Maria Yurchenko
About
My work earlier in the career was focused on the clarification of the signaling pathways and protein-protein interactions of SLAMF1/CD150 Ig-like receptor receptor in cancer and normal B cells. I have done my PhD in Ukraine, and worked as a visiting postdoc in Karolinska Institute, Sweden. I took an active part in the research focused on the assessment of SLAMF1 expression and function in various lymphoid and non-lymphoid cancers. From 2013 I have joined CEMIR, group of Prof. Terje Espevik, with SLAMF1-related project. We have suggested that SLAMF1 protein could be localized intracellularly in human innate immune cells (monocytes, macrophages), with distinct signaling and functions when compared to SLAMF1 receptor on the cell surface. This hypothesis led to the fundamental study on the role of intracellular SLAMF1 protein in the regulation of Toll-like receptor (TLR) signaling in human macrophages (JCB, 2018). In parallel I worked on the project on Rab11 family interacting protein 2 (FIP2). We demonstrated that FIP2 guides TLR4 adaptor protein TRAM recruitment to bacterial phagosome, and orchestrates actin remodelling and IRF3 activation, two events that are both required for phagocytosis of Gram-negative bacteria (PLoS Pathog, 2019).
Currently, together with my PhD students Kaja Elisabeth Nilsen and Ingvild Mestvedt, I am working on several projects exploring mechanisms of regulation and novel approaches to target TLR4 and TLR8 signaling pathways in human cells.
Competencies
Publications
2025
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
bioRxiv
Academic article
2024
-
Olsen, Maria Belland;
Kong, Xiang Yi;
Louwe, Maria;
Lauritzen, Knut Husø;
Schanke, Ylva;
Kaasbøll, Ole Jørgen.
(2024)
SLAMF1-derived peptide exhibits cardio protection after permanent left anterior descending artery ligation in mice.
Frontiers in Immunology
Academic article
2023
-
Sahanic, Sabina;
Hilbe, Richard;
Dünser, Christina;
Tymoszuk, Piotr;
Löffler-Ragg, Judith;
Rieder, Dietmar.
(2023)
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.
Heliyon
Academic article
-
Nilsen, Kaja Elisabeth;
Zhang, Boyao;
Skjesol, Astrid;
Ryan, Liv;
Vagle, Hilde;
Bøe, Maren Helene.
(2023)
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo.
Life Science Alliance (LSA)
Academic article
-
Kastnes, Martin Haugrud;
Aass, Kristin Roseth;
Bouma, Siri Anshushaug;
Årseth, Charlotte;
Zahoor, Muhammad;
Yurchenko, Mariya.
(2023)
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in Oncology
Academic article
2022
-
Nilsen, Kaja Elisabeth;
Skjesol, Astrid;
Kojen, June Frengen;
Espevik, Terje;
Stenvik, Jørgen;
Yurchenko, Mariya.
(2022)
TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells.
Biomedicines
Academic article
2021
-
Trifonov, Lena;
Yurchenko, Mariya;
Skjesol, Astrid;
Cohen, Guy;
Espevik, Terje;
Korshin, Edward E..
(2021)
Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-β) modulator.
Molecular diversity
Academic article
2019
-
Skjesol, Astrid;
Yurchenko, Mariya;
Bösl, Korbinian;
Gravastrand, Caroline S.;
Nilsen, Kaja Elisabeth;
Grøvdal, Lene Melsæther.
(2019)
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
PLoS Pathogens
Academic article
-
Moen, Siv Helen;
Ehrnstrøm, Birgitta;
Kojen, June Frengen;
Yurchenko, Mariya;
Beckwith, Kai Sandvold;
Afset, Jan Egil.
(2019)
Human Toll-like receptor 8 (TLR8) is an important sensor of pyogenic bacteria, and is attenuated by cell surface TLR signaling.
Frontiers in Immunology
Academic article
2018
-
Yurchenko, Mariya;
Skjesol, Astrid;
Ryan, Liv;
Richard, Gabriel Mary;
Kandasamy, Richard Kumaran;
Wang, Ninghai.
(2018)
SLA MF1 is required for TLR4-mediated TRAM-TRIF- dependent signaling in human macrophages.
Journal of Cell Biology
Academic article
2017
-
Ehrnstrøm, Birgitta;
Beckwith, Kai Sandvold;
Yurchenko, Mariya;
Moen, Siv Helen;
Kojen, June Frengen;
Lentini, Germana.
(2017)
Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.
Frontiers in Immunology
Academic article
2015
-
Romanets-Korbut, Olga;
Najakshin, Alexander M.;
Yurchenko, Mariya;
Malysheva, Tatyana A.;
Kovalevska, Larysa;
Shlapatska, Larysa M..
(2015)
Expression of CD150 in Tumors of the Central Nervous System: Identification of a Novel Isoform.
PLOS ONE
Academic article
2012
-
Yurchenko, Mariya;
Shlapatska, Larysa M.;
Sidorenko, Svetlana P..
(2012)
The multilevel regulation of CD95 signaling outcome.
Experimental Oncology
Academic literature review
-
Darekar, Suhas;
Georgiou, Konstantinos;
Yurchenko, Mariya;
Yenamandra, Surya Pavan;
Chachami, Georgia;
Simos, George.
(2012)
Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect.
PLOS ONE
Academic article
2011
-
Yurchenko, Mariya;
Shlapatska, Larysa M.;
Romanets, Olga L.;
Ganshevsky, Denis;
Kashuba, Elena;
Zamoshnikova, Alina.
(2011)
CD150-mediated Akt signalling pathway in normal and malignant B cells.
Experimental Oncology
Academic article
-
Shabelnik, Marianna Y;
Kovalevska, Larysa;
Yurchenko, Mariya;
Shlapatska, Larysa M.;
Rzepetsky, Yuriy;
Sidorenko, Svetlana P..
(2011)
Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system.
Experimental Oncology
Academic article
2010
-
Kashuba, Elena;
Yurchenko, Mariya;
Yenamandra, Surya Pavan;
Snopok, Boris;
Szekely, Lazlo;
Bercovich, Beatrice.
(2010)
Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53.
International Journal of Cancer
Academic article
-
Yurchenko, Mariya;
Sidorenko, Svetlana P..
(2010)
Hodgkin's lymphoma: the role of cell surface receptors in regulation of tumor cell fate.
Experimental Oncology
Academic literature review
Journal publications
-
Mestvedt, Ingvild Bergdal;
Menu, Eline;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rasheed, Kashif;
Wolowczyk, Camilla Izabel.
(2025)
Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation.
bioRxiv
Academic article
-
Olsen, Maria Belland;
Kong, Xiang Yi;
Louwe, Maria;
Lauritzen, Knut Husø;
Schanke, Ylva;
Kaasbøll, Ole Jørgen.
(2024)
SLAMF1-derived peptide exhibits cardio protection after permanent left anterior descending artery ligation in mice.
Frontiers in Immunology
Academic article
-
Sahanic, Sabina;
Hilbe, Richard;
Dünser, Christina;
Tymoszuk, Piotr;
Löffler-Ragg, Judith;
Rieder, Dietmar.
(2023)
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.
Heliyon
Academic article
-
Nilsen, Kaja Elisabeth;
Zhang, Boyao;
Skjesol, Astrid;
Ryan, Liv;
Vagle, Hilde;
Bøe, Maren Helene.
(2023)
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo.
Life Science Alliance (LSA)
Academic article
-
Kastnes, Martin Haugrud;
Aass, Kristin Roseth;
Bouma, Siri Anshushaug;
Årseth, Charlotte;
Zahoor, Muhammad;
Yurchenko, Mariya.
(2023)
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in Oncology
Academic article
-
Nilsen, Kaja Elisabeth;
Skjesol, Astrid;
Kojen, June Frengen;
Espevik, Terje;
Stenvik, Jørgen;
Yurchenko, Mariya.
(2022)
TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells.
Biomedicines
Academic article
-
Trifonov, Lena;
Yurchenko, Mariya;
Skjesol, Astrid;
Cohen, Guy;
Espevik, Terje;
Korshin, Edward E..
(2021)
Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-β) modulator.
Molecular diversity
Academic article
-
Skjesol, Astrid;
Yurchenko, Mariya;
Bösl, Korbinian;
Gravastrand, Caroline S.;
Nilsen, Kaja Elisabeth;
Grøvdal, Lene Melsæther.
(2019)
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
PLoS Pathogens
Academic article
-
Moen, Siv Helen;
Ehrnstrøm, Birgitta;
Kojen, June Frengen;
Yurchenko, Mariya;
Beckwith, Kai Sandvold;
Afset, Jan Egil.
(2019)
Human Toll-like receptor 8 (TLR8) is an important sensor of pyogenic bacteria, and is attenuated by cell surface TLR signaling.
Frontiers in Immunology
Academic article
-
Yurchenko, Mariya;
Skjesol, Astrid;
Ryan, Liv;
Richard, Gabriel Mary;
Kandasamy, Richard Kumaran;
Wang, Ninghai.
(2018)
SLA MF1 is required for TLR4-mediated TRAM-TRIF- dependent signaling in human macrophages.
Journal of Cell Biology
Academic article
-
Ehrnstrøm, Birgitta;
Beckwith, Kai Sandvold;
Yurchenko, Mariya;
Moen, Siv Helen;
Kojen, June Frengen;
Lentini, Germana.
(2017)
Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.
Frontiers in Immunology
Academic article
-
Romanets-Korbut, Olga;
Najakshin, Alexander M.;
Yurchenko, Mariya;
Malysheva, Tatyana A.;
Kovalevska, Larysa;
Shlapatska, Larysa M..
(2015)
Expression of CD150 in Tumors of the Central Nervous System: Identification of a Novel Isoform.
PLOS ONE
Academic article
-
Yurchenko, Mariya;
Shlapatska, Larysa M.;
Sidorenko, Svetlana P..
(2012)
The multilevel regulation of CD95 signaling outcome.
Experimental Oncology
Academic literature review
-
Darekar, Suhas;
Georgiou, Konstantinos;
Yurchenko, Mariya;
Yenamandra, Surya Pavan;
Chachami, Georgia;
Simos, George.
(2012)
Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect.
PLOS ONE
Academic article
-
Yurchenko, Mariya;
Shlapatska, Larysa M.;
Romanets, Olga L.;
Ganshevsky, Denis;
Kashuba, Elena;
Zamoshnikova, Alina.
(2011)
CD150-mediated Akt signalling pathway in normal and malignant B cells.
Experimental Oncology
Academic article
-
Shabelnik, Marianna Y;
Kovalevska, Larysa;
Yurchenko, Mariya;
Shlapatska, Larysa M.;
Rzepetsky, Yuriy;
Sidorenko, Svetlana P..
(2011)
Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system.
Experimental Oncology
Academic article
-
Kashuba, Elena;
Yurchenko, Mariya;
Yenamandra, Surya Pavan;
Snopok, Boris;
Szekely, Lazlo;
Bercovich, Beatrice.
(2010)
Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53.
International Journal of Cancer
Academic article
-
Yurchenko, Mariya;
Sidorenko, Svetlana P..
(2010)
Hodgkin's lymphoma: the role of cell surface receptors in regulation of tumor cell fate.
Experimental Oncology
Academic literature review
Teaching
Courses
Supervision
I have supervised more than 12 master students and suprevising 2 PhD students.
Outreach
2024
-
PosterNilsen, Kaja Elisabeth; Skjesol, Astrid; Bakke, Siril Skaret; Ryan, Liv; Stenvik, Jørgen; Espevik, Terje. (2024) SLAMF1-derived peptide inhibits signaling initiated by endosomal Toll-like receptors. TOLL 2024 , Rotterdam 2024-04-17 - 2024-04-20
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PosterMestvedt, Ingvild Bergdal; Yurchenko, Maria; Espevik, Terje; Standal, Therese; Wolowczyk, Camilla Izabel; Rasheed, Kashif. (2024) Exploring peptide derived from Signaling Lymphocytic Activation Molecule Family 1 as novel treatment for multiple myeloma. EORTC NCI and AACR (ENA) ENA 2024 Symposium on molecular targets and cancer therapeutics , Barcelona 2024-10-23 - 2024-10-25
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PosterGravastrand, Caroline Saugestad; Yurchenko, Maria; Kristensen, Stine; Skjesol, Astrid; Espevik, Terje; Husebye, Harald. (2024) The Rab11-family interacting protein 2 is a key regulator of the NLRP3 inflammasome . Douglas Golenbock, UMASS, USA Poster , Rotterdam 2024-04-17 - 2024-04-20
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PosterGravastrand, Caroline Saugestad; Yurchenko, Maria; Kristensen, Stine; Skjesol, A.; Espevik, Terje; Husebye, Harald. (2024) The Rab GTPase Rab11b and its effector Rab11-FIP2 are key regulators of the NLRP3 inflammasome . EMBO Cell death: Friend or foe in animal and plant immunity , San Feliu de Guixols 2024-10-11 - 2024-10-15
2023
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PosterNilsen, Kaja Elisabeth; Zhang, Boyao; Skjesol, Astrid; Bakke, Siril Skaret; Gravastrand, Caroline Saugestad; Ryan, Liv. (2023) SLAMF1-derived peptide could limit the inflammation mediated by several Toll-like receptors. 18th International Conference on Innate Immunity , Chania 2023-05-31 - 2023-06-05
2022
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Academic lectureHusebye, Harald; Gravastrand, Caroline Saugestad; Yurchenko, Mariya; Skjesol, Astrid; Espevik, Terje. (2022) The Rab11-family interacting protein 2 is a regulator of the NLRP3 inflammasome . School of Education, University of Iceland BNMI – Bridging the Nordic Microscopy Infrastructure , Reykjavik 2022-08-17 - 2022-08-19
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PosterHusebye, Harald; Gravastrand, Caroline Saugestad; Yurchenko, Mariya; Espevik, Terje. (2022) The Rab11-family interacting protein 2 is a regulator of the NLRP3 inflammasome . EMBO EMBO Workshop Dying in self-defense: Cell death signaling in animals and plants , Kreta 2022-05-01 - 2022-05-05
2019
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PosterSkjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Agliano, Federica. (2019) The TLR4 adaptor TRAM controls phagocytosis of E. coli through FIP2 . CEMIR, NTNU 2nd Conference on Molecular Mechanisms of Inflammation , Trondheim 2019-06-03 - 2019-06-06
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PosterGravastrand, Caroline S.; Skjesol, Astrid; Yurchenko, Mariya; Jakovljev, Aleksandra; Afset, Jan Egil; Espevik, Terje. (2019) FIP2 regulates inflammatory cell death in human macrophages. EMBO EMBL symposia Seeing is Believing - Imaging the Molecular Processes of Life , EMBL Heidelberg 2019-10-09 - 2019-10-12
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PosterAass, Kristin Roseth; Mjelle, Robin; Zahoor, Muhammad; Yurchenko, Mariya; Westhrin, Marita; Buene, Glenn. (2019) IL-32 is a novel growth factor and metabolic regulator for multiple myeloma cells. Keystone Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment. , Florence 2019-03-15 - 2019-03-19
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Academic lectureYurchenko, Mariya. (2019) TICAM2-SLAMF1 interaction: impact on signaling via Toll-like receptors. CEMIR International Conference on Molecular Mechanisms of Inflammation , Kunnskapssenteret, NTNU, Trondheim 2019-06-03 - 2019-06-06
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PosterMoen, Siv Helen; Kojen, June Frengen; Yurchenko, Mariya; Ehrnstrøm, Birgitta; Damås, Jan Kristian; Espevik, Terje. (2019) Cell surface TLRs antagonize TLR8 signaling in monocytes via an IRAK-1 dependent mechanism. CEMIR, NTNU International conference of molecular mechanisms of inflammation , Trondheim 2019-06-03 - 2019-06-06
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PosterAass, Kristin Roseth; Mjelle, Robin; Westhrin, Marita; Zahoor, Muhammad; Yurchenko, Mariya; Buene, Glenn. (2019) IL-32 is a novel growth factor and metabolic regulator in multiple myeloma cells. The Second Conference on Molecular Mechanisms of Inflammation in Trondheim June 3-6, 2019. 2019-06-03 - 2019-06-06
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PosterGravastrand, Caroline S.; Skjesol, Astrid; Yurchenko, Mariya; Jakovljev, Aleksandra; Afset, Jan Egil; Espevik, Terje. (2019) FIP2 regulates inflammatory cell death in macrophages. EMBO EMBO workshop, Cell death in immunity and inflammation , Kreta 2019-10-06 - 2019-10-09
2018
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PosterSkjesol, Astrid; Yurchenko, Mariya; Espevik, Terje; Husebye, Harald. (2018) The TLR4 adaptor TRAM controls phagocytosis of Gram-negative bacteria through TRAM and the Rab11-family interacting protein 2 . Toll 2018, Editing Innate Immunity , Porto 2018-06-06 - 2018-06-09
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PosterYurchenko, Mariya; Skjesol, Astrid; Husebye, Harald; Espevik, Terje. (2018) SLAMF1 regulates signaling via TLR4 and bacterial killing in human macrophages. Toll 2018. Editing Innate Immunity , Porto 2018-06-06 - 2018-06-09
2017
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PosterSkjesol, Astrid; Sporsheim, Bjørnar; Yurchenko, Mariya; Egeberg, Kjartan Wøllo; Espevik, Terje; Husebye, Harald. (2017) The TLR4 adaptor TRAM controls phagocytosis of Gram-negative bacteria . 17th International European Light Microscopy Initiative Meeting , Dubrovnik 2017-05-23 - 2017-05-26
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PosterSkjesol, Astrid; Yurchenko, Mariya; Espevik, Terje; Husebye, Harald. (2017) The TLR4 adaptor TRAM controls phagocytosis of Gram-negative bacteria through interaction with the Rab11-family interacting protein 2. Keystone Symposia on Molecular and Cellular Biology Type I Interferon: Friend and Foe Alike (X6) , Banff 2017-03-19 - 2017-03-23
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Academic lectureHusebye, Harald; Skjesol, Astrid; Yurchenko, Mariya; Grøvdal, Lene Melsæther; Bösl, Korbinian; Agliano, Federica. (2017) The TLR4 adaptor TRAM controls phagocytosis of Gram-negative bacteria through the Rab11-family interacting protein 2. CEMIR Cemir retreat , Taormina, Sicily 2017-10-16 - 2017-10-19
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PosterSkjesol, Astrid; Husebye, Harald; Yurchenko, Mariya; Egeberg, Kjartan Wøllo; Espevik, Terje. (2017) The TLR4 adaptor TRAM controls phagocytosis of Gram-negative bacteria . Seeing is Believing , Heidelberg 2017-10-04 - 2017-10-07
2016
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PosterSkjesol, Astrid; Yurchenko, Mariya; Agliano, Federica; Patane, Francesco; Teti, Guiseppe; McCaffrey, Mary. (2016) Rab11-family interacting protein 2 mediates phagocytosis of E.coli. CEMIR, NTNU Conference on Molecular Mechanisms of Inflammation 2016-05-30 - 2016-06-02
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LectureYurchenko, Mariya; Skjesol, Astrid; Husebye, Harald; Espevik, Terje. (2016) CD150 positively regulates TRAM recruitment to E.coli phagosomes and type I IFN secretion. Cell symposium - 100 years of phagocytes , Giardini Naxos, Sicily 2016-09-19 - 2016-09-22
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PosterYurchenko, Mariya; Skjesol, Astrid; Husebye, Harald; Espevik, Terje. (2016) CD150 positively regulates TRAM recruitment to E. coli phagosomes and TLR4-induced IFNbeta production. CEMIR Conference on Molecular Mechanisms of Inflammation , Trondheim 2016-05-30 - 2016-06-02
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PosterSkjesol, Astrid; Yurchenko, Mariya; Agliano, Federica; Patane, Francesco; Teti, Guiseppe; McCaffrey, Mary. (2016) Rab11-family interacting protein 2 (FIP2) mediates phagocytosis of E.coli. Elsevier Conferences Cell symposium - 100 years of phagocytes 2016-09-19 - 2016-09-22
2015
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PosterYurchenko, Mariya; Skjesol, Astrid; Husebye, Harald; Espevik, Terje. (2015) CD150 REGULATES TYPE I IFN PRODUCTION FROM E.COLI PHAGOSOMES BY AFFECTING TRAM TRAFFICKING. Toll Conference 2015 Targeting Innate Immunity , Marbella 2015-09-30 - 2015-10-03
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PosterSkjesol, Astrid; Patane, Francesco; Yurchenko, Mariya; Aune, Marie Hjelmseth; McCaffrey, Mary; Espevik, Terje. (2015) The small GTPase Rab11a and its partner Rab11FIP2 regulate TLR4 signaling pathways. 15th annual meeting of the European Light Microscopy Initiative (ELMI) , Sitges 2015-05-19 - 2015-05-21
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PosterSkjesol, Astrid; Patane, Francesco; Yurchenko, Mariya; Aune, Marie Hjelmseth; McCaffrey, Mary; Espevik, Terje. (2015) The small GTPase Rab11a and its partner Rab11FIP2 affect TLR4 signaling pathways. TOLL 2015 Targeting innate immunity 2015-09-30 - 2015-10-03