Misund, Kristine; Rø, Torstein Baade; Slørdahl, Tobias Schmidt. (2015) PRL-3 increases survival of Multiple Myeloma cells through Src activation. 15th International Myeloma Workshop , Roma 2015-09-23 - 2015-09-25
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PosterRustad, Even Holth; Dai, Hong Yan; Coward, Eivind; Misund, Kristine; Sundan, Anders; Waage, Anders. (2015) Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients By Digital PCR of Circulating DNA. 57th ASH Annual Meeting and Exposition , Orlando 2015-12-05 - 2015-12-08
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Academic lectureRustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Dai, Hong Yan. (2015) Exome sequencing of tumor samples as starting point for monitoring mutations in circulating DNA of patients with multiple myeloma. Norwegian Cancer Genomics Consortium (NCGC) Symposium , Oslo 2015-10-27 - 2015-10-28
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Academic lectureCoward, Eivind; Misund, Kristine; Rustad, Even Holth; Sundan, Anders; Waage, Anders. (2015) Mutations in multiple myeloma at sequential time points. NCGC Symposium 2015 , Losby Gods 2015-10-27 - 2015-10-28
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Academic lectureRustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Dai, Hong Yan. (2015) Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients by Digital PCR of Circulating DNA. Nordic Myeloma Study Group (NMSG) Annual Meeting , Stockholm 2015-11-12 - 2015-11-13
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PosterMisund, Kristine; Baranowska, Katarzyna Anna; Holien, Toril; Starheim, Kristian K.; Johansson, Ida; Buene, Glenn. (2015) Chloroquine potentiates Carfilzomib but not Bortezomib effects on myeloma cells. AACR 106th Annual Meeting 2015 , Philadelphia, PA 2015-04-18 - 2015-04-22
2014
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LectureMisund, Kristine; Coward, Eivind; Waage, Anders. (2014) Norwegian Cancer Genomics Consortium - Multiple Myeloma projects. Høstmøte for Norsk selskap for Hematologi , Oslo 2014-11-04 - 2014-11-05
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PosterRø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. American Society of Hematology Annual Meeting , San Francisco 2014-12-06 - 2014-12-09
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PosterHolien, Toril; Misund, Kristine; Buene, Glenn; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Waage, Anders. (2014) MYC gene copy number determine MYC expression and sensitivity to a MYC-inhibitor in multiple myeloma cells. AACR Annual Meeting 2014 , San Diego, CA 2014-04-05 - 2014-04-09
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LectureHolien, Toril; Grøseth, Lill Anny Gunnes; Standal, Therese; Misund, Kristine; Bruvoll, Ingrid; Nordrum, Ivar Skjåk. (2014) Hvordan jobber en kreftforsker + Besøk i medisinsk museum i Kunnskapssenteret. Klassebesøk, 5. trinn barneskole 2014-03-19 - 2014-03-19
-
Interview
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InterviewMisund, Kristine. (2014) Får penger til tre års forskning. adressa nett og papir adressa nett og papir [Journal] 2014-10-29
2013
-
PosterRao, Shalini; Selvik, Linn-Karina M.; Nørsett, Kristin Gabestad; Bakke, Ingunn; Misund, Kristine; Bruland, Torunn. (2013) NR4A2 is regulated by gastrin and influences cellular responses in gastric adenocarcinoma cells. Nuclear receptors: Linking molecules, genomes & physiology , Sorrento 2013-09-06 - 2013-09-10
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LectureHolien, Toril; Sponaas, Anne-Marit; Misund, Kristine; Rø, Torstein Baade; Brede, Gaute; Standal, Therese. (2013) "Ta livet av kreftcellene" Stand i samarbeid med Kreftforeningen. Forskningstorget , Trondheim 2013-09-20 - 2013-09-21
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PosterOlsen, Oddrun Elise; Wader, Karin Fahl; Misund, Kristine; Våtsveen, Thea Kristin; Rø, Torstein Baade; Størdal, Berit Fladvad. (2013) Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. TGF-B Superfamily: Signaling in Development and Disease 2013-07-28 - 2013-08-02
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PosterRao, Shalini; Thommesen, Liv; Nørsett, Kristin; Bakke, Ingunn; Misund, Kristine; Bruland, Torunn. (2013) Nr4A2 is regulated by gastrin and influences cellular responses in gastric adenocarcinoma cells. Kontaktmøte Norsk Biokjemisk Selskap , Røros 2013-01-17 - 2013-01-20
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PosterSlørdahl, Tobias Schmidt; Misund, Kristine; Rø, Torstein Baade; Børset, Magne. (2013) The Phosphatase of Regenerating Liver-3 (PRL-3) Is Essential for IL-6-mediated Survival of Myeloma Cells. 14th International Myeloma Workshop , Kyoto 2013-04-03 - 2013-04-07
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LectureOlsen, Oddrun Elise; Wader, Karin Fahl; Misund, Kristine; Våtsveen, Thea Kristin; Rø, Torstein Baade; Størdal, Berit Fladvad. (2013) Membrane bound and soluble endoglin protects myeloma cells from bone morphogenetic protein 9 induced apoptosis. NBS vintermøte 2013-01-17 - 2013-01-20
2012
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PosterMisund, Kristine; Baranowska, Katarzyna Anna; Holien, Toril; Rampa, Christoph Samuel; Klein, Dionne; Børset, Magne. (2012) A Method for Measurement of Drug Sensitivity of Myeloma Cells Co-Cultured with Bone Marrow Stromal Cells. The American Society of Hematology (ASH) annual meeting , Atlanta, Georgia 2012-12-07 - 2012-12-11
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PosterMisund, Kristine; Baranowska, Katarzyna Anna; Holien, Toril; Rampa, Christoph Samuel; Waage, Anders; Sundan, Anders. (2012) Attempts to predict response to cytostatics in Multiple Myeloma patients. Norwegian Biochemical Society Contact Meeting , Storefjell 2012-01-19 - 2012-01-22
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PosterSlørdahl, Tobias Schmidt; Misund, Kristine; Rø, Torstein Baade; Børset, Magne. (2012) PRL-3 Regulates Myeloma Cell Survival, Proliferation, Adhesion and Migration. The 54th Annual Meeting of the American Society of Hematology (ASH) , Atlanta 2012-12-07 - 2012-12-11
2010
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PosterBruland, Torunn; Anderssen, Endre; Misund, Kristine; Fjeldbo, Christina Sæten; Flatberg, Arnar; Selvik, Linn-Karina M.. (2010) Exploring signal-induced cellular regulatory subnetworks by use of partial least square regression (PLSR) multidimensional analysis of gene expression time series data. 13th Annual MGED meeting , Boston, Massachusetts, USA , Boston 2010-07-13 - 2010-07-15
2009
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Academic lectureSelvik, Linn-Karina M.; Misund, Kristine; Fjeldbo, Christina Sæten; Steigedal, Tonje; Bruland, Torunn; Lægreid, Astrid. (2009) Salt-inducible kinase 1 (SIK1) is involved in the gastrin-mediated growth response and is repressed by ICER and Zfp36l1. NBS Kontaktmøte 2009 , Røros 2009-01-29 - 2009-02-01
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PosterAnderssen, Endre; Bruland, Torunn; Misund, Kristine; Sandvik, Arne K.; Thommesen, Liv; Lægreid, Astrid. (2009) Using basic networks motifs and biological background knowledge to analyze transcriptomic time series data. MGED Meeting , Phoenix, USA 2009-10-05 - 2009-10-08
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PosterBruland, Torunn; Anderssen, Endre; Misund, Kristine; Beisvåg, Vidar; Sandvik, Arne K.; Lægreid, Astrid. (2009) Discovering basic network motifs that underlie gastrin induced gene expression. 10th international conference on system biology , San Francisco 2009-08-30 - 2009-09-04
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Academic lectureThommesen, Liv; Misund, Kristine; Selvik, Linn Karina Myrland; Lægreid, Astrid; Bruland, Torunn. (2009) NR4A" (Nurr1) - involved in gastrin-mediated carcinogenesis?. Contact meeting NBS , Røros 2009-01-22 - 2009-01-25
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Academic lectureBruland, Torunn; Anderssen, Endre; Misund, Kristine; Steigedal, Tonje Strømmen; Doseth, Berit; Langaas, Mette. (2009) Basic common architectural motifs underlying gastrin induced gene expression can be identified by dimension reduction methods. Contact Meeting NBS , Røros 2009-01-22 - 2009-01-25
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PosterBruland, Torunn; Anderssen, Endre; Misund, Kristine; Beisvag, Vidar; Sandvik, Arne Kristian; Thommesen, Liv. (2009) Discovering basic network motifs that underlie gastrin induced gene expression. The 10th International Conference on System Biology ICSB-2009, USA , Standford, Calefornia 2009-08-30 - 2009-09-04
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Academic lectureBruland, Torunn; Anderssen, Endre; Misund, Kristine; Steigedal, Tonje; Doseth, Berit; Fjeldbo, Christina Sæten. (2009) Basic common architectural motifs underlying gastrin induced gene expression can be identified by dimention reduction methods. NBS 43. Contact Meeting , Røros 2009-01-17 - 2009-01-20
2008
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PosterBruland, Torunn; Anderssen, Endre; Misund, Kristine; Steigedal, Tonje; Doseth, Berit; Fjeldbo, Christina Sæten. (2008) Significance analysis of gastrin-mediated transcription using dimension reduction methods for interpreting and modelling DNA microarray time series gene expression. 3rd ESF Functional Genomics Conference; Functional genomics and disease , Insnsbruck 2008-10-01 - 2008-10-04
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PosterBruland, Torunn; Anderssen, Endre; Misund, Kristine; Steigedal, Tonje; Doseth, Berit; Fjeldbo, Christina Sæten. (2008) Molecular mechanisms in cancer related gastrin responses. Cancer Epigenetics Conference , Boston 2008-05-28 - 2008-05-31
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PosterSelvik, Linn-Karina M.; Misund, Kristine; Fjeldbo, Christina Sæten; Steigedal, Tonje Strømmen; Bruland, Torunn; Lægreid, Astrid. (2008) Salt-inducible kinase 1 (SIK1) is involved in the gastrin-mediated growth response. ESF Functional Genomics and Disease , Innsbruck 2008-10-01 - 2008-10-05
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PosterBruland, Torunn; Andersen, Endre; Misund, Kristine; Steigedal, Tonje Strømmen; Fjeldbo, Christina Sæten; Lægreid, Astrid. (2008) Molecular mecanisms in cancer-related gastrin responses. Cancer Epigenetics , Boston 2008-05-28 - 2008-05-31
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PosterBruland, Torunn; Anderssen, Endre; Misund, Kristine; Steigedal, Tonje Strømmen; Doseth, Berit; Fjeldbo, Christina Sæten. (2008) Significance analysis of gastrin-mediated transcription using dimension reduction methods for interpreting and modelling DNA microarray time series gene expression data. ESF Functional Genomics and Disease , Innsbruck 2008-10-01 - 2008-10-05
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PosterMisund, Kristine; Johansen, Alice; Selvik, Linn-Karina M.; Prestvik, Wenche Slettahjell; Thommesen, Liv. (2008) miRNA and mRNA expression in HEK cells with inducible expression of tumour suppressor ICER. Functional Genomics and Disease , Innsbruck, Austria 2008-10-01 - 2008-10-04
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PosterMisund, Kristine; Selvik, Linn-Karina M.; Prestvik, Wenche Slettahjell; Thommesen, Liv. (2008) miRNA and mRNA expression in HEK cells with inducible expression of tumour repressor ICER. ESF Functional genomics and Diseases , Innsbruck, Austria 2008-10-01 - 2008-10-05
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PosterSelvik, Linn-Karina M.; Misund, Kristine; Fjeldbo, Christina Sæten; Steigedal, Tonje; Bruland, Torunn; Lægreid, Astrid. (2008) Salt-inducible kinase 1 (SIK1) is involved in the gastrin-mediated growth response. ESF Functional Genomics and Disease Conference , Innsbruck 2008-10-01 - 2008-10-04
2007
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Academic lectureSæten, Christina; Misund, Kristine; Steigedal, Tonje; Otterlei, Marit; Lægreid, Astrid; Thommesen, Liv. (2007) Complex functional studies in mammalian cells using transfected cell arrays. The Norwegian Bichemical Society 43. Contact Meeting , Lillehammer 2007-02-01 - 2007-02-04
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Academic lectureSteigedal, Tonje; Bruland, Torunn; Misund, Kristine; Thommesen, Liv; Lægreid, Astrid. (2007) Inducible cAMP early repressor (ICER) suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression. The Norwegian Bichemical Society 43. Contact Meeting , Lillehammer 2007-02-01 - 2007-02-04
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PosterMisund, Kristine; Bruland, Torunn; Anderssen, Endre; Lægreid, Astrid; Thommesen, Liv. (2007) Global gene expression in HEK 293 cells with controllable ICER I and II gamma overexpression. NBS kontaktmøte 2007 , Lillehammer 2007-02-01 - 2007-02-01
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PosterMisund, Kristine; Hoel, Sunniva; Bruland, Torunn; Anderssen, Endre; Lægreid, Astrid; Thommesen, Liv. (2007) Global gene expression in HEK 293 cells with controllable ICER I and IIg - overexpression. Norsk Biokjemisk Selskaps 43. kontaktmøte , Lillehammer 2007-02-01 - 2007-02-04
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PosterSæten, Christina; Misund, Kristine; Steigedal, Tonje Strømmen; Lægreid, Astrid; Thommesen, Liv; Bruland, Torunn. (2007) Complex functional studies in mammalian cells using transfected cell arrays. Norsk Biokjemisk Selskaps 43. kontaktmøte , Lillehammer 2007-02-01 - 2007-02-04
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PosterSteigedal, Tonje Strømmen; Bruland, Torunn; Misund, Kristine; Thommesen, Liv; Lægreid, Astrid. (2007) Inducible cAMP early repressor (ICER) suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression. Norsk Biokjemisk Selskaps 43. kontaktmøte , Lillehammer 2007-02-01 - 2007-02-04
2006
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PosterMisund, Kristine; Hoel, Sunniva; Bruland, Torunn; Anderssen, Endre; Lægreid, Astrid; Thommesen, Liv. (2006) Global gene expression in HEK 293 cells with controllable ICER I or IIgamma overexpression. The Seventh International Conference on Systems Biology; ICSB 2006 2006-10-08 - 2006-10-13
2005
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PosterSteigedal, Tonje S.; Bruland, Torunn; Ween, Ola; Misund, Kristine; Thommesen, Liv; Lægreid, Astrid. (2005) Function of splice variants of the transcriptional repressor ICER in gastrin-mediated responses. The Norwegian Biochemical Society 41st Contact Meeting 2005-01-13 - 2005-01-16
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PosterMisund, Kristine; Lægreid, Astrid; Thommesen, Liv. (2005) Constitutive and inducible expression of ICER in HEK 293. NBS kontaktmøte , Tromsø 2005-01-13 - 2005-01-16
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Academic lectureMisund, Kristine; Lægreid, Astrid; Thommesen, Liv. (2005) Constitutive and inducible expression of ICER in HEK 293. Kontaktmøtet Norsk Biokjemisk Selskap 2005 2005-01-13 - 2005-01-16
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Academic lectureNørsett, K; Bruland, Torunn; Ween, Ola; Hofsli, Eva; Thommesen, Liv; Misund, Kristine. (2005) Systems biology of the normal and diseased gastrointestinal system. 2nd ESF Function genomics and disease , Oslo 2005-09-06 - 2005-09-10
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PosterSteigedal, Tonje Strømmen; Bruland, Torunn; Ween, Ola; Misund, Kristine; Thommesen, Liv; Lægreid, Astrid. (2005) Function of splice variants of the transcriptional repressor ICER in gastrin-mediated reponses. NBS kontaktmøte , Tromsø 2005-01-13 - 2005-01-16
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Academic lectureNørsett, Kristin; Bruland, Torunn; Ween, Ola; Hofsli, Eva; Thommesen, Liv; Misund, Kristine. (2005) Systems biology of the normal and diseased gastrointestinal system. 2nd ESF Functional Genomics Conference 2005-01-10 - 2005-01-13
2004
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PosterMisund, Kristine; Stunes, Astrid Kamilla; Tømmerdal, Linda; Thommesen, Liv; Bruland, Torunn; Lægreid, Astrid. (2004) Constitutive expression of ICER in the cell-line HEK 293. Kontaktmøtet Norsk Biokjemisk Selskap 2004 2004-01-15 - 2004-01-18
2003
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PosterThommesen, Liv; Lægreid, Astrid; Misund, Kristine. (2003) Constitutive expression of ICER in the human cell line AR42J. Kontaktmøtet Norsk Biokjemisk Selskap , Geilo 2003-01-23 - 2003-01-26
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PosterThommesen, Liv; Lægreid, Astrid; Misund, Kristine. (2003) Constitutive expression of ICER in the human cell line AR42J. Kontaktmøtet Norsk Biokjemisk Selskap , Geilo 2003-01-26 -