Background and activities

Scientific, academic and artistic work

Journal publications

  • Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia; Garbelli, Anna; Maffia, Antonio; Bione, Silvia; Ferrari, Elena; d'Adda di Fagagna, Fabrizio; Francia, Sofia; Sabbioneda, Simone; Chen, Liuh-Yow; Lingner, Joachim; Bergoglio, Valerie; Hoffmann, Jean-Sebastien; Hübscher, Ulrich; Crespan, Emmanuele; Maga, Giovanni. (2021) A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres. International Journal of Molecular Sciences.
  • Fallacara, Anna Lucia; Passannanti, Raffaele; Mori, Mattia; Iovenitti, Giulia; Musumeci, Francesca; Greco, Chiara; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Tarantelli, Chiara; Spriano, Filippo; Gaudio, Eugenio; Bertoni, Francesco; Botta, Maurizio; Schenone, Silvia. (2019) Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. European Journal of Medicinal Chemistry.
  • Tassini, Sabrina; Langron, Emily; Delang, Leen; Mirabelli, Carmen; Lanko, Kristina; Crespan, Emmanuele; Kissova, Miroslava; Tagliavini, Giulia; Fontò, Greta; Bertoni, Simona; Palese, Simone; Giorgio, Carmine; Ravanetti, Francesca; Ragionieri, Luisa; Zamperini, Claudio; Mancini, Arianna; Dreassi, Elena; Maga, Giovanni; Vergani, Paola; Neyts, Johan; Radi, Marco. (2019) Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach. Journal of Medicinal Chemistry.
  • Molinari, Alessandro; Fallacara, Anna Lucia; Di Maria, Salvatore; Zamperini, Claudio; Poggialini, Federica; Musumeci, Francesca; Schenone, Silvia; Angelucci, Adriano; Colapietro, Alessandro; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Botta, Maurizio. (2018) Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment. Bioorganic & Medicinal Chemistry Letters.
  • Mentegari, Elisa; Crespan, Emmanuele; Bavagnoli, Laura; Kissova, Miroslava; Bertoletti, Federica; Sabbioneda, Simone; Imhof, Ralph; Sturla, Shana J; Nilforoushan, Arman; Hübscher, Ulrich; van Loon, Barbara; Maga, Giovanni. (2017) Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity. Nucleic Acids Research (NAR).
  • Musumeci, Francesca; Fallacara, Anna Lucia; Brullo, Chiara; Grossi, Giancarlo; Botta, Lorenzo; Calandro, Pierpaolo; Chiariello, Mario; Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni; Schenone, Silvia. (2017) Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma. European Journal of Medicinal Chemistry.
  • Tassini, Sabrina; Sun, Liang; Lanko, Kristina; Crespan, Emmanuele; Langron, Emily; Falchi, Federico; Kissova, Miroslava; Armijos-Rivera, Jorge I; Delang, Leen; Mirabelli, Carmen; Neyts, Johan; Pieroni, Marco; Cavalli, Andrea; Costantino, Gabriele; Maga, Giovanni; Vergani, Paola; Leyssen, Pieter; Radi, Marco. (2017) Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal of Medicinal Chemistry.
  • Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni. (2016) The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: implications for drug design. Bioorganic & Medicinal Chemistry.
  • Mentegari, Elisa; Kissova, Miroslava; Bavagnoli, Laura; Maga, Giovanni; Crespan, Emmanuele. (2016) DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair. Genes.
  • Radi, Marco; Schneider, Ralf; Fallacara, Anna Lucia; Botta, Lorenzo; Crespan, Emmanuele; Tintori, Cristina; Maga, Giovanni; Kissova, Miroslava; Calgani, Alessia; Richters, André; Musumeci, Francesca; Rauh, Daniel; Schenone, Silvia. (2016) A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. Bioorganic & Medicinal Chemistry Letters.
  • Samir M, El-Moghazy; Riham F, George; Essam Eldin A, Osman; Ahmed A, Elbatrawy; Kissova, Miroslava; Colombo, Ambra; Crespan, Emmanuele; Maga, Giovanni. (2016) Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line. European Journal of Medicinal Chemistry.
  • Vignaroli, Giulia; Mencarelli, Martina; Sementa, Deborah; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Schenone, Silvia; Radi, Marco; Botta, Maurizio. (2014) Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl. Journal of combinatorial chemistry.
  • Mori, Mattia; Tintori, Cristina; Christopher, Robert Selwyne Arul; Radi, Marco; Schenone, Silvia; Musumeci, Francesca; Brullo, Chiara; Sanità, Patrizia; Delle Monache, Simona; Angelucci, Adriano; Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni; Botta, Maurizio. (2013) A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. ChemMedChem.
  • Tintori, Cristina; Laurenzana, Ilaria; La Rocca, Francesco; Falchi, Federico; Carraro, Fabio; Ruiz, Alba; Esté, José A; Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni; Biava, Mariangela; Brullo, Chiara; Schenone, Silvia; Botta, Maurizio. (2013) Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. ChemMedChem.
  • Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, Adriano; Sanità, Patrizia; Crespan, Emmanuele; Kissova, Miroslava; Maga, Giovanni; Schenone, Silvia; Musumeci, Francesca; Botta, Maurizio. (2013) Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors. ACS Medicinal Chemistry Letters.
  • Moukova, Lucie; Vranova, Vladimira; Slamova, Iva; Kissova, Miroslava; Kuglik, Petr. (2012) Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in Czech Republic. European Oncology and Haematology.

Books

  • Zucca, Elisa; Crespan, Emmanuele; Bertoletti, Federica; Kissova, Miroslava; Maga, Giovanni; Bonavida, Benjamin. (2013) Book title: Molecular mechanisms of tumor cell resistance to chemotherapy. Book subtitle: Targeted therapies to reverse resistance. Chapter title: Two birds with a stone: Molecular cancer therapy targeting signal transduction and DNA repair pathways. Springer Science+Business Media B.V.. 2013. ISBN 978-1-4614-7069-4.