Mariia Yurchenko

About

My work earlier in the career was focused on the clarification of the signaling pathways and protein-protein interactions of SLAMF1/CD150 Ig-like receptor receptor in cancer and normal B cells. I have done my PhD in Ukraine, and worked as a visiting postdoc in Karolinska Institute, Sweden. I took an active part in the research focused on the assessment of SLAMF1 expression and function in various lymphoid and non-lymphoid cancers. From 2013 I have joined CEMIR, group of Prof. Terje Espevik, with SLAMF1-related project. We have suggested that SLAMF1 protein could be localized intracellularly in human innate immune cells (monocytes, macrophages), with distinct signaling and functions when compared to SLAMF1 receptor on the cell surface. This hypothesis led to the fundamental study on the role of intracellular SLAMF1 protein in the regulation of Toll-like receptor (TLR) signaling in human macrophages (JCB, 2018). In parallel I worked on the project on Rab11 family interacting protein 2 (FIP2). We demonstrated that FIP2 guides TLR4 adaptor protein TRAM recruitment to bacterial phagosome, and orchestrates actin remodelling and IRF3 activation, two events that are both required for phagocytosis of Gram-negative bacteria (PLoS Pathog, 2019).

Currently, together with my PhD students Kaja Elisabeth Nilsen and Ingvild Mestvedt, I am working on several projects exploring mechanisms of regulation and novel approaches to target TLR4 and TLR8 signaling pathways in human cells.

Publications

2022

Nilsen, Kaja Elisabeth; Skjesol, Astrid; Kojen, June Frengen; Espevik, Terje; Stenvik, Jørgen; Yurchenko, Mariya. (2022) TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells. Biomedicines
Academic article

2021

Trifonov, Lena; Yurchenko, Mariya; Skjesol, Astrid; Cohen, Guy; Espevik, Terje; Korshin, Edward E.. (2021) Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-β) modulator. Molecular diversity
Academic article

2019

Moen, Siv Helen; Ehrnstrøm, Birgitta; Kojen, June Frengen; Yurchenko, Mariya; Beckwith, Kai Sandvold; Afset, Jan Egil. (2019) Human Toll-like receptor 8 (TLR8) is an important sensor of pyogenic bacteria, and is attenuated by cell surface TLR signaling. Frontiers in Immunology
Academic article
Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther. (2019) The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathogens
Academic article

2018

Yurchenko, Mariya; Skjesol, Astrid; Ryan, Liv; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Wang, Ninghai. (2018) SLA MF1 is required for TLR4-mediated TRAM-TRIF- dependent signaling in human macrophages. Journal of Cell Biology
Academic article

2017

Ehrnstrøm, Birgitta; Beckwith, Kai Sandvold; Yurchenko, Mariya; Moen, Siv Helen; Kojen, June Frengen; Lentini, Germana. (2017) Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Frontiers in Immunology
Academic article

2015

Romanets-Korbut, Olga; Najakshin, Alexander M.; Yurchenko, Mariya; Malysheva, Tatyana A.; Kovalevska, Larysa; Shlapatska, Larysa M.. (2015) Expression of CD150 in Tumors of the Central Nervous System: Identification of a Novel Isoform. PLOS ONE
Academic article

2012

Yurchenko, Mariya; Shlapatska, Larysa M.; Sidorenko, Svetlana P.. (2012) The multilevel regulation of CD95 signaling outcome. Experimental Oncology
Academic literature review
Darekar, Suhas; Georgiou, Konstantinos; Yurchenko, Mariya; Yenamandra, Surya Pavan; Chachami, Georgia; Simos, George. (2012) Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect. PLOS ONE
Academic article

2011

Shabelnik, Marianna Y; Kovalevska, Larysa; Yurchenko, Mariya; Shlapatska, Larysa M.; Rzepetsky, Yuriy; Sidorenko, Svetlana P.. (2011) Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system. Experimental Oncology
Academic article
Yurchenko, Mariya; Shlapatska, Larysa M.; Romanets, Olga L.; Ganshevsky, Denis; Kashuba, Elena; Zamoshnikova, Alina. (2011) CD150-mediated Akt signalling pathway in normal and malignant B cells. Experimental Oncology
Academic article

Journal publications

Nilsen, Kaja Elisabeth; Skjesol, Astrid; Kojen, June Frengen; Espevik, Terje; Stenvik, Jørgen; Yurchenko, Mariya. (2022) TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells. Biomedicines
Academic article
Trifonov, Lena; Yurchenko, Mariya; Skjesol, Astrid; Cohen, Guy; Espevik, Terje; Korshin, Edward E.. (2021) Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-β) modulator. Molecular diversity
Academic article
Moen, Siv Helen; Ehrnstrøm, Birgitta; Kojen, June Frengen; Yurchenko, Mariya; Beckwith, Kai Sandvold; Afset, Jan Egil. (2019) Human Toll-like receptor 8 (TLR8) is an important sensor of pyogenic bacteria, and is attenuated by cell surface TLR signaling. Frontiers in Immunology
Academic article
Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther. (2019) The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. PLoS Pathogens
Academic article
Yurchenko, Mariya; Skjesol, Astrid; Ryan, Liv; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Wang, Ninghai. (2018) SLA MF1 is required for TLR4-mediated TRAM-TRIF- dependent signaling in human macrophages. Journal of Cell Biology
Academic article
Ehrnstrøm, Birgitta; Beckwith, Kai Sandvold; Yurchenko, Mariya; Moen, Siv Helen; Kojen, June Frengen; Lentini, Germana. (2017) Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Frontiers in Immunology
Academic article
Romanets-Korbut, Olga; Najakshin, Alexander M.; Yurchenko, Mariya; Malysheva, Tatyana A.; Kovalevska, Larysa; Shlapatska, Larysa M.. (2015) Expression of CD150 in Tumors of the Central Nervous System: Identification of a Novel Isoform. PLOS ONE
Academic article
Yurchenko, Mariya; Shlapatska, Larysa M.; Sidorenko, Svetlana P.. (2012) The multilevel regulation of CD95 signaling outcome. Experimental Oncology
Academic literature review
Darekar, Suhas; Georgiou, Konstantinos; Yurchenko, Mariya; Yenamandra, Surya Pavan; Chachami, Georgia; Simos, George. (2012) Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect. PLOS ONE
Academic article
Shabelnik, Marianna Y; Kovalevska, Larysa; Yurchenko, Mariya; Shlapatska, Larysa M.; Rzepetsky, Yuriy; Sidorenko, Svetlana P.. (2011) Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system. Experimental Oncology
Academic article
Yurchenko, Mariya; Shlapatska, Larysa M.; Romanets, Olga L.; Ganshevsky, Denis; Kashuba, Elena; Zamoshnikova, Alina. (2011) CD150-mediated Akt signalling pathway in normal and malignant B cells. Experimental Oncology
Academic article

Teaching

Courses

MOL3005 - Immunology

Språkvelger

Mariia Yurchenko