Background
Mohammad Javad Sadeghinia is currently a PhD candidate at NTNU. He has joined the biomechanics group in Spring 2019 after finishing his master's degree in Biomedical Engineering with specialization in BioMechanics at Arts et Metiers ParisTech. He is also a master graduate in Mechanical Engineering from University of Tehran.
Biomechanical Modeling of Barlow Mitral Valve
Barlow disease is characterized by the excess connective tissue, disrupted collagen and elastic layers, and excess acidic mucopolysaccharides. This drastic microstructure alteration is reflected by the more compliant mechanical properties of the diseased tissue. In addition, the Barlow tissue has marked annular dilation and thickened leaflets, distinguishing it from the healthy tissue.
This project aims to properly capture the mechanical behavior changes and represent them alongside the morphological changes in a numerical modeling, suitable for clinical assessment. The project utilizes biaxial mechanical testing with cutting the edge Second Harmonic Generation (SHG) imaging to have an informed material model, reflecting the microstructure of the diseased tissue. This material model with the 4D ultrasound images should provide the basics for a high-fidelity numerical model. The numerical model will eventually enable the planning and optimization of surgical procedure for the Barlow Mitral valve.
Research Group
Biomechanics
Supervisors
Victorien Emile Prot
Bjørn Skallerud
Gerhard Holzapfel
Stig Urheim