Mari Nordbø Gynnild

About

Mari Nordbø Gynnild is a resident physician specializing in internal medicine and cardiology at the Clinic of Cardiology, St. Olavs Hospital, and a researcher at the K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, University of Oslo.

She earned her medical degree from NTNU (2013) and holds a PhD from NTNU (2022) in collaboration with the University Medical Center Utrecht, focusing on adherence to pharmacological secondary prevention and how to predict the risk of future cardiovascular events.

Her research includes risk assessment and prevention of cardiovascular disease, cardio-oncology, and echocardiography. She is a postdoctoral fellow in the randomized PRADA II study, which investigates whether the heartfailure medication sacubitril/valsartan can prevent cardiac injury in breast cancer patients undergoing chemotherapy. She is the project leader of the study "Risk prediction for individualized cardiovascular disease prevention" (REK 590420) and collaborates internationally to test and improve models that predict the risk of cardiovascular disease.

Research

PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial

A randomized, placebo-controlled, multicenter trial assessing if sacubitril/valsartan given concomitantly with early breast cancer treatment regimens including anthracyclines, with or without trastuzumab, may prevent cardiac dysfunction.

Risk prediction for individualized cardiovascular disease prevention

This project aims to externally validate and compare guideline-recommended cardiovascular risk prediction tools, as well as tailor models to local settings, new settings and investigate whether these models can be extended by addition of new predictors.

Publications

2026

Holtrop, Joris; Gynnild, Mari Nordbø; Deo, Salil V; Lim, Carl-Emil; Logothetis, Stelios Boulitsakis; Läll, Kristi; Oksanen, Minna; Dalen, Håvard; Munkhaugen, John; Ueda, Peter. (2026) Predicting lifetime cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease: the SMART-REACH2 model. European Heart Journal
Academic article
Omland, Torbjørn; Heck, Siri Lagethon; Holte, Espen; Gynnild, Mari Nordbø; Gulati, Geeta; Wethal, Torgeir. (2026) Response by Omland et al to Letter Regarding Article, “Sacubitril/Valsartan and Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: The PRADA II Randomized Clinical Trial”. Circulation
Academic article
Kaptoge, Stephen; Keene, Spencer J; Reitsma, Tessa; Shi, Wen; Lees, Jennifer S; Lõo, Laura; Gynnild, Mari Nordbø; Chilala, Chimweta; Ritchie, Scott; Spackman, Sarah. (2026) Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. European Heart Journal
Academic article
Reitsma, Tessa H; Lim, Carl-Emil; Gynnild, Mari Nordbø; Kaptoge, Stephen; Lõo, Laura; Holtrop, Joris; Kuźma, Łukasz; Pennells, Lisa; Conrad, Nathalie; Ueda, Peter. (2026) Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. European Heart Journal
Academic article
Holtrop, Joris; Gynnild, Mari N; Richards, Matthew; Lim, Carl-Emil; Lääperi, Mitja; Deo, Salil V; Dalen, Håvard; Ueda, Peter; Rajagopalan, Sanjay; Chlabicz, Małgorzata. (2026) Improving 10-year cardiovascular risk prediction in patients with established cardiovascular disease: flexible addition of risk predictors on top of the SMART2 risk score. European Journal of Preventive Cardiology (EJPC)
Academic article

2025

Gynnild, Mari Nordbø; Holtrop, Joris; Hageman, Steven H J; Vinje, Victoria; Dorresteijn, Jannick A N; Visseren, Frank L J; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2025) External validation of the systematic coronary risk evaluation 2 (SCORE2) and SCORE2-older persons in cancer patients. European Journal of Preventive Cardiology (EJPC)
Academic article
Gynnild, Mari Nordbø; Vinje-Jakobsen, Victoria; Holtrop, Joris; Hageman, Steven H.J.; Holte, Espen; Gulati, Geeta; Heck, Siri Lagethon; Dorresteijn, Jannick A.N.; Visseren, Frank L.J.; Fagerli, Unn Merete. (2025) Prognostic Performance of a Modified HFA-ICOS Tool for Prediction of Cardiovascular Complications in Cancer Patients. JACC: Advances
Academic article
Hageman, Steven H J; Kaptoge, Stephen; Gynnild, Mari Nordbø; Holtrop, Joris; Pennells, Lisa; McEvoy, J William; Bobak, Martin; Pająk, Andrzej; Pikhart, Hynek; Tamosiunas, Abdonas. (2025) Using SCORE2 with a risk chart or online calculator: impact on model performance, treatment eligibility, and cardiovascular disease prevention. European Heart Journal - Quality of Care and Clinical Outcomes
Academic article
Gynnild, Mari Nordbø; Hageman, Steven; Holtrop, Joris; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2025) Improved risk stratification with SCORE2 on top of HFA-ICOS in cancer patients without previous cardiovascular disease. European Heart Journal, Supplement
Professional article
Holtrop, Joris; Gynnild, Mari Nordbø; Dammen, Toril; Dalen, Håvard; Saltvedt, Ingvild Tina; Ellekjær, Hanne; Hageman, Steven H J; Visseren, Frank L J; McEvoy, John William; Dorresteijn, Jannick A N. (2025) Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients. European Journal of Preventive Cardiology (EJPC)
Academic article
Omland, Torbjørn; Heck, Siri Lagethon; Holte, Espen; Mecinaj, Albulena; Gynnild, Mari Nordbø; Fagerland, Morten; Vinje, Victoria; Næs, Anne-Katrine Lislegaard; Blix, Egil Støre; Larsen, Alf Inge. (2025) Sacubitril/Valsartan and Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: The PRADA II Randomized Clinical Trial. Circulation
Academic article
Sande, Ingvild Svorkdal; Helgheim, Kamilla Lind; Saltvedt, Ingvild Tina; Røsstad, Tove Garåsen; Spigset, Olav; Ellekjær, Hanne; Gynnild, Mari Nordbø. (2025) Follow-Up in Primary Care After Ischemic Stroke - Insights From the Nor-COAST Study. International Journal of General Medicine
Academic article
Fagerli, Erlend; Ellekjær, Hanne; Spigset, Olav; Saltvedt, Ingvild Tina; Gynnild, Mari Nordbø. (2025) Three-year adherence to secondary prevention and vascular risk control after ischemic stroke. European Stroke Journal
Academic article
Hageman, Steven HJ; Kaptoge, Steven; Gynnild, Mari Nordbø; Pennels, Lisa; Pajak, Andrzej; Pikhart, Hynek; Mach, Francois; Smulders, Yvo M.; Carballo, David; Angelantonio, Emanuele Di. (2025) Assessment of CV risk by SCORE2 with an online calculator estimates CV risk better compared to 2-dimensional risk charts. European Journal of Preventive Cardiology (EJPC)
Professional article
Holtrop, Joris; Gynnild, Mari Nordbø; Dammen, Toril; Dalen, Håvard; Hageman, Steven HJ; Visseren, Frank; McEvoy, John William; Dorresteijn, Jannick; Munkhaugen, John. (2025) Integration of psychological risk modifiers on-top the SMART2-risk score for estimation of recurrent cardiovascular events in patients with atherosclerotic cardiovascular disease. European Journal of Preventive Cardiology (EJPC)
Professional article
Gynnild, Mari Nordbø; Holtrop, Joris; Dalen, Håvard; Dorresteijn, Jannick; Visseren, Frank; Holte, Espen; Omland, Torbjørn; Wethal, Torgeir; Hageman, Steven HJ. (2025) Validation of the LIFE-CVD2 model for lifetime cardiovascular risk prediction in cancer survivors. European Journal of Preventive Cardiology (EJPC)
Conference abstract

2024

Gynnild, Mari Nordbø; Holtrop, Joris; Hageman, Steven HJ; Vinje, Victoria; Dorresteijn, Jannick AN; Visseren, Frank; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2024) External validation of the HFA-ICOS risk stratification tool for prediction of cardiovascular complications after cancer treatment. European Heart Journal, Supplement
Conference abstract
Gynnild, Mari Nordbø; Holtrop, Joris; Hageman, Steven HJ; Vinje, Victoria; Dorresteijn, Jannick AN; Visseren, Frank; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2024) External validation of the Systematic COronary Risk Evaluation 2 (SCORE2) model in cancer patients. European Heart Journal, Supplement
Conference abstract
Gynnild, Mari Nordbø. (2024) Kardiovaskulær risikostratifisering. Hjerteforum
Commentary
Holtrop, Joris; Gynnild, Mari Nordbø; Munkhaugen, John; Dalen, Håvard; Lim, Carl-Emil; Ueda, Peter; Jernberg, Thomas; Tuñón, José; Chlabicz, Małgorzata; Steg, Philippe Gabriel. (2024) Estimation of individual lifetime cardiovascular disease risk and treatment benefit in patients with established atherosclerotic cardiovascular disease: the updated SMART-REACH2 model. European Heart Journal, Supplement
Conference abstract

2023

Aakerøy, Rachel; Gynnild, Mari Nordbø; Løfblad, Lena; Dyrkorn, Roar; Ellekjær, Hanne; Lydersen, Stian; Helland, Arne; Spigset, Olav. (2023) Direct oral anticoagulant concentrations and adherence in stroke patients. Basic & Clinical Pharmacology & Toxicology
Academic article

2022

Gynnild, Mari Nordbø; Ellekjær, Hanne; Spigset, Olav; Røsstad, Tove; Næss, Halvor. (2022) RESIDUAL CARDIOVASCULAR RISK AFTER ISCHEMIC STROKE Risk factors, medication adherence and risk-benefit considerations. Norges teknisk-naturvitenskapelige universitet
Doctoral thesis
Hageman, Steven HJ; McKay, Ailsa; Ueda, Peter; Gunn, Laura; Jernberg, Tomas; Hagström, Emil; Bhatt, Deepak L.; Läll, Kristi; Steg, Philippe Gabriel; Mägi, Reddik. (2022) Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: The updated SMART2 algorithm. European Heart Journal
Academic article
Gynnild, Mari Nordbø; Hageman, Steven H. J.; Spigset, Olav; Lydersen, Stian; Saltvedt, Ingvild; Dorresteijn, Jannick AN; Visseren, Frank L.J.; Ellekjær, Hanne. (2022) Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment. Open heart
Academic article

2021

Gynnild, Mari Nordbø; Hageman, Steven HJ; Dorresteijn, Jannick AN; Spigset, Olav; Lydersen, Stian; Wethal, Torgeir; Saltvedt, Ingvild; Visseren, Frank LJ; Ellekjær, Hanne. (2021) Risk Stratification in Patients with Ischemic Stroke and Residual Cardiovascular Risk with Current Secondary Prevention. Clinical Epidemiology
Academic article
Aam, Stina; Gynnild, Mari Nordbø; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Lydersen, Stian; Knapskog, Anne Brita; Ihle-Hansen, Hege; Ellekjær, Hanne; Eldholm, Rannveig Sakshaug; Fure, Brynjar. (2021) The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study. Frontiers in Neurology
Academic article

2020

Gynnild, Mari Nordbø; Aakerøy, Rachel; Spigset, Olav; Askim, Torunn; Beyer, Mona Kristiansen; Ihle-Hansen, Hege; Munthe-Kaas, Ragnhild; Knapskog, Anne Brita; Lydersen, Stian; Næss, Halvor. (2020) Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke. Journal of Internal Medicine
Academic article

2014

Anshushaug, Malin; Gynnild, Mari Aas; Kaasa, Stein; Kvikstad, Anne; Grønberg, Bjørn H.. (2014) Characterization of patients receiving palliative chemo- and radiotherapy during end of life at a regional cancer center in Norway. Acta Oncologica
Academic article

Journal publications

Holtrop, Joris; Gynnild, Mari Nordbø; Deo, Salil V; Lim, Carl-Emil; Logothetis, Stelios Boulitsakis; Läll, Kristi; Oksanen, Minna; Dalen, Håvard; Munkhaugen, John; Ueda, Peter. (2026) Predicting lifetime cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease: the SMART-REACH2 model. European Heart Journal
Academic article
Omland, Torbjørn; Heck, Siri Lagethon; Holte, Espen; Gynnild, Mari Nordbø; Gulati, Geeta; Wethal, Torgeir. (2026) Response by Omland et al to Letter Regarding Article, “Sacubitril/Valsartan and Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: The PRADA II Randomized Clinical Trial”. Circulation
Academic article
Kaptoge, Stephen; Keene, Spencer J; Reitsma, Tessa; Shi, Wen; Lees, Jennifer S; Lõo, Laura; Gynnild, Mari Nordbø; Chilala, Chimweta; Ritchie, Scott; Spackman, Sarah. (2026) Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. European Heart Journal
Academic article
Reitsma, Tessa H; Lim, Carl-Emil; Gynnild, Mari Nordbø; Kaptoge, Stephen; Lõo, Laura; Holtrop, Joris; Kuźma, Łukasz; Pennells, Lisa; Conrad, Nathalie; Ueda, Peter. (2026) Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. European Heart Journal
Academic article
Holtrop, Joris; Gynnild, Mari N; Richards, Matthew; Lim, Carl-Emil; Lääperi, Mitja; Deo, Salil V; Dalen, Håvard; Ueda, Peter; Rajagopalan, Sanjay; Chlabicz, Małgorzata. (2026) Improving 10-year cardiovascular risk prediction in patients with established cardiovascular disease: flexible addition of risk predictors on top of the SMART2 risk score. European Journal of Preventive Cardiology (EJPC)
Academic article
Gynnild, Mari Nordbø; Holtrop, Joris; Hageman, Steven H J; Vinje, Victoria; Dorresteijn, Jannick A N; Visseren, Frank L J; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2025) External validation of the systematic coronary risk evaluation 2 (SCORE2) and SCORE2-older persons in cancer patients. European Journal of Preventive Cardiology (EJPC)
Academic article
Gynnild, Mari Nordbø; Vinje-Jakobsen, Victoria; Holtrop, Joris; Hageman, Steven H.J.; Holte, Espen; Gulati, Geeta; Heck, Siri Lagethon; Dorresteijn, Jannick A.N.; Visseren, Frank L.J.; Fagerli, Unn Merete. (2025) Prognostic Performance of a Modified HFA-ICOS Tool for Prediction of Cardiovascular Complications in Cancer Patients. JACC: Advances
Academic article
Hageman, Steven H J; Kaptoge, Stephen; Gynnild, Mari Nordbø; Holtrop, Joris; Pennells, Lisa; McEvoy, J William; Bobak, Martin; Pająk, Andrzej; Pikhart, Hynek; Tamosiunas, Abdonas. (2025) Using SCORE2 with a risk chart or online calculator: impact on model performance, treatment eligibility, and cardiovascular disease prevention. European Heart Journal - Quality of Care and Clinical Outcomes
Academic article
Gynnild, Mari Nordbø; Hageman, Steven; Holtrop, Joris; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2025) Improved risk stratification with SCORE2 on top of HFA-ICOS in cancer patients without previous cardiovascular disease. European Heart Journal, Supplement
Professional article
Holtrop, Joris; Gynnild, Mari Nordbø; Dammen, Toril; Dalen, Håvard; Saltvedt, Ingvild Tina; Ellekjær, Hanne; Hageman, Steven H J; Visseren, Frank L J; McEvoy, John William; Dorresteijn, Jannick A N. (2025) Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients. European Journal of Preventive Cardiology (EJPC)
Academic article
Omland, Torbjørn; Heck, Siri Lagethon; Holte, Espen; Mecinaj, Albulena; Gynnild, Mari Nordbø; Fagerland, Morten; Vinje, Victoria; Næs, Anne-Katrine Lislegaard; Blix, Egil Støre; Larsen, Alf Inge. (2025) Sacubitril/Valsartan and Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: The PRADA II Randomized Clinical Trial. Circulation
Academic article
Gynnild, Mari Nordbø; Holtrop, Joris; Hageman, Steven HJ; Vinje, Victoria; Dorresteijn, Jannick AN; Visseren, Frank; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2024) External validation of the HFA-ICOS risk stratification tool for prediction of cardiovascular complications after cancer treatment. European Heart Journal, Supplement
Conference abstract
Gynnild, Mari Nordbø; Holtrop, Joris; Hageman, Steven HJ; Vinje, Victoria; Dorresteijn, Jannick AN; Visseren, Frank; Holte, Espen; Dalen, Håvard; Wethal, Torgeir; Omland, Torbjørn. (2024) External validation of the Systematic COronary Risk Evaluation 2 (SCORE2) model in cancer patients. European Heart Journal, Supplement
Conference abstract
Gynnild, Mari Nordbø; Aakerøy, Rachel; Spigset, Olav; Askim, Torunn; Beyer, Mona Kristiansen; Ihle-Hansen, Hege; Munthe-Kaas, Ragnhild; Knapskog, Anne Brita; Lydersen, Stian; Næss, Halvor. (2020) Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke. Journal of Internal Medicine
Academic article
Sande, Ingvild Svorkdal; Helgheim, Kamilla Lind; Saltvedt, Ingvild Tina; Røsstad, Tove Garåsen; Spigset, Olav; Ellekjær, Hanne; Gynnild, Mari Nordbø. (2025) Follow-Up in Primary Care After Ischemic Stroke - Insights From the Nor-COAST Study. International Journal of General Medicine
Academic article
Aakerøy, Rachel; Gynnild, Mari Nordbø; Løfblad, Lena; Dyrkorn, Roar; Ellekjær, Hanne; Lydersen, Stian; Helland, Arne; Spigset, Olav. (2023) Direct oral anticoagulant concentrations and adherence in stroke patients. Basic & Clinical Pharmacology & Toxicology
Academic article
Fagerli, Erlend; Ellekjær, Hanne; Spigset, Olav; Saltvedt, Ingvild Tina; Gynnild, Mari Nordbø. (2025) Three-year adherence to secondary prevention and vascular risk control after ischemic stroke. European Stroke Journal
Academic article
Anshushaug, Malin; Gynnild, Mari Aas; Kaasa, Stein; Kvikstad, Anne; Grønberg, Bjørn H.. (2014) Characterization of patients receiving palliative chemo- and radiotherapy during end of life at a regional cancer center in Norway. Acta Oncologica
Academic article
Gynnild, Mari Nordbø; Hageman, Steven HJ; Dorresteijn, Jannick AN; Spigset, Olav; Lydersen, Stian; Wethal, Torgeir; Saltvedt, Ingvild; Visseren, Frank LJ; Ellekjær, Hanne. (2021) Risk Stratification in Patients with Ischemic Stroke and Residual Cardiovascular Risk with Current Secondary Prevention. Clinical Epidemiology
Academic article
Hageman, Steven HJ; Kaptoge, Steven; Gynnild, Mari Nordbø; Pennels, Lisa; Pajak, Andrzej; Pikhart, Hynek; Mach, Francois; Smulders, Yvo M.; Carballo, David; Angelantonio, Emanuele Di. (2025) Assessment of CV risk by SCORE2 with an online calculator estimates CV risk better compared to 2-dimensional risk charts. European Journal of Preventive Cardiology (EJPC)
Professional article
Holtrop, Joris; Gynnild, Mari Nordbø; Dammen, Toril; Dalen, Håvard; Hageman, Steven HJ; Visseren, Frank; McEvoy, John William; Dorresteijn, Jannick; Munkhaugen, John. (2025) Integration of psychological risk modifiers on-top the SMART2-risk score for estimation of recurrent cardiovascular events in patients with atherosclerotic cardiovascular disease. European Journal of Preventive Cardiology (EJPC)
Professional article
Gynnild, Mari Nordbø; Holtrop, Joris; Dalen, Håvard; Dorresteijn, Jannick; Visseren, Frank; Holte, Espen; Omland, Torbjørn; Wethal, Torgeir; Hageman, Steven HJ. (2025) Validation of the LIFE-CVD2 model for lifetime cardiovascular risk prediction in cancer survivors. European Journal of Preventive Cardiology (EJPC)
Conference abstract
Gynnild, Mari Nordbø. (2024) Kardiovaskulær risikostratifisering. Hjerteforum
Commentary
Aam, Stina; Gynnild, Mari Nordbø; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Lydersen, Stian; Knapskog, Anne Brita; Ihle-Hansen, Hege; Ellekjær, Hanne; Eldholm, Rannveig Sakshaug; Fure, Brynjar. (2021) The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study. Frontiers in Neurology
Academic article
Hageman, Steven HJ; McKay, Ailsa; Ueda, Peter; Gunn, Laura; Jernberg, Tomas; Hagström, Emil; Bhatt, Deepak L.; Läll, Kristi; Steg, Philippe Gabriel; Mägi, Reddik. (2022) Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: The updated SMART2 algorithm. European Heart Journal
Academic article
Gynnild, Mari Nordbø; Hageman, Steven H. J.; Spigset, Olav; Lydersen, Stian; Saltvedt, Ingvild; Dorresteijn, Jannick AN; Visseren, Frank L.J.; Ellekjær, Hanne. (2022) Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment. Open heart
Academic article
Holtrop, Joris; Gynnild, Mari Nordbø; Munkhaugen, John; Dalen, Håvard; Lim, Carl-Emil; Ueda, Peter; Jernberg, Thomas; Tuñón, José; Chlabicz, Małgorzata; Steg, Philippe Gabriel. (2024) Estimation of individual lifetime cardiovascular disease risk and treatment benefit in patients with established atherosclerotic cardiovascular disease: the updated SMART-REACH2 model. European Heart Journal, Supplement
Conference abstract

Student thesis or dissertation

Gynnild, Mari Nordbø; Ellekjær, Hanne; Spigset, Olav; Røsstad, Tove; Næss, Halvor. (2022) RESIDUAL CARDIOVASCULAR RISK AFTER ISCHEMIC STROKE Risk factors, medication adherence and risk-benefit considerations. Norges teknisk-naturvitenskapelige universitet
Doctoral thesis

Outreach