Background and activities
Nathalie Jurisch-Yaksi is a group leader at the Department of Clinical and Molecular Medicine at NTNU and an Associate Professor (10%) at the Kavli Institute for Systems Neuroscience.
Her research program aims at understanding cellular and molecular principles regulating the development, physiology and diseases of the nervous system. Her laboratory is particularly interested in one subcellular structure, the cilium, which play both signaling and mechanical functions, and in ependymal cells and astroglia, which are non-neuronal cell types of the brain.
Her team uses the genetically tractable small model organism zebrafish and a combination of techniques including genetics, molecular and cell biology, functional imaging, quantitative behavioral assays and applied mathematics.
The aims of her research program are to:
1. Unravel the cellular, genetic, and biophysical properties of motile ciliated cells
2. Unravel the function of motile ciliated cells in the nervous system
3. Identify the impact of primary cilia in neuronal development
4. Identify the role of astroglia in brain development and physiology
Postdoc: Dr Inyoung Jung
PhD students: Mert Ege, Percival D’Gama and Sverre Myren-Svelstad (co-supervisor)
Medical students: Ahmed Jamali
Technician: Andreas Nygård
Master students: Jakob Stenersen (NTNU Molecular Medicine) and Hina Saif (NTNU Neuroscience)
List of publications: https://scholar.google.no/citations?user=MGQIp3wAAAAJ&hl=en
- NEVR2010 - Introduction to Neuroscience
- NEVR2030 - Condensed Introduction to Neuroscience
- MOL3000 - Introduction to Molecular Medicine
- MOL3100 - Introduction to Molecular Medicine with Project
Scientific, academic and artistic work
A selection of recent journal publications, artistic productions, books, including book and report excerpts. See all publications in the database
- (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell reports. vol. 37 (1).
- (2021) CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images. The European Physical Journal E : Soft matter. vol. 44 (2).
- (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. vol. 70 (1).
- (2021) Past, present and future of zebrafish in epilepsy research. The FEBS Journal.
- (2020) Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis. Science Advances.
- (2020) Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. eLIFE.
- (2020) Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia. Glia.
- (2020) Development: How the Reissner Fiber Keeps Our Back Straight. Current Biology. vol. 30 (12).
- (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. vol. 9.
- (2019) Glia-neuron interactions underlie state transitions to generalized seizures. Nature Communications. vol. 10.
- (2019) Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Current Biology. vol. 29 (2).
- (2019) The role of motile cilia in the development and physiology of the nervous system. Philosophical Transactions of the Royal Society of London. Biological Sciences. vol. 375:20190156.
- (2017) Motile-cilia-mediated flow improves sensitivity and temporal resolution of olfactory computations. Current Biology. vol. 27 (2).
- (2016) Extended structure-activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties. European Journal of Medicinal Chemistry. vol. 107.