Mark Berthold-Losleben
About
Senior consultant psychiatrist at Sykehuset Østfold, Nordre DPS in Moss, Ketamine Unit.
Associate professor at the Department of Mental Health, NTNU. (2018 - 2022 leader of the teaching unit)
Background:
- MA in religious sciences, history and philosophy (2000)
- MD (2006)
- PhD (2008)
- Specialist in psychiatry and psychotherapy (2014)
- Certified therapist, supervisor and trainer for the Cognitive Behavioural Analysis System of Psychotherapy, CBASP (2019)
Research
I am interested in chronic depression (persistent depressive disorder) and difficult-to-treat depression and engaged in reasearch projects about ketamine treatment and MDMA-assisted psychotherapy. I am a core member of the research group PsykForsk at the district psychiatric center in Moss, Norway, and participant of NORAAD, a network dedicated to do reasearch about the therapeutic use of rapid acting antidepressants.
Publications
2026
-
Kvam, Tor-Morten;
Goksøyr, Ivar W.;
Stewart, Lowan H.;
Berthold-Losleben, Mark;
Autran, Ingrid;
Andreassen, Ole A..
(2026)
Klinisk og ikke-klinisk bruk av MDMA.
Tidsskrift for Den norske legeforening (Tidsskriftet)
Academic article
-
Stewart, Lowan H;
Berthold-Losleben, Mark;
Kvam, Tor-Morten;
Lien, Lars;
Andreassen, Ole A;
Clausen, Ingmar.
(2026)
Transforming treatment-resistant depression care in Norway: Public health reimbursement for off-label intravenous ketamine.
Drug Science, Policy and Law
Academic article
-
Berthold-Losleben, Mark;
Kvam, T.M.;
Andreassen, O.;
Goksøyr, I..
(2026)
Changes in wellbeing, self-compassion and alexithymia in a proof of principle trial with MDMA-assisted therapy for Major Depressive Disorder.
Neuroscience Applied
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar W.;
Rog, Justyna;
Vooren, Inger-Tove Jentoft van de;
Stewart, Lowan Han;
Autran, Ingrid;
Berthold-Losleben, Mark;
Mørch-Johnsen, Lynn;
Holst, René;
Clausen, Ingmar.
(2026)
MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study – CORRIGENDUM.
British Journal of Psychiatry
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar Walderhaug;
Rog, Justyna;
Autran, Ingrid;
Berthold-Losleben, Mark;
Andreassen, Ole Andreas.
(2026)
MDMA-assisted psychotherapy in major depression: critical considerations for clinical translation: commentary, Kvam et al.
British Journal of Psychiatry
Academic article
2025
-
Kvam, Tor-Morten;
Goksøyr, Ivar;
Rog, Justyna;
Vooren, Inger-Tove Jentoft van de;
Stewart, Lowan H.;
Autran, Ingrid;
Berthold-Losleben, Mark;
Mørch-Johnsen, Lynn Egeland;
Holst, Rene;
Røssberg, Jan Ivar.
(2025)
MDMA-assisted therapy for major depressive disorder: A seven-month follow-up proof of principle trial.
Journal of Psychiatric Research
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar;
Rog, Justyna;
Vooren, Inger-Tove Jentoft van de;
Stewart, Lowan H.;
Autran, Ingrid;
Berthold-Losleben, Mark;
Mørch-Johnsen, Lynn Egeland;
Holst, Rene;
Clausen, Ingmar.
(2025)
MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study.
British Journal of Psychiatry
Academic article
2023
-
Berthold-Losleben, Mark;
Swan, John S.;
Liebing-Wilson, Marianne.
(2023)
The ABCs of CBASP. A Guide to the Cognitive Behavioral Analysis System of Psychotherapy for Therapists and Supervisors.
Hogrefe Publishing
Non-fiction monograph
2021
-
Berthold-Losleben, M;
Papalini, S;
Habel, U;
Losleben, K;
Schneider, F;
Amunts, K;
Kohn, N.
(2021)
A short-term musical training affects implicit emotion regulation only in behaviour but not in brain activity.
BMC Neuroscience
Academic article
2019
-
Lund, Line Knutsen;
Bakke, Ingunn;
Reitan, Solveig Merete Klæbo;
Vestvik, Vegard;
Berthold-Losleben, Mark;
Greger, Hanne Klæboe;
Martinsen, Nils;
Syverud, Kari;
Trydal, Elise Constance;
Hojem, Thea Sofie Melhuus.
(2019)
Fornyet psykiatriundervisning
og praksis ved NTNUs
medisinstudium.
Profesjonsstudiet i medisin, Fakultet for medisin og helsevitenskap, NTNU
Research report
2018
-
Berthold-Losleben, Mark;
Habel, U;
Brehl, AK;
Freiherr, J;
Losleben, K;
Schneider, F;
Amunts, K;
Kohn, N.
(2018)
Implicit Affective Rivalry: A Behavioral and fMRI Study Combining Olfactory and Auditory Stimulation.
Frontiers in Behavioral Neuroscience
Academic article
2017
-
Berthold-Losleben, M;
Wohlhueter, H;
Schneider, F.
(2017)
Psychoedukation und Angehörigenarbeit.
Non-fiction chapter
-
Papalini, S;
Berthold-Losleben, Mark;
Kohn, N.
(2017)
Influences of prolonged fasting on behavioural and brain patterns.
Academic chapter
-
Orfanos, S;
Toygar, T;
Berthold-Losleben, M;
Chechko, N;
Durst, A;
Laoutidis, ZG;
Vocke, S;
Weidenfeld, C;
Schneider, F;
Karges, W.
(2017)
Investigating the impact of overnight fasting on intrinsic functional connectivity: a double-blind fMRI study.
Brain Imaging and Behavior
Academic article
2016
-
Kohn, N;
Wassenberg, A;
Toygar, T;
Kellermann, T;
Weidenfeld, C;
Berthold-Losleben, M;
Chechko, N;
Orfanos, S;
Vocke, S;
Laoutidis, ZG.
(2016)
Prolonged fasting impairs neural reactivity to visual stimulation.
Brain Structure and Function
Academic article
2015
-
Chechko, N;
Vocke, S;
Habel, U;
Toygar, T;
Kuckartz, L;
Berthold-Losleben, M;
Laoutidis, ZG;
Orfanos, S;
Wassenberg, A;
Karges, W.
(2015)
Effects of overnight fasting on working memory-related brain network: an fMRI study.
Human Brain Mapping
Academic article
-
Kohn, N;
Toygar, T;
Weidenfeld, C;
Berthold-Losleben, M;
Chechko, N;
Orfanos, S;
Vocke, S;
Durst, A;
Laoutidis, ZG;
Karges, W.
(2015)
In a sweet mood? Effects of experimental modulation of blood glucose levels on mood-induction during fMRI.
NeuroImage
Academic article
2014
-
Berthold-Losleben, M;
Groezinger, M.
(2014)
Informationen für Patienten und Angehörige.
Non-fiction chapter
2011
-
Behrwind, SD;
Dafotakis, M;
Halfter, S;
Hobusch, K;
Berthold-Losleben, M;
Cieslik, EC;
Eickhoff, SB.
(2011)
Executive control in chronic schizophrenia: A perspective from manual stimulus-response compatibility task performance.
Behavioural Brain Research
Academic article
2010
-
Hanke, N;
Kubis, HP;
Scheibe, RJ;
Berthold-Losleben, M;
Huesing, O;
Meissner, JD;
Gros, G.
(2010)
Passive mechanical forces upregulate the fast myosin heavy chain IId/x via integrin and p38 MAP kinase activation in a primary muscle cell culture.
American Journal of Physiology - Cell Physiology
Academic article
2009
-
Himmerich, H;
Berthold-Losleben, M;
Pollmaecher, T.
(2009)
The relevance of the TNF-alpha system in psychiatric disorders.
Fortschritte der Neurologie Psychiatrie
Academic literature review
-
Berthold-Losleben, M;
Heitmann, S;
Himmerich, H.
(2009)
Anti-inflammatory drugs in psychiatry.
Inflammation & Allergy - Drug Targets
Academic literature review
2008
-
Berthold-Losleben, M;
Himmerich, H.
(2008)
The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology.
Current Neuropharmacology
Academic literature review
Journal publications
-
Kvam, Tor-Morten;
Goksøyr, Ivar W.;
Stewart, Lowan H.;
Berthold-Losleben, Mark;
Autran, Ingrid;
Andreassen, Ole A..
(2026)
Klinisk og ikke-klinisk bruk av MDMA.
Tidsskrift for Den norske legeforening (Tidsskriftet)
Academic article
-
Stewart, Lowan H;
Berthold-Losleben, Mark;
Kvam, Tor-Morten;
Lien, Lars;
Andreassen, Ole A;
Clausen, Ingmar.
(2026)
Transforming treatment-resistant depression care in Norway: Public health reimbursement for off-label intravenous ketamine.
Drug Science, Policy and Law
Academic article
-
Berthold-Losleben, Mark;
Kvam, T.M.;
Andreassen, O.;
Goksøyr, I..
(2026)
Changes in wellbeing, self-compassion and alexithymia in a proof of principle trial with MDMA-assisted therapy for Major Depressive Disorder.
Neuroscience Applied
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar W.;
Rog, Justyna;
Vooren, Inger-Tove Jentoft van de;
Stewart, Lowan Han;
Autran, Ingrid;
Berthold-Losleben, Mark;
Mørch-Johnsen, Lynn;
Holst, René;
Clausen, Ingmar.
(2026)
MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study – CORRIGENDUM.
British Journal of Psychiatry
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar Walderhaug;
Rog, Justyna;
Autran, Ingrid;
Berthold-Losleben, Mark;
Andreassen, Ole Andreas.
(2026)
MDMA-assisted psychotherapy in major depression: critical considerations for clinical translation: commentary, Kvam et al.
British Journal of Psychiatry
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar;
Rog, Justyna;
Vooren, Inger-Tove Jentoft van de;
Stewart, Lowan H.;
Autran, Ingrid;
Berthold-Losleben, Mark;
Mørch-Johnsen, Lynn Egeland;
Holst, Rene;
Røssberg, Jan Ivar.
(2025)
MDMA-assisted therapy for major depressive disorder: A seven-month follow-up proof of principle trial.
Journal of Psychiatric Research
Academic article
-
Kvam, Tor-Morten;
Goksøyr, Ivar;
Rog, Justyna;
Vooren, Inger-Tove Jentoft van de;
Stewart, Lowan H.;
Autran, Ingrid;
Berthold-Losleben, Mark;
Mørch-Johnsen, Lynn Egeland;
Holst, Rene;
Clausen, Ingmar.
(2025)
MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study.
British Journal of Psychiatry
Academic article
-
Chechko, N;
Vocke, S;
Habel, U;
Toygar, T;
Kuckartz, L;
Berthold-Losleben, M;
Laoutidis, ZG;
Orfanos, S;
Wassenberg, A;
Karges, W.
(2015)
Effects of overnight fasting on working memory-related brain network: an fMRI study.
Human Brain Mapping
Academic article
-
Behrwind, SD;
Dafotakis, M;
Halfter, S;
Hobusch, K;
Berthold-Losleben, M;
Cieslik, EC;
Eickhoff, SB.
(2011)
Executive control in chronic schizophrenia: A perspective from manual stimulus-response compatibility task performance.
Behavioural Brain Research
Academic article
-
Berthold-Losleben, M;
Himmerich, H.
(2008)
The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology.
Current Neuropharmacology
Academic literature review
-
Hanke, N;
Kubis, HP;
Scheibe, RJ;
Berthold-Losleben, M;
Huesing, O;
Meissner, JD;
Gros, G.
(2010)
Passive mechanical forces upregulate the fast myosin heavy chain IId/x via integrin and p38 MAP kinase activation in a primary muscle cell culture.
American Journal of Physiology - Cell Physiology
Academic article
-
Himmerich, H;
Berthold-Losleben, M;
Pollmaecher, T.
(2009)
The relevance of the TNF-alpha system in psychiatric disorders.
Fortschritte der Neurologie Psychiatrie
Academic literature review
-
Berthold-Losleben, M;
Heitmann, S;
Himmerich, H.
(2009)
Anti-inflammatory drugs in psychiatry.
Inflammation & Allergy - Drug Targets
Academic literature review
-
Kohn, N;
Toygar, T;
Weidenfeld, C;
Berthold-Losleben, M;
Chechko, N;
Orfanos, S;
Vocke, S;
Durst, A;
Laoutidis, ZG;
Karges, W.
(2015)
In a sweet mood? Effects of experimental modulation of blood glucose levels on mood-induction during fMRI.
NeuroImage
Academic article
-
Kohn, N;
Wassenberg, A;
Toygar, T;
Kellermann, T;
Weidenfeld, C;
Berthold-Losleben, M;
Chechko, N;
Orfanos, S;
Vocke, S;
Laoutidis, ZG.
(2016)
Prolonged fasting impairs neural reactivity to visual stimulation.
Brain Structure and Function
Academic article
-
Berthold-Losleben, Mark;
Habel, U;
Brehl, AK;
Freiherr, J;
Losleben, K;
Schneider, F;
Amunts, K;
Kohn, N.
(2018)
Implicit Affective Rivalry: A Behavioral and fMRI Study Combining Olfactory and Auditory Stimulation.
Frontiers in Behavioral Neuroscience
Academic article
-
Berthold-Losleben, M;
Papalini, S;
Habel, U;
Losleben, K;
Schneider, F;
Amunts, K;
Kohn, N.
(2021)
A short-term musical training affects implicit emotion regulation only in behaviour but not in brain activity.
BMC Neuroscience
Academic article
-
Orfanos, S;
Toygar, T;
Berthold-Losleben, M;
Chechko, N;
Durst, A;
Laoutidis, ZG;
Vocke, S;
Weidenfeld, C;
Schneider, F;
Karges, W.
(2017)
Investigating the impact of overnight fasting on intrinsic functional connectivity: a double-blind fMRI study.
Brain Imaging and Behavior
Academic article
Books
-
Berthold-Losleben, Mark;
Swan, John S.;
Liebing-Wilson, Marianne.
(2023)
The ABCs of CBASP. A Guide to the Cognitive Behavioral Analysis System of Psychotherapy for Therapists and Supervisors.
Hogrefe Publishing
Non-fiction monograph
Part of book/report
-
Berthold-Losleben, M;
Groezinger, M.
(2014)
Informationen für Patienten und Angehörige.
Non-fiction chapter
-
Berthold-Losleben, M;
Wohlhueter, H;
Schneider, F.
(2017)
Psychoedukation und Angehörigenarbeit.
Non-fiction chapter
-
Papalini, S;
Berthold-Losleben, Mark;
Kohn, N.
(2017)
Influences of prolonged fasting on behavioural and brain patterns.
Academic chapter
Report
-
Lund, Line Knutsen;
Bakke, Ingunn;
Reitan, Solveig Merete Klæbo;
Vestvik, Vegard;
Berthold-Losleben, Mark;
Greger, Hanne Klæboe;
Martinsen, Nils;
Syverud, Kari;
Trydal, Elise Constance;
Hojem, Thea Sofie Melhuus.
(2019)
Fornyet psykiatriundervisning
og praksis ved NTNUs
medisinstudium.
Profesjonsstudiet i medisin, Fakultet for medisin og helsevitenskap, NTNU
Research report
Teaching
2nd year
- Lecture: Mental state exam
- Patient interview: Suicidal ideation
4th year
- Team-based learning module: Mental state exam
6th year
- Writing course: Mental state exam
Outreach
2025
-
Feature articleBerthold-Losleben, Mark; Autran, Ingrid; Folstad, Rikke Lise Steen; Römer, Benedikt; Kvam, Tor-Morten; Vooren, Inger-Tove van de; Stewart, Lowan H.; Claussen, Ingmar; Andreassen, Ole. (2025) Ketamine in treatment-resistant depression.