Marit Bugge
About
Research Scientist at the Department of Cancer Research and Molecular Medicine (IKM), Centre of Molecular Inflammation Research (CEMIR)
Research focus: Immunology and infectious diseases, with a focus on understanding host-pathogen interactions, cellular signalling, cellular cross talk and mechanism of cell death.
- Since 2020: Researcher, member of the research group Molecular Mechanisms of Mycobacterial and Viral Infections - CEMIR - NTNU.
- 2016-2020: Post doctor, Department of Clinical and Molecular Medicine (IKOM) - NTNU, Centre of Molecular Inflammation Research (CEMIR).
- 2016: PhD in molecular medicine, Department of Clinical and Molecular Medicine (IKOM) - NTNU.
Publications
2024
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Sætra, Ragnhild Sofie Ragnhildstveit;
Bugge, Marit;
Beckwith, Kai Sandvold;
Flo, Trude Helen.
(2024)
Ninjurin 1 and cell death mechanisms in Mycobacterium tuberculosis-infected human macrophages.
Norges teknisk-naturvitenskapelige universitet
Doctoral theses at NTNU (476)
Doctoral dissertation
2023
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Nore, Kristin Grotle;
Louet, Claire;
Bugge, Marit;
Gidon, Alexandre;
Jørgensen, Marthe Jøntvedt;
Jenum, Synne.
(2023)
The Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth.
Journal of Infectious Diseases
Academic article
2022
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Borges, Jazlyn P.;
Sætra, Ragnhild Sofie Ragnhildstveit;
Volchuk, Allen;
Bugge, Marit;
Devant, Pascal;
Sporsheim, Bjørnar.
(2022)
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
eLIFE
Academic article
2020
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Ianevski, Aleksandr;
Kulesskiy, Evgeny;
Krpina, Klara;
Lou, Guofeng;
Aman, Yahyah;
Bugai, Andrii.
(2020)
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis.
Cancers
Academic article
2018
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Bösl, Korbinian;
Giambelluca, Miriam;
Haug, Markus;
Bugge, Marit;
Espevik, Terje;
Kandasamy, Richard Kumaran.
(2018)
Coactivation of TLR2 and TLR8 in primary human monocytes triggers a distinct inflammatory signaling response.
Frontiers in Physiology
Academic article
2017
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Bugge, Marit;
Bergstrøm, Bjarte;
Eide, Oda K.;
Solli, Helene;
Kjønstad, Ingrid Fadum;
Stenvik, Jørgen.
(2017)
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness.
Journal of Biological Chemistry
Academic article
2016
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Bugge, Marit;
Nilsen, Nadra J.;
Espevik, Terje.
(2016)
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells.
Norwegian University of Science and Technology
Doctoral dissertation
2015
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Nilsen, Nadra;
Gregory I., Vladimer;
Stenvik, Jørgen;
Ørning, Mathias Pontus;
Zeid-Kilani, Maria Vanessa;
Bugge, Marit.
(2015)
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Journal of Biological Chemistry
Academic article
2013
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Østvik, Ann Elisabet;
Granlund, Atle;
Bugge, Marit;
Nilsen, Nadra;
Torp, Sverre Helge;
Waldum, Helge.
(2013)
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation.
Inflammatory Bowel Diseases
Academic article
Journal publications
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Nore, Kristin Grotle;
Louet, Claire;
Bugge, Marit;
Gidon, Alexandre;
Jørgensen, Marthe Jøntvedt;
Jenum, Synne.
(2023)
The Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth.
Journal of Infectious Diseases
Academic article
-
Borges, Jazlyn P.;
Sætra, Ragnhild Sofie Ragnhildstveit;
Volchuk, Allen;
Bugge, Marit;
Devant, Pascal;
Sporsheim, Bjørnar.
(2022)
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
eLIFE
Academic article
-
Ianevski, Aleksandr;
Kulesskiy, Evgeny;
Krpina, Klara;
Lou, Guofeng;
Aman, Yahyah;
Bugai, Andrii.
(2020)
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis.
Cancers
Academic article
-
Bösl, Korbinian;
Giambelluca, Miriam;
Haug, Markus;
Bugge, Marit;
Espevik, Terje;
Kandasamy, Richard Kumaran.
(2018)
Coactivation of TLR2 and TLR8 in primary human monocytes triggers a distinct inflammatory signaling response.
Frontiers in Physiology
Academic article
-
Bugge, Marit;
Bergstrøm, Bjarte;
Eide, Oda K.;
Solli, Helene;
Kjønstad, Ingrid Fadum;
Stenvik, Jørgen.
(2017)
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness.
Journal of Biological Chemistry
Academic article
-
Nilsen, Nadra;
Gregory I., Vladimer;
Stenvik, Jørgen;
Ørning, Mathias Pontus;
Zeid-Kilani, Maria Vanessa;
Bugge, Marit.
(2015)
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Journal of Biological Chemistry
Academic article
-
Østvik, Ann Elisabet;
Granlund, Atle;
Bugge, Marit;
Nilsen, Nadra;
Torp, Sverre Helge;
Waldum, Helge.
(2013)
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation.
Inflammatory Bowel Diseases
Academic article
Report
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Sætra, Ragnhild Sofie Ragnhildstveit;
Bugge, Marit;
Beckwith, Kai Sandvold;
Flo, Trude Helen.
(2024)
Ninjurin 1 and cell death mechanisms in Mycobacterium tuberculosis-infected human macrophages.
Norges teknisk-naturvitenskapelige universitet
Doctoral theses at NTNU (476)
Doctoral dissertation
-
Bugge, Marit;
Nilsen, Nadra J.;
Espevik, Terje.
(2016)
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells.
Norwegian University of Science and Technology
Doctoral dissertation
Outreach
2025
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PosterRønningstad, Åshild; Bugge, Marit; Ryan, Liv; Flo, Trude Helen; Haug, Markus. (2025) The role of the cGAS-STING pathway in primary human CD4+ T cells. Norwegian Bioscience Society Norwegian Bioscience Society 60th Contact Meeting RØROS, NORWAY 23-26 January 2025 , Røros 2025-01-23 - 2025-01-26
2024
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Academic lectureFlo, Trude Helen; Sætra, Ragnhild Sofie Ragnhildstveit; Beckwith, Kai Sandvold; Marstad, Anne; Nonstad, Unni; Hansen, Mathilde. (2024) Control of mycobacterial infection by inflammasomes. EMBO EMBO workshop: The Inflammasomes-2024 , Planegg-Martinsried 2024-09-23 - 2027-09-27
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Academic lectureSætra, Ragnhild Sofie Ragnhildstveit; Bugge, Marit; Marstad, Anne; Beckwith, Kai Sandvold; Flo, Trude Helen. (2024) Elucidating the role of NINJ1 in Mycobacterium tuberculosis-infected macrophages. TOLL Conference 2024 2024-04-17 - 2024-04-20
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Academic lectureFlo, Trude Helen; Sætra, Ragnhild Sofie Ragnhildstveit; Bugge, Marit; Beckwith, Kai Sandvold; Hansen, Mathilde; Fjellvær, Ida. (2024) M. tuberculosis induced cell death and a new macrophage – alveolar epithelial cell co-culture model. EMBO EMBL EMBO|EMBL Symposium: Innate immunity in host-pathogen interactions , Heildelberg 2024-06-18 - 2024-06-21
2023
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Academic lectureFlo, Trude Helen; Gidon, Alexandre; Mediaas, Sindre Dahl; Bugge, Marit. (2023) Spatiotemporal studies of host responses to mycobacteria in macrophages. Nobel Symposia in Africa 178th Nobel Symposium in Chemistry Tuberculosis and antibiotic resistance - from basic drug discovery to clinic , Stellenbosch 2023-10-23 - 2023-10-27
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PosterSætra, Ragnhild Sofie Ragnhildstveit; Borges, Jazlyn P.; Volchuk, Allen; Bugge, Marit; Devant, Pascal; Marstad, Anne. (2023) NINJ1 oligomerization dynamics. Aegean Conferences 18th International Conference on Innate Immunity , Chania, Kreta 2023-05-31 - 2023-06-05
2022
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PosterFjellvær, Ida; Bugge, Marit; Flo, Trude Helen. (2022) Ex vivo lung model to elucidate host-pathogen interactions in Tuberculosis. IBA forskningsskole IBA Annual Meeting , Oslo 2022-10-27 - 2022-10-28
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Academic lectureFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre; Bugge, Marit. (2022) The Inner Life of Mycobacterium Infected Macrophages. Gordon Research Conferences Gordon Research Conference on Lysosomes and Endocytosis 2022: Physiological Adaptations of the Endo-Lysosomal System , Andover, New Hampshire 2022-06-19 - 2022-06-24
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Academic lectureFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre; Bugge, Marit. (2022) The inner life of a mycobacterium-infected macrophage. University of Connecticut Health School of Medicine Invited talk , Connecticut 2022-04-27 -
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Academic lectureFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Gidon, Alexandre; Mediaas, Sindre Dahl; Sætra, Ragnhild Sofie Ragnhildstveit. (2022) Spatiotemporal Relations of Mycobacteria and Human Macrophages. UMass Chan School of Medicine Department seminar series , Massachusetts 2022-01-26 -
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Academic lectureFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Bugge, Marit; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre. (2022) The inner life of a mycobacterium-infected macrophage. NIAID immunobiology section /Alan Sher, Katrin Mayer-Barber NIAID Invited talk , Bethesda 2022-05-19 -
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Academic lectureFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre; Bugge, Marit. (2022) Host-cell killing by Mycobacterium tuberculosis. University of Connecticut Molecular and Cell biology Invited talk , Connecticut 2022-04-26 -
2021
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Academic lectureFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Gidon, Alexandre; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit. (2021) Mycobacterium tuberculosis infection in human macrophages. Boston Children's hospital / Harvard Medical School Department seminar series 2021-09-15 -
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Academic lectureSætra, Ragnhild Sofie Ragnhildstveit; Bugge, Marit; Marstad, Anne; Flo, Trude Helen. (2021) MOLECULAR MECHANISMS IN MYCOBACTERIUM TUBERCULOSIS-INFECTED MACROPHAGES. IBA/NMBU IBA Annual Meeting 2021 , Oslo 2021-11-01 - 2021-11-02
2018
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PosterBösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran. (2018) Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response. Research School in Infection Biology and and Antimicrobials Annual Meeting Research School in Infection Biology and and Antimicrobials , Tromsø 2018-10-29 - 2018-10-30
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PosterBugge, Marit; EIde, Oda Kamilla; Solli, Helene; Kjønstad, Ingrid Fadum; Stenvik, Jørgen; Bergstrøm, Bjarte. (2018) SURFACE TOLL-LIKE RECEPTOR 3 EXPRESSION IN METASTATIC INTESTINAL EPITHELIAL CELLS INDUCES INFLAMMATORY CYTOKINE PRODUCTION AND PROMOTES INVASIVENESS. UMASS Medical School and University of Freiburg Toll 2018 Translating Innate Immunity , Porto 2018-06-06 - 2018-06-09
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Academic lectureBugge, Marit; Espevik, Terje; Nilsen, Nadra. (2018) Altered Toll-Like Receptor Expression and Signaling in Colorectal Cancer Cells promotes Invasiveness. NTNU/St. Olav’s Hospital 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer: From diagnosis to immunotherapy – why is precision medicine so difficult? , Trondheim 2018-06-14 - 2018-06-15
2017
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PosterBugge, Marit; Bergstrøm, Bjarte Aune; Eide, Oda K.; Solli, Helene; Kjønstad, Ingrid Fadum; Stenvik, Jørgen. (2017) Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Inflammatory Cytokine Production and Promotes Invasiveness. Universitats Klinikum Freiburg Development of Tissue- and Pathogen-specific Cellular Innate Immunity , Freiburg 2017-09-27 - 2017-09-29
2015
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PosterNilsen, Nadra J.; Espevik, Terje; Vladimer, G; Stenvik, Jørgen; Orning, M. Pontus A.; Zeid-Kilani, Maria Vanessa. (2015) THE ADAPTOR PROTEINS TRAM AND TRIF MEDIATE TOLL-LIKE RECEPTOR 2 SIGNALING. Wellcome Trust Innate Immune Memory , Hinxton, Cambridge 2015-03-18 - 2015-03-20
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LectureNilsen, Nadra J.; Espevik, Terje; Vladimer, G; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit. (2015) THE ADAPTOR PROTEINS TRAM AND TRIF MEDIATE TOLL-LIKE RECEPTOR 2 SIGNALING. UMass Medical School, MA; Universitats Klinikum Freiburg, D Toll2015 Targeting Innate Immunity , Marbella 2015-09-30 - 2015-10-03
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PosterNilsen, Nadra J.; Espevik, Terje; Gjerdingen, Thea Johannne; Bugge, Marit; Kjønstad, Ingrid Fadum. (2015) A TOLL-LIKE RECEPTOR 7/8 LIGAND SECRETED BY MYELOMA CELLS INDUCES PRIMARY BONE MARROW STROMAL CELLS TO PRODUCE CYTOKINES THAT PROMOTE MYELOMA SURVIVAL. Toll2015 Targeting Innate Immunity 2015-09-30 - 2015-10-03
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PosterBugge, Marit; Solli, Helene; Kjønstad, Ingrid F.; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra J.. (2015) Metastatic Intestinal Epithelial Cells Express Surface Toll-Like Receptor 3. The University of Massachusetts Medical School Toll 2015 Targeting Innate Immunity , Marbella 2015-09-30 - 2015-10-03
2013
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PosterBugge, Marit; Nilsen, Nadra; Espevik, Terje. (2013) A potential role for TLR3 expression and TLR3 mediated responses in the progression of colorectal cancer. Keystone Symposia on Cancer Immunology and Immunotherapy , Vancouver 2013-01-27 - 2013-02-01